3 replies to this topic

[Sunwind]

In my early days of learning about nootropics I read in quite a few places that I absolutely can not find now, that said consuming too much can cause depression. so my question is, is this actually the case? Why does that happen?

How much is too much will obviously depend on the person and what cholinergics they're taking, but is there a rough guide to how much you shouldn't go over per day?

Is the excess not simply excreted from the body, is it harmful if you have too much floating around up there in your brain?

I also recall something about only certain sources causing it, while Citicoline does not, is there any truth to this? I can't find anything about this no matter how hard I look.

Edited by Sunwind, 29 June 2013 - 08:58 PM.

[KoolK3n]

The hypothesis is that the excess choline triggers a reduction in other neurotransmitters. Evidence suggests chronic levodopa "depletes" serotonin concentrations while chronic 5HTP treatment "depletes" dopamine levels. SSRIs may deplete dopamine. Tyrosine may deplete serotonin eventually. Maybe the same is true with acetylcholine depleting serotonin for example? Targeting just one neurotransmitter generally isn't recommended. The system needs to be looked at as a whole. Drugs like BPAP look extremely attractive because it raises both serotonin and dopamine synthesis without one negatively interfering with the other. This thinking is highly oversimplified though and the system is much more complicated than that.

[Ukko]

The hypothesis is that the excess choline triggers a reduction in other neurotransmitters. Evidence suggests chronic levodopa "depletes" serotonin concentrations while chronic 5HTP treatment "depletes" dopamine levels. SSRIs may deplete dopamine. Tyrosine may deplete serotonin eventually. Maybe the same is true with acetylcholine depleting serotonin for example? Targeting just one neurotransmitter generally isn't recommended. The system needs to be looked at as a whole. Drugs like BPAP look extremely attractive because it raises both serotonin and dopamine synthesis without one negatively interfering with the other. This thinking is highly oversimplified though and the system is much more complicated than that.

Guys, go check this recent thread on this exact topic: http://www.longecity...mb/#entry596373

[Sunwind]

The hypothesis is that the excess choline triggers a reduction in other neurotransmitters. Evidence suggests chronic levodopa "depletes" serotonin concentrations while chronic 5HTP treatment "depletes" dopamine levels. SSRIs may deplete dopamine. Tyrosine may deplete serotonin eventually. Maybe the same is true with acetylcholine depleting serotonin for example? Targeting just one neurotransmitter generally isn't recommended. The system needs to be looked at as a whole. Drugs like BPAP look extremely attractive because it raises both serotonin and dopamine synthesis without one negatively interfering with the other. This thinking is highly oversimplified though and the system is much more complicated than that.

Guys, go check this recent thread on this exact topic: http://www.longecity...mb/#entry596373

you mean the topic with no actual answers whatsoever and is full of bloated other irrelevant crap about stack advice?

Edited by Sunwind, 30 June 2013 - 06:34 AM.