PowerfulP: I theorize that if you have high or low glutamate, Fasoracetam may work ineffectively, or TOO effectively on you. The reason being that one of the main modes of effect of Fasoracetam, is that it DIRECTLY agonises several metabotropic glutamate receptors - some of them do down-regulate the NMDA-receptors, but two of them do not, if I recall correctly.
Theoretically, that mGlur -effect might be UN-benefficial to you, then.
Dr Hakon Hakonarson did mention that the drug MAY NOT be ideal for all ADHD -groups, only specific groups, which they have apparently identified through their genome-data. We went through the data on these groups in GetOutofBox's thread, and I believe one of the things we found, is that you more or less need to have several other comorbid NPD's as well - something similar to a DAMP-diagnose.
One of the biggest groups, that would theoretically benefit the most from Fasoracetam, is apparently those with ID - intellectual Disability - the ADHD-people whom also have a comorbid problem of LOW IQ - even tho' their relatives, who do have ADHD, do NOT have this issue. ( I actually know two brothers who are like this - both have ADHD, but only one of them have ID as well - he'll never grow out of his mental teens.)
If that is correct... then the reason why it doesn't work as well for you, is that you don't have enough ADDITIONAL NPD's. That, and you have high glutamate - one of the prime theories of why certain ADHD-ers have ID, is that they have TOO LOW GLUTAMATE - their entire brain don't get enough energy, which leads to global performance-issues for the entire neural system.
You definitely don't strike me as having ID... your glutamate probably isn't exceedingly low.
Covalencies: That's a lot of heavy-duty stuff. A lot of interactions to sift through. Did you take Adderall as well, while taking Faso? That might be one of the reasons you got irritable, sounds a lot like enhanced anxiety/bad temper that you get from stimulants - it might be that Faso aggravates the side-effects of stimulants - some folks earlier in this thread theorized as much earlier.
Individually perceivable changes in dexterity, memory and cognitive function isn't enough tho' - you need to do some tests, to make sure of the effects. The typing-tests is one excellent such.
So, if you're up for it, I'd LOVE to see what your results would be in various tests, before and after Fasoracetam.
Like:
Typing
Gross motor-function ( as simple as doing some football/soccer -tricks could be enough, or basket-ball.)
Cambridge Brain Sciences cognitive tests
That would be awesome - and very helpful not just for you, but for everyone. You're a chemi-naut, man! =)
BTW - what NPD's do you have, if any? And which ones do you have diagnosed, and not diagnosed, but suspected?
Edited by Stinkorninjor, 21 August 2014 - 11:00 AM.