709 replies to this topic

[addx]

I remember reading somewhere natives in Gabon use it in smaller/micro doses during festivities...
Found it:
http://www.ibogaine....i_bastiaans.pdf

Iboga is used in two different ways in the Bwiti cult. If used in low dosages (four to twenty grams) the Iboga does not cause any
hallucinogen effects, but stimulates and causes euphoria.

Maybe a good indicator to start searching for a usefull range.

Yep, ibogaine will not cause addiction, ever. So microdosing it sounds perfectly reasonable.

I'd rather microdose pure ibogaine-hcl than root bark for long term. Taking something daily you have to make sure it's not toxic. There are many alkaloids in root bark, who knows what they do.

[penisbreath]

I find it highly suspicious that we need to order 6000 $ worth of it. If he has a stock, why can't he sell smaller quantities?

We don't need to. As I mentioned earlier in the thread, I arbitrarily asked the price for a gram because I have no idea how many people are interested.

[penisbreath]

still waiting to hear from customs, but please try let me know soon who's interested. like I said, at 100mcg every 48 hours, 10mg each should last 200 days.

pending there are any issues on my end and someone else facilitates, does anyone know if sending a small amount through customs would be possible?

[penisbreath]

customs just referred me to this list again: http://www.health.go...p-precursor.htm

I can't really tell, but is there anything in the structure that seems to explicitly clash (3R)-7-Hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide ?

I'm willing to take the risk, as long as some discreet method for sending can be arranged .. I mean, a friend was buying MDMA via Silk Road before it got shut down, so it's not like they're impenetrable.

[lammas2]

I'm definately interested.

10 mg is such a small amount, one could easily hide it in some object or toy, the customs probably wouldn't even notice it.

[penisbreath]

okay, whoever's interested, PM me your email address, since we'll have to work out payment details etc. and I can pass it on.

socialp, would you be willing to facilitate?

[celebes]

nalmefene is a kappa and mu antagonist and looks like it's (on the verge of?) being released .. is mu antagonism undesirable?

It would need to bind to KOR longer than MOR for it be usable, which it doesn't. Levallorphan has a useful profile (for chronic administration).

[celebes]

Does anyone know where to get a microgram scale for less than $20000?


socialpiranha: I'd be interested in the ibo hcl. How expensive is it?

[addx]

jdtic-hcl should be water soluble, meaning you can dilute for example 1mg as much as you want.

[penisbreath]

Is everyone still completely convinced about the safety about this stuff? that's my main concern right now, particularly since it might be difficult to get a medical professional to monitor side-effects. any ideas on how it might interact with other drugs, esp. prescription stimulants?

David Pearce (or whoever jdtic.com is run by) mentions "QT intervals need to be monitored in case of any promiscuous hERG binding, a notorious anti-target but most likely not an issue at this dose".

does the long-term binding mean that daily doses would create a cumulative effect, or does it not really work like that?

also, still looking for someone to facilitate. at this point, it could turn out to be a really small order .. 3 or 4 people

[addx]

IMO daily dosing should produce a cumulative effect by all that is written. There are several studies of JDTic pharamacodynamics IIRC. It corrupts receptors and the cells need to grow new ones. IMO this means that a certain dose of JDTic destroys a certain number of receptors, ideally. This is why I'm not really getting the "daily dosing" except as a way to ramp up the effects slowly over time - a way titrating up the does by taking advantage of the accumulation. From what has been written though, the first dose should already produce a noticeable change. Once can easily skip the second day dose or third day dose to see how long it lasts and then just try another dose to see if the plateu rises and again lasts. This doesn't seem like an issue to me.

[penisbreath]

yeah, well 'MDK' microdoses every 48 hours, so maybe it does create a steady plateau. I assume a steady-state would eventually be achieved?

I'm not too well-versed in this stuff, so I apologize, but is the receptor-corrupting property of JDTic distinct from its elimination half-life in the body i.e. akin to an irreversible MAOI like Parnate, which will destroy MAO production for 2 weeks but is listed as having a half-life of 2.5 hours?

the reason I ask is because I wondered if cumulative effects might not just include receptor corruption, but could extend to the arrhythmia produced in trials or the HERG binding mentioned above.

I found this:

JDTic was rapidly absorbed, reaching peak plasma and brain levels within approximately 30 minutes. Mean plasma concentration declined by 37% within 1 hour (p = 0.04), and 77% within 2 hours (p = 0.003). Brain levels were markedly lower than plasma, but the drug was very persistent: mean brain JDTic declined by only 56% over 24 hours, and the drug was still detectable at 1 week. The terminal half-life of approximately 9 days was comparable to the previously reported rate of decline in antagonism.

[celebes]

is the receptor-corrupting property of JDTic distinct from its elimination half-life in the body?

Yes.

[penisbreath]

I posted in the other thread in the Brain Health section that the supplier wants a minimum order of 1g, since it's a custom synthesis, which would mean 30+ buyers.

After summoning immense courage, I asked my GP about buprenorphine today and walked away with a Cymbalta starter pack (even though noradrenergics wreak havoc with me) and a reassurance about all the mood stabilizers I've yet to try.

I'm finding it hard draw the line between a healthy desire for humane treatment and feelings of entitlement, I guess. Is chasing something that will relieve anxiety and anhedonia, even at immense costs/frustration etc., ultimately unproductive and self-entitled? I know I could possibly have some marginal quality-of-life with by-the-book treatment (e.g. Neurontin relieved my anxiety, at the expense of complete brain-fog/dissociation), but as I get older, I find it hard to settle for half-measures anymore. I can't spend any more time feeling braindead, asocial etc. and getting nowhere in life. At this point, I'm considering either faking an addiction or sourcing buprenorphine on the streets to see if the kappa-antagonist route will be helpful.

Maybe this is a discussion for another topic, but it's something I wrestled with a lot this evening, particularly after my GP said (in the 'nicest' way possible) I'm manipulative, narcissistic and need to know my place. I've always been ambitious, had a rogue/non-conformist streak and sought a recovery regime that will enable me, not just numb me.

Edited by lucky.pierre, 14 November 2013 - 01:52 PM.

[socialpiranha]

yeah the answer to that question is totally up to you...in my case i've come to accept that it is slightly entitled but it's not a bad thing, it's the type of entitlement that changes the world for the better. i prefer the word determination or something similar

[addx]

AFAIK bupe is next to impossible to get off of, so you might wanna consider that.

Edited by addx, 15 November 2013 - 12:33 PM.

[penisbreath]

AFAIK bupe is next to impossible to get off of, so you might wanna consider that.

Ideally I'd combine it with ldn a la celebes and try to isolate the kappa-antagonism. Anyway, I would trade an addiction for relief at this point.

[penisbreath]

yeah the answer to that question is totally up to you...in my case i've come to accept that it is slightly entitled but it's not a bad thing, it's the type of entitlement that changes the world for the better. i prefer the word determination or something similar

Yeah, there is a determination involved, absolutely. I can't quite justify as changing the world for the better, since I'm not sure how my happiness would benefit others in any concrete way .. unless I guess you mean the general attitude of being determined and driven?

I suppose my problem is difficulty hearing 'no', accepting less-than-ideal solutions etc. With my last psychiatrist, we had a good relationship so I was more willing to try stuff I was initially against like the atypicals and so on. At this point, and after all this time, I get the sense I know what a mood-stabilizer or SSRI will feel like and don't have to exhaust the arsenal.

I guess there's a lot of OCD-related guilt there.. guilt that my behavior is entitled, if standard treatments are good enough for others why not me? and so on.

[addx]

AFAIK bupe is next to impossible to get off of, so you might wanna consider that.

Ideally I'd combine it with ldn a la celebes and try to isolate the kappa-antagonism. Anyway, I would trade an addiction for relief at this point.

just make sure you don't trade an addiction for nothing.

[penisbreath]

I won't. I'm not going into this foolhardily, and don't even presume I'd get it prescribed yet. Plus, it's clearly not a cure-all -- in an OCD study, improvement average was ~30%.

At this point, I'm just working on procuring a small supply so I can at least see if it's an avenue worth exploring.

[addx]

30% is placebo territory for brain phramacology so...

[tdmonster99]

If you want to pursue KOR antagonism you could try this source for temgesic which is 0.2 mg buprenorphine

http://www.abroadpha...roduct/-98.html

I can't vouch for this pharmacy so I am unsure of its reliability and the price is a little steep.

[tdmonster99]

Another option might be amentoflavone for selective KOR antagonism

http://www.ncbi.nlm....les/PMC2265593/
http://en.wikipedia....i/Amentoflavone

Only sources I could find were alibaba unless you guys want to do a group buy in which case it seems readily available.

[penisbreath]

If you want to pursue KOR antagonism you could try this source for temgesic which is 0.2 mg buprenorphine

http://www.abroadpha...roduct/-98.html

I can't vouch for this pharmacy so I am unsure of its reliability and the price is a little steep.

Thanks for the tip, but I would never be able to successfully import that above-the-table. Currently looking at the deep web -- buprenorphine is relatively abundant and even more costly than that source, but I would hopefully only need a small supply to know if it works.

Edited by lucky.pierre, 19 November 2013 - 08:11 AM.

[celebes]

Again, for the record, Bup on its own will do nothing. It has a higher affinity for MOR than KOR so there won't be any significant kappa antagonism until MOR get saturated at around 2mg.

This doesn't 'risk' addiction, it necessitates it.

[Sciencyst]

People attempting to ameliorate DP/DR and the like need to stay far the fuck away from suboxone.

[JustAMan]

If a jdtic group buy ever gets off the ground, I'm in.

Edited by JustAMan, 26 November 2013 - 02:48 AM.

[hzwe]

If a jdtic group buy ever gets off the ground, I'm in.

Same here.

[formergenius]

List of people who have expressed interest in the group buy so far:
socialpiranha
lourdaud
Cosma
lucky.pierre
lammas2
JustAMan
hzwe
celebes
LetMusicRule
Strangelove
uralsky
meatsauce
addx
KieranA001
formergenius (myself)

and perhaps Here_Now judging from this post.

So that's 15-16 people.. How many people are we aiming for here?

Edited by formergenius, 03 December 2013 - 03:33 PM.

[addx]

i'm still here