Logic,
Find one other study in the last 32 years that says its broken down. It fly's in the face of the research conducted over the last decade.
Thx Brian; I consider you a board friend too, but sometimes its ones friends that you want grab by the throat and shake some sense into, as its them in particular you want to help.
The only way I could think of, of doing so via 'the printed word' was my above post.
As you yourself said; no other studies exist that look at what happens to NAD/NR in the gut.
Find one other study in the last 32 years that says its NOT broken down!
It does NOT fly in the face of the research conducted over the last decade as all the research conveniently skips straight to intracellular and local extracellular pharmacology.
Assuming the one gut study to be incorrect based on studies that seem to be doing their best to avoid the subject is premature IMHO.
My argument that the secret NR may be the slow release of ribose into one's system still stands IMHO.
The "Something about taking nicotinamide riboside conveys something that taking its constituents together can not" Is still quite possibly the SLOW release of ribose into one's system.
This is why I recommended dissolving Ribose and Niacin, NB: not Nicotinamide, in one's daily drinking water.
Nicotinamid helping your skin condition is specific to you and probably point to you having an overzealous immune system, but it does look like some Nicotinanide is needed by everyone.
This is one of those things that needs more study.
"...Thus, PARP-1's functions are intimately tied to nuclear NAD+ metabolism and the broader metabolic profile of the cell. Recent studies in cell and animal models have highlighted the roles of PARP-1 and PAR in the response to a wide variety of extrinsic and intrinsic stress signals, including those initiated by oxidative, nitrosative, genotoxic, oncogenic, thermal, inflammatory, and metabolic stresses. These responses underlie pathological conditions, including cancer, inflammation-related diseases, and metabolic dysregulation..."
http://genesdev.cshl...5/417.full.html
"...poly(ADP-ribose) polymerase (PARP), an enzyme that utilizes NAD+ as a substrate to repair DNA...
...the mechanism by which NA and NAM protects cells against apoptosis does not involve a reduction in constitutive levels of oxidative stress...
...In the present study, we found that both NAD+ precursors were effective at preventing apoptosis, with NA consistently showing a greater protective effect. This could be explained by the fact that NAM is a weak PARP inhibitor, whereas NA has no effect on PARP activity...."
http://www.nature.co...l/4400658a.html
"...A growing set of published studies with PARP-1-deficient mice have revealed increased genome instability and sensitivity to genome toxic stress, a shorter life span with accelerated aging, earlier incidence of a wide spectrum of spontaneous tumors, and higher rates of malignant tumors in the liver, uterus, and lung..."
http://genesdev.cshl...5/417.full.html
Also; it recently occurred to me that Ribose taken as a standalone supplement may not get anywhere near our cells as stomach bacteria may metabolise most of it into plain glucose or similar:
"...However, many of the characterized strains can utilize ribose... but generally cannot ferment L-arabinose...Analysis of the ribose-induced transcriptome of B. breve UCC2003 revealed that the rbsACBDK gene cluster is responsible for the metabolism of ribose, a pentose sugar that can be found in the human gut..."
http://www.ncbi.nlm....les/PMC3145055/
Taking standalone Ribose is going to result in the feeding of gut bacteria that aren't going to excrete it unchanged with a small amount making it into the system causing a short, AGE causing, ribose spike and then nothing for the rest of the day.
Perhaps liposomal encapsulation is the way to actually get Ribose into one's system, but I have no idea on how to get a sustained release of Ribose???
A stained release of Niacin and a little Nicotinamide in the right ratio is also required INHO.
How to achieve this sustained release and what ratio of Niacin too Nicotinamide is required is another question!
The ratio is probably specific to each individual.
In summary:
Study and experimentation with liposomal ribose and Niacin/Niccotinamide in the correct ratio, in a form that gives a sustained release, is far from done.
Nicotinamide Riboside may be increasing SIRT etc by downregulating PARP and thus its requirement for NAD+.
This would mean less DNA repair and all that goes with it...
Edited by Michael, 14 May 2017 - 07:03 PM.
trim quotes
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