709 replies to this topic

[penisbreath]

it's a kappa antagonist

[KieranA001]

it's a kappa antagonist

Oh, that explains a lot. But, it confuses me with Salvia Divinorum though, because that stuff literally got rid of my anxiety straight away it didn't "help" my anxiety, it was just gone. It felt amazing on a low dose. Salvinorin A, which is the main active ingredient in Salvia divinorum is a K-opioid agonist so I don't know how that works. :/ confused.

http://www.ncbi.nlm....les/PMC2721268/

Edited by KieranA001, 05 November 2013 - 03:17 PM.

[socialpiranha]

JDTIc.is is closed. It was the only confirmed source that I knew of. Infact I think he was from medchemexpress

I'm swinging towards Ibogaine.

i thought you had already used ibogaine didnt we compare notes at some point? it's a kappa agonist rather than antagonist...

[addx]

Agonizing KOR causes the fear response to be activated meaning the fear memory schema is "downloaded" to working memory of the conscious for processing the detected threat that caused the fear response to activate.

The fear memory schema settles back after 6 hours in normal humans. You can extinct your fear during that window and cause the memory schema to settle down without the fear component - facilitating succesfull fear extinction.

Salvia only does the KOR agonizing. My idea is that most childhood fears are actually quite silly for adults. But they are long forgotten and subconscious meaning they only cause compulsive behavior and are unable to be extincted. They can not be accessed by the conscious - they can not be downloaded into working memory to have them resettle differently.
Salvia probably forces such memories to get activated and as they are infact silly fears, they are easily extincted once they reach the conscious.

I've seen claims that people experience even preverbal emotional memories on Salvia.

JDTIc.is is closed. It was the only confirmed source that I knew of. Infact I think he was from medchemexpress

I'm swinging towards Ibogaine.

i thought you had already used ibogaine didnt we compare notes at some point? it's a kappa agonist rather than antagonist...

Nope. Only similar thing I took was ketamine. Did you try it?

Edited by addx, 05 November 2013 - 03:24 PM.

[KieranA001]

The only drugs I've tried that are the best for treating my anxiety and depression that has worked the best was kanna. I brought the spray a year ago and I thought it was placebo until I got a 40X extract. This stuff is amazing and really helpes anxiety, not like the others I've tried which are all bogus.

I've had some good anti-anxiety effects with Kratom as well but no where near as anti-anxiety as Kanna.

http://www.ebay.co.u...=item232f76b148

It's legal and it works the best, you can get a smaller pouch if you just want to try it. I wouldn't recommend it with any other form of SSRI or MOAI though.

Edited by KieranA001, 05 November 2013 - 03:27 PM.

[addx]

it's a kappa antagonist

Oh, that explains a lot. But, it confuses me with Salvia Divinorum though, because that stuff literally got rid of my anxiety straight away it didn't "help" my anxiety, it was just gone. It felt amazing on a low dose. Salvinorin A, which is the main active ingredient in Salvia divinorum is a K-opioid agonist so I don't know how that works. :/ confused.

http://www.ncbi.nlm....les/PMC2721268/

It can all work but when used in different ways.

For example, you have LDN "therapy". It's low dow naloxone. Naloxone is a general opioid antagonist, but mostly mu-opioid.

Naloxone causes instant withdrawals(pain, immunity) in opium/heroin users.

LDN therapy consists of using naloxone at very low doses during night. The opioid antagonism causes the body to produce extra opioids to restore homeostasis. This extra opioids supposedly are leaked during the day. So you're deprived during sleep to feel better when awake.

There's different ways one can use agonists and antagonists.

JDTic IMO is infact simply a receptor destroyer rather than an antagonist. It kills/corrupts receptors which is why the effects last as long as 30 days - until the cell grows new ones.

[KieranA001]

it's a kappa antagonist

Oh, that explains a lot. But, it confuses me with Salvia Divinorum though, because that stuff literally got rid of my anxiety straight away it didn't "help" my anxiety, it was just gone. It felt amazing on a low dose. Salvinorin A, which is the main active ingredient in Salvia divinorum is a K-opioid agonist so I don't know how that works. :/ confused.

http://www.ncbi.nlm....les/PMC2721268/

It can all work but when used in different ways.

For example, you have LDN "therapy". It's low dow naloxone. Naloxone is a general opioid antagonist, but mostly mu-opioid.

Naloxone causes instant withdrawals(pain, immunity) in opium/heroin users.

LDN therapy consists of using naloxone at very low doses during night. The opioid antagonism causes the body to produce extra opioids to restore homeostasis. This extra opioids supposedly are leaked during the day. So you're deprived during sleep to feel better when awake.

There's different ways one can use agonists and antagonists.

JDTic IMO is infact simply a receptor destroyer rather than an antagonist. It kills/corrupts receptors which is why the effects last as long as 30 days - until the cell grows new ones.

I would fear scientists making a receptor destroyer that makes you fearless. Can you imagine what the world would be like if everyone took one ? You wouldn't have any survival instincts so how are you suppose to survive. Everyone would be killing everyone, or woudn't care.

[penisbreath]

I would fear scientists making a receptor destroyer that makes you fearless. Can you imagine what the world would be like if everyone took one ? You wouldn't have any survival instincts so how are you suppose to survive. Everyone would be killing everyone, or woudn't care.

Removing fear/anxiety isn't going to suddenly warp your consciousness and turn you into a murderer. You'd still logically be aware e.g. that crossing the road during a surge of traffic is likely dangerous. If it removed fear and affected impulse control, then I could see issues arising (though not on the scale you predict).

Anyway, I'd happily spend the rest of my life devoid of fear instead of being plagued by chronic, irrational, crippling anxiety. It's just as maladaptive and senseless. The fact that there's a compound that could help, yet seems out-of-reach, is so frustrating, given how bad things are for me. I wonder how David Pearce gets his.

Edited by lucky.pierre, 05 November 2013 - 03:54 PM.

[KieranA001]

I would fear scientists making a receptor destroyer that makes you fearless. Can you imagine what the world would be like if everyone took one ? You wouldn't have any survival instincts so how are you suppose to survive. Everyone would be killing everyone, or woudn't care.

Removing fear/anxiety isn't going to suddenly warp your consciousness and turn you into a murderer. You'd still logically be aware e.g. that crossing the road during a surge of traffic is likely dangerous. If it removed fear and affected impulse control, then I could see issues arising (though not on the scale you predict).

Anyway, I'd happily spend the rest of my life devoid of fear instead of being plagued by chronic, irrational, crippling anxiety. It's just as maladaptive and senseless. The fact that there's a compound that could help, yet seems out-of-reach, is so frustrating, given how bad things are for me. I wonder how David Pearce gets his.

Yeah I guess you're right. I don't want to live like this anymore, mainly because of the derealization I have all the time like you're semi-attached to your surroundings. I'm quite calm and have no anxiety but still don't know why I still have it. Let's hope scientists can make something out of salvia. All the time I have this fog in my depth of vision, not literally but that's what it feels like.

Edited by KieranA001, 05 November 2013 - 04:10 PM.

[socialpiranha]

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Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

[KieranA001]

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Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

What is ADDX ? I cannot find it anywhere.

Also, you can "think" differently to make your anxiety go away over time. I think medication would be a good aid though. Perminant would be better but I'd feel more achieved with myself it I get it to go away without the use of full-time medication.

It's like today, I managed to actually go on a bus to attend an interview all because I thought differently, I still do a bit but not as much have social phobia. You just have to feel sorry for people rather than fearing them. If you gain a different perspective over something you can pull yourslef together enough. I still had butterfly's, but I just accepted it and got on with it. Focus on something else like your breathing or get a coping method.

Excersise also helpes a lot, it's good for lowering blood pressure so when you get anxiety which causes your blood pressure to rise due to increased heart rate it wouldn't be as bad. Stay away from sugar and caffeine and MSG etc etc you get the point. Try diaphragmatic breathing and Kanna or rhodiola. They're good but I haven't tried any of the others. Stay away from weed, and try to eliminate gluten out of your diet for a couple of months to see how you feel. Try a detox for your body it will help.

Oh, and don't take rhodiola and kanna together as they both do the same thing apart from in different ways but still not recommended although I have I just took a couple of hours in between doses. Overall I feel more mentally stronger which is hard to say seen as I've never felt like that before. If only school didn't change me in the first place I wouldn't have anxiety. You can try taking D3 10,000mg for a month as well as depression and anxiety can be caused by that.

http://www.iamshaman...nna/medical.htm <----- This is how Kanna works. Just incase you wanted to know.

Edited by KieranA001, 05 November 2013 - 06:45 PM.

[sant2060]

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Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

What is ADDX ? I cannot find it anywhere.

addx is a member of this forum, and socialpiranha is explaining him effects of consuming ibogaine.

Speaking of which, socialpiranha, any long term benefits that you can name?

Edited by sant2060, 06 November 2013 - 12:46 AM.

[penisbreath]

nalmefene is a kappa and mu antagonist and looks like it's (on the verge of?) being released .. is mu antagonism undesirable?

[socialpiranha]

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Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

What is ADDX ? I cannot find it anywhere.

addx is a member of this forum, and socialpiranha is explaining him effects of consuming ibogaine.

Speaking of which, socialpiranha, any long term benefits that you can name?

thanks sant2060 sorry keiran i should have quoted addx....yes there have been many permanent effects but the experience was focused on addiction because that was my most pressing problem at the time i would do it again now that my main focus is anxiety and depression except i don't feel strong enough to go through it right now...its very taxing on the mind and body... i still havent been able to figure out what the experience was, whether it was just a naturally occuring molecule or if it was actually intelligently designed by something that the word god or alien couldnt come close to conveying... the latter was definitely the perception at the time and until i started forgetting parts of the experience...

[socialpiranha]

nalmefene is a kappa and mu antagonist and looks like it's (on the verge of?) being released .. is mu antagonism undesirable?

mu antagonism is dysphoric ..opioid pain killers are mu agonists, so you can imagine the opposite effect...it all depends on the receptor binding affinity and stuff tho it may happen to be a very weak mu antagonist or something i dunno. It could work well with buprenorphine though if the affinities even each other out

Edited by socialpiranha, 06 November 2013 - 05:09 AM.

[penisbreath]

hmm well there's also nor binaltorphimine which is discussed here http://www.longecity...tor-antagonist/

and again, a search brings up far more results for suppliers than JDTic .. but again the problem seems to be with institute-affinity .. how do people organize other group buys? Are there unique suppliers who sell to the public?

[socialpiranha]

i dont think nor b is orally active

[penisbreath]

bummer

[KieranA001]

I think I'm going to try and find a different active version of salvia that will do the same effect apart from the trip. These are all the active salvias.

http://www.drugs-for...ead.php?t=55957

[penisbreath]

socialpiranha, what did buprenorphine do for your symptoms? why did you stop taking it? I know JDTic isn't an opiate agonist, but if bup is a kappa antagonist and you had access to it, why not take that?

[addx]

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Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

So, it was good. I have seen reports of microdosing ibogaine, why don't you try it? I have this planned as the next trial - microdosing ibo. I've seen a person merge their dissociative identities by microdosing over the course of 7 days.

[formergenius]

What about Zyklophin guys? Though the lack of human trials is a bit off-putting, leaving JDtic still the most suitable substance for investigation.
As for Iboga: wow. Trippy stuff. Wouldn't do it again personally, but I had a bad trip of sorts. No long lasting changes IME.

[penisbreath]

I actually managed to bypass the company snag with the JDTic guy I've been in contact with, so he seems cool to send it now .. I'm just waiting to hear back from customs whether it's legal or not in Australia, though I still think it might be best if someone else facilitates.

6k for a gram sounds about right, price-wise, but still can't really assay a scam, since so many scammers from other companies contacted me.

can anyone work out whether www.beyond-pharma.com seems legit?

Edited by lucky.pierre, 06 November 2013 - 12:01 PM.

[socialpiranha]

.
Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

So, it was good. I have seen reports of microdosing ibogaine, why don't you try it? I have this planned as the next trial - microdosing ibo. I've seen a person merge their dissociative identities by microdosing over the course of 7 days.

its funny i was actually thinking about trying microdosing i have a gram of t.a extract left...do you know the dosage that person was taking? Thats amazing that it merged identities but i am not surprised at all...it is by far the most powerful and dynamic substance in the world....and i've tried everything... i know the french used to prescribe ibo hcl as a stimulant in like 10mg dosages or something....if you want a really reliable source let me know man

[socialpiranha]

socialpiranha, what did buprenorphine do for your symptoms? why did you stop taking it? I know JDTic isn't an opiate agonist, but if bup is a kappa antagonist and you had access to it, why not take that?

it alleviated most of my symptoms but its extremely addictive and damaging to the body due to its mu agonism

[socialpiranha]

What about Zyklophin guys? Though the lack of human trials is a bit off-putting, leaving JDtic still the most suitable substance for investigation.
As for Iboga: wow. Trippy stuff. Wouldn't do it again personally, but I had a bad trip of sorts. No long lasting changes IME.

i'm not too stoked about injecting anything and yeah the lack of studies is also a bit concerning...that being said if there were a source i'd probably try it.

[socialpiranha]

www.beyond-pharma.com looks about as legit as any chinese chem company its a risk either way but if they will send a small amount first im in

[penisbreath]

okay, well there's no stock at the moment.. he said it will take 6 weeks to synthesize+send after we place an order, so not sure the best approach ..

either we can wait until there's stock again (he said he will alert me .. but who knows how long that could take), otherwise he said he'll send a sample before he ships the order.

so I don't know what level of commitment is required, i.e. if we order 500mg, ask for a sample and then aren't satisfied .. is their any commitment on our end to purchase?

at this point, it'd probably be a good idea to get a show of hands, so we know how much we need.

[sant2060]

.
Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

So, it was good. I have seen reports of microdosing ibogaine, why don't you try it? I have this planned as the next trial - microdosing ibo. I've seen a person merge their dissociative identities by microdosing over the course of 7 days.

its funny i was actually thinking about trying microdosing i have a gram of t.a extract left...do you know the dosage that person was taking? Thats amazing that it merged identities but i am not surprised at all...it is by far the most powerful and dynamic substance in the world....and i've tried everything... i know the french used to prescribe ibo hcl as a stimulant in like 10mg dosages or something....if you want a really reliable source let me know man

I remember reading somewhere natives in Gabon use it in smaller/micro doses during festivities...
Found it:
http://www.ibogaine....i_bastiaans.pdf

Iboga is used in two different ways in the Bwiti cult. If used in low dosages (four to twenty grams) the Iboga does not cause any
hallucinogen effects, but stimulates and causes euphoria.

Maybe a good indicator to start searching for a usefull range.

[addx]

.
Yes ADDX i took it about a year ago it was the most horrific, beautiful and educational experience of my life, ketamine is like caffeine compared to this stuff it can not be defined by language its like climbing mount everest naked on acid while some super advanced intelligence is systematically reprogramming your brain using sounds and images

So, it was good. I have seen reports of microdosing ibogaine, why don't you try it? I have this planned as the next trial - microdosing ibo. I've seen a person merge their dissociative identities by microdosing over the course of 7 days.

its funny i was actually thinking about trying microdosing i have a gram of t.a extract left...do you know the dosage that person was taking? Thats amazing that it merged identities but i am not surprised at all...it is by far the most powerful and dynamic substance in the world....and i've tried everything... i know the french used to prescribe ibo hcl as a stimulant in like 10mg dosages or something....if you want a really reliable source let me know man

not sure of the dosage, but keep in mind it accumulates, metabolite noribogaine lingers for about 2 months, so start a bit stronger perhaps and then ramp it down to something sustainable. you're on your own here.

i found a guy microdosing for narcissistic peronality disorder, he's been at it a year +.. i think he's on the ebokaworld or something

okay, well there's no stock at the moment.. he said it will take 6 weeks to synthesize+send after we place an order, so not sure the best approach ..

either we can wait until there's stock again (he said he will alert me .. but who knows how long that could take), otherwise he said he'll send a sample before he ships the order.

so I don't know what level of commitment is required, i.e. if we order 500mg, ask for a sample and then aren't satisfied .. is their any commitment on our end to purchase?

at this point, it'd probably be a good idea to get a show of hands, so we know how much we need.

I find it highly suspicious that we need to order 6000 $ worth of it. If he has a stock, why can't he sell smaller quantities?