591 replies to this topic

[ryukenden]

Interesting.

It looks like in 2015 they were encapsulating D-PDMP in PEG and sebacic acid, which if someone had the D-PDMP I suspect you could accomplish the encapsulation. However in the 2020 article they are talking about encapsulating it in "nanotubes". I don't normally associate PEG encapsulation with "nanotubes" but maybe they were trying to sex it up, or maybe they actually changed their method in those 5 years. When I'm not so tried I suppose I should really read these papers.

In any case, depending on the availability of D-PDMP, a person might just be able to make some of that up.

I believe it is different drug in 2020 and they keep it secret. I can’t find out which drug they use in the nanotubes.

[smithx]

I hope they are not carbon nanotubes. Those are potentially carcinogenic.

 

[aribadabar]

I believe it is different drug in 2020 and they keep it secret. I can’t find out which drug they use in the nanotubes.

 

Correct. 2020 paper is PEGylated SWNT-based mixture, while the 2014 paper was with PEGylated D-PDMP.

 

I hope they are not carbon nanotubes. Those are potentially carcinogenic.

 

They do seem to be carbon-based:

The functionalized SWNTs were prepared as previously reported with slight modifications as follows. Raw HiPco (high-pressure catalytic decomposition of carbon) 

Attached Files

•  Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.pdf   25.6MB   2 downloads

Edited by aribadabar, 25 May 2020 - 12:59 AM.

[smithx]

Study Says Carbon Nanotubes as Dangerous as Asbestos
New research shows that long, needle-thin carbon nanotubes could lead to lung cancer (2008)

https://www.scientif...anotube-danger/

 

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats (2014)

Treatments induced tumors in all dose groups, but incidences and times to tumor differed between groups. Most tumors were histologically and immunohistochemically classified as malignant mesotheliomas, revealing a predominantly superficial spread on the serosal surface of the abdominal cavity. Furthermore, most tumors showed invasion of peritoneal organs, especially the diaphragm. All tested MWCNT types caused mesotheliomas.

 

https://www.ncbi.nlm...les/PMC4243371/

 

but:

 

Carbon nanotubes as cancer therapeutic carriers and mediators (2016)

https://www.ncbi.nlm...les/PMC5066859/

 

Odd that these are being used when they are pretty clearly carcinogenic.

[Wookie]

Unfortunately I do not believe that cyclodextrin makes it through the gut.  I wanted to do the same thing you're contemplating and found a study showing nil blood levels after ingestion.

 

Check me on that but I looked into cyclodextrin pretty hard at one point because it looked so promising.

 

I think the only means that will be useful is IV or subcutaneous.  

 

  

 

 

Perhaps but the patent I found from Aussie researchers talked about oral use and adding a Phospholipid Vesicle. Which I am assuming phosphatidylserine would be ideal? 

 

https://patents.goog...2002043742A1/en

 

 

"The cholesterol efflux achieved by hp-CD and PLN in combination was many times greater than the sum of efflux achieved by each agent added separately, indicating a synergistic interaction between these acceptors consistent with shuttling of cholesterol from hp-CD to

PLN. This also indicated that the efflux from the plasma membrane is a major limiting factor in cholesterol efflux from human foam cell macrophages."

[Wookie]

 

Funny thing AD. The chemical used to wrap drugs for intranasal delivery is the sugar 2-hydroxypropyl-Beta-cyclodextrin. The same sugar we are discussing. So there is no need to wrap the sugar, just add water, filter and inhale.  You will need a sterile syringe filter disc and there are plenty of tutorials on Youtube. Can you get enough in the brain to dissolve the cholesterol crystals? Not sure. I cannot post links so here is an abstract and patent illustrating the nasal pathway tech:

 

Cyclodextrins in nasal drug delivery

doi.org/10.1016/S0169-409X(98)00054-4

 

 

 

Your research and insights are apparent. You mention that nasal ingestion might get to the brain.

 

Do you think inhaling CD would be effective in clearing arterial plaquing? Have you tried it?

 

I am orally taking 3 grams a day with 300mg PS for the phospholipid vesicle and I if i dont spread the doses out far enough of CD, I get almost high then one very tiny step away from a panic attack (im guessing) so orally has some sort effect, no question. Just not sure what that effect is lol.

[Gal220]

Not true. Lysine was studied and shown to remove plaque in animal atherosclerosis. Pauling postulated that a combination of lysine, proline and vitamin C could increase collagen (it can but you need very high dosages) to strengthen the arteries thus removing the need for plaque to build up, but there are 3 proposed mechanism of action for the Linus Pauling therapy:

the first is reducing the formation of new plaque by reducing lp(a) (proven), the second is actively removing the plaque already there (proven), and the third is strengthening the arteries to prevent the need for plaque deposits (don't think it was ever proven but seems plausible).

 

Even if the collagen model doesn't hold true, so increasing collagen synthesis is not effective, it doesn't matter because there are other obvious mechanism of actions that can explain why the therapy works.

 

Some people have spent considerable time evaluating why the LP theory doesnt work for everyone - link

 

1. Dosage - 
2. Blockages greater than 90%
3. Prescription Medications
4. Medical and Radiation Coated Stents
5. High Blood Sugar/Type II Diabetes

I imagine number 5 is big for many people, need more insulin - "Vitamin C has an extremely short half-life, competes with glucose for Insulin-mediated transport into cells"

 

 

Testimonies using the pauline theory, these sites also have all in one combo mixes. link1 , link2

Other testimonies - link

 

Other articles

Collagen melts plaque

Readers Digest on LP protocol

 

What is the Linus Pauling Protocol? link

L-ascorbate (Vitamin C) 5-6 grams a day in divided doses

L-Lysine 5 grams a day in divided doses

L-Proline 2-3 grams a day in divided doses

Tocotrienol Vitamin E

MK-7 Vitamin K2

 

Protocol for elevated CAC score(also trial results for kyolic garlic+coq10) - link 

Aged Garlic

MK-7 version of Vitamin K2

Berberine

Co-Q-10,

L-Arginine

Reveratrol, Pterostilbene

Homocysteine reducing program (B6, B12, Methylfolate)

LinusPauling Protocol (Lysine, Proline, Vitamin C, Tocotrienols, MK-7 Vit K2)

William Davis Track Your Plaque Protocol (Niacin, Omega-3 Fish Oil, Vitamin D3, Vitamin K2, Eliminate Wheat products)

Weight Reduction,

Hormone Optimization (optimize thyroid, testosterone, estrogen progesterone)

Heal the Leaky Gut (Probiotics, Glutamine, Colostrum)

Eliminate NSAIDS, PPI’s which cause dysbiosis and leaky gut.

Eliminate Pesticides,  Glyphosate and GMO food, eat Organic.

 

Maybe mainstream science will catch up  - link 

[pamojja]

What is the Linus Pauling Protocol? link

1. L-ascorbate (Vitamin C) 5-6 grams a day in divided doses
2. L-Lysine 5 grams a day in divided doses
3. L-Proline 2-3 grams a day in divided doses
4. Tocotrienol Vitamin E
5. MK-7 Vitamin K2

 

Strictly speaking, that seems Jeffrey Dach's version of the protocol. K2 and tocotrienols weren't even around while Pauling was still alive. Alledgedly he didn't recommend vitamin D, because at that time only D2 was available. Proline was a specific addition of Matthias Rath, who otherwise greadly reduced doses in his version of the protocol, and added GTE.

 

Beside Mathias Rath's version, Owen Fonorow's seems the most known version:

 

Pauling Therapy Summary

Therapeutic

• Vitamin C (6,000 to 18,000 mg)
• Lysine  (5,000 to 6,000 mg)

Pauling Therapy Enhancements

• Proline (250 to 2,000 mg)
• Coenzyme Q10 (100 to 300 mg)
• Magnesium (150 to 1,500 mg)

Preventives

• Vitamin C (3,000 to 10,000 mg)
• Lysine  (2,000 to 4,000 mg)

Follow Pauling’s other heart and cardiovascular
recommendations

• Vitamin E - 800 to 3,200 IU
• Vitamin A - 20,000 to 40,000 IU
• Super B-Complex - 1 or 2
• Daily multiple vitamin and mineral
• Drink plenty of water

Additional Enhancements

• Eliminate trans fatty acids from the diet
• Introduce unprocessed Omega-3 and Omega-6 oils
• Eat salt, but only unrefined salt
• Reduce manganese intake
• Eliminate ordinary sugar and refined carbohydrates
• Supplement with vitamin K
• Avoid supplemental calcium
• Supplement with the amino acids taurine, arginine and carnitine (1 to 3 grams)
• Supplement with vitamin D3 (2,000 IU), especially in the winter months
• Supplement with melatonin (3 to 6 mg) before bedtime

 

Linus Pauling only added enoughof the Lp(a) binding inhibitor l-lysine against CVD to his already existing protocol - merely to maintain good health up to old age in his '84 book:

 

How to Live Longer and Feel Better

• Take vitamin C every day, 6 grams to 18 g (6000 to 18,000 milligrams), or more. Do not miss a single day.
• Take vitamin E every day, 400 IU, 800 IU, or 1600 IU.
• Take one or two Super-B tablets every day, to provide good amounts of the B-vitamins.
• Take 25,000 IU vitamin A tablet every day.
• Take a mineral supplement every day, such as one tablet of the Bronson vitamin-mineral formula, which provides 100 mg of calcium, 18 mg of iron, 0.15 mg of iodine, 1 mg of copper, 25 mg of magnesium, 3 mg of manganese, 15 mg of zinc, 0.015 mg of molybdenum, 0.015 mg of chromium, and 0.015 mg of selenium.
• Keep your intake of ordinary sugar (sucrose, raw sugar, brown sugar, honey) to 50 pounds per year, which is half the present U.S. average. Do not add sugar to tea or coffee. Do not eat high-sugar foods. Avoid sweet desserts. Do not drink soft drink.
• Except for avoiding sugar, eat what you like - but not too much of any one food. Eggs and meat are good foods. Also you should eat some vegetables and fruits. Do not eat so much food as to become obese.
• Drink plenty of water every day.
• Keep active; take some exercise. Do not at any time exert yourself physically to an extent far beyond what you are accustomed to.
• Drink alcoholic beverages only in moderation.
• Do not smoke cigarettes.
• Avoid stress. Work at a job that you like. Be happy with your family.

 

Often LP protocol gets mistaken as one of its later often shortened versions. And then surprised that the actually much lower doses, and lack of comprehensive supplementation including lifestyle addaptations, doesn't work.

 

Edited by pamojja, 19 July 2020 - 09:45 AM.

[Gal220]

Besides insulin, I think the LP protocol would benefit from some collagen.  Dr.Axe's group recommends 3 scoops of his collagen for a month as a loading phase.

 

I doubt that much is necessary considering the LP protocol will increase collagen as well, but at least you wont spend the first month just getting your collagen starved system back to normal.

 

I prefer the sports research brand, but there are many options.  Besides maintaining arteries, this article goes over the other benefits of collagen.

 

"Is collagen the fountain of youth?

Reduces skin wrinkles and hydrates skin: Collagen is the essential component of the dermis layer of skin. Supplementation with collagen has been shown to increase skin flexibility and hydration and reduce the depth of facial wrinkles. In a study among women ages 40 to 60, supplementation with collagen for eight weeks showed a 28% average increase in skin moisture levels, and 91% of subjects reported less dry skin after supplementation."

[Gal220]

Protocol for elevated CAC score(also trial results for kyolic garlic+coq10) - link 

 

Short podcast with Dr Budoff(conducted the trials mentioned above), includes the ABCs of lowering plaque - link  , link2

 

A. asprin(81mg)  B. blood pressure   C. cholesterol    D.diet(mediterranean)  E.exercise(very important)   F. Fish oil(4grams high EPA) - probably need extra E to stop oxidation  G.Garlic

 

Kyloic garlic has a blend with some of the ingredients he recommends.

 

There are some concerns with red yeast rice(liver, purity) and it is kind of a low dose of coq10.  I would opt for their most potent kyloic garlic instead, 2 pills = 6 pills of the red yeast formula in terms of garlic - link 

 

Only peculiar thing about Budoff's trials is they didnt include k2, maybe he is unaware of it?

Edited by Gal220, 21 July 2020 - 03:17 AM.

[Gal220]

I had assumed kyloic garlic had allicin in it, apparently not the case.  Seems like Jefferey Dach makes the same assumption in his article, he mentions Ayelet Gonens work in reducing and stopping plaque in mice, but she specifically used allicin.  Seems most of the human trials have used aged garlic(kyloic claims 650 trials).

 

Life extension has a fairly comprehensive page on plaque and it mentions both aged garlic and allicin, but it doesnt help much.

 

[dazed1]

So when did longecity became brocity?

Anecdotes>high lvl evidence? Why go anti science and don't implement whole food plant based diet along with rosuvastatin and ramipril, and other supplements?

[pamojja]

 So when did longecity became brocity?

 

Well this thread started on 19 September 2013 

 

Why go anti science and don't implement whole food plant based diet along with rosuvastatin and ramipril, and other supplements?

 

Anyone with a high-percentage stenosis given the invasive option of cardiology only, and having plenty of evidence those never reverse arterial plaque. One of course becomes more inclined out of a 'nothing more to loose' situation, to try interventions with less evidence.

 

 JAMA. 2019 Mar 19;321(11):1069-1080. doi: 10.1001/jama.2019.1122.

 

Levels of Evidence Supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018.

 

Fanaroff AC¹, Califf RM^2,3,4, Windecker S⁵, Smith SC Jr⁶, Lopes RD¹.

Author information

 

Abstract

 

Importance:

Clinical decisions are ideally based on evidence generated from multiple randomized controlled trials (RCTs) evaluating clinical outcomes, but historically, few clinical guideline recommendations have been based entirely on this type of evidence.

 

Objective:

To determine the class and level of evidence (LOE) supporting current major cardiovascular society guideline recommendations, and changes in LOE over time.

 

Data Sources:

Current American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology (ESC) clinical guideline documents (2008-2018), as identified on cardiovascular society websites, and immediate predecessors to these guideline documents (1999-2014), as referenced in current guideline documents.

 

Study Selection:

Comprehensive guideline documents including recommendations organized by class and LOE.

 

Data Extraction and Synthesis:

The number of recommendations and the distribution of LOE (A [supported by data from multiple RCTs or a single, large RCT], B [supported by data from observational studies or a single RCT], and C [supported by expert opinion only]) were determined for each guideline document.

 

Main Outcomes and Measures:

The proportion of guideline recommendations supported by evidence from multiple RCTs (LOE A).

 

Results:

Across 26 current ACC/AHA guidelines (2930 recommendations; median, 121 recommendations per guideline [25th-75th percentiles, 76-155]), 248 recommendations (8.5%) were classified as LOE A, 1465 (50.0%) as LOE B, and 1217 (41.5%) as LOE C. The median proportion of LOE A recommendations was 7.9% (25th-75th percentiles, 0.9%-15.2%). Across 25 current ESC guideline documents (3399 recommendations; median, 130 recommendations per guideline [25th-75th percentiles, 111-154]), 484 recommendations (14.2%) were classified as LOE A, 1053 (31.0%) as LOE B, and 1862 (54.8%) as LOE C. When comparing current guidelines with prior versions, the proportion of recommendations that were LOE A did not increase in either ACC/AHA (median, 9.0% [current] vs 11.7% [prior]) or ESC guidelines (median, 15.1% [current] vs 17.6% [prior]).

 

Conclusions and Relevance:

Among recommendations in major cardiovascular society guidelines, only a small percentage were supported by evidence from multiple RCTs or a single, large RCT. This pattern does not appear to have meaningfully improved from 2008 to 2018.

 

Conventional treatment = high level evidence that invasive surgery and lifelong pholypharmcy don't reverse artherial plaque.

 

Lifestyle modification and comprehensive supplementation = number of 1 evidence, that it works dispite lack of RCTs. And science based bro-forums, like TrackYourPlaque a lot of those #1s.

 

Having personally benefited from both, the available RCT science and individuals who blazed trails with scanty low-level evidence science, there isn't really a contradiction. Even cardiologist derive the confidence in their traide from 91.5% in low level evidence.

Edited by pamojja, 21 July 2020 - 11:40 AM.

[Gal220]

So when did longecity became brocity?

Anecdotes>high lvl evidence? Why go anti science and don't implement whole food plant based diet along with rosuvastatin and ramipril, and other supplements?

 

Tower labortories is trying to win and sell more product. They have taken the time to figure out why the LP theory fails in some cases.

 

 

As I posted, there is a 6 year study using a scaled down version of the LP protocol that showed good results - link  , not surprising people report regression using the full protocol.

 

 

You also get the benefit of eliminating your bodies collagen deficit

[Gal220]

Another thread with Patrick Theut's protocol is on the forums HERE,  good discussion on interactions of Vit C, Vit K, HDL and LDL

 

I think it is very similar to the Linus Pauling protocol and combo mixes being sold that I LINKED above

Edited by Gal220, 15 August 2020 - 06:18 PM.

[arnie]

 

 

For what it’s worth, I don’t know what I’m doing. Just a layman 

 

2014 heart attack and stent

2018 another stent just above the previous one

 

I was seeing 2 cardiologist. One hated statins and one loved them. Confused again

Both said that I need to take stains due to the stents being in place

 

I hate statins. I get muscle soreness, wife tells me my mind is “foggy”. Every thing I’ve read tells me they are bad for me.

 

So Ive been pushing my doctors for “Repatha” as an alternative. It’s  very very expensive unless our government says my numbers/ readings are so bad that I can qualify for our PBS discounts.

 

I didn’t qualify UNTIL Covid came along and I also broke my foot. 

 

No exercise for 6 months, binge eating and drinking. Got my bloods done and I now qualify for government discounts on the Repatha. Sugar, LDL, trig numbers went through the roof

 

Down here we seem to measure on a different scale to you guys

 

LDL is 2.8 per mmol/L

Trig 3.3

HDL 1.2

Non HDL 4.3

total Chol 5.5

glucose 8.2 puts me in the diabetic range

and 4 other pages of codes & numbers which I don’t understand 

 

 

I don’t have the discipline that many of you seem to have but I’ll try and have a “balanced”, Low in cards and processed foods diet and see how I go

 

I hope the Repatha helps 

Edited by arnie, 10 September 2020 - 06:48 AM.

[JamesPaul]

I don't know if increasing HDL and lowering LDL helps.  Some people get that result from taking an extract of citrus bergamot, bergamot polyphenolic fraction, from citrus bergamot grown in a region of Italy.  The manufacturer or main distributor calls it Bergamonte.

 

Read reviews here:

https://www.amazon.c...s/dp/B07GCRHYM9

 

Ten references at the end of this article by the manufacturer or main distributor:

https://hpingredient...nts/BERGAMONTE/

[ryukenden]

The findings of the study, published in the journal Nature Biotechnology, show that the molecules, called peptides, can slow the growth of bad gut bacteria.

 

Do you know which peptides are they talking about?

 

https://www.news-med...osclerosis.aspx

 

[aribadabar]

 

Do you know which peptides are they talking about?

 

 

These are cyclic peptides with the following structure and sequences:

 

Attached Files

•  Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis.pdf   6.9MB   3 downloads
•  2.PNG   265.21KB   0 downloads
•  1.PNG   41.15KB   0 downloads

[ad506]

A new cyclodextrin variant seems to work without the ottotoxicity. https://twitter.com/...9249782784?s=20

[RWhigham]

Mind's Interview with Patrick Theut :  "an astounding story of how a paper-company engineer took a deep dive into the mechanisms of heart disease and figured out a way to reverse his heart disease - which runs against the mainstream medical advice of managing heart problems with drugs - instead of actually curing the condition."

[ryukenden]

https://www.bhf.org....cks-and-strokes

 

Interesting

[DougClean]

I don't know if increasing HDL and lowering LDL helps.  Some people get that result from taking an extract of citrus bergamot, bergamot polyphenolic fraction, from citrus bergamot grown in a region of Italy.  The manufacturer or main distributor calls it Bergamonte.

 

Read reviews here:

https://www.amazon.c...s/dp/B07GCRHYM9

 

Ten references at the end of this article by the manufacturer or main distributor:

https://hpingredient...nts/BERGAMONTE/

 

Found this while researching bergamot 

I also read all of the reviews on Amazon and most people got lower numbers and some said that there BP went down.

 

Quote

Another agent, bergamot, was studied in patients with atherosclerosis over 6 months without randomization. Lipid fractions improved as anticipated during therapy with bergamot and there was a stunning decrease in the CIMT from 1.2 cm to 0.9 cm.

 

Link

kahn642.medium.com/reversal-of-clogged-arteries-is-real-here-are-some-ways-i-do-it-433b890bf77e

 

Here is the study.............. I found it searching for Bergamot CIMT 1.2cm to .9cm

ncbi.nlm.nih.gov/pmc/articles/PMC4702027/

[DougClean]

Found this while researching bergamot 

I also read all of the reviews on Amazon and most people got lower numbers and some said that there BP went down.

 

Quote

Another agent, bergamot, was studied in patients with atherosclerosis over 6 months without randomization. Lipid fractions improved as anticipated during therapy with bergamot and there was a stunning decrease in the CIMT from 1.2 cm to 0.9 cm.

 

Link

kahn642.medium.com/reversal-of-clogged-arteries-is-real-here-are-some-ways-i-do-it-433b890bf77e

 

Here is the study.............. I found it searching for Bergamot CIMT 1.2cm to .9cm

ncbi.nlm.nih.gov/pmc/articles/PMC4702027/

 

I read the study and it looks like they made an injection of what they call Bergavit^®

 

Bergavit^® Containing 150 mg of flavonoids, with 16% of neoeriocitrin, 47% of neohesperidin, and 37% of naringin

 

Not sure if the oral form of Bergamot has the same stuff in it?

They used Bergamot juice extract.

 

Just wanted to be clear I was under the impression that they were using the oral form so the trial might not be the same as taking the oral form.
 

[DougClean]

Found this book online its old like 1975?

 

This Dr is convinced that Plaque is caused by the lack of Thyroid..

 

It's a long long read and kinda fuzzy but she makes a good case for Low Thyroid causing heart attacks and CAD going all the way back to 1880

 

Copy paste

 

Removal of the thyroid gland in animals or in the

human soon leads to atherosclerosis

Thyroid administration will delay

or prevent this degenerative process

 

jeffreydachmd.com/wp-content/uploads/2013/09/Broda_Barnes_Solved_Riddle_Heart_Attacks.pdf

 

 

I don't think she can prove a case for reversing arterial plaque with thyroid treatment but prevention is pretty convincing.

 

Spoiler alert: She recommends 1-2 grains of thyroid meds..... Only 1 to start if you have had a heart attack.

[Gal220]

Testimony from city data with medical records

 

"Although it’s not yet in the mainstream medical literature, vitamin K supplements ‘cured’ my extensive atherosclerosis of arteries. I was on crutches 7 years ago at the age of 83 and heading for a wheelchair because of peripheral artery disease.

I have provided ultrasounds of some lower abdominal and leg arteries before, and 14 months after, taking 10 times the recommended daily dose of both vitamin K1 and vitamin K2. Any arteries that were less than 60% occluded showed normal tracings, and I have been walking kilometres daily in spite of the fact that occluded arteries stayed occluded

 

You can check the validity of the tracings by the name and dates on the images. Three of the images show 100% reversal of atherosclerosis , but the severely affected dorsal pedal arteries stayed stenosed."

[aza]

Much of this has been mentioned before, but i am fairly interested in the gotu kola + pycnogenol combination. Life extension has a decent write up on it, and a nice trickle of studies keep coming in.

It increases macro and microvascular blood flow, which is nice.

https://www.lifeexte...arterial-plaque

 

https://pubmed.ncbi....h.gov/31633315/

"Considering a 34.88% increase in SM subjects, the total absolute difference between SM (34.8%) and the decrease observed in group 3 (-9.95%) was 44.75% (P<0.02)."

 

https://pubmed.ncbi....h.gov/31625707/ (with aspirin as well)

"In comparison with the SM group and the cardioaspirin group the rate of 'hard' cardiovascular events, requiring hospital admissions were <4% with the combined supplement in comparison with a value >12% in the other two groups (22.22% event rate in the SM group)."

 

I believe that the glycocalx in important the prevention on damage, it deteriorates with age and can be protected by reducing inflammation, hyperglycemia etc. Exercise helps improve it as well.

https://sjtrem.biome...3049-016-0239-y

 

INTERESTINGLY though, there is some research showing that it can be repaired/supported by two of our handy little friends already mentioned earlier in, glucosamine and chondroitin.

Glucosamine is a precurser for gags that are involved in the glycocalx, which could potentially come in handy if synthesis slows down in old age OR damage outpaces repair. I dont know how much it contributes though.

chondroitin happens to be an important part of the glycocalx and is associated with reduced risk of heart attack.

Although its possible the effect is only in the unhealthy or old.

"The reduced risk among current users was observed in both short-term (<365 days, AOR = 0.58; 95%CI: 0.45–0.75) and long-term users (>364 days AOR = 0.56; 95%CI:0.36–0.87),

in both sexes (men, AOR = 0.52; 95%CI:0.38–0.70; women, AOR = 0.65; 95%CI:0.46–0.91), in individuals over or under 70 years of age (AOR = 0.54; 95%CI:0.38–0.77,

and AOR = 0.61; 95%CI:0.45–0.82, respectively) and in individuals at intermediate (AOR = 0.65; 95%CI:0.48–0.91) and high cardiovascular risk (AOR = 0.48; 95%CI:0.27–0.83),

but not in those at low risk (AOR = 1.11; 95%CI:0.48–2.56)."

 

I suspect that gags are high in commercially available gelatin but i have no clue how much would be in there.

https://pubmed.ncbi....h.gov/16308135/ this study at the very least shows gag increase in bone after shark collagen administration to rats, so thats something.

 

 

As for getting the plaque out, i'm looking at fasting as a potential way to do that.

First of all. in mice "IF can reduce circulating pro-inflammatory monocytes and adhesion of these cells to endothelium, another anti-atherogenic mechanisms of IF treatment."

"IF potentially increases plaque stability by increasing collagen and VSMC content, while decreasing necrotic cores and macrophage/foam cell content."

 

https://faseb.online...pplement.786.30

Prolonged fasting increases the cholesterol efflux capacity and anti-inflammatory functionality of HDL particles in human subjects.

"we found that PF induces stark improvements in the functionality of HDL particles. PF increases the ability of HDL to promote cholesterol efflux from cholesterol-loaded THP-1 monocytes and increases the ability of HDL to suppress TNF-α secretion from primary macrophage stimulated with pro-inflammatory citrullinated-fibrinogen immune complexes. Furthermore, increased fasting duration was directly associated with increased Reverse cholesterol transport (RCT) ability and increased anti-inflammatory capacity of HDL with the maximal effect being reached after 36hrs of fasting. To our knowledge, this is the first study to show that PF is capable of improving the RCT ability of HDL and modifying the immunomodulatory functionality of HDL towards a more anti-inflammatory phenotype. These results thereby suggest that HDL may represent a novel mechanism by which PF exerts a portion of its systemic anti-inflammatory and cardioprotective effects."

 

As for inflammation this caught my eye (curcumin is also in my stack): https://pubmed.ncbi....h.gov/35033882/

The omega-3 index is inversely associated with the neutrophil-lymphocyte ratio in adults'

"The neutrophil-lymphocyte ratio (NLR) is a biomarker of systemic inflammation and measures innate-adaptive immune system balance. The omega-3-index (O3I) measures the amount of EPA+DHA in blood. Both a low O3I and an elevated NLR are associated with increased risk for chronic disease and mortality, including cardiovascular diseases and cancer. Hypothesizing that low O3I may partly contribute to systemic chronic inflammation, we asked if a relationship existed between O3I and NLR in healthy adults (≥18 y, n = 28,871, 51% female) without inflammation [C-reactive protein (CRP) <3 mg/mL)] who underwent a routine clinical assessment. NLR was inversely associated with O3I before (p < 0.0001) and after adjusting for age, sex, BMI, and CRP (p < 0.0001). Pearson correlations of other variables with NLR were r = 0.06 (CRP), r = 0.14 (age), and r = 0.01(BMI). In this healthy population, an O3I < 6.6% was associated with increasing NLR whereas NLR remained relatively constant (low) when O3I > 6.6%, suggestive of a quiescent, balanced immune system."

 

Whats more is omega 3/6 ratio looks like it may matter quite a bit in this regard, looking on grassroots health. It took a ratio of 1:4 to get everyone over the 6% omega index line.

https://www.grassroo...-aa-epa-ratios/

Generally, i think preventing damage as much as possible with lifestyle. Taking a few select supplements (the above for example, k2+mag+d etc)  and doing a fast every once in a while is a fairly good approach.

 

[aza]

Found this book online its old like 1975?

 

This Dr is convinced that Plaque is caused by the lack of Thyroid..

 

It's a long long read and kinda fuzzy but she makes a good case for Low Thyroid causing heart attacks and CAD going all the way back to 1880

 

Copy paste

 

Removal of the thyroid gland in animals or in the

human soon leads to atherosclerosis

Thyroid administration will delay

or prevent this degenerative process

 

jeffreydachmd.com/wp-content/uploads/2013/09/Broda_Barnes_Solved_Riddle_Heart_Attacks.pdf

 

 

I don't think she can prove a case for reversing arterial plaque with thyroid treatment but prevention is pretty convincing.

 

Spoiler alert: She recommends 1-2 grains of thyroid meds..... Only 1 to start if you have had a heart attack.

 

On that note, valtsu has a nice summary of that research. Its pretty interesting stuff.

http://valtsus.blogs...disease_13.html

 

Not only that, but red light therapy also appears to help the thyroid to some extent.

http://valtsus.blogs...eated-with.html

 

Its entirely possible in my option, that some (not all) thyroid issues could effectively be the result of a kind of "sunlight deficiency" if it turns out that sunlight effects the thyroid in a similar way.

 

Heres a study on polarised light in rabbits i thought was pretty neat. Although i dont think its likely to have similar effects in people because of anatomy differences and poor light penetration, im not sure if it would reach the heart/arteries.

infared/red light only goes in around 3cm i believe, with most of it gone after the first 4mm.

Polarised light i think can go up to 5cm but im not entirely sure.

I'm still hopeful though.

https://www.ncbi.nlm...les/PMC3315201/

" 5-min PLT preferentially decreased LDL, rather than cholesterol, and thereby potentially reduced the atheroma area to 42.2%. Notably, 20-min PLT was superior to lovastatin in reducing both the cholesterol and LDL levels as well as the atheromatous plaque formation (26.4%)."

Sunlight is related to lower heart disease mortality (or at least total mortality)

https://www.karger.c...xt/441266#ref17

"Observational data from numerous large cohort studies, now summarised in several meta-analyses show that individuals with measured vitamin D levels in the lowest quartile have around twice the all-cause mortality of those in the upper quartile, and are more likely to have hypertension, cardiovascular disease, metabolic syndrome, and solid organ cancers [7,8,9]. Clinical trials of vitamin D supplementation have however shown that vitamin D is of no benefit in the prevention or treatment of hypertension, cardiovascular disease, cerebrovascular disease or metabolic syndrome, although it is important for bone health [8]. This is further supported by a recent Mendelian randomisation study, which showed that patients with genetic polymorphisms leading to lifelong reduced vitamin D levels have a higher standardised mortality and risk of solid organ cancer, but no difference in cardiovascular health [10].

These apparently conflicting observations may be explained by confounding; fit individuals, spending more time outside in the sun will synthesise more vitamin D, which is thus a marker for health. An alternative and non-exclusive explanation, consistent with the epidemiological data on latitude and season, is that sunlight, independently of vitamin D synthesis, has cardiovascular, cerebrovascular and metabolic benefits."

 

https://pubmed.ncbi....h.gov/26992108/

Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort

"Nonsmokers who avoided sun exposure had a life expectancy similar to smokers in the highest sun exposure group, indicating that avoidance of sun exposure is a risk factor for death of a similar magnitude as smoking. Compared to the highest sun exposure group, life expectancy of avoiders of sun exposure was reduced by 0.6-2.1 years."

 

As an unrelated to this topic side note, joov had a study recently showing fairly large increases in testosterone with red light use when combined with ketogenic diet (i dont believe its peer reviewed yet though, i believe it is mainly mediated by the red light not the diet).

https://joovv.com/bl...d-light-therapy

[pamojja]

Also in my case of remission of a 60% walking-disability from PAD, just got confirmation that sunlight-exposure was an essiential addition.

 

Since 2012 went always in the deepest winter to a South-Indian beach for 6 weeks, throughout 4 hrs everyday with full-body sunlight exposure (during 8 years total). 2016 experienced final remission of my walking-disability.

 

Since 2021 that vaccation wasn't possible anymore, and for the first time in 6 years got some PAD-pains middle of winter in my thighs again. Though different, it that it would improve with slow further walking - while before it always was so intense to bring any further stroll to a quick end (at worse, after 3-400 meters only).

 

However, 2021 with the first week of daily sun-bathing here in Central Europe pains were gone again. So for the 2022 I bought a 900 Watt Infraredlight setup, and was actually surprised, how only 30 minutes of daily radiation would already alleviate the thigh-pains this winter. Now with the first week this year sun-bathing - pains completely gone again.

 

PS: though my low T3 and free Testosterone remained low.

Edited by pamojja, 23 May 2022 - 02:38 PM.

[aza]

This is an interesting study in rats.

https://faseb.online...upplement.828.1

Dietary Glycocalyx Precursor Supplementation Ameliorates Age-Related Vascular Dysfunction (also, Fucoidan is apparently a heparin mimetic.)

"We sought to determine if chronic dietary supplementation of glycocalyx precursors (glucosamine sulfate, fucoidan, superoxide dismutase, and high molecular weight hyaluronan) could restore glycocalyx function"

 

It improved a number of things to almost young mice levels, including their measure of glycocalyx function 'perfused boundary region"

"PBR was ~13% higher in OC compared to YC, suggestive of an age-related impairment in glycocalyx barrier function, and this was normalized in OGP mice"

 

aortic pulse wave velocity

"after the dietary intervention, PWV decreased by ~13% in OGP (P<0.05), whereas, PWV was unchanged in OC and YC mice after the 10 week period (P>0.05)."

 

And Nitrix oxide bioavailablity "NO bioavailability (max ACh dilation - max ACh+L-NAME dilation) was ~10–14 fold higher in YC and OGP compared to OC mice (Both P<0.05; Figure 3)."

 

Also "We assessed endothelial function by endothelium-dependent dilation (EDD, maximal response to acetylcholine [ACh]) in the carotid artery. Carotid artery EDD was higher in YC and OGP compared to OC mice (92.5±2.4 and 90.7±2.3 vs. 69.0±4.9%"

 

"In conclusion, 10 weeks of dietary GP supplementation in old mice restores glycocalyx barrier function that is accompanied by reduced aortic stiffness and augmented EDD and NO bioavailability, suggesting that the glycocalyx may be an effective therapeutic target for vascular dysfunction in older adults."