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How to extend the anxiolytic effects of Magnesium ?

magnesium anxiety

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#1 BlueCloud

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Posted 09 July 2013 - 11:15 PM


Of the multitude of things I've tried through the years for my anxiety, Magnesium was one of the few that had an effect ( Buspirone is one of the few others , but very hit-or-miss from one day to the other, sometimes just leaving me with strong nausea and nothing else )

I tried all forms of Mag ( including Threonate ), and the most effective were Citrate and Glycinate. I've been taking the latter form for quite a while, and upon a dose of 400mg ( yes I need that much to feel anything ), I can usually feel a distinct reduction in both muscular tension ( also facial tics ), and mental anxiety , with very little impact on my cognitive performance ( very important ), 15 to 20 minutes after dosing.

However , I found the effect to be very short-lived, lasting barely over an hour. I need to dose several times a day, and I try not to exceed more than 800mg/1000mg per day, although Mag seems to have very little toxicity.
I usually take it on empty stomach for maximum effect.

Is there a way to extend the length of the anxiolytic effect of Magnesium ? Is there such thing as a slow-release Magnesium ( couldn't find any on iHerb ) and has anyone used it succesfully ?

Edited by BlueCloud, 09 July 2013 - 11:17 PM.


#2 Doktor

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Posted 10 July 2013 - 01:42 AM

Hmmm... Unless I take minimum 600mg of magnesium at once, I get no effects (and they could still even be placebo at this level). 800mg is a little more noticeable, and a gram seems to have definite - yet still mild - effects. Honestly, magnesium works much better as a muscle relaxant for me, and I think some of it's anxiolytic effects are probably derived from this; a relaxed body could definitely lend itself to a relaxed mind.

I doubt you could extend magnesium's effects... you should read into exactly how magnesium produces its effects, what limits/diminishes them over time, and then figure out a way to inhibit this mechanism. However, I am doubtful that you will be successful with this... magnesium is such a basic supplement, I'm not sure how much you could do with it really.

Here's the real question however: Why?! Magnesium is CHEAP! Compared to many supplements it costs basically nothing. So I guess my advice to extend magnesium's effects would be: take more magnesium.

Also, I don't think there is extended release magnesium... but there is more magnesium... and did I say it's cheap? :P

Edited by Doktor, 10 July 2013 - 01:43 AM.


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#3 BlueCloud

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Posted 10 July 2013 - 09:04 PM

. So I guess my advice to extend magnesium's effects would be: take more magnesium.


400mg every hour X 9 hours = 3600mg per day... mmm...

#4 Strelok

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Posted 11 July 2013 - 12:31 AM

Also, I don't think there is extended release magnesium...

Actually the magnesium malate that I take is time-released, and that's why I buy it specifically. It's made by JigSaw: http://www.jigsawhea...ments/magnesium

If you search around or wait for one of their 20% or 25%-off coupons, the price ends up being very competitive.

#5 norepinephrine

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Posted 11 July 2013 - 03:57 AM

Try it transdermally.

#6 Introspecta

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Posted 12 July 2013 - 09:19 PM

There is no problem taking 4 grams of magnesium a day. I think i've read some literature that say to dose 1-2 grams at a time. Not sure why you are afraid to take a little more. Transdermally would probably be the best bet though. Check out http://www.earthshif...rchResults.aspx I think they give free shipping for new customers.

I've tried a few different topicals and this one seems great. Its only about 10 bucks for the bottle. The guy that runs the site is really anal about purity of products. Big naturopath guy so I feel like the oil is high quality. Its always hard to say if some is psychosomatic but I actually felt really relaxed after using it and never felt much effect from other oils.

#7 norepinephrine

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Posted 12 July 2013 - 09:33 PM

4g of magnesium not being a problem assumes that you don't have gastrointestinal distress at that dosage. If you do, you're effectively receiving a net loss of magnesium levels.

Having taken high oral doses in the past with great short-term results only to have them reverse and start causing the exact things magnesium supplementation is supposed to treat, I would caution against dosing far above the RDA over the long-term.

No idea if any literature exists to ascertain whether the body has a better way of regulating transdermal magnesium in comparison to oral, though. With that said, I'm having mixed results on spraying magnesium chloride (the form in 'oil') vs. my homemade runs with transdermal magnesium sulphate or storebought magnesium hydroxide. YMMV, but good old Epsom salts have a pretty good track record for effective absorbsion.

#8 mrvontar

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Posted 15 July 2013 - 12:44 AM

I'm guessing you're taking this because you don't like the effects of other GABA precursors? If you're not then try phenibut, magnolia oak bark extract, and l-theanine.

#9 BlueCloud

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Posted 15 July 2013 - 06:03 PM

I'm guessing you're taking this because you don't like the effects of other GABA precursors? If you're not then try phenibut, magnolia oak bark extract, and l-theanine.


I tried Phenibut, it was horrible... Magnolia and Theanine ( both Suntheanine and "regular" form ) were pretty much useless for me , at any dose...

#10 Joni A Solis

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Posted 12 August 2013 - 06:46 PM

but good old Epsom salts have a pretty good track record for effective absorbsion.


Can you point me to some of the places online that talk about the absorbsion of Epsom salt because I just read...

"There's even decent evidence that Epsom salts can't even get past the skin barrier — Israeli soldiers can smear on magnesium rich cream without the slightest effect on their blood levels of magnesium. That's pretty damning."

Sorry, but I am new here and can not post links yet so I broke the link:
saveyourself. ca/ articles/ reality-checks/ epsom-salts. php

#11 Strelok

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Posted 12 August 2013 - 06:48 PM

I especially like combining Ashwagandha with my magnesium.

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#12 canz

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Posted 16 September 2013 - 11:56 PM

Do you all ever experience rapid pulse from high doses of magnesium? I recently started taking 200mg x 2 daily and I experienced rapid pulse. According to my research this is caused by an imbalance of calcium to magnesium? I am trying to figure this out because it makes me feel very relaxed and in a great mood, but the rapid pulse makes me a little anxious and uncomfortable. I'm trying to figure out if I need to add calcium, or if I will get used to it.





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