2266 replies to this topic

[MikeDC]

My wife's protein in urine was reduced by almost 50% after one year of Niagen. Next test will be in normal range and her microalbumin will be cured. No drug can do that now.

[pamojja]

My wife's protein in urine was reduced by almost 50% after one year of Niagen. Next test will be in normal range and her microalbumin will be cured. No drug can do that now.

 

I've seen bigger jumps up and down again, with albumin in urine out of nowhere (at least could not trace to any cause). I take no drugs and no niagen.
 

[MikeDC]

I am talking about protein dropping from 50 to 30. 1-24 is normal range.

[pamojja]

By the way, I didn't tag you ill-informed. Please guys, stop this humbug of tagging a post with ill-informed when the post gives precise number. It's ridiculous. However, use dislike if you don't like someone's stance.

 

Mine went from 15.5 end of 2011, 15.7 beginning of 2012, to 77 mg/dl by beginning of 2015 (<20 range). Beginning of 2016 - 1 year later - it was below detection limits.

[soulprogrammer]

@MikeDC and @pamoja, could you attach your testing results here, so that it will stop those keep putting ill-informed (Peace and Prosperity PP?) here. I think PP is anti NR.

 

BTW, I have taking blood test before the Niagen (after not yet), so will post result once I got my blood test after with proof.

Edited by soulprogrammer, 11 April 2017 - 01:27 AM.

[soulprogrammer]

 

I don't understand, your linked paper mentioned (I didn't read the whole paper) nicotinamide reduces histamine in vitro. But now you suggest NR increases histamine? Shouldn't NR and nicotinamide has similar effects? 

 

Hi SP,

 

Did you take a look at this guys post, I linked earlier?

 

 

It is a puzzle I am trying to understand but from this paper referenced in the post we have: 

 

Compared with those before nicotinamide load, five-hour postload plasma serotonin and histamine levels significantly increased.

 

Today I took a multi B and non-flush niacin today and the symptoms returned, flush niacin was not a problem when taken previously.

 

It seems the NAD reduces histamine it but nicotinamide increases it, presumably through methyl group degradation (if I understand it correctly), which presumably/possibly is a consequence of raised NAD levels - combatting the histamine, which is a little confusing.  

 

Speculating,  given the paper indicates serotonin levels increased in blood plasma, might it be that those undermethylated experience greater psychological benefits and perhaps explain some of the hit/miss nature of NR? 

 

 

 

Hi ambivalent, why dont u do a blood test before NR, see ur histamine level, then after NR, ur histamine level changes? That can rule out once for all whether NR is the culprit or not. The blood test is a simple test won't cost a lot.

[ambivalent]

Hi SP

 

I'm not planning on taking NR for a little while at least, I believe histamine levels are high and that environment is contributing to that. I am also very confident that NR an niacinamide worsened the problem. It I hard to say whether NR was responsible for the build up, or seasonal allergies or both. It is also possible I am undermethylated. But there was a quick and clear hay-fever like response when taking NR and niacninamide with heavy brain fog. Mostly now, it is just lessened dry coughing and breathing difficulties with light brain fog.

 

I may decide to take an NR blood test at some point, but of course any one dosing NR could see if there is an effect. It would be interesting to see if someone dosing regularly with consistent effects notices changes when taking ante-histamine supplements or still fasted for a while.

 

I suspect I will start again after a decent fast and change of environment.

 

@accord the only sources I found are the ones quoted. Nothing explicit to NR, except anecdotal.

 

@Stefan this at least suggests that fading effects may not be baseline realignment.

 

 

 

Edited by ambivalent, 11 April 2017 - 04:45 PM.

[soulprogrammer]

Sharing my sister experience UPDATE:

 

 

Week1

After taking NR 275mg/day for 1 week, now her constipation seems to improve. Really unexpected though. I mean I really can't relate the connection between constipation and NAD+. I was expecting she said something like feel more energetic, feel better sleep, etc....but she said constipation improve and getting better! of course, she doesn't have problem sleeping and constipation is her only main concern for long time...still...

 

Week2

Feel more stamina after gym, not feeling like tired or soreness after gym.

 

Week3

Stopped for 5 days due to outstation trip. No adverse feeling so far. Retake NR started today.

 

Already more than 1 month since she started NR:

 

She told me after taking NR, lots more stamina, she can now go to gym >1 hour non-stop without feeling tired. Very energetic throughout the day (she is still working, not yet retired), smell better, feel better, improve constipation problem, sleep better now. (no vivid dream though) and weight loss.

 

She will continue to take NR from now on. Will report here if there is any changes of her experience. She seems to be very happy about taking NR esp the energy boost and stamina, and most importantly weight loss.

 

The only complaint she has is the high price of NR.

 

 

 

 

 

 

Age: 57, Female, Healthy, gym 1-2 times a week. pre-diabetic, BP on high side (still normal). long time constipation problem.

Edited by soulprogrammer, 18 April 2017 - 03:28 AM.

[soulprogrammer]

Anyone here experiment NR with your pets? Chicken/dog/cat/guinea pigs/birds/snake/etc?

 

Would be interest to see if NR work in your pets.

 

For those still have lots of NR but decided not to take it, could you feed the NR to some pets and see the reaction and report here?

Edited by soulprogrammer, 22 April 2017 - 03:11 AM.

[brundall]

So my experience has been quite different to nearly every one else who has posted on this thread....

 

3 weeks ago I began taking NR in the form of 1 capsule of Thorne Research 125mg in the am on an empty stomach. About 3 hours after the first dose I experienced a definite rise in energy levels - it was not a clean energy though but rather an anxious/ nervous/ jittery feeling that lasted the remainder of the day. I was able to fall asleep without issue which surprised me somewhat.

 

The second morning I awoke after a solid nights rest (7 hours) to have red puffy eyes as if I had burst blood vessels with dark bags under them. Not normal for me. I continued to take a single dose in the am for the rest of that week but had red swollen eyes throughout. My energy levels were improved and physical stamina was excellent but it just didn't feel right to me so I stopped taking the NR. After 3 days the redness and tiredness in my eyes had vanished and I felt less anxious and 'normal'.

 

As a test, I then started taking the NR again and the symptoms immediately returned. Red swollen puffy eyes and an anxious/ nervous energy that didn't feel great to me.

 

So my experiment with NR is over. The product just didn't react well with me so I have stopped taking it.

 

 

47 year old male

5ft 8

173 lbs

Physically fit with a muscular build

No medications or health issues currently.

[MikeDC]

So my experience has been quite different to nearly every one else who has posted on this thread....

3 weeks ago I began taking NR in the form of 1 capsule of Thorne Research 125mg in the am on an empty stomach. About 3 hours after the first dose I experienced a definite rise in energy levels - it was not a clean energy though but rather an anxious/ nervous/ jittery feeling that lasted the remainder of the day. I was able to fall asleep without issue which surprised me somewhat.

The second morning I awoke after a solid nights rest (7 hours) to have red puffy eyes as if I had burst blood vessels with dark bags under them. Not normal for me. I continued to take a single dose in the am for the rest of that week but had red swollen eyes throughout. My energy levels were improved and physical stamina was excellent but it just didn't feel right to me so I stopped taking the NR. After 3 days the redness and tiredness in my eyes had vanished and I felt less anxious and 'normal'.

As a test, I then started taking the NR again and the symptoms immediately returned. Red swollen puffy eyes and an anxious/ nervous energy that didn't feel great to me.

So my experiment with NR is over. The product just didn't react well with me so I have stopped taking it.


47 year old male
5ft 8
173 lbs
Physically fit with a muscular build
No medications or health issues currently.

You are first to report this kind of reaction. Sorry to hear that. Everyone is different.

[ambivalent]

So my experience has been quite different to nearly every one else who has posted on this thread....

 

3 weeks ago I began taking NR in the form of 1 capsule of Thorne Research 125mg in the am on an empty stomach. About 3 hours after the first dose I experienced a definite rise in energy levels - it was not a clean energy though but rather an anxious/ nervous/ jittery feeling that lasted the remainder of the day. I was able to fall asleep without issue which surprised me somewhat.

 

The second morning I awoke after a solid nights rest (7 hours) to have red puffy eyes as if I had burst blood vessels with dark bags under them. Not normal for me. I continued to take a single dose in the am for the rest of that week but had red swollen eyes throughout. My energy levels were improved and physical stamina was excellent but it just didn't feel right to me so I stopped taking the NR. After 3 days the redness and tiredness in my eyes had vanished and I felt less anxious and 'normal'.

 

As a test, I then started taking the NR again and the symptoms immediately returned. Red swollen puffy eyes and an anxious/ nervous energy that didn't feel great to me.

 

So my experiment with NR is over. The product just didn't react well with me so I have stopped taking it.

 

 

47 year old male

5ft 8

173 lbs

Physically fit with a muscular build

No medications or health issues currently.

 

 

Hi Brundall,

 

I gather no seasonal allergies or histamine problems that you know of?

Edited by ambivalent, 22 April 2017 - 04:55 PM.

[brundall]

Yes, I should have mentioned that I do suffer from seasonal allergies mostly in the late summer early fall time period. Maybe my reaction was histamine related? anyone else with allergies taking NR?

[PeaceAndProsperity]

Yes, I should have mentioned that I do suffer from seasonal allergies mostly in the late summer early fall time period. Maybe my reaction was histamine related? anyone else with allergies taking NR?

Allergy-like side-effects of various kinds are very normal from NR.

 

[ambivalent]

Brundall,

 

I don't know about it being very normal, I've not seen many accounts, but I reported it after very high doses in this thread a couple of pages back and here in the other NR thread. There is evidence pointing to nicotinamide raising histamine (see prior link) which may be a problem with the undermethylaters. If you don't want to give up then you could try methods to reduce histamine - that's what I'm doing. Fasting could be worth a try or ante histamine sups/demethylators.

 

I took 250mg the other day, the first NR for a few weeks, and initially I felt alert but after that I was pretty lousy - environment is contributing, I'm sure, but it is a challenge to get the levels down. My histamine bucket is full it seems, but I took a lot of NR to get there.

[Harkijn]

Also keep in mind that Nicotinamide and NR  each have very different pharmacokinetics, so the fact that Nicotinamide raises histamine levels does not necessarily mean that NR has the same effect.

[soulprogrammer]

Anyone try to measure your biological age using GlycanAg before and after NR?

 

 https://www.glycanage.com/

 

Perhaps this is the most direct way (and scientific, rather than with or without feeling) of measuring if NR is really an anti-aging supplement or not.

 

 

 

 

[Kirito]

"Professor Sinclair is so convinced of his pill's safety that not only has he been taking it himself, so has his 77-year-old father.

The results certainly sound encouraging. Before he started taking a 500mg NMN pill every morning, 47-year-old Professor Sinclair had his blood tested and was told his body had a biological age of 58.

After consuming NMN for three months, he was tested again and his biological age was 32."

 

http://www.nzherald....jectid=11830317

 

This is David Sinclair, and we know how controversial he is. But interesting none the less. NR might have similar or better results if true.

[aribadabar]

Sinclair is a master spin "doctor" - heck , he managed to fool GSK, an industry insider, before (with resveratrol).

 

So everything he states needs to be taken with a heaped tablespoon of salt.

There may be some benefit but nowhere as dramatic as he claimed it to be.

[bluemoon]

Sinclair is a master spin "doctor" - heck , he managed to fool GSK, an industry insider, before (with resveratrol).

 

So everything he states needs to be taken with a heaped tablespoon of salt.

There may be some benefit but nowhere as dramatic as he claimed it to be.

 

You have no idea. If you have inside information on what GSK or Sinclair is working on (in his case NMN based drug), then please share 

[Tom Andre F. (ex shinobi)]

Also keep in mind that Nicotinamide and NR  each have very different pharmacokinetics, so the fact that Nicotinamide raises histamine levels does not necessarily mean that NR has the same effect.

 

You are jokin right ?

 

We have reviewed it a lot in the specific thread: more than 90% of NR is converted back into nicotinamide in vivo.

 

Btw, a guy on facebook, claims his PSA level get crazy high every time he uses NR. Anyone has info about this ?

[Harkijn]

 

Also keep in mind that Nicotinamide and NR  each have very different pharmacokinetics, so the fact that Nicotinamide raises histamine levels does not necessarily mean that NR has the same effect.

 

You are jokin right ?

 

We have reviewed it a lot in the specific thread: more than 90% of NR is converted back into nicotinamide in vivo.

 

Btw, a guy on facebook, claims his PSA level get crazy high every time he uses NR. Anyone has info about this ?

 

No, I am not joking...

[mrkosh1]

Where is this evidence that 90% of the NR is converted into nicotinamide?

 

I have seen no evidence of this. What I have read are papers that show NR is very well absorbed and distributed throughout the body.

[MikeDC]

Where is this evidence that 90% of the NR is converted into nicotinamide?

I have seen no evidence of this. What I have read are papers that show NR is very well absorbed and distributed throughout the body.

If I remember correctly, Nicotinamide level does not increase after NR supplementation.

[Tom Andre F. (ex shinobi)]

Where is this evidence that 90% of the NR is converted into nicotinamide?

 

I have seen no evidence of this. What I have read are papers that show NR is very well absorbed and distributed throughout the body.

 

Yeah pure marketing... I remember a very interesting paper where they used nampt knocked mices and where nad+ levels increased only a very bit. While once the nampt was active in mices, NAD+ increased significantly.  also please keep in mind this protocol is much more acurate to check if NR increased NAD+ only though its kinases or using its conversion into nicotinamide because NAD+ is anyway consumed by NAD ase into nicotinamide

 

If anyone know what paper im speaking about, please post it, I want to found it back

 

The paper . Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

 

already reviewed it. As this paper :Digestion and absorption of NAD by the small intestine of the rat

"This evidence indicates that NR is converted to NAm before absorption occurs and that this reaction is the rate-limiting step."

[Harkijn]

Do not let yourselves get sidetracked by a link to a paper dated 1983. 'Some people' have a covert commercial interest in the supplement market and it is sort of gratifying to see that they are getting nervous about their medium term business prospects because more and more people are turning from taking antioxidants etcetera to taking NR.

 

[MikeDC]

Where is this evidence that 90% of the NR is converted into nicotinamide?

I have seen no evidence of this. What I have read are papers that show NR is very well absorbed and distributed throughout the body.

Yeah pure marketing... I remember a very interesting paper where they used nampt knocked mices and where nad+ levels increased only a very bit. While once the nampt was active in mices, NAD+ increased significantly. also please keep in mind this protocol is much more acurate to check if NR increased NAD+ only though its kinases or using its conversion into nicotinamide because NAD+ is anyway consumed by NAD ase into nicotinamide

If anyone know what paper im speaking about, please post it, I want to found it back

The paper . Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

already reviewed it. As this paper :Digestion and absorption of NAD by the small intestine of the rat
"This evidence indicates that NR is converted to NAm before absorption occurs and that this reaction is the rate-limiting step."

It is true that Nicotinamide Riboside is unstable in water and thus in the stomach. But Niagen is stable in the stomach since niagen is a NR salt. NMN is also unlikely to be stable in water and stomach so be careful with NMN oral supplements. Might be a waste of money

[Tom Andre F. (ex shinobi)]

wow what a very dumb and personal attack...

 

Im a member here since 2013 while you a member since a february... So I understand you didnt followed my posts here especially regarding NR. You should before placing such attack.

 

You not aware I could also sell NR or NMN right ?

 

You use only NR as strategy to increase your NAD ? I dont... I even opened this thread to found a way to truly increase NAD using beta lapachone (that I also dont sell) :http://www.longecity...dnadh-increase/

 

You also not aware im a pro Niacin... That I dont sell ! Niacin is shown in data at least as effective as NR. Why niacin over NR ? Because it does not convert into Nam and is much more cheaper !

 

The link you shared like you found something on me is just ridiculous as its definitely not hidden you see ? So next time speak science instead of bs, especially when you trust everything coming and sponsored from chromadex...

 

Jeez...

[Harkijn]

Do not let yourselves get sidetracked by a link to a paper dated 1983. 'Some people' have a covert commercial interest in the supplement market and it is sort of gratifying to see that they are getting nervous about their medium term business prospects because more and more people are turning from taking antioxidants etcetera to taking NR.

Just a brief reminder....

[soulprogrammer]

wow what a very dumb and personal attack...

 

Im a member here since 2013 while you a member since a february... So I understand you didnt followed my posts here especially regarding NR. You should before placing such attack.

 

You not aware I could also sell NR or NMN right ?

 

You use only NR as strategy to increase your NAD ? I dont... I even opened this thread to found a way to truly increase NAD using beta lapachone (that I also dont sell) :http://www.longecity...dnadh-increase/

 

You also not aware im a pro Niacin... That I dont sell ! Niacin is shown in data at least as effective as NR. Why niacin over NR ? Because it does not convert into Nam and is much more cheaper !

 

The link you shared like you found something on me is just ridiculous as its definitely not hidden you see ? So next time speak science instead of bs, especially when you trust everything coming and sponsored from chromadex...

 

Jeez...

 

 

Isn't that obvious??? Conflict of interest!

 

From your website:

Welcome to Dynveo

Website specialized anti-aging and antioxidant, specifically designed for your well-being.

 

Your company carry products of trans-resveratrol, grape seed extract, honokiol, etc. Your company products is targeting anti-aging audience, same audience as NR. 

 

Why you never mention any negative testimonials about resveratrol, honokiol, etc? Obviously you won't, because that will affect your sales. I mean, do we need rocket scientist to understand what is conflict of interest???

 

Yes, you could also sell NR/NMN, but I believe your company has no intention of doing so for the near future. 

 

And this is a thread sharing experience about NR, obviously you never try NR before, so why bother posting here? Your "theory" of NR just nicotinamide or niacin is NOT PERSONAL EXPERIENCE of NR! Post elsewhere!  The only reason why you are posting NR just niacin/NAM/whatever here, is because this thread is attracting would be NR consumer, and your intention is obvious!!!!

 

"especially when you trust everything coming and sponsored from chromadex"

No, I don't. I only trust published papers from renowned researchers.

 

Let's get back to PERSONAL SHARING OF NR POSTING HERE!  Post only if you have try NR and share your experience here.