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5-HTP only gave me chest pains. This one really bothers me because I blindly took it for awhile hoping that it was helping. I guess it was enough time for the negative effects to build up, a risk I was not aware of at the time.
L-Tyrosine felt like it was causing vasoconstriction and made me agitated
Beta-alanine, because it blocks taurine from entering the cell. I never felt a difference when I was on it.
PEA/Hordenine - another one to fund the cardiology dept.
Serotonin is such a shitty compensation hormone in my book, the vast amount of it's effects are very negative on the entire neuroendocrine system. In regards to supplements, Agmatine is the biggest piece of garbage I ever wasted money on.
agmatine has one of the sweetest most enticing wiki pages. after i went through the page, i got so damn excited, i got me good amount of it only to get really confused as to wtf does it really do. it had so much potential from wiki and to add also ncbi that i just coudnt let it go for a while. kept going at the doses and trying it and i just finally decided fuck this! its a prime example of shitty deceitful edits done on wiki and also obstructive nature of the actual positive studies you can read on ncbi about
Exactly, and who in the right mind would market it (especially alone) for a pump,pre-workout or for building mass - this is false labeling. Some companies have said that agmatine boosts vasodilation...but did anybody bother to look at how it actually does this?
Agmatine is A SYMPTAHOLITIC - it depresses the nervous system in a manner similar to Clonidine; has imidazoline agonist properties, and it also blocks NMDA-receptor channels.
I think knowing with just that MOA - one could say high amounts can put someone's blood pressure too far down, luckily, the half life of this so called "amino byproduct" is short enough to where it won't matter.
On the other hand, I can see moderate - high - doses of agmatine, causing high blood pressure. It actually directly inhibits nitric oxide synthase.......and this is a pump product???? It's NONSENSE.
http://www.ncbi.nlm....pubmed/20035742
http://www.ncbi.nlm..../pubmed/7906055
http://www.ncbi.nlm....pubmed/11125020
http://www.ncbi.nlm..../pubmed/9918557
Edited by Area-1255, 31 August 2014 - 03:06 PM.