2 replies to this topic

[StabMe]

Hey guys!

 

I've been doing nirHEG for about half a year now to improve my ADD symptoms, working memory, initiative etc. 

 

I was wondering, would administering hGH alongside with nirHEG practice be helpful in terms of enhancing the effects of the latter? 

 

Here is one of the descriptions i found on the net on the mechanism of action of the HEG exercise:

 

"Brain activation is an exercise. Fresh blood brings in the necessary

nutrition, oxygen and the glucose, that supplies the energy for a

brain module to efficiently do its assigned job. Exercise affects

the brain much like it affects muscles. New capillaries are formed

to feed neurons. New connections between neurons are formed to carry

information. Like a muscle, with exercise, the brain builds a

vascular system, enabling more brain tissue for use by this brain

area. The brain grows physically. With exercise, the brain builds a

vascular system, enabling more brain efficiency in its use. Exercise

is the road to a healthy brain!"

 

So, nirHEG works by improving vascular system of the brain. Can't we add hGH in order to speed up this process a bit? Doesn't hGH help with new capillaries growth?

 

Any other way of enhancing the effects of nirHEG you guys can think of? Maybe EPO?

[Flex]

Exercise shouldnt be underestimated for new blood vessels formation.

 

the factors are:

shearing stress depent increase of fgf-2 ( afaik due sportactivities)

Shear Stress Induces the Release of an Endothelial Elastase:

Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release. In: Journal of Vascular Research, Nr. 6: S. 453-464

http://epub.ub.uni-muenchen.de/16635/

 

Vegf and Bdnf  induced by sport

Circulating plasma VEGF response to exercise in sedentary and endurance-trained men.

http://www.ncbi.nlm....pubmed/14660505

 

The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function

http://www.ncbi.nlm....pubmed/17414812

BDNF: A Newly Described Mediator of Angiogenesis

http://www.ncbi.nlm....les/PMC2268985/

 

But what You describe is another interreting thing.

The way how the growth of the synapses &etc. works is different to that as we think.

Afaik( no guarantee) the brain provides constantly the building proteins at every synapse,

but not the growth signal.

So the training of the brain is very important, for the growth and maintaince of the brain connection.

Therefore it has been said that social contact is valuable for a healthy brain.

 

Here are some more informations regarding how the Brain works:

With the right rehabilitation, paralyzed rats learn to grip again

http://www.mediadesk...greifen_en.html

[StabMe]

Hey Flex,

 

Thanks for chiming in.

 

Yeah, i do exercise 3-4 times a week. Usually weights but i keep sure to include 1-2 cardio sessions as well.

 

I was able to get my hands on a pack of EPO (10 amps of 4000I.U. each). That was a few years ago and i bought it with the intention to boost my stamina for my kick-boxing training. I've never pulled the trigger, though - the stuff was too scary. 

 

But then i read about the study that some european handsome lady did, where she found that EPO has some cognitive boosting abilities. So, i was thinking, since HEG has to do with blood oxygen levels and EPO has a direct effect on that... maybe EPO can speed up the effects of HEG biofeedback?

 

There is a very handsome european girl, Kamilla Miskowiak, who did a few studies on EPO and its abilities as a cognitive enhancer. In one of the studies, she used 40.000IUs to see the effects. 3 days and 7 days after the administration, there was no effect on the Hb or RCC levels. They used one single dose to avoid the rise in hematocrit and hemoglobin levels. So, the effects of EPO were due to its direct effects on cognitive abilities, rather than from increased Hb or RCC. The dose they used seems very huge to me. From what i know, athletes use 3-5000 IUs, but they do it for several weeks on an EOD basis.

 

I am thinking, what would be a relatively safe dose that i could administer every week. A 4000iu ampule? What about the route of administration - would IV would be significantly more potent than IM?

 

Here is the abstract of the study i spoke of:

 

Abstract Erythropoietin (Epo) has neuroprotective and neurotrophic eVects and improves cognitive function in ani- mal models of neurodegenerative and neuropsychiatric ill- ness. In humans, weekly Epo administration over 3 months improves cognitive function in schizophrenia. The neural underpinnings and time-course of this eVect of Epo are cur- rently unknown. It is also unclear whether the cognitive improvement reXects direct neurobiological actions or is secondary to hematological eVects. We therefore assessed the actions of single administration of Epo (40,000 IU) vs. saline to healthy volunteers on cognitive and neural mea- sures of executive function using a verbal Xuency task and N-back working memory (WM) paradigm during func- tional magnetic resonance imaging (fMRI) on day 3 and 7 after administration in two separate cohorts of subjects. Epo modulated neuronal response in a fronto-parietal network during WM performance at both time points; on day 3 after administration, activation was increased in left- hemisphere frontal and cingulate cortex and reduced in the right parietal cortex; in contrast, neural response was enhanced in a right-lateralized fronto-parietal network and reduced in left-side regions 1 week post-administration. In addition, Epo-treated volunteers displayed improved verbal Xuency performance 1 week post-administration. These eVects occurred in the absence of changes in hematological measures suggesting that they reXect direct neurobiological actions of Epo. The Wndings are co

nsistent with enduring eVects of Epo on neurotrophic signaling and induction of neurochemical changes over time in neural networks typically aVected in neuropsychiat- ric illness. The present study supports the notion that Epo may have clinical applications in the treatment of psychiat- ric disorder characterized by cognitive dysfunction.