15 replies to this topic

[Virtual Reality]

http://www.youtube.com/watch?v=BYZacKcGjhM

http://www.unibas.ch...1&&&o_lang_id=2

Would you take it? Discuss.

[xEva]

It's Benadryl (diphenhydramine) used for seasonal allergies and symptoms of cold.

http://www.nlm.nih.g...ds/a682539.html

On March 2, 2011, the Food and Drug Administration (FDA) issued a safety alert about certain unapproved prescription cough, cold, and allergy products containing this drug in combination with other drugs. These products are not currently approved by the FDA for safety, effectiveness, and quality. FDA asked drug companies to stop shipping most of these products for sale in the US within the next 6 months.

The study used 50 mg. Who will be the first to try it out?

[Eruditus]

Maybe a few weeks back I would have been inclined to say yes because I have some pretty fucked up memories that still make me cringe in shame and anxiety from time to time when I am reminded of them.

However just today I had this breakthrough realization as I was walking through the forest. This may sound a bit meta-physical and like philosophical pseudo-intellectualism to some, but to me the notion has great meaning. Think of the brain as a forest and as time passes so do the seasons change in the forest and the trees shed their leaves to grow new leaves; maybe so should we as humans always try to change and move forward in favor of forming new neural pathways rather than re-enforcing the old negative neural pathways by reliving the emotional association each time we trigger them. So the analogy to me is that our neurons are like the tree-leaves and should always be changing rather then stagnating.

[revenant]

Truth of the matter is, long term episodic memory degrades slightly over a period of about 3 years. Interestingly, after three years details actually become increasingly more accessible for about two years. By 5 years it becomes fairly stable. If the memory isn't re-potentiated (recalled) every once in a while it may fade. However, every time a memory is recalled, details may become overwritten a little by your brains tendency to view the past through a lens of the present.

[▲420MD]

How do we know its diphenhydramine? Just wondering...

[xEva]

we know its diphenhydramine from reading the original paper

[BlueCloud]

It's Benadryl (diphenhydramine) used for seasonal allergies and symptoms of cold.
....
The study used 50 mg. Who will be the first to try it out?

?? Isn't Diphenydramine an old and extremely common and ordinary OTC antihistamine ? It's not like it's an unknown substance, it has always been very popular. In the US it's also sold as a sleeping aid. I have taken it on or off for the last decade for my insomnia, and never noticed anything special in relation to effects on bad memories, and never heard of anyone who did...
Very odd...

Edited by BlueCloud, 16 November 2013 - 09:17 PM.

[Eruditus]

DPH haha lol aka most crappy otc sleep aid in existance; used three nights the minimum dose will lose all effifacy in helping you get to sleep and will more likely then not cause insomnia also known to cause delirium in psychoactive doses 5 to 10 times doses for sleep inductive purposes, repeated excessive use can lead to psychotic breaks with reality. I once read a forum post of some deluded teen junk who abused to many otc meds like dph and dextromethorphan; he was actually so far gone he thought his stepfather and every female he laid eyes wanted to rape him due to his super sexy pheromones being secreted as a consequence of his dph use... I definitely think I'll pass on this little miracle pill then :p

[Virtual Reality]

Forget the study i posted. Watch the video only they say its not a anti histamine. Did you guys even watched what i posted?

[JohnD60]

Forget the study i posted. Watch the video only they say its not a anti histamine. Did you guys even watched what i posted?

I just watched it. They clearly say it is based upon a known antihistamine. Maybe you should watch it again, and be sure to not take any benadryl within an hour of watching the video.
Scientific American had a article on memory about six months ago. where they described research on how memories were formed and reinforced. There was one particular compound that was effective in preventing memories from forming, but it had to be taken within about ten minutes of the event, or immediately after recalling the event, I think it was Ketamine, but I am not sure, it was definitely not an OTC drug, I am not motivated enough to look it up.

Edited by JohnD60, 25 November 2013 - 08:15 AM.

[eon]

isn't it because diphenhydramine is Benadryl? It's sleep inducing, so technically it might make you erase bad memories (short term?) and or since you'd be well rested then? And or since this could put you to sleep (forever?). I think it is also hallucinogenic in very high dose but I am not sure if this is the same drug I read about that is OTC, when used in higher dosage. I think anything hallucinogenic will make you erase some bad memories (like shrooms and LSD). I've used shrooms before. The nootropic I currently use brought back the memories as it's supposed to. LOL.

Then again I just watched this video and there was no mention of which antihistamine it was. There are several out there. The video mentioned "if you could just take 1 pill" but never mentioned the dose. LOL. The only antihistamine I've used was chlorpheniramine maleate (ChlorTabs). Interesting how low the dosage is at only 4mg a pill. I only take 1 pill at a time for sneezing and water eyes/runny nose. But such low dose tells me that this is a powerful drug. Something about the name of the drug should reveal what it's other potential should be, right?

Edited by eon, 04 January 2014 - 11:09 AM.

[killahbeatz]

Could it be hydroxyzine. Hydroxyzine is claimed to have strong anxiolytic and mild antiobsessive as well as antipsychotic properties. Also there is Metyrapone. Metyrapone is not a antihistamine. Metyrapone has been found in early human trials to reduce recollection of emotional memories in normal volunteers. The volunteers showed significant impairment in ability to retrieve memories with negative emotional content while not impairing memories with neutral content. This has significant implication in the study of the process of emotional healing in post traumatic stress disorde

[eon]

Are those Otc drugs?

[eon]

Those seem to be obsolete drugs? I didn't look hard enough though. If metyrapone is not antihistamine then it's not it but interesting story on the drug itself. Last I checked if it's not hallucinogenic it won't be highly effective for PTSD (like magic mushrooms or LSD is said to be).

Metyrapone could be used to treat hypercortisolism as well. Could be interesting since I have used phosphatidylserine for cortisol lowering possibilities at 400mg daily. But not sure anything noticeable happened. I think it was because I split it in 2 dosing a day, 200mg in the am and 200mg in the pm, when I probably should have been dosing it at 400mg 1x a day. I'll try next time.

Edited by eon, 27 January 2014 - 10:01 AM.

[xks201]

Fascinating. diphenhydramine=benadryl

[eon]

well 50 mg is a normal dose as well, I think for sleep aid. For antihistamine aid it's 25 mg. I'd try it out only if I am not using any nootropics related drugs so it does not "interfere" with whatever diphenhydramine is purported to do.

I would think its effect on bad memories would only work for those with actual bad memories that seem to be bothering a person for life like in the case of people with PSTD or anxieties on certain situations due to bad experiences.

It's Benadryl (diphenhydramine) used for seasonal allergies and symptoms of cold.
....
The study used 50 mg. Who will be the first to try it out?

?? Isn't Diphenydramine an old and extremely common and ordinary OTC antihistamine ? It's not like it's an unknown substance, it has always been very popular. In the US it's also sold as a sleeping aid. I have taken it on or off for the last decade for my insomnia, and never noticed anything special in relation to effects on bad memories, and never heard of anyone who did...
Very odd...

I think alex921 clearly took more than 50 mg. He went to sleep typing.

I wish I could find that Scientific American article you mentioned. So let's say a bad experience just happened. Do I take this drug within 10 minutes of it and the memory of this bad experience vanishes? Or if not within 10 minutes, the next time I recall the bad experience? Though a lot of some nootropics are said to be for memory and recall, I hope they do not bring back such bad memories. LOL. There was a story of a man that I read about who took Hydergine (good for memory) and ended up recalling events in great details from decades ago. Hopefully it only brings back good memories.

Forget the study i posted. Watch the video only they say its not a anti histamine. Did you guys even watched what i posted?

I just watched it. They clearly say it is based upon a known antihistamine. Maybe you should watch it again, and be sure to not take any benadryl within an hour of watching the video.
Scientific American had a article on memory about six months ago. where they described research on how memories were formed and reinforced. There was one particular compound that was effective in preventing memories from forming, but it had to be taken within about ten minutes of the event, or immediately after recalling the event, I think it was Ketamine, but I am not sure, it was definitely not an OTC drug, I am not motivated enough to look it up.

Edited by eon, 31 January 2014 - 09:18 AM.