48 replies to this topic

[Flex]

Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin.

http://www.ncbi.nlm....pubmed/23624370

 

Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression.

The concentration of cAMP in the hippocampus was increased by genipin compared to the CUMS-exposed model group. The mRNA expressions of 5-hydroxytryptamine 1A receptor (5-HT_1AR), cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in rats were decreased exposed to CUMS, which were reversed by genipin-treated rats exposed to CUMS. Compared to the CUMS-exposed model group, the mRNA expression of 5-hydroxytryptamine 2A receptor (5-HT_2AR) was decreased significantly by genipin-treated rats. The mRNA and protein expression of CREB, BDNF were increased in genipin-treated rats compared to the CUMS-exposed model group. Moreover, the levels of corticosterone in serum were decreased by genipin-treated compared to the CUMS-exposed model group.

http://www.ncbi.nlm....pubmed/24972301

 

Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function

Results from the present study demonstrated that Shuyusan could decrease the serum contents of CRH, ACTH, and CORT. It also could increase the expression of hippocampus GR receptor in the rat model of depression. Our results suggested that the mechanisms of action of Shuyusan were due to decreasing the serum contents level of CRH, ACTH, and CORT and increasing the expression of hippocampus GR receptor. Fluoxetine is selective serotonin reuptake inhibitors’ (SSRIs) medications, it could increase the levels of NE, 5-HT, and DA in the brain of rat and was related to downregulation of 5-HT receptor, but not decreased the serum contents level of CRH, ACTH, and CORT and increased the expression of hippocampus GR receptor.

http://www.hindawi.c...am/2012/940846/

Tables showing the reduction of CRH ACTH CORT and mRNA

http://www.hindawi.c...12/940846/fig4/

http://www.hindawi.c...12/940846/fig5/

Ingredients of Shu-Yu-San:  

Albiziae Flos, Acori Tatarinowii Rhizoma, Bupleuri Radix, Curcumae Radix, Gardeniae Fructus, Menthae Herba, Polygalae Radix, Poria, and Ziziphi Spinosae Semen.

http://www.hindawi.c...12/930908/tab1/

 

Related to Shu-Yu-San:

Ameliorative Effects of a Combination of Baicalin, Jasminoidin and Cholic Acid on Ibotenic Acid-Induced Dementia Model in Rats

Additionally, the expression levels of 19 genes in the forebrain were significantly influenced by CBJC; approximately 60% of these genes were related to neuroprotection and neurogenesis, whereas others were related to anti-oxidation, protein degradation, cholesterol metabolism, stress response, angiogenesis, and apoptosis. Expression of these genes was increased, except for the gene related to apoptosis. Changes in expression for 5 of these genes were confirmed by western blotting.

http://www.plosone.o...al.pone.0056658

 

Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells.

http://www.ncbi.nlm....pubmed/23695964

 

Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor.

http://www.ncbi.nlm....pubmed/19596036

 

Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress.

Paeoniflorin treatment markedly increased sucrose consumption and decreased serum corticosterone and adrenocorticotropic hormone levels in the CUS-treated rats. Furthermore, paeoniflorin treatment significantly attenuated CUS-induced reductions in noradrenaline, serotonin and its metabolite 5-hydroxyindoleacetic acid as well as CUS-induced increases in the ratio between the latter two factors

http://www.ncbi.nlm....pubmed/23481217

 

Paeoniflorin acts as a liver X receptor agonist.

http://www.ncbi.nlm....pubmed/23281636

+

Treatment of stroke with a synthetic liver X receptor agonist, TO901317, promotes synaptic plasticity and axonal regeneration in mice.

http://www.ncbi.nlm....pubmed/19724285

+

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.

http://www.ncbi.nlm....pubmed/23292650

 

 

Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson's disease.

http://www.ncbi.nlm....pubmed/24797334

 

Nobiletin

Positive NMDA allosteric modulator [1]
* Ameliorates beta-amyloid-induced memory impairment [2]
* Positive AMPA allosteric modulator via increased PKA phosphorylation [3]
* Neurotrophic [4]
* Ameliorates cholinergic neurodegeneration associated with chronic cognitive dysfunction [5]

* Interfers with gene expression of cartilage destroying enzymes [6]
* Exceptionally orally bioavailable anticancer agent [7,8,9, exc.]

http://forum.bodybui...php?t=110152021

 

 

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

Interestingly, nobiletin administration (50mg/kg i.p.) rescued reduced levels of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation and phosphorylation at Thr-34 of dopamine- and cAMP-regulated phosphoprotein-32 (DARPP-32) in striatum and hippocampal CA1 to levels seen in sham-operated mice. Likewise, CaMKII- and cAMP kinase-dependent TH phosphorylation was significantly restored by nobiletin treatment. MPTP-induced reduction of dopamine contents in the striatum and hippocampal CA1 region was improved by nobiletin administration (50mg/kg i.p.)

http://www.ncbi.nlm....pubmed/24316474

 

DARPP-32 and CDK-5 regulate the transmission of dopamine. This is one of the mechanisms of cocaine in the Nucleus accumbens.

Although, this is also reversable with Acetyl-carnitine

 

Repeated acetyl-l-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum.

http://www.ncbi.nlm....pubmed/15066157

 

DARPP-32 mediates the actions of multiple drugs of abuse

http://www.ncbi.nlm....les/PMC2750972/

 

Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment.

hese findings suggest that chronic heroin use induces long-lasting striatal DAT reductions. DAT availability remained unchanged during a 6-month period of abstinence. Treatment with Jitai appears to be effective at increasing striatal DAT availability.

http://www.ncbi.nlm....pubmed/23715641

 

Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice.

The mice were treated with the ethanol extract from ZJP (5, 10, 20mg/kg) or fluoxetine (7.5mg/kg), which could antagonize reserpine-induced ptosis and hypothermia, moreover, both of them could elevate the contents of NE, 5-HT in hippocampus as well as NE, 5-HT, DA in striatum significantly.

http://www.ncbi.nlm....pubmed/23702040

 

--------------------------------

 

I´m no Doc, so I cant predict whether something is improtant or reversible so correct me if I´m wrong.

Anyway,I found a possible link in regards of the reversal of Vmat2 decline, caused by Methamphetamine

 

Neuroprotective effect of aqueous extract of Selaginella delicatula as evidenced by abrogation of rotenone-induced motor deficits, oxidative dysfunctions, and neurotoxicity in mice.

Biochemical analysis revealed that ROT-induced elevation in the levels of oxidative markers in cytosol/mitochondria of striatum were normalized with SDAE supplements. In addition, SDAE also restored the ROT-induced elevation in the levels of oxidized and nitrated proteins.

http://www.ncbi.nlm....pubmed/23868340

 

Methamphetamine-Induced Oxidation of Proteins and Alterations in Protein Processing

Eyerman and Yamamoto (2007) showed that decreases in VMAT2 after METH were likely due to the nitrosylation of VMAT2 as early as 1 h after METH. Furthermore, the nitrosylation and the long-term reduction in VMAT2 and DA transporter protein were attenuated by inhibition of neuronal nitric oxide synthase (nNOS). This indicates that METH causes a rapid glutamate and nNOS-dependent oxidation of VMAT2 that precedes the long-term reductions in DA and 5HT content,

http://www.nature.co...pp2011173a.html

 

---------------------

 

And this is my most promising compound against depression and (a certain) anxiety:

 

Effects of gastrodin on the dopamine system of Tourette's syndrome rat models.

After intervention by gastrodin, stereotyped behaviors of TS rats were significantly inhibited and levels of homovanillic acid (HVA) were significantly increased. We conclude that gastrodin effectively inhibited stereotyped behaviors and controlled TS symptoms by promoting dopamine metabolism, thereby increasing levels of HVA in sera.

http://www.ncbi.nlm....pubmed/20103948

 

Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease.

http://www.ncbi.nlm....pubmed/24661139

 

Gastrodin ameliorates Parkinson's disease by downregulating connexin 43.

http://www.ncbi.nlm....pubmed/23783886

 

Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1beta level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder.

http://www.ncbi.nlm....pubmed/24020812

 

Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: involvement of its anti-inflammatory action.

http://www.ncbi.nlm....pubmed/24613238

 

------------------

 

If someone has problems to find and obtain Paenoflorin, Naringin, Nobiletin and Gastrodin,

then the two first are found in sytrinol.

Gastrodin is found in Life extensions Brain shield

Paeoniflorin is found in Life extension Peony immune.

 

-----------

 

I dont promote any of theese products since e.g. Life extension is very expensive

and I would gladly know a cheaper albeit safe recource even for my self.

 

Pleas consider the Anti-coagulant and/or Aggregation blocking effects of each compound !!

Afaik Paenoflorin, Naringin, Nobiletin and Gastrodin have those properties and it could be dangerous to mix them all up !!

 

Edit: lol what a huge text^^

Edited by Flex, 19 July 2014 - 10:05 PM.

[Valor5]

Thanks. Any idea about the dosing for Genipin? http://www.genipin.org/ says,

 

 

It has a low acute toxicity, with LD₅₀ i.v. 382 mg/kg in mice, therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking regents.

 

 

We believe in the near future Genipin will be an effective pharmaceutical raw material that will significantly benefit patients who need it.

 

Edited by Valor5, 19 July 2014 - 10:45 PM.

[Flex]

Hmm, I would look out for research articles.

 

But better find the chinese name of the plant and find out the dosages suggestion from traditional chinese medicine (TCM).

This may be an indirect dosage suggestion, in regards of the Genipin ammount, but it should be far safer e.g. bleeding or hypoglycemia or any other side effects, than just converting the Rat/Mouse to human ratio from a, probalby, random study.

 

I found this:

Geniposide is an irioidglyco compound isolated from Gardenia fruits which has been used for many years in Chinese medicine for the treatment of hepatic disorders and inflammatory diseases. Genipin, the metabolite of geniposide, is a natural product present in fruit of Gardenia jasminoides. The relative bioactivity of genipin and geniposide has been widely reported in many studies and the potential application of these compounds in the treatment of liver diseases has come to light.

 

http://esciencecentr...7.php?aid=14314

 

 

 

Edited by Flex, 19 July 2014 - 11:04 PM.

[Valor5]

Wow, just realized this very plant is growing at my church and I actually plucked off its flowers not to long ago. They smell AMAZING. But I am not sure about eating the flower, though or even boiling it in water. What do you think? Would the fruit be the thing that has the flower inside before the flower comes out? It is great for arthritis which would help me and also inflammation and depression a very good thing and cancer which some people I know have.

 

I know you mentioned other things but I am just looking at this for now.

 

Below is a toxicological study but I suppose it is not to discount the beneficial effects?

 

 

 

Orally administered genipin 200 mg/kg resulted in a 78% mortality rate in rats [27]. Khanal et al. [90] reported that genipin but not geniposide was associated with cytotoxicity. They also demonstrated that human Intestinal microflora (IM) was able to metabolize geniposide genipin, and the resulting biological activity induced apoptosis through ROS/JNK signaling.   Further research is needed to more fully characterize the toxic effects of geniposide and genipin.

 

 

[Valor5]

Here is the abstract to the study the above study I posted referred to.

 

 

Toxicol Lett. 2012 Mar 25;209(3):246-54. doi: 10.1016/j.toxlet.2011.12.017. Epub 2012 Jan 9.

Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells.

Khanal T¹, Kim HG, Choi JH, Do MT, Kong MJ, Kang MJ, Noh K, Yeo HK, Ahn YT, Kang W, Kim DH, Jeong TC, Jeong HG.

Author information

• ¹Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.

Abstract

Intestinal microflora (IM) is able to produce toxic and carcinogenic metabolites and induce more potent cytotoxicity against cells than non-metabolites. This study was performed to investigate the cytotoxic responses of geniposide (GS) and its metabolite and to determine the role of metabolism by IM in GS-induced cytotoxicity. Genipin (GP), a GS metabolite, increased cytotoxic effects in cells, but GS did not. Following GS incubation with IM for metabolic activation, increased cytotoxicity was detected compared to GS. Western blot analysis revealed that the activated GS inhibited Bcl-2 expression with a subsequent increase in Bax expression. Likewise, GS activation by IM stimulated caspase-3 and the production of reactive oxygen species (ROS). In addition, activated GS-induced apoptosis was confirmed by apoptosis and ROS assays; N-acetyl-l-cysteine (NAC) suppressed ROS production and apoptotic cell death. Activated GS induced sustained JNK phosphorylation. Moreover, activated GS-induced cell death was reversed by SP600125. Taken together, these findings suggest that human IM is able to metabolize GS into GP, and the related biological activities induce apoptosis through ROS/JNK signaling.

 

[Flex]

Yes its not benefical.

Heard once about the JNK pathway but forgott it mostly.

 

The problem is that some plants do have healing and intoxicating effects as well.

And this is just one integrient of severals in the plant. So if You ask me, I would look out and rely on the chinese suggestions

for safety´s sake and avoid untill then even the slightest dosage.

 

Maybe there are some other compounds for arthritis.

 

 

 

Edited by Flex, 20 July 2014 - 12:20 AM.

[Flex]

For anyone from Germany who have problems with delivery from the US or Asia,

You could buy it here:

http://internet-apot...rdeniae-0666696

 

Just wanted to extend the first post:

 

Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin.

treatment with smilagenin significantly elevated the dopamine receptor and DAT density in aged rats. Furthermore, smilagenin enhances glial cell-derived neurotrophic factor (GDNF) release both in the striatum and midbrain. These results indicate a possible role of smilagenin in the treatment of age-related extrapyramidal disorders.

http://www.ncbi.nlm....pubmed/23624370

 

 

Edited by Flex, 21 July 2014 - 12:07 AM.

[GoingPrimal]

Awesome finds, will have to look into these more 

[Flex]

Thanks Youre Welcome :-)

[Metagene]

For anyone from Germany who have problems with delivery from the US or Asia,

You could buy it here:

http://internet-apot...rdeniae-0666696

 

Just wanted to extend the first post:

 

Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin.

treatment with smilagenin significantly elevated the dopamine receptor and DAT density in aged rats. Furthermore, smilagenin enhances glial cell-derived neurotrophic factor (GDNF) release both in the striatum and midbrain. These results indicate a possible role of smilagenin in the treatment of age-related extrapyramidal disorders.

http://www.ncbi.nlm....pubmed/23624370

 

 

 

 

Awesome finds, will have to look into these more 

 

What he said. 

 

Too bad smilagenin also refer to as cogane (PYM50028) failed to improve symptoms of patients with early stage Parkinson's disease in the phase II clinical trial.

 

https://www.michaelj...-clinical-trial

 

You guys might like this one

 

 

 

Cognitive-Enhancing Effect of Steamed and Fermented Codonopsis lanceolata: A Behavioral and Biochemical Study.

Weon JB1, Yun BR1, Lee J1, Eom MR1, Ko HJ2, Lee HY3, Park DS4, Chung HC5, Chung JY5, Ma CJ6.

Author information

 

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Codonopsis lanceolata (C. lanceolata) has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis. The present study was undertaken to evaluate the effect of fermented C. lanceolata (300, 500, and 800 mg/kg) on learning and memory impairment induced by scopolamine by using the Morris water maze and passive avoidance tests. To elucidate possible mechanism of cognitive-enhancing activity, we measured acetylcholinesterase (AchE) activity, brain-derived neurotrophic factor (BDNF), and cyclic AMP response element-binding protein (CREB) expression in the brain of mice. Administration of fermented C. lanceolata (800 mg/kg) led to reduced scopolamine-induced memory impairment in the Morris water maze and passive avoidance tests. Accordingly, the administration of fermented C. lanceolata inhibited AchE activity. Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C.lanceolata. These results indicate that fermented C. lanceolata can ameliorate scopolamine-induced memory deficits in mouse and may be an alternative agent for the treatment of AD.

 

 

 

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata.

Weon JB1, Yun BR1, Lee J1, Eom MR1, Ko HJ2, Lee HY3, Park DS4, Chung HC5, Chung JY5, Ma CJ6.

Author information

 

Abstract

Codonopsis lanceolata has been used as an herbal medicine for several lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and fermented C. lanceolata (SFC) in vitro and in vivo. In the current study, the treatment of HT22 cells with SFC decreased glutamate-induced cell death, suggesting that SFC protected HT22 cells from glutamate-induced cytotoxicity. Based on these, we sought to elucidate the mechanisms of the neuro-protective effect of SFC by measuring the oxidative stress parameters and the expression of Bax and caspase-3 in HT22 cells. SFC reduced contents of ROS, Ca(2+) and NO. Moreover, SFC restored contents of glutathione and glutathione reductase as well as inhibited Bax and caspase-3 activity in HT22 cells. These results indicate that steamed and fermented C. lanceolata(SFC) extract protected HT22 cells by anti-oxidative effect and inhibition of the expression of Bax and caspase-3.

 

http://www.ncbi.nlm.nih.gov/pubmed

[Flex]

Wow nice findings.

 

I just realized that Your Borneol thread could be mind blowing.

I didnt read everything, but if borneol would make it possible that e.g. NGF or anything else could get trough the Blood-Brain-Barrier, 

then we could reach a new level of Neuro enhancement ^^ 

 

Edit:

 

I´ve searched why Cogane wasnt helpful.

It seems, at least to me, that it does indeed increase Gdnf, but Gdnf doesnt seem to be helpful in alpha synucelin induced toxicity, which plays a role in Parkinson according to this forum:

http://www.parkinson...ad/54928?page=1

 

So correct me if I´m wrong.

Edited by Flex, 25 July 2014 - 06:06 PM.

[Metagene]

Wow nice findings.
 
I just realized that Your Borneol thread could be mind blowing.
I didnt read everything, but if borneol would make it possible that e.g. NGF or anything else could get trough the Blood-Brain-Barrier, 
then we could reach a new level of Neuro enhancement ^^ 
 
Edit:
 
I´ve searched why Cogane wasnt helpful.
It seems, at least to me, that it does indeed increase Gdnf, but Gdnf doesnt seem to be helpful in alpha synucelin induced toxicity, which plays a role in Parkinson according to this forum:
http://www.parkinson...ad/54928?page=1
 
So correct me if I´m wrong.

 
Sorry I wouldn't know. I'm just a lay person.
 
Borneol certainly holds potential. Even if the natural form doesn't light your fire...
 
 
 

In this work, the complex of borneol–methyl-β-cyclodextrin was prepared both by supercritical carbon dioxide processing and by the sealed heating treatment at mild pressure and temperature. An amorphous complex was obtained by the sealed heating treatment. A crystalline inclusion complex was obtained by the supercritical carbon dioxide processing. The crystalline complex is more stable than the amorphous complex. The apparent aqueous solubility of borneol could be enhanced about 70 times by complexation with methyl-β-cyclodextrin.

 
 
 
 
https://drive.google...dit?usp=sharing
 

"wait till they get a load of me."
 
untreated NB was difficult to be dissolved in water, and the
aqueous solubility of pure NB is about (4.0±0.4)×10−3 mol/L
(He and Li 2009). For the physical mixture of NB and β-CD,
6.03% and 9.53% dissolution were observed at 10 and 150 min,
respectively. The increase in dissolution rate observed for physical
mixture may be explained with the enhancing solubilization of
the drug in aqueous β-CD solutions (Corrigan and Stanley 1982;
Naidu and others 2004; Lu and others 2009) and the hydrophilic
effect of the carrier, which can reduce the interfacial tension between
the poorly soluble NB and the dissolution medium, thus
leading to a dissolution (Mura and others 2002; Li and others
2005). However, after forming inclusion complex, the dissolution
rate of borneol was significantly increased with over 79.78%
dissolution within 60 min. Since NB formed an inclusion complex
with β-CD at a mass ratio of 1/6, the enhancement of NB
dissolution was more significant than the physical mixture.
 
 
https://drive.google...dit?usp=sharing

 

Anyway I want to read up on some other things before the next update.

Edited by Metagene, 25 July 2014 - 09:35 PM.

[Flex]

Goingprimals comment is pointless, timewasting ?

That little comment ?

Did someone called the vigilantes ?

 

My thanks to him:

Ill informed ?

 

Another comment of me: unsure ?

wasnt the prevorious comment allready unsure or off topic?

Since Parkinson is not the subject of the topic and if something fails to improve Parkinson it doesnt mean that this isnt increasing Gdnf.

Did it bother me ?

I just corrected it, nothing more !

 

Is Parkinson caused by a loss of Gdnf or could be Alphasynuclein be implicated among others ?

What is so unsure about it ?

Or did You seeked just for the chance to make any negative feedback ?

 

Seems that some People with soziophatic tendencies are trolling here arround !!

 

I´ve made this thread to help the People !

Example: A few threads have been allready  made to find something what could increase Gdnf and they have afaik only found Vaproic acid.

and I wanted to share this information to help

What is the Response? Pointless, time wasting

 

Is this trolling the Response for this ?  

Are You sane ?

Where are Your Contributions ?

 

This just Forum is full of unthankful People !

Even when answering a Question, they dully note this..

And I´m not thinking of Valor5 above, there were other obvious posts that I mean.

 

 

Edited by Flex, 26 July 2014 - 03:21 PM.

[Flex]

Sorry, nothing against You Metagene !

I was just in Rage..

Edited by Flex, 26 July 2014 - 04:45 PM.

[Metagene]

Sorry, nothing against You Metagene !

I was just in Rage..

 

No worries Flex. 

 

The asinine finally have a means to express themselves. I wouldn't take it personal. 

[Metagene]

I think it's time for another Clausenamide thread.

 

 

Clausenamide (lour) Skeels in the family of Rutaceae [67]. 

Animal studies demonstrated that L-clausenamide is 

capable of improving the spatial discrimination disorders 

of rats induced by Aβ via enhancing the activities of 

cholineacetyltransferase of the cortex (68). Further, 

L-clausenamide promoted the release of glutamic 

acid from synaptosomes of cerebellum, enhanced 

the amplitude of long term potentiation (LTP) in the 

hippocampus CA1 zone, and increased cerebral cortex 

thickness, thereby improving learning and memory 

ability of rats (68). It was demonstrated that the nootropic 

effect of L-clausenamide is more potent than that of 

piracetam (44). 

 

 

 

Drug Discoveries & Therapeutics. 2013; 7(2):46-57. 

Edited by Metagene, 26 July 2014 - 06:52 PM.

[Flex]

Thanks..

 

Wow Great finding

[blood]

I've ordered a bottle of gastrodin (LEF). 

I'm curious to see what effects it has, if any, on alertness, memory, mood & wellbeing.

 

[Flex]

Ok.

 

This is, at least to me, something very interresting and maybe promising:

 

9-me-BC Regeneration of dopaminergic neurons

http://www.longecity...ns/#entry677822

 

 

9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture.

http://www.ncbi.nlm....pubmed/17913302

[Boopy!]

well if smilagenin did work they could call it for marketing purposes SmileAgain:)
 

[Flex]

well if smilagenin did work they could call it for marketing purposes SmileAgain:)
 

 

Why must im smiling, when reading this :-)

[Metagene]

#21 lol that was an accident man.

Oxymethacil can enhance stroop preformance? I'll do some digging on google ru for a study that's not from 20 years ago.

Influence of an antioxidant on the impulse activity of neurons of the prefrontal and inferotemporal cortex during visual recognition in monkeys.

AuthorsDudkin KN, et al. Show allJournal
Neurosci Behav Physiol. 1994 Jul-Aug;24(4):329-40.
Affiliation
Abstract
The impulse activity of individual neurons of the prefrontal and inferotemporal cortex was recorded during the performance of a task of delayed visual differentiation of stimuli of various colors in monkeys before and after the systemic administration of the antioxidant, oxymethacil (4-5 mg/kg). The improvement in cognitive characteristics induced by oxymethacil was accompanied by changes in the activity of neurons of the prefrontal cortex in which activation dependant upon the stage of recognition and intensifying during an increase in the duration of the delay predominated. Inhibition of activity predominated during recognition without delay in these neurons; by contrast, activation predominated in neurons of the inferotemporal cortex under these conditions. During delayed differentiation, the activity of these neurons under the influence of oxymethacil changed principally in the same way as in neurons of the prefrontal cortex: activation predominated in the majority of the stages of recognition. Oxymethacil induced a substantial increase in the coefficients of cross correlation between simultaneous respondent reactions of groups of neurons in these different areas of the cortex. The results obtained attest to the contribution of neuronal structures of the prefrontal and inferotemporal cortex to the improvement of cognitive characteristics of monkeys in the presence of the effect of oxymethacil, and to the increase in synchronization of informational processes in these regions of the cortex.

http://www.ncbi.nlm....7969884/related

Edited by Metagene, 03 August 2014 - 12:09 AM.

[Flex]

Wow cool !

Nice findings like ever.

I have somehow neglected to look out for something for the PFC, in the recent time.

So, a good Reminder

Just have to find oput whether this is Ok for the Health and obtainable.

 

 

[Metagene]

Thanks but I enjoy novelty more than anything else. It takes work to separate the wheat from the chaff. Here's the rest of the information on Oxymethacil or Оксиметилурацил (oxymethyluracil) I could gather.

https://docs.google....sp=docslist_api

http://www.ncbi.nlm....oxymethyluracil

[Flex]

This is the hammer:

Advances in Neuroprotective Ingredients of Medicinal Herbs by Using Cellular and Animal Models of Parkinson’s Disease

https://www.scienceo...8f479075eb4.pdf

Read e.g. page 7 or see the table at page 10

Edited by Flex, 14 August 2014 - 09:45 PM.

[Shorty]

This is the hammer

 

This is the most German thing I've ever read

(for non germans: he is expressing amazement/excitement)

[Flex]

Yeah this expression came out of exitement^^

[normalizing]

 

This is the hammer

 

This is the most German thing I've ever read

(for non germans: he is expressing amazement/excitement)

 

 

yeah i seen germans going psycho saying this on trance and techno forums

[Flex]

Next (quiet fancy ) one:

 

Pharmacological Effects of Active Compounds on Neurodegenerative Disease with Gastrodia and Uncaria Decoction, a Commonly Used Poststroke Decoction

http://www.hindawi.c...wj/2013/896873/

http://www.hindawi.c...13/896873/tab1/

Chapter 6.2. p-Hydroxybenzyl Alcohol

p-Hydroxybenzyl alcohol is one of the major components in Gastrodia elata Blume (GE)....

...It also increased the expressions of PDI, nuclear factor-E2-related factor 2 (Nrf2), and several neurotrophic factor genes including glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and myelin basic protein (MBP) genes [166]. The results indicate that p-Hydroxybenzyl alcohol can protect against neuroinflammation and brain damage....

 

Optimization and application of a fluorimetric assay for the identification of histone deacetylase inhibitors from plant origin.

http://www.ncbi.nlm....pubmed/21554009

 

RESULTS:

In the experimental design autofluorescent coumarins and tannins were identified to disrupt the assay. Possibilities to avoid disturbances are demonstrated and the applicability of the method in the bioactivity-guided search for new HDACi was proven on the example Leonuri herba (Leonurus cardiaca L.; Lamiaceae).

CONCLUSION:

The optimization of the assay led to a highly efficient fluorimetric method to study plant extracts and fractions of medium/high polarity for HDAC inhibition. In the bioactivity-guided fractionation of extracts from Leonuri herba the applicability for the aimed purpose was clearly demonstrated.

 

--> So Leonuri herba may or may not contains a HDAC inhibitor !...

Unfortunaetly, the answer and futher Hdac´s ,from plant origin, can only be found in the Full-text.

Edited by Flex, 15 August 2014 - 09:53 PM.

[Flex]

I´ve made a similair topic, so I gonna post the link to connect each other

Brainrepair Topic

http://www.longecity...inrepair-topic/