450 replies to this topic

[Chadwick]

Ok, so I've been in this "state" while in college.  Oh how the sunday hangovers allowed me to be so productive.  I Identify with this thread so much...Anyways, tetrahydrobiopterin is a major player in this.   I just came here to say you need to try Liposomal Vitamin C + your flavanoid of choice.  The Liposomal vitamin c stimulates BH4 creation somehow through hydrogen peroxide (isn't hydrogen peroxide bad).  The flavanoid is necessary to ''couple" the endothelial system and promote enos.  Without enough BH4 you don't produce enough enos, and create inos and peroxynitrite instead. 

ANYways you guys need to definitely try liposomal vitamin c with your flavanoid of choice. Let me know what you think.Cheers

 

I've personally stopped using the BH4 supplement I was using before due to costs and storage difficulties. Nowadays I use a combo of hydroxy-B12 (250 mcg once a day), methylfolate (200 mpg 3 times a day) and vitamin C (1000 mg 2 times a day) instead. The vitamin C seems to make a big different in the way that I have more energy, motivation and it's easier for  me to socialise on the days I take it. I use regular vitamin C though, not the liposomal version and without any flavonoid.

[Helllllo]

If I used methyl folate with hydroxy a couple of days in a row and nothing happened. Could I assume that bh4 was not my problem? Also, what flavanoid suits best?

[christianme]

IDK. If you feel "good" during a hangover, the best way I can try to recapture that is by trying Resveratrol (it stimulates the formation of endogenous bh4)  an nadph inhibitor. (without affecting methylation)  I use flax seed oil.   I've never used spirulina but been wanting to.  Alcohol does something to the NAD pathway, cant remember what. Take some vitamin c for good measure. Vitamin c regenerates bh2 back to bh4.  Peroxynitrite oxidizes bh4 to bh2.  I think I read somewhere that the ratio of bh4 to bh2 matters for proper endothelial function.  

 

 

 

[Helllllo]

So could 1000mg of lipsomal vitamin c, a couple of cubes of 70% cocoa chocolate and a sip of flax seed oil be a good protocol to gauge wether this helps?

[Helllllo]

and maybe a 500mg of resveratrol?

[Golodnyy]

 

Ok, so I've been in this "state" while in college.  Oh how the sunday hangovers allowed me to be so productive.  I Identify with this thread so much...Anyways, tetrahydrobiopterin is a major player in this.   I just came here to say you need to try Liposomal Vitamin C + your flavanoid of choice.  The Liposomal vitamin c stimulates BH4 creation somehow through hydrogen peroxide (isn't hydrogen peroxide bad).  The flavanoid is necessary to ''couple" the endothelial system and promote enos.  Without enough BH4 you don't produce enough enos, and create inos and peroxynitrite instead. 

ANYways you guys need to definitely try liposomal vitamin c with your flavanoid of choice. Let me know what you think.Cheers

 

I've personally stopped using the BH4 supplement I was using before due to costs and storage difficulties. Nowadays I use a combo of hydroxy-B12 (250 mcg once a day), methylfolate (200 mpg 3 times a day) and vitamin C (1000 mg 2 times a day) instead. The vitamin C seems to make a big different in the way that I have more energy, motivation and it's easier for  me to socialise on the days I take it. I use regular vitamin C though, not the liposomal version and without any flavonoid.

 

You did decrease Hb12 dose because low dose Hb12 is enough? Any sides effects of excess Hb12 ?

[jack black]

I've personally stopped using the BH4 supplement I was using before due to costs and storage difficulties. Nowadays I use a combo of hydroxy-B12 (250 mcg once a day), methylfolate (200 mpg 3 times a day) and vitamin C (1000 mg 2 times a day) instead. The vitamin C seems to make a big different in the way that I have more energy, motivation and it's easier for  me to socialise on the days I take it. I use regular vitamin C though, not the liposomal version and without any flavonoid.

 

 

Chadwick, thanks a lot for coming back and giving updates. I went through all the 11 pages of this thread like a fiction book with several different plots (while taking notes) and I was kept in suspence not knowing how it would end up. Sounds like it was a happy end for some but not for others. Turns out people who got here together with a common symptom (hangover high) are diverse with different issues and solutions. Welcome to personalized medicine.

 

Here is my story. I don't have a hangover high. I came here while doing a search on my 23andMe results that I tried to make sense of. The explanation on 5MTHF vs dopamine Chadwick gave on the page 3 is superb. Even though I have a different set of SNPs that shouldn't make me low in dopamine, but makes me low in BH4, so I went ahead and tried methylfolate (low dose of 400ug) combined with cyancobalamine (50ug, part of Swanson's B50 complex that I have been taking for a while with some minor but noticeable effect). That clearly was beneficial giving me a noticeable boost in energy and concentration (I suspect I have adult ADHD, never properly diagnosed or treated). Recently I added SAM-e and that gave me even more energy, but after a few days it feels like too much methylation and I need to skip a dose or 2 (of either methylfolate or SAM-e).

 

Here is my question. In USA, hydroxy-B12 is harder to get as cyancobalamine is the more popular option. Should cyancobalamine and hydroxy-B12 be equivalent in action or should I get the hydroxy-B12 to get full benefit from the Chadwick's protocol?

Edited by jack black, 27 June 2016 - 10:02 PM.

[YOLF]

Just a though.... probably not related, but when I was still eating gluten, I'd either get very sick or feel wonderful after binge drinking due to my body's response in the morning. Try removing gluten?

[Golodnyy]

Best Type of B12 based on COMT V158M and VDR Taq SNPs

Best Type of B12 based on COMT V158M and VDR Taq SNPs

COMT V158M VDR Taq B12 types that should be tolerated

– – ++ (TT) All three types of B12

— +- (Tt) All three types with less methyl B12

— — (tt) Hydroxy B12 and Adenosyl B12

+- ++ All three types with less methyl B12

+- +- Hydroxy B12 and Adenosyl B12

+- — Hydroxy B12 and Adenosyl B12

++ ++ Hydroxy B12 and Adenosyl B12

++ +- Hydroxy B12 and Adenosyl B12

++ — Mostly Hydroxy B12

 

 

Important information about B12 form. 

http://mthfrliving.c...-for-mthfr-b12/

 

So, Hydroxy B12 is the most multipurpose form.

Edited by Golodnyy, 11 July 2016 - 06:55 AM.

[jack black]

So, Hydroxy B12 is the most multipurpose form.

 

 

I understand that. My question was about cyancobalamine

[.Moose.]

Okay so this is interesting. A couple of us have been wondering recently, assuming we have the same problem as Chadwick, why we wouldn't have any reaction to supps like Methyl Folate that made such a difference for him. And then all the stuff about NMDA seemed like a massive curveball and weird that peeps were seeing improvements there.

 

 

So, two recent discoveries that might address these issues:

 

-the transsulfuration pathway/ CBS can disrupt BH4 levels (as involved in breaking down ammonia?) and apparently (looking for source) methylfolate can be useless unltil any transsulfuration issues are addressed

 

-THIS. http://forums.phoeni...-receptor.1460/ "Anxiety, Ammonia, and the NMDA Receptor."

 

 

So the fact myself and the other guy have high cysteine and likely sulfur intolerance respectively, plus his very positive reaction to FIR saunas (thought to assist ammonia breakdown, hence boosting BH4 http://www.ncbi.nlm....ubmed/1845745),and benefitting from Sarcosine (NMDA) is interesting as they all heavily suggests ammonia/transsulfuration issues, right? I mean it's a problem with BH4 production, but potentially a different problem to that of Chadwick's?

 

Extremely excited to find out, hopefully someone else will find that thinking out loud useful 

Edited by .Moose., 13 July 2016 - 12:26 AM.

[.Moose.]

Furthemore, sarcosine and glycine (NMDA modulators talked about here for their benefits) both somehow interact with ammonia http://www.ncbi.nlm....pubmed/11542465 so I'm really hoping transulfuration could be the missing link between BH4/ methylfolate and NMDA talk?

 

 

Edited by .Moose., 13 July 2016 - 12:42 AM.

[.Moose.]

And NAC and NAG are both related to sulfur as well, for anybody who's mentioned them here...

 

And ammonia is a "potent activator of the NMDA receptors," 

Edited by .Moose., 13 July 2016 - 01:59 AM.

[Helllllo]

I've discovered what the culprit is for me I believe. After trying a few ammonia detox supplements with no luck, I tried a holistic heals SUOX sulphite ingestion supplement with an additional 400mg of molybdenum and it gave me terrible insomnia for 3 days. After those 3 days though, I felt incredibly calm and relaxed. Not manic but no obstruction of thoughts. Just fine. I now use the SUOX supplement with vitamin c and everyday saunas to maintain homeostatis. I think the sulphites were stealing my ATP. Disrupting my dopinamergic signalling and driving my noradrenaline as well as other fight or flight hormones. I'm sure many other aspects of my well being were affected. 

 

Should I get a minerals test to see if i'm deficient in molybdenum as i hear it can be neurotoxic if not used with a deficiency. I'm also worred that thiamine was depleted with the continuous drinking/sulphites swimming around. My memory is absolutely shot and i know all that stress might have caused some potential damaged. Anyone have any advice on what to do now? 

 

[Multivitz]

Good lad Kingsley, you saved me having to type lists o stuff.
MSM Sulfur increases cell permeability ,builds inner cellular transport fibres, protects cell from parasite damage, carries Oxygen, used for raw protien repair and old scare repair by tye body, cell hydrator, heavy metal transport, oh and I think it's got those negative ions that non oxidised Magnesium exhibits . Feels like Sodium bicarb or chelated Magnesium , but only if the radio active Potassium is present.

Once the body is whole, only then can one be as a rock and experience all.

[Multivitz]

ZMA should counteract the Molybdenum, but in the early days of man, he came about in a world of perpetual red dawn. Slept when he felt like it, under the first suns heliosphere no stars were visible, time was less regimented. So don't worry about a little insomnia, make sure you have an apatite, alkalis, alkali Omega oils, red light, learn about yin yang principles etc. Hope this helps.
Molybdenum brings diligence, Zinc gives focus, Mangesium allows speed. They all use vitamins, aminos and oils to function.

[Golodnyy]

Hi people.

I try to use folate during 4 months. Three times during this period I got flu-like symptoms, in march, in the beginning of june, and right now.

All three times I used 1mg / day. So may be it is too much and I need to lower the dose.

_____________________

MethylB12 - good for sleep (5mg) and energy (10-15-20 mg). 

HydroxoB12 - "sleepless" drug but energy is some uncontrollable. 

_____________________

In addition I add to regime 100mg pyridoxine shot - quite good for mood, concentration and hand-shake-tremor (handwriting improved). 

Also try p-5-p - can't say if it is as good as pyridoxine shot.

[ThreeKings12341]

guys. any other idea how to overcome emotional numbness..?

 

i tried nac.. it gave me euphoria and motivation.. but lost that after 2 months...

 

what elsecould i try ? is there anything similar to nsi-189 ? ive read somewhere that that helped people curing emotional numbness.,,.,

 

is this emotional numbness related to the 5ht1a gene somehow??

 

shit... im lost :/

 

[tronatula2]

 

Ok, so I've been in this "state" while in college.  Oh how the sunday hangovers allowed me to be so productive.  I Identify with this thread so much...Anyways, tetrahydrobiopterin is a major player in this.   I just came here to say you need to try Liposomal Vitamin C + your flavanoid of choice.  The Liposomal vitamin c stimulates BH4 creation somehow through hydrogen peroxide (isn't hydrogen peroxide bad).  The flavanoid is necessary to ''couple" the endothelial system and promote enos.  Without enough BH4 you don't produce enough enos, and create inos and peroxynitrite instead. 

ANYways you guys need to definitely try liposomal vitamin c with your flavanoid of choice. Let me know what you think.Cheers

 

I've personally stopped using the BH4 supplement I was using before due to costs and storage difficulties. Nowadays I use a combo of hydroxy-B12 (250 mcg once a day), methylfolate (200 mpg 3 times a day) and vitamin C (1000 mg 2 times a day) instead. The vitamin C seems to make a big different in the way that I have more energy, motivation and it's easier for  me to socialise on the days I take it. I use regular vitamin C though, not the liposomal version and without any flavonoid.

 

 

Hi Chadwick, I think I'm just like you, cause after taking your protocol (400 mcg methylfolate 3 times + 250mg hydroxo B12), my Digit span scores at CambridgeBrainSciene increased from 17 to 18. I need more time to play around with this protocol. But at the mean time, may I ask how are you doing? Do you still take the same protocol?

[Chadwick]

 

 

Ok, so I've been in this "state" while in college.  Oh how the sunday hangovers allowed me to be so productive.  I Identify with this thread so much...Anyways, tetrahydrobiopterin is a major player in this.   I just came here to say you need to try Liposomal Vitamin C + your flavanoid of choice.  The Liposomal vitamin c stimulates BH4 creation somehow through hydrogen peroxide (isn't hydrogen peroxide bad).  The flavanoid is necessary to ''couple" the endothelial system and promote enos.  Without enough BH4 you don't produce enough enos, and create inos and peroxynitrite instead. 

ANYways you guys need to definitely try liposomal vitamin c with your flavanoid of choice. Let me know what you think.Cheers

 

I've personally stopped using the BH4 supplement I was using before due to costs and storage difficulties. Nowadays I use a combo of hydroxy-B12 (250 mcg once a day), methylfolate (200 mpg 3 times a day) and vitamin C (1000 mg 2 times a day) instead. The vitamin C seems to make a big different in the way that I have more energy, motivation and it's easier for  me to socialise on the days I take it. I use regular vitamin C though, not the liposomal version and without any flavonoid.

 

 

Hi Chadwick, I think I'm just like you, cause after taking your protocol (400 mcg methylfolate 3 times + 250mg hydroxo B12), my Digit span scores at CambridgeBrainSciene increased from 17 to 18. I need more time to play around with this protocol. But at the mean time, may I ask how are you doing? Do you still take the same protocol?

 

I'm still experimenting. So far I've come up with three different protocols that work for me:

 

1. Methylfolate 400 mcg x 3 + Hydroxy-B12 125 to 250 mcg x 1 + Liposomal vitamin C 5 ml (1000 mg) x 1. This works okay, and I can feel a distinct effect from it. Liposomal vitamin C definitely adds something.

 

2. BH4 1.25 mg x 2. This is amazing. It removes all of my initial problems and puts me in a productive and energized state without a stimulant feeling. As I said before storage, costs and availability are three problems that keep me from using it though.

 

3. Uridine 250 mg x 2 + 400 mcg folic acid or methylfolate. Many people use DHA 700 mg in combination with uridine, but fish oil makes me lethargic so I'm skipping that. The folate in this protocol is only used to prevent the folate deficiency that uridine can cause. This protocol is what I'm on right now, and it works great for me. Uridine has a dopaminergic feel to it without a stimulant feeling, just like BH4. 

[tronatula2]

 

 

 

Ok, so I've been in this "state" while in college.  Oh how the sunday hangovers allowed me to be so productive.  I Identify with this thread so much...Anyways, tetrahydrobiopterin is a major player in this.   I just came here to say you need to try Liposomal Vitamin C + your flavanoid of choice.  The Liposomal vitamin c stimulates BH4 creation somehow through hydrogen peroxide (isn't hydrogen peroxide bad).  The flavanoid is necessary to ''couple" the endothelial system and promote enos.  Without enough BH4 you don't produce enough enos, and create inos and peroxynitrite instead. 

ANYways you guys need to definitely try liposomal vitamin c with your flavanoid of choice. Let me know what you think.Cheers

 

I've personally stopped using the BH4 supplement I was using before due to costs and storage difficulties. Nowadays I use a combo of hydroxy-B12 (250 mcg once a day), methylfolate (200 mpg 3 times a day) and vitamin C (1000 mg 2 times a day) instead. The vitamin C seems to make a big different in the way that I have more energy, motivation and it's easier for  me to socialise on the days I take it. I use regular vitamin C though, not the liposomal version and without any flavonoid.

 

 

Hi Chadwick, I think I'm just like you, cause after taking your protocol (400 mcg methylfolate 3 times + 250mg hydroxo B12), my Digit span scores at CambridgeBrainSciene increased from 17 to 18. I need more time to play around with this protocol. But at the mean time, may I ask how are you doing? Do you still take the same protocol?

 

I'm still experimenting. So far I've come up with three different protocols that work for me:

 

1. Methylfolate 400 mcg x 3 + Hydroxy-B12 125 to 250 mcg x 1 + Liposomal vitamin C 5 ml (1000 mg) x 1. This works okay, and I can feel a distinct effect from it. Liposomal vitamin C definitely adds something.

 

2. BH4 1.25 mg x 2. This is amazing. It removes all of my initial problems and puts me in a productive and energized state without a stimulant feeling. As I said before storage, costs and availability are three problems that keep me from using it though.

 

3. Uridine 250 mg x 2 + 400 mcg folic acid or methylfolate. Many people use DHA 700 mg in combination with uridine, but fish oil makes me lethargic so I'm skipping that. The folate in this protocol is only used to prevent the folate deficiency that uridine can cause. This protocol is what I'm on right now, and it works great for me. Uridine has a dopaminergic feel to it without a stimulant feeling, just like BH4. 

 

Wow, you are exactly like me, I react badly to fish oil too, and react well to uridine. May I ask you did you find that the protocol 3 (uridine) works better than 1 (hydroxy)? Why? What is the role of uridine in your gene mutation?

Edited by tronatula2, 13 September 2016 - 04:48 PM.

[Chadwick]

Wow, you are exactly like me, I react badly to fish oil too, and react well to uridine. May I ask you did you find that the protocol 3 (uridine) works better than 1 (hydroxy)? Why? What is the role of uridine in your gene mutation?

 

I find that protocol 3 works better than 1, yeah, and I believe this is caused byt the fact that methylfolate can BOTH increase BH4 availability (and hence dopamine, norepinephrine etc) and increase methylation and thereby COMT activity (causing breakdown of dopamine, norepinephrine etc).

 

As I understand it uridine does not change BH4 availability, which seems to be my problem. It does however modulate dopamine release, which is what I need BH4 for.

Edited by Chadwick, 13 September 2016 - 05:01 PM.

[tronatula2]

I find that protocol 3 works better than 1, yeah, and I believe this is caused byt the fact that methylfolate can BOTH increase BH4 availability (and hence dopamine, norepinephrine etc) and increase methylation and thereby COMT activity (causing breakdown of dopamine, norepinephrine etc).

 

As I understand it uridine does not change BH4 availability, which seems to be my problem. It does however modulate dopamine release, which is what I need BH4 for.

 

 

I guess I will try uridine + methyl folate then. DId you take it sublingually or orally? I have Jarrow formula uridine 250mg capsules.

 

So the protocol is : 200mcg metafolin + 250mg uridine with meal twice daily right? Is 400 mcg methyl folate a day too low?

[Chadwick]

 

I find that protocol 3 works better than 1, yeah, and I believe this is caused byt the fact that methylfolate can BOTH increase BH4 availability (and hence dopamine, norepinephrine etc) and increase methylation and thereby COMT activity (causing breakdown of dopamine, norepinephrine etc).

 

As I understand it uridine does not change BH4 availability, which seems to be my problem. It does however modulate dopamine release, which is what I need BH4 for.

 

 

I guess I will try uridine + methyl folate then. DId you take it sublingually or orally? I have Jarrow formula uridine 250mg capsules.

 

So the protocol is : 200mcg metafolin + 250mg uridine with meal twice daily right? Is 400 mcg methyl folate a day too low?

 

I take the uridine orally twice a day, and folic acid once a day. I don't know yet how much folate or folic acid is needed - I'm still experimenting around. Here the purpose of the folate is to prevent an induced deficiency, and I haven't come across any data on how much extra folate the body needs when supplementing uridine.

 

 

[tronatula2]

I take the uridine orally twice a day, and folic acid once a day. I don't know yet how much folate or folic acid is needed - I'm still experimenting around. Here the purpose of the folate is to prevent an induced deficiency, and I haven't come across any data on how much extra folate the body needs when supplementing uridine.

 

 

Thank you, if you find any new information, please post them here.

[bob21]

Chadwick, I ve tried your protocol methylfolate plus hydroxo b12 but so far no change only my OCD get worst plus anxiety pop up any adwise on this ? I m kind off running out of bullets. I ve also tried NAC and NAG plus Inositol but this seems have even worst effect on me.

 

Yop and sorry for my bad English.

[bob21]

 

Hello:

 

Here's my take on some of your numbered questions.

 

1.

Your problem may or may not involve a glutathione deficiency, but is probably more tied to glutamate dysregulation.  NAC actually does two things.  Yes, it increases the production of glutathione, but on top of that, it activates something called the cystine-glutamate antiporter, which basically shuffles glutamate around to parts of the brain where it causes less stimulation.  That is why it is so helpful for OCD, which is associated with overstimulation of the glutamate receptors.

 

2.

I doubt you'll find anything better than NAC.  It is one of the more studied and effective supplements and is right in your wheelhouse.  I'd also make sure you have the basics in place, i.e. a high quality daily multi-vitamin and plenty of magnesium.  Other than that, it's hard to say, since supplements are so hit-or-miss.  A high quality curcumin supplement might help, since curcumin has NMDA-antagonist and anti-inflammatory properties.  However, don't bother unless you are willing to spring for one of the specially formulated bio-available versions, like Longvida curcumin.

 

3.

Don't bother.  NAC will give you all the glutathione you need, and is scientifically proven, whereas supplementing glutathione is iffy at best. 

 

4.

There are plenty of supplements that can supposedly help with libido, and different people swear by different things.  It takes experimentation.  I find zinc helpful.

 

5.

Again, many supplements out there that supposedly help sleep which you can google.  Melatonin is a big one and I have found it very effective.  Other than that, l-theanine maybe? 

 

6.

Here's hoping you don't crash from the hypo-mania.  You need to find a way to sleep and calm the hell down : ). 

 

 

1.
so if i take nac and that helps immensive- i probably have a glutathione defiecy - right?
Does nac. Help so the glutathione gets in my body or brain where it should has to be ? I read something that a reduced gluthione oxidised after 1.6 minutes .. So if i feel good through nac alrwady .. That means also that the gluthione is higher intercellucar?

2.
What else should i consider taking if u read my story? Anything better for me? - im looking for the perfect solutions through doctors and especially through here because what u PEOPLE write is soooo FANTASTIC. I cant thank xou enough !!

3.
S-acetyl-glutathione anyone? Seems to be a high quality product which should be the best form to increase glutathione .. The brand is eumetabol .. German site .. Maybe u guys know anything about s-acetyl-glutathione

So are there any supplements 2 take so i can get away from the dulled emotional condition?

4.
anything to take to help my libido ..
Any suggestions? L-carnitine-got them but only took them 1 time and already have them for a long time? Or a viagra 1 week therapy?

5.
What could i trY taking so i sleep more so i dont get up after 2-3 hours of sleep starting with full energy ...
My hypermania state :
Im quick, focused dont spend a lot of money have neaerly every smyptom what a hympomaniac should have except that i dont spend so much money on studf because
I dont have the money... I can be really energized but if i want to relax i am able to just sit on a sofa and relax so
I can switch

6.
I would like 2 know how many people on earth have a hypomania ... And is this a hypomanie if i dont have any depression episode at all??!???!??
Somewhere i read 1-3 % ? I think on wiki but a hypomania with depression episode ..
Would love 2 know something about this

.Cheers ! And im so looking foward 2
Your answers.. People here THANKS for this godly MASTER-Thread

 

Hi Kingsley, 

I ve tried your protocol with NAG and NAC plus Inositol and my OCD get even worst any ideas why ?

I m kind of hopeless at the moment.

[tronatula2]

I take the uridine orally twice a day, and folic acid once a day. I don't know yet how much folate or folic acid is needed - I'm still experimenting around. Here the purpose of the folate is to prevent an induced deficiency, and I haven't come across any data on how much extra folate the body needs when supplementing uridine.

 

 

 

 

 

Hey Chadwick, I think both you and I have excess acetylcholine level (react badly to cholinergic stuff, such as fish oil, DMAE, nicotine, Centrophenoxine, Phosphatidyl Serine....; as well as the reason you mentioned in the first post:  Excess acetylcholine. Alcohol decreases acetylcholine synthesis and release, and too much acetylcholine seems to interfere with dopamine signaling). I also have good short-term memory and logical thinking, what about you?

 

The question I'd like to discuss is Methylfolate contributes to Methylation, and Increased methylation can deplete dopamine, norepinephrine and 5-HT; increase acetylcholine.

​

What do you think about this?

[Chadwick]

 

Hey Chadwick, I think both you and I have excess acetylcholine level (react badly to cholinergic stuff, such as fish oil, DMAE, nicotine, Centrophenoxine, Phosphatidyl Serine....; as well as the reason you mentioned in the first post:  Excess acetylcholine. Alcohol decreases acetylcholine synthesis and release, and too much acetylcholine seems to interfere with dopamine signaling). I also have good short-term memory and logical thinking, what about you?

 

The question I'd like to discuss is Methylfolate contributes to Methylation, and Increased methylation can deplete dopamine, norepinephrine and 5-HT; increase acetylcholine.

​

What do you think about this?

 

 

Yeah, methylation can be a problem and I've mentioned this before. This is why I try to keep B12 supplementation low, to not increase methylation too much.

 

In regards to excess acetylcholine I though about that a few years back, but I've discarded that theory. I generally react well to cholinergics like nicotine, choline etc. Phosphatidyl serine gives me a very nice dopaminergic feeling (which is probably caused by it's effects on tyrosine hydroxylase) but I build tolerance quickly. My reaction to fish oil was most likely caused by using high doses of a low quality oil that didn't include vitamin E or any other antioxidant. I've used other brands of fish oil with vitamin E in the past without any problems. 

[Helllllo]

Hey Chadwick, just wondering why you discontinued hydroxyb12? Couldn't that potentially cause problems due to a methyl trap? Was also wondering why you didn't add the uridine to your no.1 protocol. Seems like it could work synergisticly?