Thank you very much for your information Tolerant and samson75!
Yes,i am interested in participating in both nemifitide and vorinostat group buy.
A lot of our trouble make sense, due to genetic dispositions.
I was recruited for a clinical trial where scientists were trying to discover wether treatment resistance depression
links with certain genes of an individual's DNA code.
The clinical trial was part of a French university's research program.
My current psych who is a professor in a Greek university, but also participates
in projects organized by European Union in collaboration with other universities, asked me if i wanted to be part of that
clinical trial. The only thing i had to do was to give a small blood sample.
Briefly there are probably hundreds, or maybe thousands of genes which combined
with life experiences, are responsible for wether we are happy or sad.I will not be using medical terms but i will try
to present why this is not a totally wrong and simplified aspect of our states of mind and life in general.
Yes, happiness and sadness are mainly defined by our DNA.
After long conversations with my doctor and a couple of other "openminded and out of the box thinking"professors ,
i have accepted this (maybe a bit "nonconformist")theory. I will present you this aspect.
I will also be simplifying terms and examples.
So guys! There are people who wake up
in the morning, being able to stay in the house doing nothing apart from laying on the sofa and enjoying pure happiness.
In other words they feel joy just from
existing!(lucky them)
There are people who wake up in the morning and in order to feel joy they will have to go out,
be productive, try different things.In other words they experience happiness
by assigning and accomplishing tasks.
There are also people who wake up in the morning, thinking that this world sucks, one day we are all going to die
so life is meaningless. Clearly depressive thoughts and nihilistic life attitude in general.
Of course it is not that simple but this is the main idea.
Funny thing is that all those categories are part of the evolution of human species and important
parts of keeping human race evolving!
People from the first group have in their subconscious the responsibility of providing societies with stability
and of showing other people how being happy looks like, in a way.
People from the second group have in their subconscious the responsibility of providing societies with
new discoveries. Of making sure that creation and defying dangers also leads to the achievement of happiness.
Making sure in a way that human race will never be characterized by complacency and that it will keep improving and mentally evolving.
People from the third category have in the subconscious the responsibility of spotting dangers so that humans
must work out ways of avoiding them and of keeping the human race more "down to earth" sort of speaking.
(I know that in Europe maybe we are overdoing by trying to find ways of including philosophy in everything, even
in the Science of Medicine lol)
Some people may be facing extremely tough situations and still retain their confidence and sense of happiness.
When they stop being under psychological pressure,they achieve full remission of their depressive symptoms.
There are some people who suffer from depression since they were old enough to notice.
On the contrary, there are people who, without facing depression at all in the past,
after having to deal with tough situations, they collapse mentally.
As my psych and other doctors told me, the brain has similar ways of functioning with all other
human bodies's organs.
For example there are people who are predisposed to have a very strong heart. Even if they eat junk food, smoke, abuse alcohol, do drugs etc
they will never suffer a heart attack,or face any problems with their heart in general. (if you replace heart problems with lung problems,the perfect
paradigm is that of an 98 years old lady who after having a check up in the hospital the other day asked the doctor for a cigarette. She informed
us that she smokes 2 packets a day since she was 15!!!)
On the contrary, there are people who work out daily, who follow a healthy diet,never stress about situations etc
and still suffer from heart attack coming out of the blue during their lives.
There is third category, where individuals are predisposed to suffer a heart attack only if they live an unhealthy life. So it is clearly a matter
of choices/external factors. Obviously a heart organ after going through a heart attack is never the same again.
Brain is a body organ itself, and in many cases due to depression, damaged neurons are impossible to repair themselves
and certain important chemicals cease from being produced, or they are destroyed just after their production without having
the chance to help the brain function normally (genetical predisposition).
So scientists were able to spot some of those genes (it will take many years till they are able to spot all of those genes).
They can tell if you are predisposed to some mental illnesses.
Some of those genes are: 5-HTTPLPR, 5-HT2CR, DRD2, DRD3 etc
Every day more genes are proven to play an important role in our mental health after being spotted.
Good news is that one day there will be gene therapies "reprogramming" part of our DNA and eliminating all mental illnesses.
Then it will be a matter of CURING rather than treating depression.
Bad news i that according to scientists, these therapies are probably 30 to 40 years away...
Underfunding medical researches are responsible for that. Brain is an extremely complex organ and there is a risk of taking too long for
investments to start making profits (if they ever do).
Strict FDA and similar other countries'administration rules and regulations,not necessary in many cases, are also responsible for the delay.
10,15 or more years in some cases (partially due to bureaucracy) till a new drug becomes available is a very long procedure.
(Even PETA is partially responsible lol)
Samson75, i do not exclude ketamine as part of my recovery knowing that using Lamictal (part of my therapy) clearly
limits the effectiveness of that drug.
Also it's not ketamine itself which helps with depression, rather
than a byproduct (i am not sure about it's name) created from our body while methylating ketamine.
I know for sure that this byproduct has been spotted and scientists are already working on that.
So therapies based solely on that byproduct could be far more effective treating depression.
I am starting to believe that many of treatment resistant depression forms are the outcome of endogenous cannabinoid deficiency
syndrome, (the existence of an endogenous cannabinoid system was discovered not earlier than late 70's!!!)
so it is clearly poorly analyzed and examined).
Buprenorphine is the answer to that problem.
Knowing that using it is habit forming (people will have to take Buprenorphine for life due to extremely "cruel"withdrawal and PAWS),
choosing this therapy is a big decision for anyone.
Taking buprenorpfine for life makes you addicted to it although the term addict
in this case is completely false in my opinion.Honestly does for example insulin turns a diabetic into
an addict? If some people are unable to produce their own opiates, clearly, they will have to receive them from an external source. Finding the sweet spot
could by a pain though (no more,no less). Even eating or drinking water is habit forming lol,try living without them :-)
A big benefit is that this therapy has been proven to be very very helpful, effective and usually there is no matter of tolerance (it is not clearly an opiate,it has a unique mechanism
of action).In some cases (let's say 15%) patients will indeed have to face tolerance issues. Then, discontinuation of therapy is the right thing to do instead of keep increasing the dosage (bad idea).
I would suggest waiting for ALKS 5461.It is a new antidepressant in ALKERMES's pipeline (big pharmaceutical company). If everything goes as planned, it will probably be available in late 2017. It will be already tested and legally available.
In my opinion this whole procedure is stupid and hypocritical because
instead of combining buprenorphine with naloxone, a blocker which exists only to prevent people from injecting it, (used in suboxone which is a tablet already available in the market),in ALKS 5461 naloxone will be replaced by samidorphan, a substance doing exactly the same thing.Obviously this is done solely for trademark purposes( repatenting the same drug which will prevent other companies from producing it for 20 years).
I love to be informed about any other options if available!
Thank you.
PS.There may by some mistakes but English is not my mother tongue.
