41 replies to this topic

[Multivitz]

Not a word about copper, only posts about stuff that uses it up or stops the metabolism of it.....and remember nothing happens without boron.

Edited by Multivitz, 14 July 2018 - 10:06 PM.

[John250]

I just ate two FULL Sticks of Butter with my Pancakes, that 'oughta do he Trick!

Haha nice!

[StevesPetRat]

Did some reading into this compound, dibutyryl cAMP: https://en.wikipedia...iki/Bucladesine

 

Seems far more potent than butyrate; the human equivalent dose is something like 50 - 100 mg.

 

https://www.ncbi.nlm.../pubmed/7595558

 

Should probably cross post this in the dopamine thread...

[normalizing]

how do you acquire blucadesine? im more interested in its opiate withdrawal maintenance

[John250]

how do you acquire blucadesine? im more interested in its opiate withdrawal maintenance

Never use them but:

https://zageno.com/p...ExoCpuIQAvD_BwE


Have you tried Naltrexone? Irc has it on sale

[normalizing]

i have naltrexone prescribed but what is it suppose to do, block dopamine? that doesnt sound like fun to me besides you shouldnt take it with alcohol and opiates, which i tend to take

[StevesPetRat]

i have naltrexone prescribed but what is it suppose to do, block dopamine? that doesnt sound like fun to me besides you shouldnt take it with alcohol and opiates, which i tend to take

No, (levo)naltrexone is a strong mu- and weaker kappa- opioid receptor antagonist. (Dextro)naltrexone is a TLR4 antagonist, which means it blocks endotoxin induced inflammation. Commercially available naltrexone is racemic, and its only influence on dopamine is indirect through its antagonism of other receptors - opioid blockade would tend to reduce dopamine, whereas TLR4 blockade would tend to increase it.

[normalizing]

what happens if to take naltexone after using opiates and alcohol previous day? im not sure how long to wait before taking it. i did read it will make you sick if you take it together with them

[normalizing]

just saw this today; https://www.medicaln...cles/322542.php

[StevesPetRat]

what happens if to take naltexone after using opiates and alcohol previous day? im not sure how long to wait before taking it. i did read it will make you sick if you take it together with them

 

Are you thinking of antabuse? If you're addicted to opiates, naltrexone will accelerate / exacerbate withdrawals, but otherwise it just keeps you from getting high. I guess it might make the come down a bit harder or give you diarrhea if you've taken opiates recently, but in the absence of addiction, there should be no problem.

 

I guess another risk is overdose if excessive opiates are taken and then the naltrexone wears off.

[normalizing]

i dunno i guess ill try it especially when i feel cold. what would go wrong right

[John250]

What about Ibudilast. Seems promising for opi withdrawal.

Edited by John250, 26 July 2018 - 04:14 AM.