#31
Posted 09 February 2014 - 04:18 PM
#32
Posted 09 February 2014 - 11:35 PM
Of course I think that with a tool like cron-o-meter, you'll do fine. Better than fast food junkies in fact.
Edited by bracconiere, 10 February 2014 - 12:03 AM.
#33
Posted 10 February 2014 - 03:42 AM
#34
Posted 10 February 2014 - 05:40 AM
Don't get me too wrong, I personaly use both. And don't think that a couple glasses of wine to get to sleep would be that bad for your health. And especially doubt wither it would cause social problems?
#35
Posted 13 February 2014 - 12:01 AM
Britton, A., M. G. Marmot, and M. Shipley. "Who benefits most from the cardioprotective properties of alcohol consumption—health freaks or couch potatoes?." Journal of epidemiology and community health 62.10 (2008): 905-908.
Aims: To examine the association between average alcohol intake per week and the incidence of fatal and non-fatal myocardial infarction during 17 years of followup for 9655 men and women without prevalent disease in the general population; and to test whether the level of cardioprotection differs according to subjects’ other health behaviours (healthy, moderately healthy, unhealthy) at entry to the study.
Results: A significant benefit of moderate drinking compared with abstinence or heavy drinking was found among those with poor health behaviours (little exercise, poor diet and smokers). No additional benefit from alcohol was found among those with the healthiest behaviour profile (>3 hours of vigorous exercise per week, daily fruit or vegetable consumption and non-smokers).
My thought is there's a finite total benefit to be achieved with hormetins like exercise or fruit/vegetable intake. Direct health effects of alcohol are superfluous in those who are already have good blood lipids or are activating Nrf2 and other hormetic pathways by other means.
#36
Posted 13 February 2014 - 07:59 AM
Alcohol also appears to have a J-curve dose response for all cancer mortality. It appears to be working as a hormetin, inducing xenobiotic/antioxidant response and heat shock response transcriptomes.
The most interesting cellular mechanism for me is induction of aldehyde dehydrogenase 2 (ALDH2), which clears both acetaldehyde, the initial metabolite of alcohol, and also other reactive carbonyls (including those resulting from oxidative stress, lipid peroxidation and early glycation products).
Its the acetaldehyde, rather than alcohol, that mediates most harmful effects. There was an interesting study that compared alcohol dehydrogenase (ADH) genotypes with alcohol induced breast cancer risk. Those who metabolized alcohol to acetaldehyde quickly were at much higher risk. Heavy drinkers with less active ALDH2 are at much higher risk of stomach cancer. If the acetaldehyde, which forms DNA adducts, is the main carcinogenic agent, then those expressing fast ADH/slow ALDH2 would be a much higher risk from a given alcohol intake than those with slow ADH/fast ALDH2 genotypes. Incidentally, more active forms of ALDH2, which reduce the severity of aversive hangovers and flushing, are strongly associated with alcoholism. Perhaps hangovers offer a useful gauge of how much genetic damage one is doing.
There are other ways of inducing aldehyde dehydrogenase 2. Lipoic acid works, as do other Nrf2 inducers. Probably best to drink your Nrf2-inducing hangover cure (may I suggest rosemary & and turmeric seasoned broccoli sprout puree) before your binge.
Very interesting. I think that might explain why I've never had a hangover in my life. As it happens, I've even actually contemplated how easy it would be to drink indefinitely.
#37
Posted 11 December 2020 - 09:13 AM
I came up with an idea what if you drink alcohol and when it gets into the blood stream it kind of cleans you by killing bacteria and such? But then it probably also kills good bacteria and alcohol itself takes a toll on the body's resources so it would counteract any good if the amount that gets into the system even does anything, perhaps it is better for just cleaning your esophagus ,intestines and stomach etc? Or water works as well. I would say cold water is better since cold will increase metabolism because your body heats up.
So all in all its bad I would say.
Edited by kurdishfella, 11 December 2020 - 09:44 AM.
#38
Posted 12 December 2020 - 11:59 AM
I have always thought that one component of the "benefits" that some studies show - when drinking moderate amounts of alcohol - stems from the relaxation factor. People who lead stressful lives or work in strenuous jobs, might benefit from de-stressing - when having a drink or two after work. Stress factors huge into the rate of aging. Maybe alcohol helps a little in that regard.
#39
Posted 08 November 2024 - 06:26 PM
Alcohol consumption at any level is associated with a small increase in cancer risk. More and more doctors and nutritionists are referring to alcohol as a carcinogen - and I am dismayed.
The reason why I advocate for biological rejuvenation is so that I can enjoy things in life to some degree. Yet many leading anti-aging advocates call for the removal of pretty much all the simple pleasures in life.
No alcohol
No saturated fat (or almost no fat at all if you follow the Esselstyn diet.)
Meditate a lot
Avoid all meat
Avoid all refined sugar
Avoid all dairy products
Avoid the sun (skin cancer, ya know)
Avoid sex (yes, it has been argued in these forums that abstinence is good for longevity)
Avoid excess calories
Don't eat chocolate
etc....
If I wanted to be a monk, I would have joined a monastery!!
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