I have made this to enlighten the dope fiends across other forums. I am still a newb to neurochemical interaction so I ask you to please point out where I have gone wrong and share some of you geniusness.
Cannabis acts mainly on one cannabinoid receptor in the brains neural cells. Receptors are basicly the input in a brain cell for the different chemicals in your brain and those chemicals (neurotransmitters) tell the neuron what to do. So by introducing THC to a neuron, it soon alters natural neurotransmitter communication. Therefor, thoughts of different natures.
By constantly pushing Cannabinoid receptors into overdrive by putting THC through them, they wear out and become less excited (Neuronal Excitability). By disabling them when not high, can help them to become more sensitive and therfor eliminates some of the tolerance to THC or other Cannabinoids. This processes is refered to as Antagonism. Just like a bad guy antagonist in a story, he doesn't let the receptor work. The opposite is called Agonism and helps the receptor to flourish.
Cannabinoid receptors also control a lot of other chemical neurotransmitter interactions within the brain (Neuromodulation) and this produces the same effect as above (overdrives them into not working properly. This is a classic case of a stupified dope fiend, whose normal neurotransmission has been modulated, slowed and shot by consuming too much THC too soon via the cannabinoid receptors.
These neurotransmitters, that are affected by Marijuana use, are responsible for concentration, learning, memory retention and nerve growth factor among many others.
So by now you can start to see how Marijuana can affect the brain negatively or positevly if you like your thought processes to diminished and subdued. I will now describe how you can use this knowledge for supplementation that can diminish these scientificly known negative effects of Marijuana.
Tolerance
Cannabinoid Receptor Antagonists are still not yet on the public market but are being trialed for obesity as CB1 receptors use the naturally produced cannabinoid Anandamide for hunger. Natural antagonists are still available.
Other alternatives look at NMDA receptor antagonism as an effective method to reduce the rate of tolerance. NMDA receptors greatly improve the brain to form memories (long term memory similar to learning when young).
Memantine
Memantine has been widely used as a tolerence reducer for benzodiapine abuse aswell as marijuana. It is a NMDA receptor antagonist and can reduce marijuana impct on overloading NMDA receptors. Similar to Memantine is Amantadine.
Huperzine A
Huperzine is also an NMDA antagonist and increases Acetylcholine which is an important neurostransmitter responisble for concentration and learning. It also increases REM sleep which can help sleep issues caused by Marijuana. Also prevents neurotoxic effects of glutatamate.
Magnesium & Zinc
Magnesium & Zinc is also a NMDA atagonist. Magnesium L Theronate can especially assist with memory loss. Magnesium also prevents glutamate overactivity in a NDMA voltage dependant manner.
American Ginseng
Proven to increase metabolism of THC to its inactive version 11-nor-9-carboxy. This means american ginseng is a working detox. Prevents CB1 activation after intoxication, reducing ones tolerance. American Ginseng also contains CB1 Inverse agonist falcarinol (Studies show it reverses CB1s effects at certain sites). Some slight hormonal type improvements have also been noted. American Ginseng also increases dopamine production in certain areas of the brain improving memory and tolerance. American Ginseng also works as a choline uptake enhancer exactly as racetams (nootropics) do.
Carrot Extract or Capsules
Carrots contain falcarinol which is a CB1 antagonist therby increasing the receptors sensitivity by it not being activated.
Fish Oil
Helps to rebuild and maintain Cannabinoid receptors.
Japanese Raisen Tree (Hovenia Dulcis)
Has shown to be an active detox for Marijuana and especially alchol.
Memory Impairment
Marijuana affects long-term and short-term memory potentiation and synaptic plasticity which refers to the connectivity between neurons and affects how often they fire over time. Increasing or decreasing the neurotransmitters and there actions can have a positive effect and many are used worldwide to increase the processes in working memory that Marijuana specificly deteriorates. The highest concentration of cannabinoid receptors in the brain exists in the hippocampus, which soley responsible for memory production.
Alpha GPC
Alpha GPC increase a very important neurotransmitter called Acetylcholine which is predomintly used for attention, arousal, learning, memory and muscle contraction. Compounds in cannabis inhibit the release of Acetylcholine.
cAMP
cAMP pertains to signal transduction and memory. Low levels have been related to mariuana psychosis. A reduction of cAMP levels in glutaminergic neurons, lowers the activity of the NMDA function in the hippocampus. It is found in lowered concentrations in both schizophrenic and psychotic bipolar disorder patients. This protein enhances Long Term Potentiation Memory.
cAMP can be obtain from Forskolin. Forskolin is made from Coleus which is also a slight hallucinogenic available at most garden stores.
Forskolin should be taken with Artichoke Extract to enhance PDE 4 Long Term Memory Formation.
L-Glutamine
Glutamate receptors are responsible for neuronal communication, memory formation and learning. Excessive Glutamate receptor depreciation and densetization has been scientificly observed after Cannabis use. L-Glutamate can increase Glutamic Acid and help curve its inactivity after Marijuana use.
Vassopressin
Marijuana is said to inhibit the release of vasopressin, and thus perhaps interfere with memory-imprinting. Similar to Vassopressin is Hydergine, Centrophenoxine, Selegiline and Desmopressin.
ALCAR
Acetyl-L-carnitine has the ability to cross the blood–brain barrier and enter the brain, where it acts as a powerful antioxidant and helps in prevention of the brain cells' deterioration. Also can relieve symptoms of brain fog.
Ginkgo Biloba
Used worlwide for Memory & Attention.
Dihydromyricetin Extract
A natural proven intoxication blocker. Studies show this type of chemical diminishes nearly all memory impairments caused by THC. Contains a chemical called ampelopsin that influences GABA(a) receptors in an inhibitory fashion. This compound not only reverses memory effects caused by GABA, it also prevents long term anxiety caused by THC. This compound can be used to reverse even non-drug induced anxiety.
L-Glutathione
This herb increases BDNF(Brain derived Neutrophic factor), NGF(Nerve Growth Factor), and activates the CREB cycle in neuronal learning. This herbal compound has been shown to increase the major anti-oxidant glutathione in the brain (to a LARGE extent) and improve memory. This herb works to counter act the decrease in Aldehyde dehydrogenase(deficiencies cause hangovers) caused by THC. Glutathione deficiencies have been shown to lower short term memory and help cause schizophrenia. This compound has been shown to protect dopamine neurons from damage and increase their activation. Glutathione precursors have also been shown to help chronic marijuana users quit if they wanted to. This herb has also been found to thwart brain damage and inflammation caused from smoke, lipoxygenase, and even removes aluminum from brain tissue.
Concentration
Aniracetam
Is a Nootropic that can provide relief for people who have difficulty concentrating. It reduces glutamate receptor desensitization and blocks NMDA exitotoxicity. Which makes it a good supplement to consider for any Marijuana user. Aniracetam and other racetams upregulate the AMPA receptor which marijuana removes from the cell surface.
Oxiracetam
Is also a Nootropic that is a NMDA agonist so will not alleviate the negative impact of marijuana on the NMDA receptor but can provide noticable concentrative effects in other circumstances. Oxiracetam and other racetams upregulate the AMPA receptor which marijuana removes from the cell surface.
Sleep & Depression
GABA
GABA is a neurotransmitter important for regulating & suppressing thoughts. It promotes better sleep and relaxation. Endocannibinoids are known to suppress GABA release in certain cells. GABA, Phenibut, Picamilon and Valerian Root Extract are notable forms of GABA supplementation.
5-htp
Is a Seratonin Reuptake Inhibitor that improves mood and sleep. Cannabis can antagonize serotonin receptors. Also it can help to reduce some anxiety felt from THC.
B Vitams
They help convert tryptophan into niacin and serotonin, making 5htp and niacen work more efficiently. They also help increase oxygen in the blood among an array of other effects. B12 can also cause de-realisatin in high doeses.
Melatonin
Is a hormone that is released when your eyes stop seeing light. It is released by the pineal gland and helps to maintain healthy sleeping patterns.
Herbal Alternatives
- Wild Dagga
- Blue Lotus
- Kanna
- Damiana
- Wormwood
- Skullcap
- Hops
- Catnip
- Calamus Root
- Galangal Root
- Betel Nut
- Marihuanilla
- Masterbation
- Coleus
- Zornia Latifolia
- Calea Zacatechichi
It is wise to do additional research before stacking these supplements as they may reverse the effects of each other either chemically or synaptically
http://www.buzzle.co...-functions.html
http://www.longecity...h-a-supplement/
http://chonps.org/20...with-marijuana/
http://www.longecity...e-does-it-work/
http://www.longecity...drug-tolerance/
http://www.biopsychi...om/canaforg.htm
https://en.wikipedia...ptor_antagonist
http://www.bluelight...etam-discussion
http://www.pnas.org/.../10936.full.pdf
https://en.wikipedia...f_schizophrenia
