I've been trying to figure out which of these supplements I should take, and the information regarding them is extremely confusing. For instance idebenone is often marketed as an analogue to CoQ10 that will cause less oxidative stress however a study found that "Among the quinones tested, idebenone is particularly effective in inducing a dramatic increase of superoxide production . Because idebenone is clinically used in mitochondrial cytopathies and neurodegenerative diseases, its strong pro-oxidant effect raises doubts on its safety as a drug." I want input on how these choices fare relative to the different factors listed, as well as ideas about what factors should also be considered. One factor we have to consider when choosing between Idebenone and some form of CoQ10 is what one can do that the other can't, for instance Idebenone has nootropic effects whereas I'm not sure if CoQ10 does. This is less of a problem when choosing which version of CoQ10 to take because the body can convert Ubiquinone to Ubiquinol and vice versa at need since they are redox pairs. CoQ10 (in the ubiquinol form) has been demonstrated to oxidize fat which partially limits its antioxidant effects, Idebenone has been shown to have oxidative effects (but it should be noted that this study referenced is a review of of studies done on bovine/rat heart and liver submitochondrial particles and not in vivo), Ubiquinol can be converted to normal CoQ10 so it should have the potential for oxidative effects as Ubiquinone (unless its the conversion from Ubiquinone to Ubiquinol itself that causes the oxidation). In the above cited study about idebenone they say "Complex I inhibitors, acting at the level of iron-sulfur clusters, such as p-hydroxymercuribenzoate, inhibited superoxide production" are there ways of inhibiting the oxide production for all of these supplements, are these ways safe? And do they all oxidate things in the same ways? For instance Idebenone has an antioxidative effect in the mitochondria but in the case of the respiratory chain has an oxidative effect.CoQ10 turns prooxidative in the case of lack of oxygen/hypoxia. ISo which supplement causes the least oxidation (especially relative to its antioxidant effect)? I think I heard somewhere that CoQ10 residue builds up in your heart, is this a problem and does Idebenone do this? One advantage of CoQ10 is that when you take it your body has access to both forms of it since it's a redox, I'm not sure if you have something similar in Idebenone. Are there any variants of Idebenone that we have to consider like there are for CoQ10? One advantage of Idebenone is its effects on learning while one advantage of CoQ10 is that it is much better researched. If we're looking at Idebenone we have to consider its bio-availability and the efficiency of its different forms. Out of Idebenone and the two forms of CoQ10 which has the best bioavailibility? And is it possible for the less bioavaiblible supplements to reach comparabale levels of bioavailiblity by using techniques like oil suspension or novel carriers like leitchin or liposomes ? If we're looking at CoQ10 we have to consider which form we should take, for instance an average Ubiquinol will higher bioavailbility than an average Ubiquinone supplement because it has higher water solubility, but Ubiquinone can also be made more bioavailable like it is in the supplement BioQ10 (of course even if BioQ10 absorbs as well as your normal Ubiquinol there could be a way of taking ubiquinol that would be more bioavailible ). It's probably best to take the form of CoQ10 that is most used by the body so the body will have to convert less, does the body use more Ubiquinone or Ubiquinol. And is it as easy for the body to convert Ubiquinol to Ubiquinone as it is to convert Ubiquinone to Ubiquinol or is one harder than the other? We also should compare Idebnone to targeted forms of CoQ10 (are there any targeted forms of Idebnone?) for instance the paper "Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants" found that MitoQ (mitochrondrial targeted version of CoQ10) was several hundred times more potent at protecting ataxia than Idebenone .Which supplement has the worst risks, which has the most benefit? We have to consider whether one of these has any synergistic effect when paired with certain supplements that the others can't imitate. So which supplement do you think has the best ratio of bioavailiblity, safety, power of effect, and the range of effects? Which do you like the most? Are there any other variants of CoQ10 or synthetic analogues like Idebenone that should be brought into the discussion? Or do you not think any of them are useful?
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