2266 replies to this topic

[Phoebus]

a month in and...holy sht!

 

first off wrinkles on face are noticably lessened, skin tone much better 

 

but the big one is 2 severely arthritic shoulders that NOTHING has helped (and trust me I have tried everything) are actually getting better!!

 

seriously did not even expect this to happen

 

at 500mg i got better skin, but at 1 gr/day the shoulders started getting better. I am nearly crying as this is a major boost to my quality of life 

 

Coincidence? Maybe, but for now I am going to keep taking this stuff. I hope and pray this is not temporary. 

 

52 year old male 

 

btw - I take at least 2/day sublingual, that really seems the most affective. 

Edited by Phoebus, 12 June 2018 - 08:21 PM.

[Wave Txlitl Met]

Dear Devil's Advocate,

 

I unashamedly pack my own pills. A brand name does not matter. What matters is purity %. Since the discussion regards a singular ingredient, it is critical that ingredient is >98% pure. But to name a brand, on proprietary blends, I absolutely agree! Such as Synaptolean or SynaptaGenX, which is a complex blend of multi-amines and herbs. Or, fat burners and pre-workouts, generally. The blessing of singular ingredients is that only dosage and purity matter. I won't get into the quibble of 98.5% or 99.1% pure, since at the >98% it really does not matter. So, I supply the milligram amount and I presently refer that to the classic Niagen dosage others take. Truthfully, I've seen very high daily doses of the analogue NMN given to mice, but not satisfactorily found a dosage of NR in the literature. I may have missed it. But, I am grateful to tell this singular ingredient has such and such effects. I would further state that brand name does not matter unless per brand there are different extras. 

[able]

a month in and...holy sht!

 

first off wrinkles on face are noticably lessened, skin tone much better 

 

but the big one is 2 severely arthritic shoulders that NOTHING has helped (and trust me I have tried everything) are actually getting better!!

 

seriously did not even expect this to happen

 

at 500mg i got better skin, but at 1 gr/day the shoulders started getting better. I am nearly crying as this is a major boost to my quality of life 

 

Coincidence? Maybe, but for now I am going to keep taking this stuff. I hope and pray this is not temporary. 

 

52 year old male 

 

btw - I take at least 2/day sublingual, that really seems the most affective. 

 

Great to hear Phoebus - hope it continues.

 

Can you clarify your protocol?  You started at 500 mg a day for x days, then increased to 1g a day for x days?

 

When you say 2/day sublingual - I understand there is some variation, but are you taking approximately 1/2 your dosage sublingual, or what?

 

Are you going to switch to taking all sublingual?  

[MikeDC]

Dear Devil's Advocate,

I unashamedly pack my own pills. A brand name does not matter. What matters is purity %. Since the discussion regards a singular ingredient, it is critical that ingredient is >98% pure. But to name a brand, on proprietary blends, I absolutely agree! Such as Synaptolean or SynaptaGenX, which is a complex blend of multi-amines and herbs. Or, fat burners and pre-workouts, generally. The blessing of singular ingredients is that only dosage and purity matter. I won't get into the quibble of 98.5% or 99.1% pure, since at the >98% it really does not matter. So, I supply the milligram amount and I presently refer that to the classic Niagen dosage others take. Truthfully, I've seen very high daily doses of the analogue NMN given to mice, but not satisfactorily found a dosage of NR in the literature. I may have missed it. But, I am grateful to tell this singular ingredient has such and such effects. I would further state that brand name does not matter unless per brand there are different extras.

If 1% is poison, it can still kill you.

Brand name matters a lot. It is a trust issue. Are you going to test each bottle or each pill you buy from the flea market?

[Phoebus]

Great to hear Phoebus - hope it continues.

 

Can you clarify your protocol?  You started at 500 mg a day for x days, then increased to 1g a day for x days?

 

When you say 2/day sublingual - I understand there is some variation, but are you taking approximately 1/2 your dosage sublingual, or what?

 

Are you going to switch to taking all sublingual?  

 

10-ish days 500 mg/day

 

20-ish days 1 g/day 

 

2 caps/250 mg/day I do sublingual. I would do more but its just a pain in the ass. 

 

I have pure NMN powder on order (coming soon its been on back order), so when that gets here I will do that sublingual and compare to NR 

 

there is no NR pure powder available and it really annoys me since the Niagen has whatever nonsense filler in there and it interferes with sublingual absorption 

[Advocatus Diaboli]

Hi, Wave,

 

Re: post 1832, I take it you buy your NR powder, that you DIY into capsules, directly from ChromaDex? I'm making a bold leap here in thinking that you're actually buying powder and not capsules (TruNiagen, for example) which you subsequently empty out and then re-capsulate to your preferred dosage. If your "pure" (within limits) NR powder is not from ChromaDex directly, then perhaps from a distributer? 

 

Also, do I correctly assess your stance as being that if someone is reporting their results in this thread and that they are taking TruNiagen, e.g., (and not a proprietary blend for which you agree that the brand should be reported) then they don't need to state the fact that their NR is TruNiagen and that we, the readers, should automatically make the assumption of TruNiagen?

 

(n,b,--being captious is part of my job specs--see my nick   , Also, some reading my posts may be aware of where the nexus of my above Q's is headed--the denouement will probably appear shortly  .)

 

"To measure is to know"

 

 

edit: added Tru to Niagen

 

Edited by Advocatus Diaboli, 14 June 2018 - 10:21 PM.

[Phoebus]

 

-Skin, this is a two folded story as after couple weeks I decided to make my own skin cream so I cannot really say whether its oral or topical. On the wrincle side they are still there but less pronounced. But I look a younger. I have taken almost daily pics of my face and looked at them multiple times where that perception comes from. I am now fairly sure it is because my skin is somewhat tighter, my eyes are more open so like lifting of eyelids. Also the skin looks somewhat fuller. I started to have some part the skin to fall in/thin so I am speculating has it reactivated collagen production? THen the skin also looks somewhat more even colored but that got some kind of acceleration after I started to take Honikiol orally. I later found Honikiol is used in asia for skin whitening.

 

Stefan

 

 

can you tell me the recipe you used to make the topical NR treatment? 

 

are you still using NR topically? 

 

thanks 

[Phoebus]

Dear Devil's Advocate,

 

I unashamedly pack my own pills. A brand name does not matter. What matters is purity %.

 

hold on a minute. Are yo saying you can get hold of pure NR powder? 

 

how? where? 

 

I keep looking and cant find any. 

 

thanks 

[able]

I got a couple of jars of pure NR (not niagen) from Revgenetics earlier this year, but seems they have stopped selling it.  Probably scared off by Chromadex lawyers is my guess.

 

https://www.amazon.c...namide riboside

 

These guys are selling a non Niagen NR in capsules. So is likely not too difficult to purchase in bulk from China.  Maybe we could convince them to sell the pure powder.  

 

Really seems like someone should step up and offer it.  Chromadex is way too slow on this imo.

[Wave Txlitl Met]

Energy Metabolism depends much on NAD+. 

 

I take 62.5mg--187.5mg/day of NR. I also take 600mg of Niacin, divided into two/day. I've read Niacin is an NAD+ precursor of lesser conversion. I will say both give a distinct NAD+ feel, except NR is an NAD+ feel that changes your perspective (or apperspective, more accurately) on what is possible for supplements to accomplish. 

 

Another key is energy balance. I stack NR with 4-DMA-7, 8-DHF. If you don't know what that is, search it on ncbi. Some astounding results will appear. It's a highly absorbed BDNF receptor agonist! I felt the NR surfeit of cellular information with the neuron creation button being pressed like a child's brain. Plasticity, harmony, balance. On NR I lost weight, on 4-DMA-7, 8-DHF I am not being overcome by need to sleep at the wrong times. Dosage is .4mg/kg for humans, based on the 5mg/kg for mice. 

[Phoebus]

so all the posts about NR sources were just erased in this thread, I guess off topic? 

 

where can we discuss sourcing pure NR powder? I cannot find a NR sourcing thread 

 

thanks 

[Harkijn]

so all the posts about NR sources were just erased in this thread, I guess off topic? 

 

where can we discuss sourcing pure NR powder? I cannot find a NR sourcing thread 

 

thanks 

https://www.longecit...and-discussion/

[Advocatus Diaboli]

Thanks, for the link in post 1842, Harkijn. I, for one, was unaware of it.

 

I expressed my opinion in this thread that vendor information, as well as dosage, would be helpful, at least for me. Others disagree.

 

Here is an analogy that might emphasize my point more clearly:

 

Suppose that there is a thread that reports on automobile performance (a component of automobile "experience"). A number of people posting to the thread report data that might be considered to be terrific acceleration and cornering ability, for example, for their automobiles. Others report data that might be considered to be abysmal acceleration and cornering.

 

Someone posting to that thread points out that it might be helpful to the readers of the thread if those reporting would specify the make of their automobiles--thinking that there might be some specific reason(s) for such a wide variation of automobile acceleration/cornering experiences and that specifying make (brand) might give a clue (or might not, also helpful) to help explain the disparities.

 

Someone else in the thread asserts that an automobile is an automobile, and make (brand) doesn't matter.

 

A mind reader reads the minds of all posters to the thread and finds that those reporting terrific acceleration and cornering all own Corvettes, Tesla Roadsters, Ferraris and Lamborghinis. And, that those reporting abysmal acceleration and cornering are driving Isettas, Mitsubishi iMievs, and Smart CDIs. Aha!

 

So, if people don't report the make (brand) of their automobile it might be the case that some people reading the thread, that aren't mind readers, are left scratching their heads wondering why such significant disparities exists and might be of the opinion that more information (brand, vendor) would be helpful in potentially explaining the observed differences.

 

I think it would be appropriate in this thread to simply mention brand and vendor along with the reported experiences. That way, if someone reports that their NR made them vomit for a week and they also reveal that it was Fèihuà brand supplied to customers by Jiǎ distributing. Then, one of the possible reasons for such a bad reaction might be suggested (also being mindful of "post hoc, ergo propter hoc").

 

I'm not advocating any "My dog's bigger than your dog."-type debates over brand and vendor--just simple statements of fact. The "dog" debates rightly should appear in the thread that Harkijn cites in his post 1842.

 

 

"To measure is to know"

 

 

[Advocatus Diaboli]

Wave,

 

In post 1819 (June 11, 2018) you report having taken 125 to 250 mg/day NR for one month.

 

Then, In post 1842 (currently post 1840) (June 15, 2018) you report your daily intake of NR as being 62.5-187.5 mg.

 

Why did you change dosage from 125-250 mg/d to 62.5-187.5 mg/d (3 intervening days) when your post 1819 documents what might be considered to be salubrious effects?

Edited by Advocatus Diaboli, 16 June 2018 - 07:29 PM.

[MikeDC]

Energy Metabolism depends much on NAD+.

I take 62.5mg--187.5mg/day of NR. I also take 600mg of Niacin, divided into two/day. I've read Niacin is an NAD+ precursor of lesser conversion. I will say both give a distinct NAD+ feel, except NR is an NAD+ feel that changes your perspective (or apperspective, more accurately) on what is possible for supplements to accomplish.

Another key is energy balance. I stack NR with 4-DMA-7, 8-DHF. If you don't know what that is, search it on ncbi. Some astounding results will appear. It's a highly absorbed BDNF receptor agonist! I felt the NR surfeit of cellular information with the neuron creation button being pressed like a child's brain. Plasticity, harmony, balance. On NR I lost weight, on 4-DMA-7, 8-DHF I am not being overcome by need to sleep at the wrong times. Dosage is .4mg/kg for humans, based on the 5mg/kg for mice.

Messing with TrkB seems to be extremely dangerous. High and low levels are associated with many diseases and cancer.

[Wave Txlitl Met]

It's funny that this personal experience thread is truly about the journey with NR. Some people in this forum sit on the sidelines and guttersnipe, for reasons of who knows? Devil's Advocate, so coy with the "some people say an automobile is an automobile." Your analogy falls apart since you don't preface the automobile condition with who makes them. The claim is simple to understand, even for the godless. The Creator made these pure, individual substances and what matters is whether these are reasonably pure. Your automobiles all have different designers, many different patented components, and different secrets inside. Provided NR is made to a purity level, all of the secrets of the Creator are invested in any given *automobile* regardless of brand. 

 

That's the point MikeDC first caught on. Not being branded. I surmise as much from his useless and unproductive comment(s). It's a big issue to pull others from commercialism. It's almost offensive to encourage people to pull up their bootstraps and buy these things on the manufacturer's market. The value is I can dose one, two, three times, four, five, six times, each pill individually formulated by me with smatterings of NR. What's your regime Devil's Advocate? I'd like to see your credentials for putting on the tall pointed hat of an inquisitor. Do you vary your dosing? A veteran like myself will understand the requirement to lessen or to increase, to take or to abstain throughout the week. It's a shame I may take this mg or that mg a day or a week, but don't you see I'm reporting the effects of NR? I have been faithful to that. 

 

I encourage everyone to try NR. I am experimenting with lower limits of mgs for expediency. I have not taken in the grams, yet, but the dosage is ~2g/day. There is some dose-dependence, subjectively, for the experience. I am seeing it if is an inverted-U, the top being fatiguability and the bottom being energetic. Some have written and I experienced myself some yawns on this; the good kind of yawns. It may be a healing or house tending fatiguability that subsides after chronic application. I have been less than one month in, so I can't report long term results. 

 

 

[Advocatus Diaboli]

Wave, in post 1846 you wrote: "What's your regime Devil's Advocate? ". 

 

I started on a particular brand of pure NR on June 15, 2018. I take two 125mg capsules in the morning before breakfast--generally between 6am and 9am. Thus far (as of June 18, 2018), I detect no out-of-the-ordinary effects (i.e., no deviations from the status quo).

 

As a side note, I recently finished a two month regimen of NMN from a particular brand that sells "pure" NMN (as indicated on the bottle label) made in the USA--for which I felt no effects. I subsequently learned that the capsules from that brand contained 1/10th the label-claimed amount of NMN (see the appropriate posting on LongeCity for additional information). I suspect that my lack of effects can at least be partially explained by the fact that I was taking 1/10th the amount of pure NMN that I thought I was taking. I suggest that you don't buy that brand.

 

Your friend,Tomas, err, I mean Advocatus Diaboli.

[smithx]

Could you please link to this? I haven't heard of it and need to know, since I am taking both NR and NMN.

 

 

I subsequently learned that the capsules from that brand contained 1/10th the label-claimed amount of NMN (see the appropriate posting on LongeCity for additional information).

 

 

 

Edited by smithx, 19 June 2018 - 08:11 PM.

[LawrenceW]

K2GO brand is a scam.  They only put 12mg of product in their 150mg capsule.

 

 For more info:  https://www.longecit...pplier-concern/

[Advocatus Diaboli]

I'm now on my 5th day of an unnamed brand of NR and I still can't report any substantive changes in the status quo. Although, there does seem to be a slight lowering of blood pressure, but I'm unsure if that isn't just part of normal fluctuation. I'll hold off on further reporting until after a month or so use.

 

PS--Thanks for the info, Lawrence. I hesitated to mention the brand in this thread because "A brand name does not matter." if it's pure. Well, in K2GO it is pure (what little of it there is, lol).

Edited by Advocatus Diaboli, 19 June 2018 - 09:31 PM.

[Advocatus Diaboli]

Phoebus, in post # 1831 you write: "a month in and...holy sht!" referring to your exceptional NR experience. At the risk of me incurring the disapprobation of some readers for asking,  would you state the brand and vendor of the NR you're using?

 

I was recently burned in an NMN purchase and think that revealing the brand name of pure NR that apparently works (at least for one person) is a potentially good piece of information to know in that it might help in the winnowing process for NR selection.

 

Oakman, in post # 1752 you write "In the last nearly two years, I've taken NR in all the ways you've mentioned. Unlike some, I haven't found significant difference in feeling or effect." Would you be amenable to disclosing brand and vendor of the NR for which you appear to have experienced null-like effects?

 

Thanks

[Advocatus Diaboli]

NR appears to help the symptoms (and more?) of arthritis, for at least one person writing in this thread. According to Wikipedia "There are over 100 types of arthritis.^[4][5] The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis.^[6]".

 

For those people reporting improvement (or not) of their arthritis symptoms, while using NR, I think it would be interesting for them to also report on the type of arthritis that they suffer from. That way a relationship(s) might possibly be established as to what forms of the disease may be more receptive to NR-mediated treatment.

 

If, for example, some people report great improvement in their "arthritis" and some report little, or no, improvement it may be the case that all of those reporting great improvement suffer from osteoarthritis and that all of those who report little no improvement suffer from a different form of the disease. Established relationships might serve to temper the expectations of those with a particular form of arthritis, that from analysis of accumulated data, appears to be less amenable to the action of NR.

 

 

Edited by Advocatus Diaboli, 21 June 2018 - 01:03 PM.

[Oakman]

 

Oakman, in post # 1752 you write "In the last nearly two years, I've taken NR in all the ways you've mentioned. Unlike some, I haven't found significant difference in feeling or effect." Would you be amenable to disclosing brand and vendor of the NR for which you appear to have experienced null-like effects?

 

Thanks

 

Let's see, AliveByNature, ProHealth, Thorne Research, Nectar7, Live Cell Research, maybe others. Of course, not all of these brands sell Chromadex Niagen any longer.

 

But your question misinterprets what I said - I didn't say anything about "null-effects", I said I hadn't noticed any significant difference between brands. As to mg taken, there was a time when I think I was taking too much, as I was having joint soreness. When I stopped and then lowered the dose, symptoms went away.

Edited by Oakman, 21 June 2018 - 12:58 PM.

[Advocatus Diaboli]

Thanks for the info (post 1853), Oakman. Sorry for my misinterpretation. 

 

 

[Phoebus]

quick note 

 

anything above 1.2 grams or such gives me slight nausea, nothing severe and it passes but still discomfort 

 

1 grams seems to be the sweet spot for me 

[MikeDC]

I don’t remember anyone has posted about cataracts before.
This is a review from Amazon.

“I am 71 had cataracks in my eyes went 6 months later for operation with eye doctor and they had reversed no operation needed swear by this product.”

[triguy]

is there a reliable source yet found??????

 

thx

[Boopy!]

looks like that review on Amazon is reliable/s

[male_1978]

I just want to add as experience, that the skin below my hair seems less irritated than 6 month ago. I use a topical lotion (thiocyanate) whenever the hair feels unhealthy and i now see that my consumption of this lotion dropped to about one third.

 

I cannot say whether or not it protects against hair loss or even promotes regrowth. However, in the past having an irritated skin often preceeded hair loss, so i simply assume that NAD+ helps here.

 

I am 40 and currently taking between 200 and 300 mg NR / day.

 

 

What i will try now is to mix some NR powder with my hair lotion when i apply it to sensitive areas ( i put some powder on my finger and massage it into the wet skin after applying the hair lotion). I made pictures so we can check afterwards.

 

 

[Phoebus]

this stuff if really great for my skin 

 

I have taken 5 years off my face in 2 months. Less wrinkles, smoother skin and better skin tone 

 

and now today i realized the age spots on my arms and torso are dramatically lightened. Not gone, but most definitely much lighter. I would say they are on their way to dissapearing altogether if I keep this up. 

 

amazing stuff