16 replies to this topic

[dannyfc]

Suffered for 8 months with low libido, poor mental processing, low motivation, inability to socialise, anhedonia. Occurred following discontinuation of Finasteride.

For 8 months I've tried near enough every nootropic, supplement, pharmaceutical, and drug that could possible reverse these symptoms.

The only relief I've found is through Methoxetamine, an analogue of Ketamine and an NMDA antagonist.

After the initial experience, the improvements to energy, mental clarity and overall well-being were profound. This generally lasts around a week before fading. Further reading suggests it relates to the interaction between inflammation, glutamate, dopamine and excitotoxicity that I won't pretend to understand.

Ideally I'd like to recreate and/or sustain these positive effects. I know tolerance builds quickly with Methoxetamine, as with Ketamine, how frequently could I use these before this occurs? Could a lower than recreational dose reproduce the same after-effects without altering tolerance?

Alternatively, what other NMDA Antagonists should I explore? Memantine seems a more sustainable option, and Ibogaine is touted for being able to reset neurotransmitters.

Any advice would be massively appreciated. I'm a little out of my depth here but feel I may have finally landed on something that can work to reclaim some of my life back.

[dannyfc]

Could someone interpret Finasterides role in this study please, does it imply it induces LTD through low frequency stimulation?

Metaplastic LTP inhibition after LTD induction in CA1 hippocampal slices involves NMDA Receptor-mediated Neurosteroidogenesis - Izumi - 2013 - Physiological Reports - Wiley Online Library

[Isochroma]

DXM from your local drugstore - cough syrup.

I used it in the Summer of 2009 to exceed all bounds for over three months every day.

One dose of only 15mg (one teaspoon syrup) or 30mg (two) just before going to bed each night.

Bounced out of bed each morning. Running with energy and vicious power all day.

The only two minor sides (personal): it dried my lungs up too much after a while and gave me the runs. I get the runs from almost everything so not likely to happen to you.

And cheap. No major tolerance increase but if it happens then a bit of NMDA antagonist will reverse it for DXM. DXM is an opiate analog, that's why.

I've got a better plan to fix you up.

All your symptoms match perfectly with low Testosterone.

Get your blood tested ASAP and report the value back here or to me by PM.

Values to test: Total Testosterone, TSH, and if possible SHBG, Free Testosterone, T3, T4.

Edited by Isochroma-Reborn, 05 November 2013 - 11:32 PM.

[dannyfc]

Get your blood tested ASAP and report the value back here or to me by PM.

Values to test: Total Testosterone, TSH, and if possible SHBG, Free Testosterone, T3, T4.

Testosterone 23.4 nmol/L (9.9 - 27.8 ) July 2013
Testosterone 33.9 nmol/L (8.8 - 36.7) August 2013
SHBG - 77 nmol - (20 - 60)
Albumin - 51.0 nmol - (35 - 50)
Estradiol - 89 pmol (28-156)
Free T4 - 17.5 pmol/l ( 12 - 22)
TSH - 2.180 mU/l ( 0.270 - 4.2)

You're right, my Free Testosterone is drastically low as a result of SHBG & Albumin. However as far I can tell there's no logical explanation for either, estrogen is normal, no hyperthyroidism.

[Isochroma]

Odd.

[dannyfc]

Liver tested, perfectly functional from what I can tell. Bemused. Any insight?

Total Protein 67 ( 66-87 ) g/L

Albumin 45 ( 35-50 ) g/L

Globulin 22 ( 20-40 ) g/L

Sodium 141 ( 136-145 ) mmol/L

Potassium 4.3 ( 3.5-5.1 ) mmol/L

Urea 8.5 H ( 1.7-8.3 ) mmol/L

Creatinine 109 H ( 62-106 ) umol/L

eGFR 76

Total Bilirubin 6 ( 0-20 ) umol/L

Alkaline Phosphatase 107 ( 40-129 ) IU/L

AST 27 ( < 37 ) IU/L

ALT 22 ( < 41 ) IU/L

Gamma GT 19 ( 8-61 ) IU/L

LDH 362 ( 240-480 ) U/L

Creatine Kinase 88 ( 26-140 ) IU/L

UIBC 39.0 ( 20-62 ) umol/l

Ferritin 107 ( 30-400 ) ng/mL

Cholesterol 6.0 H ( <5.0 ) mmol/l

Triglycerides 1.28 ( < 2.30) mmol/L

HDL Cholesterol 1.61 H ( 0.9-1.4 ) mmol/L

LDL (Calculation) 3.89 H ( < 3.0 ) mmol/L

[Virtual Reality]

Here are some articles for this topic http://www.addiction...ications-1.html my english isnt very good u guys might find something interesting.
This is one of them released in 2007 http://www.addiction...1/ScienceMM.pdf

Edited by alex921, 16 November 2013 - 02:04 AM.

[Hip]

NMDA antagonists

Magnesium — a potent NMDA inhibitor. High dose transdermal application, or injection, required for maximum effect.

Zinc

Progesterone (a hormonal supplement usually sold as a transdermal cream)

Huperzine A (a supplement)

Taurine (taurine also activates GABA receptors)

Amantadine (antiviral drug, also used for Parkinson's and Alzheimer's)

Agmatine (a supplement)

Lithium

Dextromethorphan (DXM) — an over-the-counter cough mixture (cough suppressant)

Dextrorphan (DXO) is an active metabolite of DXM. DXO a psychedelic drug and cough suppressant, is a much more potent NMDA antagonist than DXM. DXM is converted to DXO in the body by cytochrome P450 2D6 isoenzyme (aka: CYP2D6). Thus cytochrome P450 2D6 inhibitors such as imipramine, propranolol, quinine and citalopram may decrease the effect of DXM.

Dantrolene (muscle relaxant)

Orphenadrine (muscle relaxant)

Methadone (opiate)

Dextropropoxyphene (weak opiate)

Ketamine — an anesthetic and recreational drug.

Riluzole (ALS drug)

Memantine (Namenda)

Ibogaine — the hallucinogenic active principal from the root bark of Tabernanthe iboga. Microdoses of around 50 mg daily of Tabernanthe iboga root bark will not produce a hallucinogenic effect, but still have therapeutic effects. Tabernanthe iboga root bark is legal to buy in the UK, but not in the US.

Nitrous oxide (N2O) — an anesthetic gas (often used in dentistry) and and recreational drug. Also know as laughing gas. Depletes vitamin B12.

Guaifenesin (possibly?) — an over-the-counter decongestant. The guaifenesin protocol is a fibromyalgia and ME/CFS treatment.

Xenon gas. An anesthetic gas.

Cat's claw (Uncaria tomentosa) — the rhynchophylline constituent of this herb may inhibit the NMDA receptor.

Syrian rue (Peganum harmala) — a MAO-inhibitor herb. MAO-inhibitors should never be taken with nexavir/kutapressin.


Dangerous NMDA inhibitors:

Lead is a potent inhibitor of the NMDA receptor

Phencyclidine (PCP, angel dust) Some studies found that, like other NMDA receptor antagonists, phencyclidine can cause a certain kind of brain damage called Olney's lesions in rats.

Kynurenic acid (high levels associated with schizophrenia and pychosis)

NMDA agonists

Glutamate
Glycine
Ammonia

[August59]

I've used memantine, amantadine and agmatine. I had good results with all 3, but was very conservative with agmatine dosage as there seems to be some possible side effects based on a particular persons situation. I think memantine worked the best and after shopping around I found it to be fairly inexpensive. I usually only take them for about 3 months then just take magnesium for 6 months then back to one of the antagonists. Occasionally I'll just take some Delsym for a month, but I keep my dose low as it dose a number on my blood pressure.

[Nootropic Milk Hotel]

Phencyclidine (PCP, angel dust) Some studies found that, like other NMDA receptor antagonists, phencyclidine can cause a certain kind of brain damage called Olney's lesions in rats.

I don't want to derail the thread, but haven't Olney's lesions never been observed in humans? I doubt anyone here is going to use PCP for this purpose anyway, and one should always be careful with powerful drugs, but I'm pretty sure it doesn't do that to humans.

[Hip]

I don't want to derail the thread, but haven't Olney's lesions never been observed in humans? I doubt anyone here is going to use PCP for this purpose anyway, and one should always be careful with powerful drugs, but I'm pretty sure it doesn't do that to humans.

I believe you are right. It's probably not anything thing to worry about.

[Hip]

Dannyfc said above: "Ibogaine is touted for being able to reset neurotransmitters."


You might try taking Iboga in a series of daily micro-doses, rather than going for a full-on 10 hour Iboga trip. If you search Iboga microdosing online, you will find that some people claim that such microdosing is also beneficial, and a far less scary alternative to undertaking a full Iboga trip.






NOTE TO THE MODERATORS / WEBMASTER >>
Why isn't there a QUOTE and MULTIQUOTE button available on the very first post in this thread?

Edited by Hip, 20 November 2013 - 07:12 PM.

[Justchill]

3-meo-pcp. Almost too good to be true.

I was also suffering from depression, social anxiety, anhedonia etc.

Within a couple of days I felt better. I can just feel 'normal' when around other people. Almost unbelievable.

I am microdosing 1mg/day. 

It is a strong nmda-antagonist and a DRI. I don't know what mechanism is responsible for its effects.

It's worth a try.

Anecdotally it reduces stimulant hangovers!

Edited by Justchill, 01 August 2017 - 02:41 PM.

[normalizing]

3-meo-pcp? it doesnt seem controlled in US for some reason. interesting!

[Nate-2004]

I've literally had the same issue lately and I don't know what I did or what I may be doing currently to have caused it. My diet changed a bit when I started cutting out a lot of meat and anything cooked above boiling temp and getting a heap load more veggies into my diet with smoothies. I don't know if this somehow changed something or what. 

 

I heard, however, that saffron is a possible candidate for reversing the libido stunting effects of anti-depressants. I'm not on anti-depressants but I am considering this as an option.

 

[normalizing]

you are not on antidepressants but suffer low libido? then you say you cut off a lot of your meat, maybe that can be related since meat and dairy and other cholesterol and fat and protein rich foods are what boosts one's libido

[Nate-2004]

I'm still eating eggs and drinking whey shakes (muscle feast) before workouts though. Not sure I need meat necessarily, but I haven't cut it out completely. I'm also eating fish, salmon in particular.

Edited by Nate-2004, 03 August 2017 - 02:02 PM.