659 replies to this topic

[Nick Kyz]

I can empathize with TLR. 3pa would be cost prohibitive for how expensive it was to synthesize (they would probably need several grams of the stuff), plus there's no reference sample so developing one would also be costly. If we did a group buy there would likely be no 3pa (unless costs came down dramatically).

[Azedia]

Hey all, count me in for any future group buys of nrx-1074.

[opusensemble]

TLR is tainted
https://m.reddit.com...o_buy_from_tlr/

[lgrootnoob]

i read sass is buying allergan stocks, and allergan shares are plummeting. will this have any difference on the release of nrx? im really antsy about getting ahold of this compound. thanks

[Nick Kyz]

I'm talking to a polish organic chemist about custom synthesis, how much would we want? 10 grams?

[Reformed-Redan]

I'm talking to a polish organic chemist about custom synthesis, how much would we want? 10 grams?

 

Don't want to get my hopes up yet; but, yeah 10g would be ideal as an initial order to trial and see what ROA is best and at what doses...

[franbird]

Sounding hopeful

[ceridwen]

I'm interested

[Brazzo]

I'd  be also in.

[Reformed-Redan]

We found a supplier!

 

Extremely happy about this!

[Der Springende Punkt]

That's great news! I'm definitely in. The price of the supplier will dictate the route of administration given the high amount to take via the oral route (https://clinicaltria...how/NCT02366364).

[Adr1n]

We found a supplier!

Extremely happy about this!

Is it the polish lab?... What do they say about the chemical complexity?

Edited by Adr1n, 07 April 2016 - 06:57 PM.

[Reformed-Redan]

 

We found a supplier!

Extremely happy about this!

Is it the polish lab?... What do they say about the chemical complexity?

 

Yes, they can make it despite the chemical complexity. It ain't an easy compound to synthesize; but, is definitely worth it given that I think 5 mg per 1 ml  of a nasal spray would be as effective as GLYX-13. If not, then we would be able to ascertain whether the scientists behind its creation were telling the truth about it being thousands of times more potent than GLYX-13.

Edited by redan, 07 April 2016 - 07:28 PM.

[franbird]

I hate to ask, but is it the sort of thing that would be days/weeks/months away?

 

I'm not sure how long these things take

[. Gymscience]

im interested , living in poland

[lgrootnoob]

yes, how long would this take?

[uppercut1991]

I'm willing to take part also

[sentics]

me too.

[Reformed-Redan]

I'd like to get a feel for how much people are willing to pay for this compound.

 

We got a quote for 10g of NRX-1074 at 7000 USD from a Polish lab. Including 1k for shipping, liability costs, and 3'rd party analysis (amounting to something like 8k USD), the amount needed per participant could be quite high if we decide to go with 10-20 participants...

 

Just kinda reminding that this stuff costs a lot to make and further obtain; but, the potential rewards can literally be life-changing in terms of treating depression, negative symptoms of schizophrenia, and anything pertaining the advantage of potentiating NMDA receptor activity (downstream effects of very strong nootropic potential as I posted here). 

 

I'm quite stoked to get this rolling; but, want to be cautiously optimistic as to when it comes down to putting down the money, enthusiasm dies down quite a bit... 

 

As an econ major, this is the best investment one can make in terms of cognitive enhancement and improvement of wellbeing. 

Edited by redan, 09 April 2016 - 09:11 PM.

[Nick Kyz]

Lead time for a custom synthesis is 6-10 weeks after paying. So the way this would have to go is, a period of fundraising (maybe kickstarter/indiegogo) then 2 months lead time on the synthesis, then another week or two for fulfillment (measuring, packing, etc).  Altogether 3-4 months. 

[Adr1n]

Notably, if you wish to get say even 5 people pooled together before the sale ends you can all get 100mg for the 500mg basis of $1320/500mg which is $264/100mg. After the sale ends it will be as per the site ~$1650/500mg and therein $330/100mg. Right now if you just wish to procure 100mg 'alone' it is $320, 20% less ~$400 as on the site, which is valid through Sunday and will NOT be held for a longer period.

So it is way cheaper than what teamtlr offered. This one beign at 80$/100mg compared to 264$/100mg . If NRX-1074 is as potent as they say, 100mg could last for months.

Edited by Adr1n, 10 April 2016 - 02:57 AM.

[Reformed-Redan]

We're going to have 15 spots made available (first come first serve) with the cost to be 400 USD which would include shipping and a 3'rd party analysis provided for that sum for the amount of 500 mg of NRX-1074, which is more than enough for a good trial of its effects on cognition and depression... The only reason I'm opting for 15 members is because it lowers the chance of liability, shipping costs, and practicality of sending the compound around to members.

 

I honestly don't think that should break the bank and obviously one can sell their amount of NRX-1074 whenever possible or share the costs between members, which I encourage.

 

Anyway, PM me or post here if still interested. 

 

Also, if one suffers from depression, then you get priority over previous members who have posted interest here if they also want to obtain the compound.

 

Exciting times.

 

 

 

Edited by redan, 10 April 2016 - 06:15 AM.

[rena123]

Count me in. Would highly appreciate the compound to combat treatment resistant MDD and possibly also PTSD.

Could you further elaborate on the exact dosage for oral administration, the only information I found so far was rather vague ranging from 25-125mg.

Edited by rena123, 10 April 2016 - 06:27 AM.

[Reformed-Redan]

Count me in. Would highly appreciate the compound to combat treatment resistant MDD and possibly also PTSD.

Could you further elaborate on the exact dosage for oral administration, the only information I found so far was rather vague ranging from 25-125mg.

 

 

I emphatically recommend intranasal administration for a variety of reasons. 

 

It will maximize bioavailability, hasten onset of effects, and be much more economical. If, what the scientists at Naurex said is true, then take the doses used for GLYX-13 intranasal dosing, which I assume is somewhere in the ballpark of lets say 30 mg and then divide that by " thousands of times more potent" and you actually end up in the microgram range or less. 

 

Personally, I will try 1 mg per 1 ml of nasal spray just to see what effects I get at those doses. 

[Reformed-Redan]

So, two spots already taken.

 

rena123

franbird

 

13 left.

[Jul89]

how do you know if intranasal works??

[Reformed-Redan]

how do you know if intranasal works??

It's an assumption that there is better absorbtion of the compound through intranasal dosing, making the stuff last longer and having more immediate effects...

 

Though in the studies 5 mg orally was as effective. So, 500mg will still last quite a while.

[HouseElisabeth]

Hello,my name is Savvas and i am a depression sufferer ( the last two years), due to some extremely difficult situations i found myself in. I live on a small Greek island (Skiathos). I consider my self as treatment resistant and i hope to find a way to help and be helped through this forum. I have been following your posts since i discovered the potentials of nrx 1074 for treating depression (personal research). I decided to join longecity today in order to be able to join the group buy. Ketamine is another option but i am not sure about the side effects and there are no doctors in Greece who provide this type of treatment. Please count me in. If you have any questions about my personal status i will be more than happy to reply.I have a good feeling about this guys!  

Best regards!

[Reformed-Redan]

Glad to have you Savvas. I'll put you down for another spot in this group buy.

 

12 spots left to go.

[Jul89]

5mg oral is effective?

How do you know?