161 replies to this topic

[Geoff1892]

Are you following a specific protocol? I thought only one single dose was needed?

Hey John,

Although it looks like I recently joined longecity, I actually have an old profile that no longer works. I still get notifications everyone writes on topic i follow. My name was “Madhacker”, and you can see my posts above.

I’m going to do you a favour in what you’re looking for on this topic and save you a lot of time. I’ve had HPA dysfunction for over a decade and I tried to hack it on my own. Spent tons of money and caused myself more problems than not. I tried Mifepristone, spent a fortune on the stuff, only to have it fail on me. I will start by saying you should not waste your time on this stuff because HPA dysfunction can be degenerative and you’re on HRT. If you want to stop taking TRT and HGH and take this shit for your HPA dysfunction it still will not work.
I have a few questions, how do you know the amphetamines caused damage? Do you have labs showing it’s primary or secondary problems? Are you producing to much ACTH indicting a secondary or is the gland not producing enough ACTH?
At 1iu hgh suppresses ACTH by up to 30% after a month of treatment. After 6 months are participants show suppression of ACTH by at least 30%. TRT suppresses cortisol in the long run as well.

In your case first I would find out the problem, primary or secondary. Second if you are to stay on HRT (which you should) you should consider taking 0-2mg of growth hormone with 0-.5mg of IGF. (Lower the dose by 10x for IGF LR3.) You should have your IGF levels up to at least 300 but to do that you have shown that you need to take to high of a dose. Take thyroid, testosterone, progesterone, melatonin, and other hormones to optimal ref. ranges.
Those are the basics... Now you need to raise cortisol and get a rhyme.
1) pregnenolone at least 100mg
2) pregnenolone 50mg and 20mg of progesterone
3) take LDN. Takes weeks to stimulate the pituitary.
4) take adrenal Cortex or hydrocortisone

Cortisol is more important than you think. If it’s not in optimal ranges you increase your risk of mortality by 30%.
Also watch the Anabolics many block cortisol signaling as they compete with androgen receptors. Look into every single on before taking it to see if it does that before deciding on one. I wish I had.

[John250]

Hey John,

Although it looks like I recently joined longecity, I actually have an old profile that no longer works. I still get notifications everyone writes on topic i follow. My name was “Madhacker”, and you can see my posts above.

I’m going to do you a favour in what you’re looking for on this topic and save you a lot of time. I’ve had HPA dysfunction for over a decade and I tried to hack it on my own. Spent tons of money and caused myself more problems than not. I tried Mifepristone, spent a fortune on the stuff, only to have it fail on me. I will start by saying you should not waste your time on this stuff because HPA dysfunction can be degenerative and you’re on HRT. If you want to stop taking TRT and HGH and take this shit for your HPA dysfunction it still will not work.
I have a few questions, how do you know the amphetamines caused damage? Do you have labs showing it’s primary or secondary problems? Are you producing to much ACTH indicting a secondary or is the gland not producing enough ACTH?
At 1iu hgh suppresses ACTH by up to 30% after a month of treatment. After 6 months are participants show suppression of ACTH by at least 30%. TRT suppresses cortisol in the long run as well.

In your case first I would find out the problem, primary or secondary. Second if you are to stay on HRT (which you should) you should consider taking 0-2mg of growth hormone with 0-.5mg of IGF. (Lower the dose by 10x for IGF LR3.) You should have your IGF levels up to at least 300 but to do that you have shown that you need to take to high of a dose. Take thyroid, testosterone, progesterone, melatonin, and other hormones to optimal ref. ranges.
Those are the basics... Now you need to raise cortisol and get a rhyme.
1) pregnenolone at least 100mg
2) pregnenolone 50mg and 20mg of progesterone
3) take LDN. Takes weeks to stimulate the pituitary.
4) take adrenal Cortex or hydrocortisone

Cortisol is more important than you think. If it’s not in optimal ranges you increase your risk of mortality by 30%.
Also watch the Anabolics many block cortisol signaling as they compete with androgen receptors. Look into every single on before taking it to see if it does that before deciding on one. I wish I had.

I had a 4 part saliva cortisol test and all my levels were normal. I never had ACTH tested though I’ll do that next. I have a feeling my adrenal issues are amphetamine related. It may not even be adrenals it may be I’m just so burnt out from them. Maybe I’ll just get this test done to rule it out.

https://www.walkinla...blood-test.html

[Geoff1892]

I had a 4 part saliva cortisol test and all my levels were normal. I never had ACTH tested though I’ll do that next. I have a feeling my adrenal issues are amphetamine related. It may not even be adrenals it may be I’m just so burnt out from them. Maybe I’ll just get this test done to rule it out.

https://www.walkinla...blood-test.html

 

If you're cortisol is okay, you're adrenals should be okay but keep us posted on your ACTH. 

What are your symptoms? 

 

[John250]

If you're cortisol is okay, you're adrenals should be okay but keep us posted on your ACTH.

What are your symptoms?

Symptoms are extreme fatigue and less I’m flooded with amphetamines.

Anxiety, depression, and major major procrastination

[Geoff1892]

Symptoms are extreme fatigue and less I’m flooded with amphetamines.

Anxiety, depression, and major major procrastination

Have you seen an integrative doctor, how’s your thyroid levels? Your T3 levels aren’t in the upper 75th percentile.
Is your fatigue worse when resting? Is it harder to get up and going after sitting or resting?
If you have all day fatigue cortisol, dopamine or other neurotransmitters should be looked into. Unless it’s more unlikely problems such as mitochondrial.

[John250]

Have you seen an integrative doctor, how’s your thyroid levels? Your T3 levels aren’t in the upper 75th percentile.
Is your fatigue worse when resting? Is it harder to get up and going after sitting or resting?
If you have all day fatigue cortisol, dopamine or other neurotransmitters should be looked into. Unless it’s more unlikely problems such as mitochondrial.

Thyroid was always good with T3 being in the upper range but still in range and a normal TSH and other thyroid values. That was with and without HGH. Fatigue is not worse when resting it’s pretty much the same. I find at night I get more energy so I think my circadian rhythm is off.

[Izan]

This is incredible stuff. Can Nyles get this in powder form for us?

[FitnessMike]

Hi All, im currently on my 4th day of mifepristone for insomnia caused by chronic stress, how long after stopping mifepristone should see difference?

 

[jacobjerondin]

Hi All, im currently on my 4th day of mifepristone for insomnia caused by chronic stress, how long after stopping mifepristone should see difference?

 

I'm following your trial of mifepristone with great interest since I have been suffering from horrendous, life destroying constant stress from my HPA axis becoming incredibly hypersensitive. By the way, this happened from me significantly undereating for a year and a half, then overeating and eating bad meal replacement powders as a response for another year and a half, along with a massive phenibut withdrawal that I went thru far too quickly, in case anyone is interested.

 

How has the mifepristone worked out for you now that you stopped it (I assume?). Also, do you have any other issues aside from insomnia? Personally, I've had massive metabolic dysregulation/insulin resistance, sweating issues, extreme hunger, lack of concentration/inability to relax, anhedonia, and many other things. If you have any of those, I'd love to hear if mifepristone helped with them, if at all. I'm hoping it can help me significantly since I've seen all kinds of doctors and the like and none of them know what to do.

Edited by jacobjerondin, 17 March 2020 - 08:46 PM.

[FitnessMike]

I'm following your trial of mifepristone with great interest since I have been suffering from horrendous, life destroying constant stress from my HPA axis becoming incredibly hypersensitive. By the way, this happened from me significantly undereating for a year and a half, then overeating and eating bad meal replacement powders as a response for another year and a half, along with a massive phenibut withdrawal that I went thru far too quickly, in case anyone is interested.

 

How has the mifepristone worked out for you now that you stopped it (I assume?). Also, do you have any other issues aside from insomnia? Personally, I've had massive metabolic dysregulation/insulin resistance, sweating issues, extreme hunger, lack of concentration/inability to relax, anhedonia, and many other things. If you have any of those, I'd love to hear if mifepristone helped with them, if at all. I'm hoping it can help me significantly since I've seen all kinds of doctors and the like and none of them know what to do.

hi mate, well i have had blood sugar imbalances also which shows as hungers or high blood sugar at night, i had to completely clean diet eating only whole foods including oats nut butters seeds nuts eggs quinoas brown rices etc etc, had to stop eating even fruits as they would cause my blood sugar to spike at night and make me feel super hot etc. In my case the only problem was insomnia as a cause of occasional spikes in stress hormones, antidepressant amitryptyline helped with blood sugar imbalances and with sleep to some point, but its really difficult as i was abusing coffee for like 10 years among other stressors, i also had to quit gym because even low intensity resistance trening was causing setback in healing as i start piss every hour at night, last time i ate pizza which i never do and started pissing whole night lol. So i dont know what are your main problems but cleaning diet, eating frequently try maybe amitryptyline which u can get of united pharmacies, good luck.

[jacobjerondin]

hi mate, well i have had blood sugar imbalances also which shows as hungers or high blood sugar at night, i had to completely clean diet eating only whole foods including oats nut butters seeds nuts eggs quinoas brown rices etc etc, had to stop eating even fruits as they would cause my blood sugar to spike at night and make me feel super hot etc. In my case the only problem was insomnia as a cause of occasional spikes in stress hormones, antidepressant amitryptyline helped with blood sugar imbalances and with sleep to some point, but its really difficult as i was abusing coffee for like 10 years among other stressors, i also had to quit gym because even low intensity resistance trening was causing setback in healing as i start piss every hour at night, last time i ate pizza which i never do and started pissing whole night lol. So i dont know what are your main problems but cleaning diet, eating frequently try maybe amitryptyline which u can get of united pharmacies, good luck.

 

Thanks for the super quick response man, I assume since you're prob under a lot of stress constantly it would be fair to say that you have anxiety/lack of concentration/stress issues as well?

 

Yes cleaning up your diet is incredibly important, I would say fruit making you super hot isn't necessarily a bad thing as temperature tends to be associated with metabolic health (when food makes me super hot I tend to feel great, most of the time I'm pretty cold), however spiked blood sugar for extended periods is never good. I used to have really bad blood sugar issues as well but I cut down on carbs significantly and just eat massive amounts of protein now because it's the only thing that can shut down my hunger/satiate me, without that I can't relax, sleep decently, or be myself at all. It's not an ideal way to eat for long term health by any means as I believe in accordance with ray peat's thinking that carbs (meaning fruit, not starch generally) are incredibly important for a healthy metabolism. However my metabolism is far from healthy rn so I need to eat differently from most to adjust for it.

 

I don't believe *amitriptyline* would help me because I'm incredibly sensitive to anything that boosts norepinephrine (since it's very stressful on the body) and that's partially a NRI but it's interesting that it works for you, I wonder what the mechanism is.

 

I saw your response on reddit by the way, thanks for that too. So it sounds like you haven't noticed any improvements yet really? If it's a couple days since you finished your cycle I really think any improvements would've shown up by now but I guess it depends on the half life. Definitely please update us on whether you notice any improvements in any of the issues I mentioned in a couple more days.

[FitnessMike]

Thanks for the super quick response man, I assume since you're prob under a lot of stress constantly it would be fair to say that you have anxiety/lack of concentration/stress issues as well?

 

Yes cleaning up your diet is incredibly important, I would say fruit making you super hot isn't necessarily a bad thing as temperature tends to be associated with metabolic health (when food makes me super hot I tend to feel great, most of the time I'm pretty cold), however spiked blood sugar for extended periods is never good. I used to have really bad blood sugar issues as well but I cut down on carbs significantly and just eat massive amounts of protein now because it's the only thing that can shut down my hunger/satiate me, without that I can't relax, sleep decently, or be myself at all. It's not an ideal way to eat for long term health by any means as I believe in accordance with ray peat's thinking that carbs (meaning fruit, not starch generally) are incredibly important for a healthy metabolism. However my metabolism is far from healthy rn so I need to eat differently from most to adjust for it.

 

I don't believe *amitriptyline* would help me because I'm incredibly sensitive to anything that boosts norepinephrine (since it's very stressful on the body) and that's partially a NRI but it's interesting that it works for you, I wonder what the mechanism is.

 

I saw your response on reddit by the way, thanks for that too. So it sounds like you haven't noticed any improvements yet really? If it's a couple days since you finished your cycle I really think any improvements would've shown up by now but I guess it depends on the half life. Definitely please update us on whether you notice any improvements in any of the issues I mentioned in a couple more days.

Hi, in regards to getting hot at night it wad related to high blood sugar, if i eat any high sugar fruit during the day, this is what happens. In regards to amitryptyline yes i had problem with adjusting it and it was fucking with my sleep further initially but i dont quit quickly and bought 10mg pills and got my body to uset to it then i could take even higher dosages without any sleep deterioration, thing is that it will calm hpa axis somehow from what i know, and it would explain why it helped with my low blood sugars at night etc. It was my last night of mifepristone but it can supposed stay up to 72h in system, night wasnt relay improved and as usually i had to wake up like every 2-2,5 h to pee, but what i noticed before started taking mifepristone that just off gym and taking amitryptyline before bed was slowly im-proving me, will see if in few days will change when my body will get rid of mifepristone. In respect to any anxiety etc no i dont have this stuff, my problem was usually sleep deprivation etc as i was getting 4-5g at max with breaks for urinating every one or one and half sleep cycle, but i dont have apparently predispositions to mental health problems because long time ago i would get nuts from all this sleep im getting :D ,  i just wish to find way to get a  bit better sleep so my body can have more of regeneration at night and it would heal it self over time but i have tried loads of stuff and there are stuffs like PS/seriphos which are good but you build tolerance quickly.