659 replies to this topic

[Ark]

Curious any price break for buying $400 worth?

[Milkyway11]

So are we talking about synrthesising NRX or GLXY?  If it is the NRX what amount at what cost would each member be expected to buy?

[irony]

I've been trying to find out more about NRX-1074/AGN-241660.

 

It appears to have the same MOA as GLYX-13, but more potent, is that correct?   GLYX-13 is IV... can NRX be taken orally?

 

GLYX-13 appears to be more tested than NRX.   Why are people more focussed on NRX?  

 

I've spent almost 2 decades now looking for something that really works for depression and I've been disappointed with many promising stars.   A few high profile ADs have crashed and burned as late as phase III in the past couple years (ALKS-5461, Amitifadine, AZD-6423 (an NMDA antagonist), Basimglurant... and many more dead).    Still trying to figure out what happened to ALKS-5461 - they had a really high placebo response rate in phase III which made them withdraw their application.

 

There are a number of other NMDA ants...  why NRX and none of these?   e.g. AVP-786

 

 

Thank you.

 

[Reformed-Redan]

Curious any price break for buying $400 worth?

As per my previous posts, the amount for 400 USD is 500 mg. For 200 USD you'd get 250 mg. 

[Nick Kyz]

There is a big price break for joining the group buy. I'm buying 2.5 grams for myself. What I don't personally use I'll list for sale on irc.bio, at a markup.

[opusensemble]

Just as curiosity, messaged the Alibaba sellers this week and got this response: 

 

 

Dear Joao,

 

Thank you for your kindly reply.

 

Yes, we are able to synthesis NRX-1074 for you.

We can offer you $10,000 for 50grams;

Purity: 99%;

Sythesis period: 8 weeks ;

 

We are manufacturer of Nootropics and SARMs, and we offer customer sythesis for our clients.

 

Any other questions please let me know.

 

Best regards,

Sanny

 

[Reformed-Redan]

 

Just as curiosity, messaged the Alibaba sellers this week and got this response: 

 

 

Dear Joao,

 

Thank you for your kindly reply.

 

Yes, we are able to synthesis NRX-1074 for you.

We can offer you $10,000 for 50grams;

Purity: 99%;

Sythesis period: 8 weeks ;

 

We are manufacturer of Nootropics and SARMs, and we offer customer sythesis for our clients.

 

Any other questions please let me know.

 

Best regards,

Sanny

 

Nice,

 

Can you forward the info to Nick of the contact or do so for me also... 

 

Based on this we could get much more than 500 mg or 250 mg for the price paid per participant. 

 

Thank you!

 

EDIT:

 

However, I should also state... We are synthesizing the compound from a professor and a university lab in Poland. This should be a sort of reassurance that we are getting what we ordered in the quality and authenticity desired. I'll ask Nick if he wants to switch suppliers or stick with the proven and trustworthy one from Poland...

 

I'm open to suggestions. 

 

Can you ask them for the quantity they could provide for 6000 USD?

 

Thanks.

Edited by redan, 15 April 2016 - 09:18 PM.

[Nick Kyz]

We had a previous quote for 100g/$20000, so that's not unexpected. It's just a question of whether we want to

A) Use a Chinese lab (I'm fine with this)

B) Fundraise for a larger more economic order  

 

And remember, we need to add roughly $1500-2000 for testing and distribution. @opusensemble, I would ask them for quotes on 10g, 25g. If you like you can forward them to me at groupbuys@irc.bio

Edited by Nick Kyz, 15 April 2016 - 09:43 PM.

[chemicalspiral]

I have a question about the shipping of the product: As far as I can see, the laboratory is located in europe, but the organizers are from the US. Is there any way that the product gets shipped to from within europe to avoid issues with customs?

The issue is that the product will have to be put through a 3'rd party analysis, which will likely take place outside of Europe. 

 

I'll see what I can do in regards to this matter.

 

 

 

The best way to handle the shipping would be to find a trusted member from the EU who will receive the order from the lab, take the amount needed for the members from europe and forward the rest to the US. I don't see any problem with the 3'rd party analysis taking then place outside of the EU, as you need just a tiny fraction of the batch to test it. That way you could avoid any unnecessary issues with customs. I'd really like to take part in this group buy, but shipping is a big problem for many countries if it does not come from another EU member state.

Edited by chemicalspiral, 15 April 2016 - 09:56 PM.

[Dayfob]

Personally I would opt for synthesis in Poland. Not because I'm polish, but somehow it seems more safe, faster, and reasonable solution. Some of us are suffering really bad, and I think if we could get 6K USD now, and product would gain possitive feedback, people in the future will be more likely to participate in bigger order, for example from China. Redan, if you would PM me any contact to the professor, I can try to make a call to him, or get more information about his persona, and the university in which he is teaching. 

[Reformed-Redan]

Personally I would opt for synthesis in Poland. Not because I'm polish, but somehow it seems more safe, faster, and reasonable solution. Some of us are suffering really bad, and I think if we could get 6K USD now, and product would gain possitive feedback, people in the future will be more likely to participate in bigger order, for example from China. Redan, if you would PM me any contact to the professor, I can try to make a call to him, or get more information about his persona, and the university in which he is teaching. 

I agree.

 

I think we should stick to what we are currently doing. If all goes well (higher likelihood in my mind), then we can request a custom synthesis from China...

 

I hope we are all in agreement on continuing with the university based synthesis lab in Poland.

 

PM Nick for his contact details; but, be aware that the professor is under the impression that this compound being made by him is only for research purposes. If he thinks that people will be trying this out on themselves, he'll likely cancel the synthesis...

 

Best regards.

 

All in all, I'm quite happy that Chinese labs are now willing to take up the project. I'm sure we'll be placing orders from them after this group buy works out.

[Reformed-Redan]

If Nick is willing to put in an order with the Chinese lab listed, I'm ok with that.

 

The only problem is that I'm not sure we will be collect 10000, as we're sort of struggling with getting to 6000 for this group buy...

 

 

[neuroatypicow]

as one who ponied up full price according to the original plan, i would like to keep to the original plan, to get to $6000 before we'd consider any alterations to the buy structure. i fear things losing focus, goalposts shifted.

[Azedia]

as one who ponied up full price according to the original plan, i would like to keep to the original plan, to get to $6000 before we'd consider any alterations to the buy structure. i fear things losing focus, goalposts shifted.

 

Another already-paid group buy member here, for what it's worth I agree with this 100%.

[HouseElisabeth]

I personally suggest that we stick to the original plan. Testing the component is essential. If,fingers crossed, NRX 1074 is the answer to our prayers,then we can proceed to ordering a larger amount of the component from a Chinese lab. If not,it's better to loose 6000$ rather than 10000$.Plus the fact,that it will take more time to find people willing to participate  in a 10000$  scale group buy. Having a university professor working for us sounds like the best and safest option.

[HouseElisabeth]

PS.If this goes as planned and we,at last,find a way to treat this terrible disease through NRX 1074, i am throwing a salvation summer party in Skiathos island. You are all invited! (i live 10 min away from the beach in the picture)              

 

[Reformed-Redan]

PS.If this goes as planned and we,at last,find a way to treat this terrible disease through NRX 1074, i am throwing a salvation summer party in Skiathos island. You are all invited! (i live 10 min away from the beach in the picture)              

Holy shit!

 

I'm definitely in!

 

Can I move there permanently? :DDD

[HouseElisabeth]

As long as you know how to swim

[Reformed-Redan]

As long as you know how to swim

[Reformed-Redan]

So the deadline has passed for putting in orders for NRX-1074. I made an exception for one member... 

 

I'll talk with Nick as to how many prospective spots are available, until we reach 6000 USD. 

 

Hold tight. I won't give up on this compound and interest from other people will definitely help me get this realized.

 

Best regards.

[Reformed-Redan]

If interested just post here. 

 

We have some space available for new participants. 

 

Either send a PM or post your interest here. I can contact you with payment details.

 

Just want to get this process done so we can move onto synthesizing the stuff and then testing it, and then finally trial it... Ehh.

[franbird]

Could you possibly update the first post with a running total of collected funds? For those curious about our progress

[Reformed-Redan]

Could you possibly update the first post with a running total of collected funds? For those curious about our progress

We're at 5000 even right now.

 

We're really close. And the amount of progress we have made in 1 week in my opinion is astounding. 

 

I hope we can still get some more people for 500 mg or at least 250 mg. 

EDIT:

 

We're almost at 6000. If you haven't paid yet, now is the time.

 

Thank you all for helping me make this happen, along with Nick from http://irc.bio/

 

Thanks again and best regards.

Edited by redan, 18 April 2016 - 03:51 PM.

[derzahla]

Im in for 250

[derzahla]

Any data on taking this concurrently with SSRI's?

[HouseElisabeth]

Good point derzahla...Trial and error?

[opusensemble]

I agree with what is said above about going with the Polish lab as it's likely to be a more reliable source. 

Just for your future eventual reference, the contact of the Chinese producer from whom I got the above quotation is hhdpharm@hotmail.com (Alibaba page: http://hhdpharm.en.a...3228.0.0.lGJHn3 ) 

What puzzles me about this group buy is the customs barriers. If the product is sent from Poland as a research chemical, I assume (subject to confirmation) that within the European Union zone, it can travel freely without customs issues.

Being redan and Nick from the US, it they are the ones distributing the fractions to the group buy members, it will be processed by US customs in bulk as a research chemical, and will then need to be shipped to the members in a discreet letter envelope as standard mail, in order to avoid destruction by customs upon reentering the EU. If the distribution is made from within the EU, then the parcels being sent to the US probably need to be sent in discreet mail to avoid similar seizing from US customs, as the US members' fractions of the powder would travel without certificate of origin (since it wouldn't match the client and quantity issued in the invoice from the Polish lab)

I don't know how other group buys took place, but I think the customs issues can become troublesome and eventually lead to the loss of all the costs if the product is seized and destroyed for whatever reason customs authorities may come up with. I don't know if research chemicals can travel freely across borders, specially when bought by individuals without any special licenses (if any apply) to deal with these substances, 

I can give you the example of some herbal extracts I recently bought at Alibaba, which are being held in France Charles de Gaulle airport's customs, which according with Fedex, will take several weeks and is due to lab analysis being performed to the powder. https://www.fedex.co...S&cntry_code=us


I can see something like this easily happening with our order if we don't know the customs rules of the countries involved. @redan @Nick, please make sure these issues are checked before any shipping. If the receiver of the order is within the EU, it's important to make sure that the receiver's country customs will not apply local laws and simply seize and destroy the goods. 

Other issue that I'm not sure has been discussed is the method of administration of the NRX-1074 powder. I've seen people asking if a nasal-spray could be made. I speculate if mixing the powder with ... say aqueous or even 70% ethyl alcohol (ethanol) would allow a preparation of such spray. Similarly, I wonder if anyone has considered the hypothesis of a solution delivered topically in the forearms, similarly to what someone tried with Dihexa, by using DMSO; https://www.reddit.c...ial_in_review/ 
I assume that considering NRX-1074 is not as "insanely active" as Dihexa, the topical solution loses in favor of the nasal spray. I know absolutely nothing about this topic so all I'm saying here should be subject to review. 

Source: Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?
http://www.ncbi.nlm....les/PMC3795377/

"Intranasal transport is the direct transport of therapeutic agents from the nasal cavity to the brain. This is a mainly extracellular and transcellular transport, involving the olfactory and respiratory regions of the nasal cavity. Intranasal administration has already been used for many years in the clinic to administer substances that cannot be given orally. These substances will reach the systemic circulation through intranasal instillation. Only a few decades ago, the potential of intranasal administration to reach the central nervous system (CNS) gained interest [20,21]. Pharmacological agents can bypass the BBB during this transport and enter the CNS." 

 

https://en.wikipedia..._administration

Nasal Drug Delivery: A Potential Route for Brain Targeting
http://www.thepharma...rch_2013/14.pdf

Excipents used in Aqueous Nasal Products
http://www.dptlabs.c...nufacturing.pdf


Aqueous excipient doesn't seem to be good according to this reference, if NRX-1074 is not very water soluble (research/confirmation needed); 

"Depending on aqueous solubility of drug it require high volume of dose (25-200ml)"

Source: NASAL DRUG DELIVERY SYSTEM: AN EMERGING APPROACH FOR BRAIN TARGETING

http://www.wjpps.com.../1397642827.pdf
 

I'm assuming that snorting the powder will be less efficient (and would eventually lead to less optimal use of the powder, as will probably be prone to losses into the lungs and stomach) than using an excipient nasal spray. But again, I know nothing about the issue and don't know what excipient would be most suitable. 

Nasal route seems to have been used even by Shaolin monks, so maybe is the way to go for this compound if it's more bioavailable through nasal route than through oral way (my total speculation. reference needed) 
An Herbal Nasal Drop Enhanced Frontal and Anterior Cingulate Cortex Activity
http://www.ncbi.nlm..../PMC3140066/#B3

These are issues I would like to see discussed here, apart from the 3rd party lab analysis, as I think they are very critical to the whole endeavour. 

Attached Files

•  Ensuring_a_Streamlined_Approach_for_Nasal_Spray_Product_Development_and_Manufacturing.pdf   584.97KB   4 downloads
•  Nasal Drug Delivery A Potential Route for Brain Targeting.pdf   755.41KB   2 downloads
•  NASAL DRUG DELIVERY SYSTEM AN EMERGING APPROACH FOR BRAIN TARGETING.pdf   506.24KB   2 downloads

Edited by opusensemble, 19 April 2016 - 08:18 AM.

[Reformed-Redan]

1 more spot open for 500 mg and we're at 6000 or two spots for 250 mg.

 

Last chance!

[Jul89]

Good luck guys. Will you post your experience here?

[Reformed-Redan]

Good luck guys. Will you post your experience here?

I'll post my experiences via nasal route first.

 

I expect drastic differences versus oral route.