Yes, I found sunifiram enhanced social interactions, sensory awareness, and talking. But for me, since I didn't have a problem in those areas in the first place, when I was around people who did have some deficits or extremes in those areas, this enhancement could be a problem in terms of how they could interact easily with me.
Sunifiram also did seem to cause some mild hypomanic symptoms for me. Since I don't have bipolar, mild hypomania was enjoyable and very limited. I did not do anything regrettable and enjoyed myself immensely. But I can see where this effect could be a problem for people with bipolar.
Sunifiram was very fun and enjoyable for me, but it's effects wore off and I had some doubts about brain safety for the long term. So I see it as an occasional noot, rather than a regular one.
Nice report, could you elaborate on how can be a problem people interacting with you? I think I am getting what the problem might be with other people, not being able to follow in some ways? It seems an interesting observation, could you put more detail to it?
OK. What I think was going on for me in those social situations under the influence of sunifiram:
under normal conditions (no noots) I already tend to process relational issues rapidly, but with empathy and some self-preserving self-awareness (how I might seem to others), so generally it isn't hard for me to pace myself to others in social settings. The mild hypomanic state that sunifiram induced reduced the empathy somewhat and increased my egocentric self-awareness. This is not always a bad thing. But I was going at an even higher speed than normal in terms of expressing myself and noticing things that were important to me, but paying less attention to how others might be feeling. This wasn't a problem around my friends, but around people with autism spectrum this can be a big problem. Their processing speed is microseconds slower and relational awareness is very different than a neurotypical person, so I could lose them in conversation. This would be very problematic in my work, as a number of my clients have ASD.
In other words, not only would I not be giving some people enough time to form their responses to me, I wouldn't notice or care as much as normal under the influence of something like sunifiram. Bipolar can cause similar effects, as well as some stronger stimulants. That said, sunifiram probably would not be problematic for me, since I'm aware of the effect on communication. Not that I would take it in a work setting.
This also should address the op's question, which did mention public speaking and presentation, I believe. I wouldn't use sunifiram for public speaking without thoroughly trialing it first for that purpose.
I hope this makes sense. It's actually a pretty complicated topic. I've probably stepped on someone's toes.
Edited by MizTen, 21 February 2014 - 09:12 PM.