591 replies to this topic

[pamojja]

With all due respect, elevated blood pressure is an indication of arterial plaque. Contrarily, blood pressure decreasing indicates the potential that arteries are more flexible, possibly because of a decrease in arterial plaque - or at least an improvement in arterial stiffening.

 

Guess you missunderstood my remark. With blood pressure being not being my concern I meant only in my case, I had constant 110/70 during the last 11 years. In this time a walking-disabilty from a 80% stenosis - only able to walk 10 minutes a time at worse - came and went again. Without any obvious contribution from my constantly low BP.

 

For anyone else with high pressure it is of course of concern.

Edited by pamojja, 28 August 2019 - 05:09 PM.

[Rocket]

 Daredevil reported several facial fat loss with more use DQ than I did. So, I am reticent to use DQ again.

 

Daredevli also re-used needles and gave himself a nasty infection because he thought there was nothing wrong with re-using needles as its "your own germs". He also injected GDF11 as a "pick me up" like caffeine. I would not trust anything coming from that user. There were many questionable things from that particular member.

 

There is no mechanism for Dasatanib to destroy body fat, nor limit it to facial fat.

 

Dasatanib can make someone feel very ill like the flu and not like eating. 

 

I've used D+Q and never lost fat even though my dosages are were very high compared to other members.

Edited by Rocket, 28 August 2019 - 07:17 PM.

[Daniel Cooper]

I agree with the above.  Nice guy, but his laboratory technique left something to be desired.  

 

 

 

Edited by Daniel Cooper, 28 August 2019 - 07:27 PM.

[mikey]

Daredevli also re-used needles and gave himself a nasty infection because he thought there was nothing wrong with re-using needles as its "your own germs". He also injected GDF11 as a "pick me up" like caffeine. I would not trust anything coming from that user. There were many questionable things from that particular member.

 

There is no mechanism for Dasatanib to destroy body fat, nor limit it to facial fat.

 

Dasatanib can make someone feel very ill like the flu and not like eating. 

 

I've used D+Q and never lost fat even though my dosages are were very high compared to other members.

 

Wow. Yes, a nice guy.

Didn't know about the "lab technique."

Whatever effect Dasatinib has on reducing fat cell progenitors, D doesn't feel good. 
 

I remain in wait of Trodusquemine's availability - AND for the Nova Biosciences' human trial to be completed.

[Daniel Cooper]

Wow. Yes, a nice guy.

Didn't know about the "lab technique."

Whatever effect Dasatinib has on reducing fat cell progenitors, D doesn't feel good. 
 

I remain in wait of Trodusquemine's availability - AND for the Nova Biosciences' human trial to be completed.

 

 

At least if their trial goes well we might have enough interest to get a synthesis of actual trodusquemine done.  

 

It's a difficult compound to synthesize, but since it's found in nature there's no reason I know of that it couldn't be sold as a supplement.

 

I suspect that if the right people looked at the problem hard enough a better higher yielding synthesis route could be achieved.

[mikey]

At least if their trial goes well we might have enough interest to get a synthesis of actual trodusquemine done.  

 

It's a difficult compound to synthesize, but since it's found in nature there's no reason I know of that it couldn't be sold as a supplement.

 

I suspect that if the right people looked at the problem hard enough a better higher yielding synthesis route could be achieved.

 

If it becomes a drug, odds are that FDA won't allow it to be sold OTC.

 

However, if it becomes a sought-after drug there are other countries that flaunt the patents and make a drug to deliver to their population for cheap.

This "socialized" medical approach happened in Brazil, when effective HIV drugs were first introduced.

Brazil tried to make a deal with drug companies to supply their population at a low cost and couldn't get a good deal so that said "FU" to the drug companies and their patents and made the drugs themselves for their HIV+ population. My Brazilian travel booking agent was HIV+ and told me that this occurred and the government gave him his drugs for very low cost. This was in 2004. So, it may be different now and I never see Brazil as a source of pharmaceuticals in the internet.

[arnie]

Let me be a devils advocate here.
Looks like we are concentrated too much on the calcium depositions and treat this as end-all progress bar of a heart disease.
What if this is just a coincidental marker of damage and works only when averaged to the the population level, and doesnt reflect disease progression if individual takes supplements that influence calcium metabolism(or that metabolism genetics is different from average)
Ive just put some average numbers into MESA risk calculator and for 80 yo man with zero CAC score 10 year risk is about 10% which is better then 42% for this age but still.

As far as I understand it people with zero CAC are 3 times less likely to suffer hard event https://www.ncbi.nlm...les/PMC2766514/, but its still a significant risk.
And I recall hearing that majority of ruptures happen in noncalcified regions of the arteries.

Is it possible that shifting calcium metabolism doesnt help much with heart disease an we are just `fixing` the test result instead of disease?
Shouldnt we concentrate more on soft plague removal, inflammation markers, endothelial health?

I had a CAC done and my reading was a very low 7. The Cardioligist said I had an incredibly slim chance of a heart attack.
12 months later I did.....go figure
2 stents later. I did my yearly stress echo test today so I’ll be interested to get my results

[Andey]

I had a CAC done and my reading was a very low 7. The Cardioligist said I had an incredibly slim chance of a heart attack.
12 months later I did.....go figure
2 stents later. I did my yearly stress echo test today so I’ll be interested to get my results

 

   Yep, I think CAC is helpful on a population level (as well as LDL-C is a marker on a population level). On individual level person could have different calcium metabolism and just dont accumulate calcium. And one could probably take supplements to shift calcium metabolism and have low CAC score but advanced disease.

 

I would say best bet to treat it and prevent further events is to reverse metabolic syndrome if you have one (probably the best sign of it is high triglycerides and insulin resistance, and the best chance to get red it of it is a ketogenic diet), take nattokinase  (it shown to reduce soft plague), and probably take something like Taurine (I believe Turnbuckle hypothesis about sulfonate groups that reduce plagues).

And if one have very high cholesterol and a family history of early deaths from heart disease than taking statins would help too, it was designed for guys with familial hypercholesterolemia and works well for those cases.

Edited by Andey, 11 September 2019 - 08:07 AM.

[pamojja]

Dr Malcolm Kendrick: the True Causes of Heart Disease are Not What You Think!

https://thefatempero... ... you-think/

[ryukenden]

https://www.genengne...d-by-rnai-drug/

Unlike cells elsewhere in the body, the cells that form the inner walls of our arteries become inflamed when transforming growth factor-β (TGF-β) proteins circulate. This observation, made by scientists based at Yale University, suggests that interfering with TGF-β receptors could lessen chronic inflammation in blood vessels, which is believed to cause atherosclerosis. The Yale scientists, in fact, have developed a drug that relies on RNA interference (RNAi) to silence TGF-c receptor genes in endothelial cells—and only endothelial cells. This cell-level selectivity is achieved by packing the RNAi drug into an endothelial-cell-targeting nanoparticle.


https://vasrx.com/about/


Hopefully we can get this kind of therapy asap.

[Guest]

https://www.genengne...d-by-rnai-drug/

Unlike cells elsewhere in the body, the cells that form the inner walls of our arteries become inflamed when transforming growth factor-β (TGF-β) proteins circulate. This observation, made by scientists based at Yale University, suggests that interfering with TGF-β receptors could lessen chronic inflammation in blood vessels, which is believed to cause atherosclerosis. The Yale scientists, in fact, have developed a drug that relies on RNA interference (RNAi) to silence TGF-c receptor genes in endothelial cells—and only endothelial cells. This cell-level selectivity is achieved by packing the RNAi drug into an endothelial-cell-targeting nanoparticle.


https://vasrx.com/about/


Hopefully we can get this kind of therapy asap.

 

 

Fear not! It is I - the Glucosamine prophet! 

 

No joke though - GS seems to be able to do just what you ask for:

 

"IL-10 and TGF-β: Roles in Chondroprotective Effects of Glucosamine in Experimental Osteoarthritis?" (2017)

https://www.research...eoarthritis.pdf

 

It's a small trial in rats, undergoing treatment to induce inflammation in their joints. Using a moderatly high dose of oral GS, much of the inflammation could be prevented (GlcN = Glucosamine in the diagram):

 

 

 

This of course is only indicative of a potential role in endothelial cells. Luckily there is some epidemiological data in humans available concerning CVD-risk (at a rather low dose) and a rabbit-model for arterial disease, which demonstrated some remarkable results of GS for inflammation and CVD - albeit at a really high dose:

https://www.longecit...e-5#entry879575

 

I guess at the moment - given the safety and cheap online-prices of GS - it beats waiting a couple more years for the RNAi drug.

[Izan]

https://knowledgeofh...lesterol-drugs/

[ryukenden]

Fear not! It is I - the Glucosamine prophet!

No joke though - GS seems to be able to do just what you ask for:

"IL-10 and TGF-β: Roles in Chondroprotective Effects of Glucosamine in Experimental Osteoarthritis?" (2017)
https://www.research...eoarthritis.pdf

It's a small trial in rats, undergoing treatment to induce inflammation in their joints. Using a moderatly high dose of oral GS, much of the inflammation could be prevented (GlcN = Glucosamine in the diagram):




This of course is only indicative of a potential role in endothelial cells. Luckily there is some epidemiological data in humans available concerning CVD-risk (at a rather low dose) and a rabbit-model for arterial disease, which demonstrated some remarkable results of GS for inflammation and CVD - albeit at a really high dose:
https://www.longecit...e-5#entry879575

I guess at the moment - given the safety and cheap online-prices of GS - it beats waiting a couple more years for the RNAi drug.

Interesting. What dose are you taking? Any evidence that it’s working for you?

[ryukenden]

https://knowledgeofh...lesterol-drugs/

Thank you. Do you take it and what dose? Do you take it with Gluosamine?

[brosci]

What's the consensus on glucosamine / chondroitin and liver health?

[ryukenden]

Are you aware of any best supplememt combo to reverse atherosclerosis?

[mikey]

Dr Malcolm Kendrick: the True Causes of Heart Disease are Not What You Think!

https://thefatempero... ... you-think/

 

Dr. Kendrick provides a tremendous variety of well-founded information. Why he doesn't look like he is eating the type of diet that he certainly knows is best for cardiovascular health causes concern, though.

 

David Sinclair does look younger in current videos than he did a few years back.

 

A question for me is "Would I seek the services of an anti-aging specialist that looks his age or older?"

 

I found this to be true of a "world-leader" in stem cells. While he bragged that he was "living the anti-aging lifestyle," he looked like an old delusional man. I knew someone that did extensive stem cell therapy with this doctor that looked 20 years older after five weeks of treatments and died six months later.

Considering the source is, for me, a constant.

 

Dr. Kendrick, on video, certainly did keep my attention, though.

[mikey]

Thank you. Do you take it and what dose? Do you take it with Gluosamine?

 

Rather perhaps take a daily tablespoon or two of hydrolyzed collagen, as glucosamine - and chondroitin are provided in their natural format. 

The cost is much less than taking tablets or capsules of isolated glucosamine, etc...

[ryukenden]

Rather perhaps take a daily tablespoon or two of hydrolyzed collagen, as glucosamine - and chondroitin are provided in their natural format. 

The cost is much less than taking tablets or capsules of isolated glucosamine, etc...

 

Thank you and are you taking it regularly? Which brand do you recommend?
 

[pamojja]

Dr. Kendrick provides a tremendous variety of well-founded information. Why he doesn't look like he is eating the type of diet that he certainly knows is best for cardiovascular health causes concern, though...

 

Dr. Kendrick, on video, certainly did keep my attention, though.

 

With his understanding, understandable:

 

 

https://drmalcolmken...isease-part-59/

 

There are many, many, things that can do this. Here is a list. It is non-exhaustive, it is in no particular order, but it may give you some idea of the number of things that can cause CVD, by accelerating endothelial damage:

Smoking
Systemic Lupus Erythematosus
Use of oral steroids
Cushing’s disease
Kawasaki’s disease
Rheumatoid arthritis
High blood pressure
Omeprazole
Avastin
Thalidomide
Air pollution
Lead (the heavy metal)
Mercury
High blood sugar
Erythema nodosum
Rheumatoid arthritis
Low albumin
Acute physical stress
Acute mental stress
Chronic negative mental stress
Chronic Kidney Disease
Dehydration
Sickle cell disease
Malaria
Diabetes/high blood sugar level
Bacterial infections
Viral infections
Vitamin C deficiency
Vitamin B deficiency
High homocysteine level
Chronic kidney disease
Acute renal failure
Cocaine
Angiotensin II
Activation of the renin aldosterone angiotensin system (RAAS) etc.

Blimey, yes, that list was just off the top of my head, I could get you another fifty without much effort. And no, I did not just make it up. I have studied every single one of those factors, and many more, in exhaustive detail. The extent of how many factors there are, should not really come as a surprise to anyone, but it usually does.

 

If I remember him right, only Kawasaki and Sickle cell disease are sufficient causes for plaque to grow even in children. If one has a Zero CAC score at his age, why worry?

[mikey]

Thank you and are you taking it regularly? Which brand do you recommend?

[mikey]

Yes. 1-2 tblsp/day. Great Lakes brand from grass-fed cows. But there are numerous good brands. Hydrolyzing collagen isn't rocket science. Note: I was a paid consultant on team when Knox brought it to market.

[ryukenden]

Yes. 1-2 tblsp/day. Great Lakes brand from grass-fed cows. But there are numerous good brands. Hydrolyzing collagen isn't rocket science. Note: I was a paid consultant on team when Knox brought it to market.

Thank you. I will buy some to try.

[ryukenden]

By giving mice the nano-encapsulated D-PDMP, the authors concluded,“disease markers of atherosclerosis and cardiac hypertrophy can be ameliorated.” In addition totreating the manifestations of cardiovascular disease, thepolymer-encapsulated D-PDMP is a potential therapy for a “spectrum of diseases,” including cancer and other diseases characterized by excessive GSL biosynthesis.

 

 

https://www.mdlinx.c...-in-mice/lfc-38

 

 

Are they not testing on this anymore?

Edited by ryukenden, 22 May 2020 - 07:27 AM.

[ryukenden]

The researchers found that the nanotherapy reduced plaque by 40% in both female and male mice with less advanced plaque, and it reduced the plaque by 20% in male mice with more advanced plaque.

 

 

 

https://med.stanford...e-arteries.html

 

 

It will be interesting to see human trials.

[Daniel Cooper]

The thing you have to be careful about is that mice really don't want to get atherosclerosis.  So you put them on a high fat diet and give it to them, then you do almost anything (or nothing besides remove the high fat diet) and they tend to reverse.

 

That said, I am hopeful about this and a few other therapies. Assuming that it does work, unfortunately here in the US we're looking at many years till this is even potentially available to patients. Our FDA doesn't do much quickly (except maybe approve a covid vaccine - we'll see).

 

 

 

 

 

[ryukenden]

The thing you have to be careful about is that mice really don't want to get atherosclerosis.  So you put them on a high fat diet and give it to them, then you do almost anything (or nothing besides remove the high fat diet) and they tend to reverse.

 

That said, I am hopeful about this and a few other therapies. Assuming that it does work, unfortunately here in the US we're looking at many years till this is even potentially available to patients. Our FDA doesn't do much quickly (except maybe approve a covid vaccine - we'll see).

 

Yes, I agreed. Hopefully many other countries will use more of nanoparticle technology. I could not find which drug they used in the Nanotherapy. They keep it as a secret?

[Daniel Cooper]

Yes, I agreed. Hopefully many other countries will use more of nanoparticle technology. I could not find which drug they used in the Nanotherapy. They keep it as a secret?

 

 

The compound is in that first article you gave us.  D-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP).  You could buy it and encapsulate in liposomes pretty easy I think, but that's not quite what they are using (I think they used PEG to encapsulate it). But, without reading the original paper I'm guessing they are injecting this stuff IV rather than giving it orally.  I certainly would not be prepared to inject some homemade encapsulation into myself as I don't know how I'd ever ensured sterility.

 

But good info.  Hopefully we'll have access to this one day.

[aribadabar]

But, without reading the original paper I'm guessing they are injecting this stuff IV rather than giving it orally

 

Surprisingly, it was orally.

 

 

(treated with vehicle only, 5% Tween-80 in PBS), 5 mg/kg D-PDMP solubilized in vehicle, and 10 mg/kg D-PDMP solubilized in vehicle. Vehicle and D-PDMP were delivered daily by oral gavage

[Daniel Cooper]

Surprisingly, it was orally.

 

Interesting. 

 

It looks like in 2015 they were encapsulating D-PDMP in PEG and sebacic acid, which if someone had the D-PDMP I suspect you could accomplish the encapsulation.  However in the 2020 article they are talking about encapsulating it in "nanotubes".  I don't normally associate PEG encapsulation with "nanotubes" but maybe they were trying to sex it up, or maybe they actually changed their method in those 5 years.  When I'm not so tried I suppose I should really read these papers.

 

In any case, depending on the availability of D-PDMP, a person might just be able to make some of that up.