2266 replies to this topic

[Empiricus]

In May I reported in this thread my observation that different bottles of NR from the same company seemed to effect me both extremely positively and indiscernibly. That brand was Thorne.  I have also taken 3 bottles of HPN (2 of the glass bottles, one of the dark plastic bottle with the blue label), which seemed to effect me positively.

 

Lately I've been wondering if sublingual vs swallowing could explain the differences in short-term effects I have noticed. And it's entirely possible some other dietary, supplement, or lifestyle factor that I haven't nailed down might account for the differences in effect.  Nevertheless, for the reasons indicated in the above post, I still think inconsistency of formulation to be most likely explanation.

Edited by Empiricus, 28 June 2017 - 04:12 PM.

[jjnz]

I have a somewhat interesting observation which I can clinically verify.
My bone density (I have quite bad osteoporosis 46/m of unknown cause) in my hip has risen 4.4% and lumber spine 5.5% in 12 months. This period reflects the time I've been taking nr. (took a month off late last year)
In addition to NR I take
10 prunes/day,
vit d,
maintain 1200mg calcium,
vitamin k (both mk4 and 7)
and a bit of boron.
One of the reasons I took nr was that sirt1 has been
http://osteoporosis-...egory/sirtuins/
Seen to increase osteoblastic activity. The prunes (breakfast) on the other hand slow down osteoclasts.
The spine figures are good but the femur is quite amazing. Very pleased.

[El Castor]

I'm a 76 year old male, somewhat supplement prone. At the moment I'm taking the usual vitamin D, fish oil, potassium, and magnesium. As happens in the (ahem) elderly I have been bothered by bleeding under the skin on the backs of my arms and hands, so a few years ago I started taking 450mg of Rutin, a flavonoid, and when the Columbia study was published, 375mg of Mars Cocoavia, another flavonoid (and expensive!). Both are reputed to be helpful with circulation and blood vessel strength, and my arms mostly cleared up. Then I read about NR, and 5 weeks ago started the AliveByNature product, one 250mg capsule in the morning on an empty stomach. A couple of days later, one evening I experienced an often reported, and very weird, 5 minute period of pleasant euphoria which came and went -- just once. I then experimented with a 500mg dose (250 morning, 250 evening), had headaches and went back to just 250 in the morning. A couple of weeks ago I picked up some HPN 100mg tabs. I take the 250 in the morning and a 100mg HPN with dinner, for a total of 350mg, and don't intend to go any higher. So far no headaches on 350. There were three other possible effects ...

 

1. A little more energy. I do a lot of walking, and my pace seems to have picked up.

2. I'm not sure I can attribute this to NR, but I have several projects I've been putting off, and lately I have been motivated to get them moving. Due to NR? Who knows, but maybe.

3. The third effect is the reason for this post. I am fairly certain I can attribute this to NR. As we know, as we get older certain parts of the male anatomy tend to go limp and stay that way. Very true of me, for years -- until now. I first noticed this on the 500mg headache dose, but it has stayed with me. Frequently I wake up with what is sometimes referred to as "morning wood" -- and can get the same effect later in the day -- whenever the need arises, if you get my drift. I have never read reports of NR being the new Viagra, so I doubt this is common, but I wonder if there might be a synergistic effect with the Rutin and Cocoavia flavonoids?

 

This report is a little embarrassing, so probably no more posts on the subject. (-8

[MikeDC]

I'm a 76 year old male, somewhat supplement prone. At the moment I'm taking the usual vitamin D, fish oil, potassium, and magnesium. As happens in the (ahem) elderly I have been bothered by bleeding under the skin on the backs of my arms and hands, so a few years ago I started taking 450mg of Rutin, a flavonoid, and when the Columbia study was published, 375mg of Mars Cocoavia, another flavonoid (and expensive!). Both are reputed to be helpful with circulation and blood vessel strength, and my arms mostly cleared up. Then I read about NR, and 5 weeks ago started the AliveByNature product, one 250mg capsule in the morning on an empty stomach. A couple of days later, one evening I experienced an often reported, and very weird, 5 minute period of pleasant euphoria which came and went -- just once. I then experimented with a 500mg dose (250 morning, 250 evening), had headaches and went back to just 250 in the morning. A couple of weeks ago I picked up some HPN 100mg tabs. I take the 250 in the morning and a 100mg HPN with dinner, for a total of 350mg, and don't intend to go any higher. So far no headaches on 350. There were three other possible effects ...

1. A little more energy. I do a lot of walking, and my pace seems to have picked up.
2. I'm not sure I can attribute this to NR, but I have several projects I've been putting off, and lately I have been motivated to get them moving. Due to NR? Who knows, but maybe.
3. The third effect is the reason for this post. I am fairly certain I can attribute this to NR. As we know, as we get older certain parts of the male anatomy tend to go limp and stay that way. Very true of me, for years -- until now. I first noticed this on the 500mg headache dose, but it has stayed with me. Frequently I wake up with what is sometimes referred to as "morning wood" -- and can get the same effect later in the day -- whenever the need arises, if you get my drift. I have never read reports of NR being the new Viagra, so I doubt this is common, but I wonder if there might be a synergistic effect with the Rutin and Cocoavia flavonoids?

This report is a little embarrassing, so probably no more posts on the subject. (-8

I can confirm your third point that Niagen improves sexual performance. It also helped to cure my prostate inflammation. I was able to reduce inflammation with Lowe dose finasteride, Niagen seemed to repaired the nerve on a more permanent basis. Then a few shots of GHRH/GHRP finished up the job. It is back to perfectly normal. Long term use of GHRH is not good, but a few shots once in a while can fix a lot of things.

[stefan_001]

Same observation here wrt sexual performance

[Gayle63]

Soon-to-be-54-year-old female. I've been taking Basis daily since Feb. 2015 and recently added another 150 mg NR. I also take ubiquinol, resveratrol, turmeric, magnesium, Vit. D, alpha lipoic acid and acetyl l-carnitine, PQQ, huperzine and vinpocetine, a B complex, astaxanthin, and schisandra (these last two are more recent additions to my pill pile). So after that list, you can see it's not entirely clear if it's the NR making much of a difference, but I can report that my blood pressure has dropped from 110/80 to 100/70 the following year, to 90/60 last year. I also have my CRP levels tested, and I don't have the paperwork in front of me right now, but from memory, I know it was under 1 mg/L consistently for three years. All other blood measurements are in normal range, kidney function, cell size, etc., all that good stuff. Thyroid is normal. Total cholesterol under 200, with triglycerides low and HDL high, LDL low. The most interesting thing is that I haven't gone through menopause, and why that's interesting is that I'm pretty sure I was starting before I began taking the NR. I hadn't stopped having periods (sorry if this is TMI for some of you guys, lol), but I was having some other symptoms, and now they've all gone. I've noticed that NR is mentioned on fertility boards as a fertility supplement (not that I am interested in getting pregnant, ha), so it could be a factor for sure. Exercise-wise, I'm a daily walker, covering about 40 miles a week, and I use weights, but I'm not a gym rat by any means. Vegetarian (ovo lacto) for 33 years -- high intake of veg and fruit. I love the way I feel am excited about the future and seeing how the pursuit of anti-aging progresses.

[MikeDC]

My wife was one year into menopause and got a period after taking Niagen. Then she reduced dose and it never came back. Niagen can definitely extend fertility time. Taking it from 30's may extend to 60's probably. It has been shown in mouse that NMN turned messed up DNA in eggs into well organized DNA.

[Gayle63]

My wife was one year into menopause and got a period after taking Niagen. Then she reduced dose and it never came back. Niagen can definitely extend fertility time. Taking it from 30's may extend to 60's probably. It has been shown in mouse that NMN turned messed up DNA in eggs into well organized DNA.

Interesting! Why did she reduce the dose, if you don't mind my asking? I'm perfectly happy never going through menopause if I can help it. After all, there are only three animals on the planet that do, and the other two species are whales.

[MikeDC]

My wife was one year into menopause and got a period after taking Niagen. Then she reduced dose and it never came back. Niagen can definitely extend fertility time. Taking it from 30's may extend to 60's probably. It has been shown in mouse that NMN turned messed up DNA in eggs into well organized DNA.

Interesting! Why did she reduce the dose, if you don't mind my asking? I'm perfectly happy never going through menopause if I can help it. After all, there are only three animals on the planet that do, and the other two species are whales.

Some think high estrogen during fertility years can cause cancer late in life before menopause. Since Niagen prevents cancer, I would think the cancer rate is reduced even if you extend your fertility years.

[Female Scientist]

Yay! Another female here. I'm 49 and been on 125-250 mg NR since Feb 2016. I also have a big stack that I rotate that includes D3, ALCAR, pterostilbene, MSM, Korean red ginseng, PQQ, leucine, Vitex, a custom Ayurvedic combination, Lion's Mane mushroom, B complex, coconut oil caps, powdered spirulina, and a rotating night stack that includes Honokiol, glycine, magnesium spray, melatonin, apigenin, and a different Ayurvedic sleep combo.

I too was having menopausal symptoms including hot flashes. My thyroid (TSH) was also high and my cholesterols were borderline. BP has always been low. I reluctantly exercise several times a week. Weight is normal range. I took maca to good effect for the hot flashes initially but eventually found I just didn't need it anymore, after taking the NR for a few months.

About 10 months into adding NR my TSA and cholesterols and hot flashes were all normalized. I started getting a persistent patch of eczema on my elbows and found it was the NR, and simultaneously found the Mitochondrial Manipulation thread so decided to do 2-3 NR-only days per week, and take the other mito-fusion supps 2-3 days per week. I've always believed rotating seems best for my constitution but just started with this fusion/fission protocol so we shall see.

Huperzine and vinpocetine and schizandra sound interesting. I cannot do fish oil due to blood thinning problems so I stay away from astazanthin too. Ubiquinol makes me feel lousy. But like many of you I'm fortunate enough to be able to try lots of these things, so thanks for the discussion.

I do believe the NR has major fertility impacts. My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby. Not a guarantee that it was the NR of course, but wanted to add that happy comment to the thread

Soon-to-be-54-year-old female. I've been taking Basis daily since Feb. 2015 and recently added another 150 mg NR. I also take ubiquinol, resveratrol, turmeric, magnesium, Vit. D, alpha lipoic acid and acetyl l-carnitine, PQQ, huperzine and vinpocetine, a B complex, astaxanthin, and schisandra (these last two are more recent additions to my pill pile). So after that list, you can see it's not entirely clear if it's the NR making much of a difference, but I can report that my blood pressure has dropped from 110/80 to 100/70 the following year, to 90/60 last year. I also have my CRP levels tested, and I don't have the paperwork in front of me right now, but from memory, I know it was under 1 mg/L consistently for three years. All other blood measurements are in normal range, kidney function, cell size, etc., all that good stuff. Thyroid is normal. Total cholesterol under 200, with triglycerides low and HDL high, LDL low. The most interesting thing is that I haven't gone through menopause, and why that's interesting is that I'm pretty sure I was starting before I began taking the NR. I hadn't stopped having periods (sorry if this is TMI for some of you guys, lol), but I was having some other symptoms, and now they've all gone. I've noticed that NR is mentioned on fertility boards as a fertility supplement (not that I am interested in getting pregnant, ha), so it could be a factor for sure. Exercise-wise, I'm a daily walker, covering about 40 miles a week, and I use weights, but I'm not a gym rat by any means. Vegetarian (ovo lacto) for 33 years -- high intake of veg and fruit. I love the way I feel am excited about the future and seeing how the pursuit of anti-aging progresses.

Edited by Female Scientist, 05 July 2017 - 01:28 PM.

[Gayle63]

 

Soon-to-be-54-year-old female. I've been taking Basis daily since Feb. 2015 and recently added another 150 mg NR. [..]  The most interesting thing is that I haven't gone through menopause, and why that's interesting is that I'm pretty sure I was starting before I began taking the NR.  [...] I love the way I feel am excited about the future and seeing how the pursuit of anti-aging progresses.

Yay! Another female here. I'm 49 and been on 125-250 mg NR since Feb 2016. I also have a big stack ...

I too was having menopausal symptoms including hot flashes. My thyroid (TSH) was also high and my cholesterols were borderline. BP has always been low.  ... I took maca to good effect for the hot flashes initially but eventually found I just didn't need it anymore, after taking the NR for a few months.

About 10 months into adding NR my TSA and cholesterols and hot flashes were all normalized. I started getting a persistent patch of eczema on my elbows and found it was the NR ...

I do believe the NR has major fertility impacts. My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby. Not a guarantee that it was the NR of course, but wanted to add that happy comment to the thread

 
Hi! *Waving* Also very happy to find another woman here! That's very cool about your SIL. It's not easy to find information about menopause and how to delay (or prevent) it -- it seems as if the entire scientific community just shrugs off women's concerns with "it's inevitable" and "learn to love your wrinkles and brittle bones." I've been taking the huperzine and vinpocentine for years as nootropics. My mom had dementia (although probably not Alzheimer's -- we think probably vascular dementia), so that is my motivation for taking those. My husband and I added the shisandra just a couple of months ago. I can report a nice boost in libido. It's also supposed to be good for your skin, but my skin is already good, so I don't know how much better it can get. I don't look 20, but I don't look 54 either (or so I like to think, lol). I'm wondering when NMN will come on the market. Great chatting with you!

Edited by Michael, 05 July 2017 - 04:36 PM.
trim quote

[PeaceAndProsperity]

My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby.

Giving birth at 40 is NEVER healthy. Mutations occur rapidly in the aging female and she will pass them on to poor child. How the heck would doctors know if the child is healthy if they haven't done a dna test?

 

[Gayle63]

 

My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby.

Giving birth at 40 is NEVER healthy. Mutations occur rapidly in the aging female and she will pass them on to poor child. How the heck would doctors know if the child is healthy if they haven't done a dna test?

 

I'm not sure that's true. My mom was 40 when she had me, and here I am 54 years later in sterling health, and I know other women with adult children who had kids in the 40-ish range. What studies do you have to back up your assertion that it's "never healthy"?

[MikeDC]

My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby.

Giving birth at 40 is NEVER healthy. Mutations occur rapidly in the aging female and she will pass them on to poor child. How the heck would doctors know if the child is healthy if they haven't done a dna test?

I'm not sure that's true. My mom was 40 when she had me, and here I am 54 years later in sterling health, and I know other women with adult children who had kids in the 40-ish range. What studies do you have to back up your assertion that it's "never healthy"?

Having children late in life is good for the mother and bad for the baby. Study shows the mother will live longer and the child will live shorter. Better to have child in the 20s.

[Gayle63]

 

 

 

My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby.

Giving birth at 40 is NEVER healthy. Mutations occur rapidly in the aging female and she will pass them on to poor child. How the heck would doctors know if the child is healthy if they haven't done a dna test?

I'm not sure that's true. My mom was 40 when she had me, and here I am 54 years later in sterling health, and I know other women with adult children who had kids in the 40-ish range. What studies do you have to back up your assertion that it's "never healthy"?

Having children late in life is good for the mother and bad for the baby. Study shows the mother will live longer and the child will live shorter. Better to have child in the 20s.

 

Which studies? Please include links. I agree with you, it's generally safer to have children younger and the odds of things going wrong are less, but I'm not sure it's quite a dire as you may think for older moms or their offspring. For instance, here are some articles about the benefits of delaying motherhood: http://www.slate.com...ay-live-longer/

http://time.com/4574...ay-live-longer/

http://www.telegraph...-and-healthier/

[Gayle63]

I think we're getting off topic here, so I'll just conclude by saying so far, great experience with NR, seems to be rejuvenating.!

[stefan_001]

 

 

 

I'm not sure that's true. My mom was 40 when she had me, and here I am 54 years later in sterling health, and I know other women with adult children who had kids in the 40-ish range. What studies do you have to back up your assertion that it's "never healthy"?

Having children late in life is good for the mother and bad for the baby. Study shows the mother will live longer and the child will live shorter. Better to have child in the 20s.

 

Which studies? Please include links. I agree with you, it's generally safer to have children younger and the odds of things going wrong are less, but I'm not sure it's quite a dire as you may think for older moms or their offspring. For instance, here are some articles about the benefits of delaying motherhood: http://www.slate.com...ay-live-longer/

http://time.com/4574...ay-live-longer/

http://www.telegraph...-and-healthier/

 

 

Hi Gayle63 & Female Scientist first off thanks for posting its been a while since I read something new here. I have wondered for some time what would be the effects on women approaching menopause as my speculation in my mind was it might get delayed. N=3 (incl. the sister) is not statistical proof and hopefully there are more readers that can report on this but I would say its incredible as it shows that NR & supplementation delays a "milestone" in humans aging.

 

I am not convinced of the mutations concern, mitochondrial DNA is passed on already for ages and ages and seems quite robust so I am more of the view of Gayle63. Personally I gave some credence to the views that methylation of DNA might be passed on and perhaps that may influence the child.

 

[Female Scientist]

Gee, I wonder why there aren't more women on this board? Before you make such assertions, you should really check the literature. The vast number of babies born to women later in life are perfectly healthy. Yes, the incidence of difficulties does increase, but mostly things go well. I know from personal experience as well as reading up about it, because I myself had my children at ages 33, 34, 37, and 41. Grateful to report that each one of my 4 kids is quite healthy and happy.

Fertility issues are often age related, and as an important topic here, I would hope we would have an open opportunity to explore how NR impacts age related fertility decline. It's actually quite amazing.

My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby.

Giving birth at 40 is NEVER healthy. Mutations occur rapidly in the aging female and she will pass them on to poor child. How the heck would doctors know if the child is healthy if they haven't done a dna test?

[Female Scientist]

Yes! Fascinating stuff. Seems to me that female fertility is a prime indicator of aging in general. If I could wave a magic wand, I would design a study where we would do a randomized adminstration of NR or placebo to 2 groups of women at perimenopausal age, and regularly check their FSH levels. (FSH is the key hormone they use to determine your fertility status. The lower the better.) They usually say that nothing can reverse a rising FSH level. I would put money on NR to be successful here....

Looking forward to trying a couple of the items from your stack. Oh, and I forgot that I also rotate rhodiola and fisetin.

Aloha!

Soon-to-be-54-year-old female. I've been taking Basis daily since Feb. 2015 and recently added another 150 mg NR. [..] The most interesting thing is that I haven't gone through menopause, and why that's interesting is that I'm pretty sure I was starting before I began taking the NR. [...] I love the way I feel am excited about the future and seeing how the pursuit of anti-aging progresses.

Yay! Another female here. I'm 49 and been on 125-250 mg NR since Feb 2016. I also have a big stack ...

I too was having menopausal symptoms including hot flashes. My thyroid (TSH) was also high and my cholesterols were borderline. BP has always been low. ... I took maca to good effect for the hot flashes initially but eventually found I just didn't need it anymore, after taking the NR for a few months.

About 10 months into adding NR my TSA and cholesterols and hot flashes were all normalized. I started getting a persistent patch of eczema on my elbows and found it was the NR ...

I do believe the NR has major fertility impacts. My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby. Not a guarantee that it was the NR of course, but wanted to add that happy comment to the thread

Hi! *Waving* Also very happy to find another woman here! That's very cool about your SIL. It's not easy to find information about menopause and how to delay (or prevent) it -- it seems as if the entire scientific community just shrugs off women's concerns with "it's inevitable" and "learn to love your wrinkles and brittle bones." I've been taking the huperzine and vinpocentine for years as nootropics. My mom had dementia (although probably not Alzheimer's -- we think probably vascular dementia), so that is my motivation for taking those. My husband and I added the shisandra just a couple of months ago. I can report a nice boost in libido. It's also supposed to be good for your skin, but my skin is already good, so I don't know how much better it can get. I don't look 20, but I don't look 54 either (or so I like to think, lol). I'm wondering when NMN will come on the market. Great chatting with you!

[MikeDC]

https://www.google.c...-in-life-2015-6

[Female Scientist]

Yes! Fascinating stuff. Seems to me that female fertility is a prime indicator of aging in general. If I could wave a magic wand, I would design a study where we would do a randomized adminstration of NR or placebo to 2 groups of women at perimenopausal age, and regularly check their FSH levels. (FSH is the key hormone they use to determine your fertility status. The lower the better.) They usually say that nothing can reverse a rising FSH level. I would put money on NR to be successful here....

Looking forward to trying a couple of the items from your stack. Oh, and I forgot that I also rotate rhodiola and fisetin.

Aloha!

[quote name="Female Scientist" post="820610" timestamp="1499258576"][quote name="Gayle63" post="820535" timestamp="1499187986"]
Soon-to-be-54-year-old female. I've been taking Basis daily since Feb. 2015 and recently added another 150 mg NR.
Hi! *Waving* Also very happy to find another woman here! That's very cool about your SIL. It's not easy to find information about menopause and how to delay (or prevent) it -- it seems as if the entire scientific community just shrugs off women's concerns with "it's inevitable" and "learn to love your wrinkles and brittle bones." I've been taking the huperzine and vinpocentine for years as nootropics. My mom had dementia (although probably not Alzheimer's -- we think probably vascular dementia), so that is my motivation for taking those. My husband and I added the shisandra just a couple of months ago. I can report a nice boost in libido. It's also supposed to be good for your skin, but my skin is already good, so I don't know how much better it can get. I don't look 20, but I don't look 54 either (or so I like to think, lol). I'm wondering when NMN will come on the market. Great chatting with you!

[Female Scientist]

This is just for starters, but there is much research out there along these lines, supporting what my perinatologist told me, which is that while there are increasing risks with age, the vast majority of these babies are healthy, and there are also specific benefits of having an older mother. Given that life is unpredictable and we can't always determine when we have children, I think it's important to know the full range of benefits and risks to parental age before making broad, sweeping statements about how being an older mother is "good" or "bad". Oh and PS: increasing PATERNAL age has been significantly related to difficulties for the baby as well, so I would think fertility would be a topic to interest most of us, not just one gender...

http://www.bmj.com/c...t/345/bmj.e5116

https://www.nytimes....re-iphone-share

https://en.m.wikiped...rnal_age_effect




Having children late in life is good for the mother and bad for the baby. Study shows the mother will live longer and the child will live shorter. Better to have child in the 20s.[/quote]

[Gayle63]

Gee, I wonder why there aren't more women on this board? Before you make such assertions, you should really check the literature. The vast number of babies born to women later in life are perfectly healthy. Yes, the incidence of difficulties does increase, but mostly things go well. I know from personal experience as well as reading up about it, because I myself had my children at ages 33, 34, 37, and 41. Grateful to report that each one of my 4 kids is quite healthy and happy.

Fertility issues are often age related, and as an important topic here, I would hope we would have an open opportunity to explore how NR impacts age related fertility decline. It's actually quite amazing.
 

 

My sister in law started taking it at age 40 for menopausal symptoms, and now at age 41 just gave birth to a 9.5 pound healthy "surprise" baby.

Giving birth at 40 is NEVER healthy. Mutations occur rapidly in the aging female and she will pass them on to poor child. How the heck would doctors know if the child is healthy if they haven't done a dna test?

 

I think David Sinclair might be doing a study on NAD+ and fertility -- that guy has got a lot going on! Here's an article about it. I agree, fertility is an important topic.  Here's the article: http://genetics.med....ir/research.php

[Female Scientist]

Interesting point, Stefan about methylation. The FSH and egg quality issue is fascinating and perhaps doesn't get as much attention as warranted.....

Hi Gayle63 & Female Scientist first off thanks for posting its been a while since I read something new here. I have wondered for some time what would be the effects on women approaching menopause as my speculation in my mind was it might get delayed. N=3 (incl. the sister) is not statistical proof and hopefully there are more readers that can report on this but I would say its incredible as it shows that NR & supplementation delays a "milestone" in humans aging.

I am not convinced of the mutations concern, mitochondrial DNA is passed on already for ages and ages and seems quite robust so I am more of the view of Gayle63. Personally I gave some credence to the views that methylation of DNA might be passed on and perhaps that may influence the child.

[/quote]

[banhorn]

Long time reader, but this is my first real post!  

 

I'm male, 39 years old and about 5 months from turning 40.  I was skeptical of NR, but started taking Basis after reading a bunch of the study materials in November 2016 and really hadn't noticed much of an effect... aside from feeling less tired in the afternoon.  As any parents on here understand, I've got 2 little kids at home and they make me tired.  Basis seemed to lessen the impact, so I kept taking it.

 

Fast forward to the past week.  I'm an avid practitioner of yoga, player of hockey and do quite a bit of walking here in New York.   Again, I really hadn't noticed an impact on any of these things while taking Basis until this week.  Specifically with hockey, I'm a goalie and underwent pretty major spine surgery in my early 30's (Artificial Disc Replacement).  I was able to get back on the ice and play, but usually ended up with a tight/sore back for a day or so after playing too many games back to back, or generally pushing my back too far with exercise.

 

However, I just played 7 games in 7 consecutive nights, with very minimal fatigue and soreness across the board.  I haven't been able to do this in years, especially since my back surgery!  The only change to my regime of supplements and exercise has been the addition of Basis to my daily vitamin d and regular multivitamin.  There's no way to know for sure that is was Basis helping me, but I'm going to keep taking it.  

 

-Brett

[Oakman]

Unfortunately, I’m back to describe another incident from taking Niagen. Previously last year I had possibly thought Niagen had something to do with some chest pains in the right side sternum area. Stopping Niagen did cause this to subside after a period of time. I did, however, resume Niagen and all seemed well. I could not definitively say that the pains and their eventual disappearance was caused by Niagen, but it was a bit strange.

 

Fast forward  to the March/April timeframe this year where I was taking 250mg/250mg Niagen in an AM/PM schedule. I was also doing resistance weights ~x5/week. Things were normal. Starting in May I began to notice my upper left arm feeling some tinges of a strain. I really didn’t think much of it... pains come and go away while training. Then in May I changed to a 500mg/250mg AM/PM schedule of Niagen for no particular reason, just experimenting.

 

By the end of May the strained arm became an issue I wasn’t able to ignore. I stopped upper body resistance training, basically anything using my arm. I figured that doing nothing upper body would let the arm rest and all would eventually be well again in time. That's what I usually experience with pains.

 

The problem itself was what felt like a strained muscle and/or tendon/ligament all up and down between the elbow and shoulder, biceps side. Worse, I couldn’t raise my arm due to shoulder joint pain. Things that came to mind were perhaps developing arthritis and/or whatever I’d done somehow in training causing inflammation. However, it didn’t get better with resting it for eight weeks, in fact, it got worse and worse, and occasionally maybe marginally better, but never going away. I simply was losing the ability to do anything useful with the left arm. I could not even sleep on that side due to the pain.

 

So fast forward to last weekend, I had to do something different to change this. It seems silly now, but I had never thought of Niagen as a potential culprit for these pains. However, with nothing to lose, I did stop completely July 28th.

 

Almost immediately my arm started to feel better. Now yesterday and today, August 3rd, I’ve resumed some upper body resistance training with only minimal pain, something I was completely unable to do just last week. The shoulder now has full movement with only a bit of pain. This major improvement is all within a week of stopping supplementation.

 

My initial reaction is, “What to hell?” I’m left wondering just what is it about Niagen that can cause some random body muscles / tendons / ligaments (not sure which combination exactly), to become inflamed and irritated? Why does this happen only in a specific area, not all over the body? Is long term NR use not well advised? Does some effect of NR accumulate and eventually cause these problems? Or should a washout period be used regularly to minimize this?

 

There’s also the question of interaction with other supplements I take, which are a lot. Could that be a problem? If I was simply taking Niagen alone would it be fine at any dose? Lot’s of questions.

 

For now I’m off Niagen, and I’m thinking I’ll start again in a few weeks, seeing how I feel... possibly at the 125 mg or 250 mg daily dose and cycle it. In the mean time... my suggestion is… if you notice any muscle pains or weakness, remember what I experienced.

[MikeDC]

I think we need to be patient and don't be too greedy and take a large dose of Niagen. 250 to 375mg is plenty.
A lot of things can be coincidence. I also had a major pain with my left shoulder while taking Niagen. It lasted a few months and eventually it went away while I continued to use Niagen.

Edited by MikeDC, 03 August 2017 - 10:38 PM.

[Nate-2004]

So far I've been consistently taking HPN niagen for about 15 months. I've had aches, pains, cramps and other various bodily functions coming and going over that period of time. I stopped getting cramps when I started learning how to stretch every day. Other things have come and gone as well. I don't think I can attribute any of them to niagen since I never stopped and these things also happened before I started taking it. I imagine that if I had blamed niagen and stopped taking it and then the cramps or whatever went away, I would have assumed I was right and that niagen was the cause. Well, they went away anyway while I continued taking the NR. I'm not so quick to blame some new feeling on whatever I'm taking. There are just too many variables in any n=1 experimentation to consider, including the nocebo effect.

 

The only thing I know for sure is that I have more energy than I used to, and I also notice a vast improvement in sleep quality when I take it near bedtime because I wake up feeling pretty damn good.

 

I've also been in two accidents, one this past Sunday and another back in December. Both bike accidents. In one case I tore my rotator cuff. It healed, I've been lifting weights and doing pull ups/push ups since Feb. This past Sunday I hit a sewer grate at 25mph and flew over my handle bars. No I wasn't wearing a helmet, though if I had been I'm not so sure, based on where I hit my head, that it would have done any good. I hit my eyebrow on the concrete and there was blood everywhere, I looked like a disaster. The ambulance came quick and I was stitched up. The first day I had concussion symptoms, I took extra niagen that night and my usual dose of melatonin and went to bed early. The next day there were fewer symptoms and I did the same thing. Yesterday most of the cuts and scrapes on my face that made me look like I joined a fight club are gone and I've got no concussion symptoms at all. I didn't even follow the instructions to get cognitive rest though I didn't go to the gym at all this week. I get my stitches out tomorrow. The only remaining damage left now is a possible $87 bill that is the remainder of my deductible and a bike repair bill of $45.

 

I'll probably keep taking niagen every day, 375mg, till I see the results of the latest study at least.

Edited by Nate-2004, 04 August 2017 - 05:02 AM.

[DalamarB]

I stopped Niagen because of chest pain, it disappeared, when I came back to Niagen again the chest pain came back.

I realized that it was reflux in the esophagus, it might be related to the effects of NR on the microbiome.

[Richard McGee]

Some of the reported side-effects of NR might be averted by periodically stopping it for a short period. I believe this would be especially important for higher doses of NR. I would encourage NR users to incorporate a scheduled time out. This time-out would provide an opportunity to allow mitochondrial fusion to occur naturally, or to stimulate it using PQQ, BroccoMax, stearic acid or other substances (see Manipulating mitochondrial dynamics).

Edited by Richard McGee, 05 August 2017 - 06:41 AM.