6 replies to this topic

[SeekingSerenity]

Many forum members have said that NAC supplements can be problematic.


Is there any amount of NAC that you consider to be safe? What about 25 mg?

[normalizing]

25mg is too low. you need at least 2 grams for w/e reason you are using it.

[hamishm00]

Sources for that statement?

[SeekingSerenity]

25mg is too low. you need at least 2 grams for w/e reason you are using it.

I'm not taking it for any particular reason.

It's in my antioxidant pill, and I'm wondering if I should be concerned at all:

http://www.aor.ca/pr...nt-synergy-old/

[cuprous]

I've yet to come across a single reason not to take NAC. Every time it comes up there is invariably mention of the study that showed it causing pulmonary hypertension in mice. The corresponding human dosage would be something like 20 grams. Meanwhile other studies have shown it to help with hypertension.

NAC is one of the best ways to boost glutathione as it is the limiting factor in its synthesis. You want your body to be able synthesize all the glutathione it needs to. This is a pretty big deal IMO.

The only potential downside to NAC is that it is itself a powerful anti-oxidant and there is conjecture that it inhibits certain ROS-dependent pathways such as that necessary to signal the generation of red blood cells.

25mg is too low. you need at least 2 grams for w/e reason you are using it.

Rubbish. A lot of studies use in the order of 800mg.

[hav]

Here's a human NAC study that has a chart showing what looks like about a 25% increase in hypoxic ventilatory response at a dosage of 600 mg taken 3x a day.

http://www.ncbi.nlm....pubmed/11861267

That compares to about a 66% increase in pulmonary arterial hypertension measured in the mouse study. I'm not sure how to equate the dosages but the mouse study also found no increase when it reduced dosages by a factor of 10. Unfortunately, the human study didn't identify a no-effect dosage. Maybe its somewhere between 300 and 600 mg a day.

Howard

Edited by hav, 23 October 2013 - 01:12 AM.

[TheKidInside]

NAC is one of the best ways to boost glutathione as it is the limiting factor in its synthesis. You want your body to be able synthesize all the glutathione it needs to. This is a pretty big deal IMO.

Or like...normalize your insulin and leptin.