38 replies to this topic

[ta5]

 

 

Yes, MitoQ eye drops are in the pipeline.  Not exactly sure when we will get them to market but watch this space. 

 

 

Cool. Thanks Greg. I would be very interested in eye drops. There are so few options for delaying, preventing, or reversing cataracts (and maybe hopefully presbyopia) and other age-related eye problems. It would be great to have another option that possibly works by another mechanism than N-Acetyl-Carnosine drops.

[abelard lindsay]

I was looking into the electron transport chain lately for an article I'm writing.  Seems Ubiquinol has some serious exercise benefits in healthy individuals over CoQ10:

 

http://www.ncbi.nlm....pubmed/22966414

 

 

We conclude that treatment with CoQ10 in healthy, exercise-trained subjects increases total and reduced blood CoQ10, but this increase does not translate into improved exercise performance or decreased oxidative stress.

 

vs 

 

http://www.ncbi.nlm....pubmed/23627788

 

 

 

This study demonstrates that daily supplementation of 300 mg Ubiquinol for 6 weeks significantly enhanced physical performance measured as maximum power output by +0.08 W/kg bw (+2.5%) versus placebo in young healthy trained German Olympic athletes. While adherence to a training regimen itself resulted in an improvement in peak power output, as observed by improvement in placebo, the effect of Ubiquinol supplementation significantly enhanced peak power production in comparison to placebo.

 

[Asor]

Joining the discussion because i have a mitochondrial myopathy and one of the few treatments given to patients are Coenzime Q10 or Idebenone.

One neurologist prescribed me Coenzime q10, another Idebenone.

The second neurologist seems more educated about mitocondrial miophaties, but the first one is legit as well.

When asked the first neurologist about idebenone, he told me "it's pretty much the same as CoQ10".

 

Now im reading this thread.

 

 

[gregmacpherson]

Hi Asor, 

 

Idebenone is a slightly modified CoQ10 and has marginally better effect because it is able to cross the mitochondrial membrane however MitoQ is significantly better as it has a positive charge attached causing it to be drawn into the mitochondria some 800-1200 times more than both Idebenone and CoQ10(ubiquinol). 

 

Kind regards

 

Greg

[holdout]

PQQ (pyrroloquinoline quinone) may also be of interest to you, to combine with Co-enzyme Q10

[Asor]

Hi Asor, 

 

Idebenone is a slightly modified CoQ10 and has marginally better effect because it is able to cross the mitochondrial membrane however MitoQ is significantly better as it has a positive charge attached causing it to be drawn into the mitochondria some 800-1200 times more than both Idebenone and CoQ10(ubiquinol). 

 

Kind regards

 

Greg

 

 

PQQ (pyrroloquinoline quinone) may also be of interest to you, to combine with Co-enzyme Q10

 

 

Thanks guys, i heard about PQQ and i was considering it, as you say it seems to work very well in combination with CoQ10.

 

Greg, i see you are the CEO of MitoQ, do you have any link/paper that i can show to my neurologist regarding MitoQ?

Im also in contact with a researcher at Cambridge University who's doing studies on NAD precursors and their effect on mitochondria, so i could also ask his opinion as well.

 

 

Edited by Asor, 12 July 2014 - 07:28 AM.

[abelard lindsay]

I finished the article I was talking about earlier in the thread.  Here's the conclusion I came to : COQ10 is not worth supplementing, IMHO.  Ubiquinol and Idebenone have different benefits as far as supplementation goes. 

 

 

http://optimalperfor...k-mitochondria/

 

 

Our first metaphorical pumping station, Complex I, turns NADH to NAD+.  It pumps protons by transferring electrons to coenzyme Q10 turning it into ubiquinol which, through a series of reactions, pump protons out of the membrane and to the high side of the metaphorical dam.  Coenzyme Q10 and ubiquinol are both sold as supplements.  Improvements in exercise performance for users of supplemental coenzyme Q10 are not significant[10] nor has it shown much benefit in parkinson’s disease[11].  The reduced form of coenzyme Q10, ubiquinol, has some interesting data.  It enhanced athletic performance in healthy athletes[12] and has shown some beneficial effects in studies in managing diabetes[13].

 

A synthetic analog of coenzyme Q10 known as idebenone has some interesting effects at complex 1.  Idebenone’s mechanism of action may be in its ability to help utilize NADH to pump protons when complex 1 is not functioning properly[14], possibly via complex III[15]. In studies it increased nerve growth factor production in an animal model of brain damage[16].  In another study it slowed down the development of dementia symptoms in Alzheimer’s patients[17].

 

Here are the citations for your reading pleasure:

 

[10] Bloomer RJ, Canale RE, Mccarthy CG, Farney TM. Impact of oral ubiquinol on blood oxidative stress and exercise performance. Oxid Med Cell Longev. 2012;2012:465020. PMID 22966414

[11] Beal MF, Oakes D, Shoulson I, et al. A randomized clinical trial of high-dosage coenzyme q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71(5):543-52. PMID24664227

[12] Alf D, Schmidt ME, Siebrecht SC. Ubiquinol supplementation enhances peak power production in trained athletes: a double-blind, placebo controlled study. J Int Soc Sports Nutr. 2013;10:24. PMID23627788

[13] Mezawa M, Takemoto M, Onishi S, et al. The reduced form of coenzyme Q10 improves glycemic control in patients with type 2 diabetes: an open label pilot study. Biofactors. 2012;38(6):416-21. PMID 22887051

[14] Haefeli RH, Erb M, Gemperli AC, et al. NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels. PLoS ONE. 2011;6(3):e17963. PMID 21483849

[15] Giorgio V, Petronilli V, Ghelli A, et al. The effects of idebenone on mitochondrial bioenergetics. Biochim Biophys Acta. 2012;1817(2):363-9. PMID 22086148

[16] Nitta A, Murakami Y, Furukawa Y, et al. Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 1994;349(4):401-7.PMID 8058112

[17] Bergamasco B, Scarzella L, La commare P. Idebenone, a new drug in the treatment of cognitive impairment in patients with dementia of the Alzheimer type. Funct Neurol. 1994;9(3):161-8. PMID7988944

 

 

Edited by abelard lindsay, 13 July 2014 - 02:28 AM.

[jroseland]

The Mitochondrial process that drives our trillions of individual cells and defines the grace with which we age has been a particularly hot arena of scientific research the past few years.

You can find +350 human studies specific to CoQ10 in the past 5 years on Pubmed. A essential chemical ingredient to the Mitochondrial process that powers our bodies on a cellular level with the production of Adenosine Triphosphate (ATP).

 

The Godfather of antiaging, Ray Kurzwiel includes CoQ10 in his daily regimen of supplements and recommends it in his book Fantastic Voyage: Live Long Enough to Live Forever.

There's two types of it, the original form of CoQ10 synthisized and supplemented was Ubiquinone, however it is difficult to absorb. Ubiquinol is more bioavaliable and found to be 40% more effective than Ubiquinone in reducing aging in animal studies and 90% more effective in human fatigue studies. Therefor we recommend the Ubiquinol form of the supplement.

It is sometimes criticized for it is high price although it has an impressive preponderance of human trials in comparison to other other drugs and supplements that benefit the same conditions.

Longetivity & Antiaging Properties

There is some debate as to weather it is a net positive or negative for longevity which seems to stem from a study of CoQ10 in worms wherein it acted as pro-oxidative and slightly decreased the lifespans of worms. Although a rat study found the opposite effect.

The Godfather of antiaging, Ray Kurzwiel includes CoQ10 in his daily regimen of supplements and recommends it in his book Fantastic Voyage: Live Long Enough to Live Forever.

"For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract..."

a 2008 Perdue University study of 10 human subjects, showed it decreased harmful age related arNOX levels:

"...arNOX activity was reduced between 25 and 30% by a 3 x 60 mg daily dose Coenzyme Q10 supplementation. Inhibition was the result of Coenzyme Q10 presence."

The consensus is that it is lacking a decent study showing a clear effect on human longevity.

To quote "The Miracle Nutrient Coenzyme Q10" by Emile G. Bliznakov MD

"That CoQ plays a crucial role in aging is beyond doubt. The same applies to CoQ's role in the immune system. And there is a vital connection between the immune system and aging that cannot be ignored."

Athletic Performance Enhancer

Three double blind human studies demonstrated an anti-fatigue effect in exercise with 300 milligrams CoQ10 daily, specifically in long periods of exercise, after 210 minutes

To quote one self monitor:

"Within about 3 weeks i went from walking at a normal pace for several blocks to running the same distance with no problems. My cardio has been something that has always let me down. As a martial artist it really helped with my cardio endurance immensely. going from being worn out from a warm up to wanting to do ALOT more training at the end of every class."

Antioxidant

UBIQUINONE-10 AS AN ANTIOXIDANT published in 2008 in the Journal of Food Biochemistry

"This study was done to determine if the oxidized form of coenzyme Q, ubiquinone, was capable of acting as an antioxidant. In this study, it is shown that it can function in this manner."

Depression

To quote a 2009 Belgian study of 35 patients suffering from treatment resistant depression:

"The results show that lower CoQ10 plays a role in the pathophysiology of depression"

Fatique

Common sense would suggest that something which empowers the mitrochondrial process would be profoundly helpful to those suffering from low energy levesl. A 2005 human study of 13 patients confirmed this:

"Subjects with unexplained chronic fatigue of unknown etiology for at least 6 months were recruited... The percentage of users who found a treatment helpful was greatest for coenzyme Q10 [was] 69%..."

Originally it was discovered by the University of Wisconsin in a series of experiments isolating it from beef hearts in 1957 by Dr Fred Crane.

Sources

CoQ10 comes from a variety of animal sources:

Beef

Liver

Pork and Chicken Heart

Sardines

Herring

Mackeral

Along with

• Butter

• extra virgin Olive Oil

Supplemental CoQ10 can be extracted from food sources, but it is prohibitively expensive to do so and the majority of CoQ10 supplements are synthesized from bacteria in a laboratory:

Neuro1 by Nutrition53

LifePak Nano

Super Ubiquinol CoQ10

Given the dietary problems western society faces at large, it is no surprise that CoQ10 deficiency is rampant and associated with the following diseases

• Heart attack related fibromyalgia (post-myocardial infarction)

• Depression

• Migraines

• Prader-Willi syndrome

• Male infertility

• Peyronie's disease

• Parkinson's disease

According to a 2009 paper published in Journal of Neuropsychiatric Disease and Treatment:

"(CoQ10) is an essential cofactor in the mitochondrial respiratory chain... Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress."

Cofactors:

Creatine is a synchronous agent in combination for a potent neuroprotective effect:

"(CoQ10) and creatine are promising agents for neuroprotection in neurodegenerative diseases via their effects on improving mitochondrial function and cellular bioenergetics and their properties as antioxidants."

L-Carnitine, a synergistic intermediate with CoQ10 in mitochondrial function.

The CoQ10 process in the body requires Tyrosine and Vitamin B6.

Alpha-Lipoic Acid

Grape Seed Extract

Resveratrol

 

[Kalliste]

Heres a vast e-book on CoQ10, Creatine, MitoQ and Skq1

http://www.researchg...92e9663caf1.pdf