2 replies to this topic

[ironfistx]

I have heard that Type 1 And 3 collagen are found in the skin, and TYpe 2 and some others are found in the joints and connective tissues.  I have seen it said that applying collagen to the skin has no effect, but what about taking it orally?

 

There are pills that have like 500mg oc collagen, but then there are powders that have like 10g.

 

Here is a site talking about gelatin (collagen) also being responsible for weight loss and growth hormone release, although I have no idea if this is legit, or who this woman is.

 

Have there been any studies about Types 1 and 3 collagen supplementation improving he production of collagen in the skin which would lessen the appareance of wrinles?

[Trevor]

From what I have read, the 500mg capsules of type 1 fish collagen are a smaller molecule and have greater absorption than the bovine variety.  I used to take a 6 gram scoop of types 1 & 3 but now I have changed my regimen to 4 grams of the type 1 fish collagen.  Seems to be a slight improvement in skin smoothness over the bovine collagen, but I'm relatively young so I'm not the best guinea pig for that.  
 
Hydrolyzed collagen is effective over gelatin because it is absorbed as a peptide rather than being broken down into it's amino acid constituents by the stomach.
 
You may consider taking MMP inhibitors as well.  In addition to all the usual suspects, white tea extract and polypodium leucotomos seem to be the best in the game at this point.  

Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells.

→ source (external link)

Lots of other studies about.  Life extension just wrote an in depth article on polypodium leucotomos.  They sell it as "Fernblock" but you can buy the bulk powders for a fraction of the price.  I emailed LEF and they told me that their extract is 4:1 so it's the same stuff as you can get much, much cheaper.  I've taken it for a couple years now.

 

Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.

→ source (external link)

 

Animal study: hydrolysed collagen keeps skin young

→ source (external link)

[Logic]

Thx for the 'Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants' study Trevor.

White tea seems to be the bomb in this study and is easy to find, though relatively expensive.

" RESULTS:

Anti-elastase activities were observed for nine of the extracts with inhibitory activity in the following order: white tea (approximately 89%), cleavers (approximately 58%), burdock root (approximately 51%), bladderwrack (approximately 50%), anise and angelica (approximately 32%). Anti-collagenase activities were exhibited by sixteen plants of which the highest activity was seen in white tea (approximately 87%), green tea (approximately 47%), rose tincture (approximately 41%), and lavender (approximately 31%). Nine plant extracts had activities against both elastase (E) and collagenase © and were ranked in the order of white tea (E:89%, C:87%) > bladderwrack (E:50%, C:25%) > cleavers (E:58%, C:7%) > rose tincture (E:22%, C:41%) > green tea (E:10%: C:47%) > rose aqueous (E: 24%, C:26%) > angelica (E:32%, C:17%) > anise (E:32%, C:6%) > pomegranate (E:15%, C:11%).Total phenolic content varied between 0.05 and 0.26 mg gallic acid equivalents (GAE)/mL with the exception of white tea (0.77 mg GAE/mL). For anti-oxidant assessment, the Trolox equivalent anti-oxidant capacity (TEAC) assay revealed activity for all extracts. White tea had the highest activity equivalent to approximately 21 microM Trolox for a 6.25 microg aliquot. In addition, seven extracts exhibited activities = 10 microM Trolox with witch hazel (6.25 microg = 13 microM Trolox) and rose aqueous (6.25 microg = 10 microM Trolox) showing very high activities at low concentrations. A high activity for white tea was also found in the superoxide dismutase (SOD) assay in which it exhibited ~88% inhibition of reduction of nitroblue tetrazolium. High activities were also observed for green tea (86.41%), rose tincture (82.77%), witch hazel (82.05%) and rose aqueous (73.86%).

CONCLUSION:

From a panel of twenty three plant extracts, some one dozen exhibit high or satisfactory anti-collagenase or anti-elastase activities, with nine having inhibitory activity against both enzymes. These included white tea which was found to have very high phenolic content, along with high TEAC and SOD activities."

 
Now this study is an in vitro study?; so its important to  find out if the concentrations used are acheavable from drinking white tea and to find out how much white tea is required.
I would ask Nner about this but am loth to do so yet again 
 
 
Dill and Blackberry leaf extract are very interesting:
http://www.longecity...nd-utilization/


I take 5-10g of Gelatine in water (hydro) daily as I am trying BHT.
BHT is said to increase collagen production, but I am more interested in its anti viral effects.
http://www.longecity...opic/42592-bht/