12 replies to this topic

[Joe Cohen]

What do you guys think of this?
http://selfhacked.co...hout-taking-it/

[unregistered_user]

I think, nice abs.

[Patrick Sylvester]

the primary method of action behind the eugeroic properties of χdafinil are still not completely understood however that selfhack ignored much about the other mechanisms of modafinil. simply taking curcumin (which has not even the same bio-availability) with dopamine precursors is a gross and misguided attempt at reproducing the eugeroic effects. aside from the dopamine receptor D2, which is cited in the article enough times to recognize it as the cornerstone for this assumption, χdafinil also acts on Noradrenaline, Glutamate, Serotonin and Histamine-Orexin. in order to clear up the brain-fog maybe a lower dose would have fixed everything.

Edited by Patrick Sylvester, 15 June 2013 - 07:12 AM.

[Tom_]

entirely agree with Patrick - the guy is talking bull.

[noos]

Is the curcumin supplement linked really better?
http://www.nutrivene...item.php?id=331

[Metagene]

"Just drink a cup of coffee." lol

- YouTube Modafinil fearmonger.

Jokes aside why didn't he report the effects of his hack?

[Galaxyshock]

Ginseng and Bacopa benchmarked against modafinil

http://www.ncbi.nlm....pubmed/23043278

[Joe Cohen]

Is the curcumin supplement linked really better?
http://www.nutrivene...item.php?id=331

Planta Med 2012; 78 - PH5
DOI: 10.1055/s-0032-1320664
Acute human pharmacokinetics of a lipid-dissolved turmeric extract

• Congress Abstract

Curcumin is a lipophilic compound found in the rhizome of turmeric (Curcuma longa Linn.) that targets several inflammatory and neurological pathways. Dosing of turmeric extract is associated with safety and tolerability in humans, yet literature on its efficacy is limited, possibly due to its low bioavailability in plasma and high rate of metabolism, mainly to glucuronide conjugate. The primary aim of this study was to quantify plasma and red blood cell levels of curcumin by HPLC after ingestion of 40mg curcumin from a lipid-dissolved turmeric extract formulation (SLCP-1) at a dosage of 200mg in healthy human volunteers. The secondary aim of this study was to determine the relationship between plasma and red blood cell (RBC) curcumin in blood samples treated with and without glucuronidase enzyme. An HPLC system (Shimadzu 1100) with PDA detector and C18 column using mobile phase gradient of 0.1% phosphoric acid and acetonitrile was used, as previously published. The mean peak concentration (Cmax) of free curcumin in blood prepared with and without glucuronidase was 48.3 and 39.2ng/mL, respectively, with time of maximum concentration (Tmax) occurring at 6 hours. Most of the curcumin from dosing of the formulation was detected in blood in free form in plasma and RBC fractions. The concentrations of curcumin detected are in the range offering therapeutic impact in various models.

Abstract


Background

Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.
Methods

The present study was conducted in healthy middle aged people (40–60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.
Results

Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.
Conclusion

Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.

[norepinephrine]

One of the defining features of modafinil is its effects generally last all day. You'd be hardpressed to do that with any of the supplements listed in the article.

If you're looking for natural alternatives, CILTEP is still probably the best. Honestly, from a personal perspective neither on their really seem to enhance my cognition to much of a degree, though they certainly allow you to trade in future fatigue for a current energy-surplus.

[BLimitless]

Harmala alkaloids possess similar wakefulness promotion effects to Modafinil but they are a lot smoother on the body and there is no "comedown" per se.

Harmine is your best bet.


Harmala alkaloids hit dopamine D2 receptors I believe, which is responsible for the wakefulness perhaps. They inhibit MAO-B dose dependently, primarily MAO-A, all reversibly so. A dose of 100mg freebase harmala extract provides energy, clarity, focus and attention for 6-8 hours. These are my go-to stimulant, unlike most stims which tax the body, harmalas cleanse the body and move the bowels into action.

So this is one avenue of exploration.

Edited by BLimitless, 16 June 2013 - 12:27 PM.

[Joe Cohen]

Harmala alkaloids possess similar wakefulness promotion effects to Modafinil but they are a lot smoother on the body and there is no "comedown" per se.

Harmine is your best bet.


Harmala alkaloids hit dopamine D2 receptors I believe, which is responsible for the wakefulness perhaps. They inhibit MAO-B dose dependently, primarily MAO-A, all reversibly so. A dose of 100mg freebase harmala extract provides energy, clarity, focus and attention for 6-8 hours. These are my go-to stimulant, unlike most stims which tax the body, harmalas cleanse the body and move the bowels into action.

So this is one avenue of exploration.

Source please?

[Galantamine]

The article listed in the OP is completely asinine. Curcumin, save for certain patented delivery systems, has almost zero bioavailability - even up to 20-30 grams. Tyrosine is subject to numerous feedback mechanisms and rate limiting enzymes.

[Joe Cohen]

The article listed in the OP is completely asinine. Curcumin, save for certain patented delivery systems, has almost zero bioavailability - even up to 20-30 grams. Tyrosine is subject to numerous feedback mechanisms and rate limiting enzymes.

That abstract was referring to the patented longvida curcumin, which nutrivene distributes.