136 replies to this topic

[BioHacker=Life]

i just got my 1gram of bluebrainboost dihydroxyflavone and im not sure at what amount to take for any effect yet. at just 1gram not sure i can take this for more than few days and let alone the price is killing me, its too expensive.

 

I've noticed strong effects at 100-200 mg.

Edited by BioHacker=Life, 18 December 2017 - 11:31 AM.

[BioHacker=Life]

 

Tridax procumbens a natural source of 7,8 DHF has been used for centuries traditionally in Indian without any reported serious issues.

 

Judging a chemical by it's name is utterly ridiculous and irrational. If you were in severe pain you probably should take morphine. And if you were at risk for stroke, head injury, certain surgeries, drowning, tbi, etc you would want to be taking Hydergine daily.

 

it's been concentrated many times over to an unnatural level, and procured specifically for it's BDNF-mimicking effects.

 

and then i would ask, from which ailment must you be afflicted to justify the use of 7,8- dihydroxyflavone?  dementia.. depression?  are there not better, more tested choices on the market?

 

 

It also naturally occurs in fruits and veggies so we get some in our diet everyday. This is just increasing it selectively. Doesn't matter what it's being bought for.

 

As far as BDNF agonists goes I would consider it the best option and the studies so far are amazing!

[gamesguru]

Doesn't matter what it's being bought for.

 

So if I don't have depression, if a lot of my great-grandparents lived over 100 years, do I still have the green light to go experimenting with ginseng and resveratrol and other interesting stuff that I don't really need?  Or should I maybe hang up my curiosity in the closet, and let the universities do the research?

 

And the studies may be great for it, but the studies are great for lots of things.  Doesn't mean it's a be-all end-all for your ailments, doesn't even mean it's more effective than a cup of tea, doesn't even mean it's safe.  The more potent something is, the bigger the question mark I hang upon it..

[airplanepeanuts]

 

 

 The more potent something is, the bigger the question mark I hang upon it..

https://translationa...15-0048-7#Sec10

 

"Notably, it is orally bioactive and is safe for chronic treatment."

[gamesguru]

look i'm about to respectfully step down from this debate, but bruh do you have any idea how many lashes my 11th grade English teacher would give you for making a non .edu or .org citation?

[normalizing]

im trying to take more again but i drink regularly so i guess im not good test subject. thats the problem with all the crap i brought from the net, i end up not using because i can just relax with beer and then fall asleep. not really needing anything else

[playground]

 

 

 

 The more potent something is, the bigger the question mark I hang upon it..

https://translationa...15-0048-7#Sec10

 

"Notably, it is orally bioactive and is safe for chronic treatment."

 

 

 

On page 5 of the paper you cite, it says:

      The oral bioavailability is increased from 4.6 % (parental 7,8-DHF) to 84.2 % (R7).

 

The Abstract and Conclusions sections make a point that 7,8-DHF is orally active.

But if you read the whole paper you discover that the oral availability is under 5%. (specifically 4.6%)

Although it's 'technically' true that this compound is orally active... practically, you have to swallow

20 times your intended biological dose to see any effects.

 

This is perhaps, why some users, have been disappointed by 7,8-DHF.

Antaeus labs, for example, were/are offering 7,8-DHF, in 20mg capsules. 

In effect, these are equivalent to 1mg dosages.

 

I seem to remember, that in one of the studies, they were administering 5mg per Kg to mice

(and that's by injection, not orally).   

So on that basis, 1mg for a ~75 kilo Longecity guinea pig probably isn't going to

have much impact.

 

Some simple arithmetic:

Let's imagine that the human equivalent dose of this 5mg/Kg (for mice) is, say, 1mg/Kg.

(Note: In order to ensure publishable results, researchers often max the dosages to

obtain a nice, sizable effect size -- in short, rodents are routinely over-dosed)

 

But I digress, so 1mg/kg for humans (hypothetically).  For a 75 Kilo guinea pig, that would be

75mg as an active dose, ... but note... that would be 75mg, taken by injection.

Orally, we need to multiply that 75mg figure by 20, since oral administration is only ~5% bioavailable.

So 75mg X 20 = 1500mg  (based on a hypothetical 1mg/kg dose)

 

So i repeat my point.   I suspect that, some longecity denizens, may have been disappointed

by 7,8-DHF because they simply haven't taken a sufficient dose.

 

(Please don't read this and think it's okay to take a big dose, as always,

titrate up from a small dose -- and keep notes of your dosages and experiences)

 

So on this basis, i'm left wondering if anyone has tried 78DHF nasally.

And if so, what dosages seemed, subjectively, effective ?

If you have tried snorting 78DHF, please reply to this thread and tell us about

your experiences.

 

Best wishes

 

PG

Edited by playground, 23 January 2018 - 04:10 PM.

[playground]

Addendum:

 

One possible route of administration, which, as far as i know, hasn't been suggested yet, is ... topically.  

 

Rosehip oil is notable in that it penetrates the skin very readily. 

When you put rosehip oil on your skin, it magically melts right into your skin, with minimal greasiness.

(Rosehip oil is readily available on ebay, amazon and lots of other stores)

 

Both NSI-189 and 78DHF are practically insoluble in water, but soluble in oils.

So perhaps, rosehip oil would be a good carrier oil, for home-made topical NSI-189 and 78DHF.

 

PG

[Junipersun]

 

 

 

So on this basis, i'm left wondering if anyone has tried 78DHF nasally.

And if so, what dosages seemed, subjectively, effective ?

If you have tried snorting 78DHF, please reply to this thread and tell us about

your experiences.

 

Best wishes

 

PG

 

 

Yes, there are some experience reports of people taking ~20mg nasally. You are right with your assumptions, nasally or sublingual is the way to go with this compound, you see this reflected in the positive reviews from people taking it with these routes of administration. 

Edited by Junipersun, 26 January 2018 - 04:24 PM.

[normalizing]

i see. i already took few caps orally and i didnt notice anything. ill try sublingual next

[BioHacker=Life]

 

Doesn't matter what it's being bought for.

 

So if I don't have depression, if a lot of my great-grandparents lived over 100 years, do I still have the green light to go experimenting with ginseng and resveratrol and other interesting stuff that I don't really need?  Or should I maybe hang up my curiosity in the closet, and let the universities do the research?

 

And the studies may be great for it, but the studies are great for lots of things.  Doesn't mean it's a be-all end-all for your ailments, doesn't even mean it's more effective than a cup of tea, doesn't even mean it's safe.  The more potent something is, the bigger the question mark I hang upon it..

 

 

If you want to protect against brain aging and promote your cognitive and other abilities to their peak you do.

 

If not take drugs and eat anything and don't do p.e.

 

Didn't say it would cure everything but it's promising and deserves an open mind. So far I am enjoying the benefits immensely and want to see more people chime in.

[normalizing]

as i mentioned already, i got some of that stuff and it was completely useless for my depression or anything related to cognition. i did polygala tenuifulia too which claims same effect, and surprisingly it completely helped with limiting alcohol and giving you satisfaction without overdrinking. i tried the same with this crap, and no chance it did shit. polygala by itself is useless too.

[John250]

Any updates on this? Seems like a must have for amp users.

[normalizing]

still no effect from it when it comes to limiting alcohol but polygala is something different.

[Elusive]

This latest research on 7 8 DHF is a bit disturbing!

https://www.google.c...isBnIWWUhlsfwlx

[Galaxyshock]

Feels like a game-changer supplement to me, but you need the Eutropoflavin (4'-Dimethylamino-7,8-dihydroxyflavone) form for the intense effects. 

[gamesguru]

This latest research on 7 8 DHF is a bit disturbing!

https://www.google.c...isBnIWWUhlsfwlx

 

How is this super disturbing? Any time I see sex differences, where one sex differs wildly in its response from another, I try to look for explanations — and if I can't find any, I become a bit suspicious that the data is inaccurate. Not that it's intentionally inaccurate, but it needs to be reconfirmed by independent teams.

 

Most of the markers in the study are either positive or neutral. Triglyceride and leptin levels are both down. Female mice report a decrease in body weight.

 

 

Some of the main concerns with DHF haven't dissuaded me from recently experimenting with small amounts on an infrequent basis, and they include:

 

1. Association of cancer with TrkB (TrkB inhibitors are being studied to treat neurogenic tumors)

2. Possibility of TrkB down-regulation and subsequent dendritic loss or neuronal atrophy during the withdrawal phase