196 replies to this topic

[Nate-2004]

I'm just now discovering this thread. I've been approaching aging from the exact same angle. Attacking from all sides, for at least a year now. It's good to see I haven't been alone in this thinking.

 

A lot of what you're doing is like what examine.com does except with a focus on aging. I have been using Examine as a resource for saving money, so similar motives. I definitely don't want poverty by supplementation either.

 

Buying in obscenely large bulk helps for the ones I plan to stick with.

 

Carnosine is one of them.

 

I'd also noticed you put Rosmarinic Acid on there. That has since come out as an AGE-breaker of some kind that supposedly out performs ALT-711 but no information on what kind of AGEs it breaks. I doubt glucosepane. I'd also heard it gets better bioavailability if it's taken with piperine, somewhat like curcumin. 

[Oakman]

Likewise Nate, where has this been hiding.... Excellent summary of supplementary info... Probably needs updating a bit.... but still excellent effort.

[Logic]

Ye Solarfingeres breezed in here, put his all together in a matter of a month or three, saw a nice improvement in himself and breezed of to carry on with his life!  
I point a lot of people to this thread for a good start in why we age and what can be practically done about it.

He does pop in occasionally and will be looking at Senolytics (Dasatinib, Navitoclax) for some age reversal when he next does so!  

 

[dazed1]

Hi guys, anyone can help me understand the table in the first post?

 

Does rutin offer most benefits on that list, also are the highlighted supplements in the first few rows best and this is the reason for the color?

 

Also what is the conclusion on resveratrol, empty stomach vs empty with vitamin C and Na-rala, vs with food, or food with the mixture of the tree? 

 

And what about empty stomach but with bioperine, would this cause massive irritation since black pepper is terrible in that regard?

Edited by dazed1, 07 November 2017 - 01:17 AM.

[jack black]

Wow! I just saw this (thanks for the person before me bumping it up). Very helpful. I'm taking 17 supplements already that are on the list. Good for me (self study and self observation).  I used to take low dose aspirin and then I got gout. Aspirin is known to precipitate gout and it's no fun for sure. especially when the attack catches you traveling overseas and you suddenly can't walk anymore. Be aware.

[dazed1]

Aspirin is very hard on the kidneys, i hurt mine with it......

[markmsb]

I'm surprised there isn't much talk about Purslane (Portulaca oleracea). A plant rich in omega 3's and is thought to be one of the several supplements that extend telomerase. Maybe when the list was created it wasn't well known?

[dazed1]

Hi guys, anyone can help me understand the table in the first post?

 

Does rutin offer most benefits on that list, also are the highlighted supplements in the first few rows best and this is the reason for the color?

 

[markmsb]

From what I gather the substances aren't listed in any certain order of importance.

[dazed1]

So the last 3 supplements are equally effective as the first rows if their stats are same? example they got same A/3 rates?

[dazed1]

Also is 3 best results and A as well? or 1 and C?

[markmsb]

They key(guide) is at the bottom of the table.

[markmsb]

This was such a well discussed and informative thread. I'd hate to see it die out. I'm sure we can get the discussion going again somehow.

[Kimer Med]

I like and appreciate the idea and approach of the OP.

 

Regarding the specific supplement choices, though, there are a few on the list that, after considerable research, I wouldn't want to take on a regular basis for the long term:

 

-- Aspirin

-- Milk Thistle

-- IP6 (binds zinc)

-- SAMe (with the wrong genetics, it can cause excessive methylation, including high homocysteine)

-- Quercitin

 

I guess one challenge is how to narrow the list to something effective, while at the same time accounting for individual variations in genetics, environment and overall nutritional and health status.

 

Personally, I use lab tests to help get me pointed in the right direction -- things like 23andMe with SNP analysis, organic acids and whole blood minerals -- but even so, with the current state of the art, it's still challenging.

 

[GABAergic]

the table at the start of this thread is quite outdated, its been 6 years since. anyone has any ideas of how the table holds on today??

AceNZ, why wouldnt you take milk thistle regularly long term? i understand about the others, but this one confuses me. from studies, it shows long term supplementation is likely beneficial for the liver, but not short term.

[Kimer Med]

AceNZ, why wouldnt you take milk thistle regularly long term? i understand about the others, but this one confuses me. from studies, it shows long term supplementation is likely beneficial for the liver, but not short term.

 

First, Milk Thistle (silymarin) has a pretty broad side-effect profile, due in part to its interference with Cytochrome P450 (an important detox enzyme):

 

https://www.stylecra...f-milk-thistle/

 

In addition, although the research shows it can benefit people with liver disease, it actually may not be useful if you have a healthy liver:

 

http://www.berkeleyw...ver-supplements

 

Used in cancer treatment, silymarin can increase apotosis (cell death) by weakening mitochondrial membranes. While perhaps useful if you have cancer, that's probably not an effect you would want for the long term:

 

https://www.ncbi.nlm...pubmed/19317806

[GABAergic]

well i have been taking it regularly not just for liver health but for me, it lowers my blood sugar a lot after each meal. it feels pretty good actually. im not actually using basic extract, but 10:1 extract made by Indena which is high quality and much more potent. although from what you posted i may consider taking it regularly in the future. i dont see the point long term. thanks for studies