I've been dosing myo-Inositol in medium-high doses (1g-8g daily) recently without a choline source and have been experiencing some brain fog. I have trouble finding my words and speaking spontaneously. It seems my vocabulary has diminished. It helps if I reduce my dose for a couple days but I'd rather take higher amounts since there have been many positives at those doses. Those positives include feeling more present/in the moment, a slight antidepressant effect (more social too), and possibly hormone control as my acne has been reduced (some women use inositol to treat their PCOS). I also feel like I have a bit more energy.
My question is whether anyone who has experienced side effects from Inositol has been able to alleviate them and how. My current attempt will be to include 250mg CDP-Choline daily. I have seen supplements including Inositol and Choline which makes sense because they are both phospholipid precursors. Would taking an excess amount of Inositol deplete your choline sources causing brain fog? "Deplete" might be the wrong word to use. Since I read that choline can be used in 4 different pathways in the body, I suspect the increased Inositol intake allocates equal amounts of Choline in your body to be used to synthesize the phospholipid or something, and in the process taking away from some other vital brain function (basically acetylcholine production is lowered).
Basically my theory is that Inositol REQUIRES a choline source just like a -racetam to prevent side effects. does this hold up?
also this article explains the different routes that the choline can take.
http://advances.nutr...ent/1/1/46.full
They include:
- Methyl group donator
- Precursor to Acetylcholine
- Precursor to "the predominant phospholipids in membranes (phosphatidylcholine and sphingomyelin)
I swear there was a 4th one, but I hope that this better illustrates my theory since Inositol is a component of phospholipids.
Edited by Oner, 19 June 2014 - 06:34 PM.