31 replies to this topic

[Geoffrey]

Man Sunifiram is a really dirty nootropic. If you want the benefits from Sunifiram, take 5g Piracetam, L-Theanine, and a dose of Unifiram.

Sorry, I have no idea what you mean by "dirty". Sunifiram is basically unifiram without the "dirty" fluorine and sulphur. The effects are the same, only sunifiram needs a lower dose.

[Geoffrey]

I recently came back to sunifiram and unifiram after I basically "forgot" about my stash of these, due to my having moved on to fasoracetam and then tianeptine. I notice that sunifiram is now out of stock almost everywhere, and wonder what happened. Unifiram is still available, but having compared both this week, I find unifiram to be less clean in its effects, and much less predictable. Sunifiram at 10mg gives me noticeable thermogenesis for about 10 minutes, followed by a steady ramp into a state of high concentration. Unifiram has no thermogenesis and just creates pressure in my head (probably due to increased blood flow).

Is anyone else still taking these? And if not, what have you found that has similar effects (if you did take either in the past)? I've been interested by the combination of sunifiram and tianeptine, since "in animal models, tianeptine inhibits the pathological stress-induced changes in glutamatergic neurotransmission in the amygdala and hippocampus" (Wiki). Although sunifiram has been shown in assays not to bind directly to NMDA or AMPA, there has been concern expressed about possible over-excitation of these receptors in the presence of glutamate, etc., due to its effect on their glycine binding sites. Theoretically, tianeptine may have a moderating influence. In my limited experience this week, taking tianeptine *before* sunifiram does not produce any over-excitation, but instead a smooth focus, excellent recall, and a general sense of well-being. I'm worried now that once my current stash runs out, it'll be curtains for this interesting combo, since vendors seem to have sold off their supplies and are not renewing.

Edited by Geoffrey, 19 September 2016 - 05:15 PM.