14 replies to this topic

[Hope47]

Moderator's Note:

The study below demonstrates that nicotine, regardless of administration method causes Smoker's Melanosis, and it is likely that by extension, whether specifically demonstrated or not, this action will accelerate the visible signs of skin aging by a similar uneven discoloration and an increase in the number of moles which smokers and their families get. 

The long-term effect of nicotine on the oral mucosa.

 

Hey guys, what do you think of nicotine for concentration. It has also the appetite suppressant properties which is need. Should i try it?

Edited by YOLF, 25 March 2017 - 01:25 AM.

[niner]

Only if you're already addicted to nicotine.  Otherwise, you'd probably end up addicted to it.  The biggest danger is that you might be tempted to switch to a tobacco product to get a bigger dose.

[hamishm00]

The vasoconstriction and addictive nature of the nicotine is a huge draw back long term.

[Luminosity]

Bad idea.  

 

Don't flirt with destructive stuff.  

[Jim Morrison]

I disagree, nicotine can be a very useful nootropic drug. It helped me through many months of studying and I never developed the slightest dependence. A large part of the addiction that goes along with smoking has to do with the social component. Sitting down with a nicotine gum in your mouth for studying is quite different.

Edited by Jim Morrison, 28 May 2014 - 07:29 AM.

[niner]

I disagree, nicotine can be a very useful nootropic drug. It helped me through many months of studying and I never developed the slightest dependence. A large part of the addiction that goes along with smoking has to do with the social component. Sitting down with a nicotine gum in your mouth for studying is quite different.

 

Well, you were lucky.  I don't think you're right about the social component of smoking.  I'd say that was a small part of it overall, because the physiological part is so huge.  It might be a trigger that encourages you to smoke, but believe me, you could get deeply addicted to nicotine if you were the last person on earth.

 

To get the nootropic effects of nicotine with minimal addiction potential, you should probably use a transdermal patch.  Anything that gives you a bolus dose (smoking, vaping, snuff, and many forms of chewing tobacco) is going to be a problem.  I think that the gums are designed to release the nicotine slowly, so they are safer than traditional sources.

[hamishm00]

 

I disagree, nicotine can be a very useful nootropic drug. It helped me through many months of studying and I never developed the slightest dependence. A large part of the addiction that goes along with smoking has to do with the social component. Sitting down with a nicotine gum in your mouth for studying is quite different.

 

Well, you were lucky.  I don't think you're right about the social component of smoking.  I'd say that was a small part of it overall, because the physiological part is so huge.  It might be a trigger that encourages you to smoke, but believe me, you could get deeply addicted to nicotine if you were the last person on earth.

 

To get the nootropic effects of nicotine with minimal addiction potential, you should probably use a transdermal patch.  Anything that gives you a bolus dose (smoking, vaping, snuff, and many forms of chewing tobacco) is going to be a problem.  I think that the gums are designed to release the nicotine slowly, so they are safer than traditional sources.

 

 

100% agree with Niner. I, and others in my office, suffered from nicotine gum addiction (btw I have never ever smoked cigarettes, I used the gum purely for nootropic purposes). It was tough to kick - nicotine (gum) is an extremely and nefariously addictive substance, partly because depending on the size of the dose it can act a stimulant or a depressant, and you can effectively modulate that response at your election of dose size / gum strength.

[mrnootropic]

 

I disagree, nicotine can be a very useful nootropic drug. It helped me through many months of studying and I never developed the slightest dependence. A large part of the addiction that goes along with smoking has to do with the social component. Sitting down with a nicotine gum in your mouth for studying is quite different.

 

Well, you were lucky.  I don't think you're right about the social component of smoking.  I'd say that was a small part of it overall, because the physiological part is so huge.  It might be a trigger that encourages you to smoke, but believe me, you could get deeply addicted to nicotine if you were the last person on earth.

 

To get the nootropic effects of nicotine with minimal addiction potential, you should probably use a transdermal patch.  Anything that gives you a bolus dose (smoking, vaping, snuff, and many forms of chewing tobacco) is going to be a problem.  I think that the gums are designed to release the nicotine slowly, so they are safer than traditional sources.

 

 

When it comes to Cigarette Addiction, its obviously Nicotine that plays a massive part.

But its also the act of smoking, ive stopped smoking for around 2 years and don't feel the Urge to smoke anymore.

 

I could see how the Nicotine Gum itself could become addictive.

The act of Chewing Gum and receiving Nootropic effects from doing so, could result in addiction.

 

However, I dont think you will start to crave cigs from chewing gum, people use Nicotine Gum to stop smoking. 

That being said, im sure you could find other Nootropics that are safer than Nicotine with more efficacy ??  

 

Even though Nicotine Gum or Patches wont make you crave cigs, They could possibly lead to smoking, you could be craving nicotine and have run out of Nicotine Gum or Patches, and you could think screw it, im just going puff on my friends cig. So Gum could lead to smoking, in one way or another.

 

And i dont recommend doing this either, unless you already smoke..

But if you must, only do it for a short term such as 30 days and then discontinue for 30 days and cycle it, to avoid an addiction. Or only use gum as needed, such as for a test or an interview or presentation etc, not daily use.

Edited by Mr.Nootropic, 28 May 2014 - 03:46 PM.

[knightly]

I remember trying Nicotine patches with my medication, and IT WAS LIKE WOW !!!!

The amount of stuff I learned, THE AMOUNT I engaged regarding social, the amount of spring I had back was awesome.

 

BUT IT CAME WITH 100% downside, that the Nicotine made me REALLY REALLY dizzy.... I was not using enough, and was not addicted to cigs, so I would always become dizzy in the evening and the next couple of days if I used the Nicotine......

 

 

[Jim Morrison]

 

I disagree, nicotine can be a very useful nootropic drug. It helped me through many months of studying and I never developed the slightest dependence. A large part of the addiction that goes along with smoking has to do with the social component. Sitting down with a nicotine gum in your mouth for studying is quite different.

 

Well, you were lucky.  I don't think you're right about the social component of smoking.  I'd say that was a small part of it overall, because the physiological part is so huge.  It might be a trigger that encourages you to smoke, but believe me, you could get deeply addicted to nicotine if you were the last person on earth.

 

To get the nootropic effects of nicotine with minimal addiction potential, you should probably use a transdermal patch.  Anything that gives you a bolus dose (smoking, vaping, snuff, and many forms of chewing tobacco) is going to be a problem.  I think that the gums are designed to release the nicotine slowly, so they are safer than traditional sources.

 

 

Without a doubt, nicotine is a powerful substance that can lead to physiological addiction. But so are many other useful substances. Its just a matter of using them properly. I wouldn't want to miss nicotine from my nootropic cabinet.

 

Also I wouldn't underestimate the psychosocial component of smoking. If you quit smoking you suddenly cut many social "rituals" out of your life. Thats not easy... 

 

On the topic of patches: At least for non smokers / inexperienced people, I advice against it. The patches form a depot under the skin. If they are removed nicotine continues to be released into the blood for a while. So, once you realize you overdosed (which is VERY nasty) and you remove the patch, the ride only starts... Gum or inhaler are better for dosing. 

Edited by Jim Morrison, 29 May 2014 - 09:53 PM.

[Dazzcat]

I agree with Niner and others on here who strongly suggest to stay clear of Nicotine. I am also an unusual case where I developed an addiction to nicotine before I picked up a tobacco habit, (picking up tobacco was very easy when I found myself out of gum). Now I find myself back addicted to oral nicotine and after some research it's hard to justify it's use, not to mention the heavy tolerance I have to any cognitive benefits.

 

For a smoker trying to wave their tobacco habit, it can be a god sent. For those naive to nicotine, it certainly does not deserve to be considered a nootropic, as others have mention, it's still addictive despite the lack complementary MAO inhibitors. Of course there will be people who will find it only mildly addictive, but there are plenty who will fall into it's trap so easily, like myself.

Also note, nicotine has alot of evidence for being pro-cancer invitro and in some animal cancer models. Most notably, oral nicotine is suspected to metabolize into N-Nitrosonornicotine (a class 1 carcinogen) within the acidid environment of the stomach, even at far greater concentrations than tobacco smokers.*

I would be patient and see how a7 nicotinic receptor agonist pan out, though there still needs to be some caution as the a7 nicotinic pathway has been suggested to mediate tumor growth.

 

*http://www.ncbi.nlm....63/#!po=2.63158

Edited by Dazzcat, 29 May 2014 - 11:42 PM.

[Jim Morrison]

I agree with Niner and others on here who strongly suggest to stay clear of Nicotine. I am also an unusual case where I developed an addiction to nicotine before I picked up a tobacco habit, (picking up tobacco was very easy when I found myself out of gum). Now I find myself back addicted to oral nicotine and after some research it's hard to justify it's use, not to mention the heavy tolerance I have to any cognitive benefits.

 

For a smoker trying to wave their tobacco habit, it can be a god sent. For those naive to nicotine, it certainly does not deserve to be considered a nootropic, as others have mention, it's still addictive despite the lack complementary MAO inhibitors. Of course there will be people who will find it only mildly addictive, but there are plenty who will fall into it's trap so easily, like myself.

Also note, nicotine has alot of evidence for being pro-cancer invitro and in some animal cancer models. Most notably, oral nicotine is suspected to metabolize into N-Nitrosonornicotine (a class 1 carcinogen) within the acidid environment of the stomach, even at far greater concentrations than tobacco smokers.*

I would be patient and see how a7 nicotinic receptor agonist pan out, though there still needs to be some caution as the a7 nicotinic pathway has been suggested to mediate tumor growth.

 

*http://www.ncbi.nlm....63/#!po=2.63158

 

Sorry to hear you good hooked up using oral nicotine. If I may ask, how long/much did you use until you found yourself addicted? How do you apply the nicotine? Also, how do you define beeing "addicted"?

 

Concerning NNN: I dont think its the nicotine that is converted into NNN, its nornicotine. Content of nornicotine in the different brands of gums / inhalers vary. Also the formation of NNN depends on your own biochemistry and nutritional habits. It doesn't happen in everybody.

 

Short term use of the gums and other smoking cessation tools has been investigated thoroughly and has not been found to go along with increased risk for cancer. But again, it should certainly be used cautiously and only for short periods. And as you mentioned tolerance can negate the positive (nootropic) effects.

 

Just to throw this into the discussion here: Nicotine has actually been found to be neuroprotective. http://www.ncbi.nlm....les/PMC3685410/

 

Edited by Jim Morrison, 30 May 2014 - 07:31 AM.

[Dazzcat]

 

I agree with Niner and others on here who strongly suggest to stay clear of Nicotine. I am also an unusual case where I developed an addiction to nicotine before I picked up a tobacco habit, (picking up tobacco was very easy when I found myself out of gum). Now I find myself back addicted to oral nicotine and after some research it's hard to justify it's use, not to mention the heavy tolerance I have to any cognitive benefits.

 

For a smoker trying to wave their tobacco habit, it can be a god sent. For those naive to nicotine, it certainly does not deserve to be considered a nootropic, as others have mention, it's still addictive despite the lack complementary MAO inhibitors. Of course there will be people who will find it only mildly addictive, but there are plenty who will fall into it's trap so easily, like myself.

Also note, nicotine has alot of evidence for being pro-cancer invitro and in some animal cancer models. Most notably, oral nicotine is suspected to metabolize into N-Nitrosonornicotine (a class 1 carcinogen) within the acidid environment of the stomach, even at far greater concentrations than tobacco smokers.*

I would be patient and see how a7 nicotinic receptor agonist pan out, though there still needs to be some caution as the a7 nicotinic pathway has been suggested to mediate tumor growth.

 

*http://www.ncbi.nlm....63/#!po=2.63158

 

Sorry to hear you good hooked up using oral nicotine. If I may ask, how long/much did you use until you found yourself addicted? How do you apply the nicotine? Also, how do you define beeing "addicted"?

 

Concerning NNN: I dont think its the nicotine that is converted into NNN, its nornicotine. Content of nornicotine in the different brands of gums / inhalers vary. Also the formation of NNN depends on your own biochemistry and nutritional habits. It doesn't happen in everybody.

 

Short term use of the gums and other smoking cessation tools has been investigated thoroughly and has not been found to go along with increased risk for cancer. But again, it should certainly be used cautiously and only for short periods. And as you mentioned tolerance can negate the positive (nootropic) effects.

 

Just to throw this into the discussion here: Nicotine has actually been found to be neuroprotective. http://www.ncbi.nlm....les/PMC3685410/

 

 

 

No need to be sorry, it's my own silly fault really because it did take a long time to get hooked (years) as at first it was only intermittent gum/lozenge use (no issues there), but the moment I started to introduce casual tobacco use into the equation I was thrown off and slowly but surely I was forming a habit. For example I would smoke in the weekends and consume oral nicotine during the week, I can't say that I solely became addicted to nicotine from the lozenges alone, however it did make tobacco alot more appealing, especially when I ran out of oral nicotine.

How do I define addiction? Well when I found I consumed nicotine daily in every situation, even during times when it wasn't appropriate for cognitive enhancement (say watching a movie), it became more about making me feeling "better", and it was like having a comforting friend around all the time. There is a fine line between the medicinal effects of nicotine and the pleasure/comfort that nicotine provides in my experience, especially in social situations, I believe nicotine addiction is the most pronounced in social settings.

 

I can't speak for others, I may just be a rather unusual case, but I'm convinced nicotine in some people still has alot of potential for dependency. If you find you are fine with it, just whatever you do, take serious breaks from it, only use when necessary, I think chronic use is where much of the problem lays, it's one of those habits that sneak up on ya.

 

Regarding NNN, I'm not sure, but I believe nicotine is metabolized into nornicotine, which is then converted to NNN, this may all happen within the stomach. How else do you explain the extremely high levels of NNN in the urine samples of oral NRT users? This could easily be avoided by using patches anyway.


Figure 2: (http://www.ncbi.nlm....es/PMC2783463/#) Graph A is patches and graph C is oral NRT

 

 

 

Edited by Dazzcat, 01 June 2014 - 10:27 PM.

[Hope47]

Thanks for all replies guys.. I just tried 2mg gum, so far not feeling anything except for weird taste. Yes,I am following the instructions written on the gum box.

[Falco78]

Not worth it to me. I was a smoker for about a decade and two months ago I switched to vaping, yet the addiction remains...