612 replies to this topic

[LongLife]

PLAYGROUND:

Thank you for your post about sci-hub.io. I take it you found the paper you were looking for there:

http://www.sciencedi...031942297001441

 

 

 

[resveratrol_guy]

Do you think all this was initiated by your consumption of 'largish' dosages of beta-NGF ?

 

Your dosages were clearly much bigger than mine

 

I think the effects of beta-NGF are persistent long after you stop taking it.

(a bit like steroids or growth hormone, i suppose).

 

For example... I'm definitely _still_ experiencing more vivid dreams.

And it's just really obvious that i'm _still_ sleeping much longer than i used to.

I had 9.5 hours last night, 10 hours the night before... i think it was only 8 hours

before that, but it was 9.5 the night before that. 

 

I used to get by quite happily on 7.

During busy weeks at work, it might only be 6 per night.

 

So the contrast, the difference, is quite stark.

And it's been weeks since i last had any.

 

However, you're not reporting excessive sleeping.... so.... i wonder if

it really is the beta-NGF that's bestowing this bounty of sleep.

 

But going back to your visualisation skills.

I will eventually take the dosages you originally took.

So I will eventually know if it's your NGF dosages, or not,

that's yielding your visual gifts.

 

playground

 

Sorry I've really busy. Anyway, to your points, I do think the dream enhancement, and ultimately the visualization enhancement, was due to NGF. However, I don't entirely ascribe the effect to the betaNGF that I insufflated; rather, it's many pathways by which NGF has been upregulated, exogenous betaNGF being but one. I'm doing so many things to enhance mental function that it wouldn't be fair to single out any one supplement. For that matter, I'm still calorically restricted, and thinner than I've ever been at this height, and I'm still doing LLLT every few days.
 

I'm not surprised by your increase in sleep duration and dream enhancement, both of which would be consistent with some degree of neurological rejuvenation. I've been sleeping probably 8 hours a day on average, although I sleep more on days that I eat.

 

I will be interested to see what happens when your dose increases, although this is all so subjective for lack of good metrics.

[Lsdium]

Resveratrol_guy any update? Really interesting to hear about your progress 

 

So what do you think about betaNGF and Ashitaba chalcone?

 

Beneficial overrall?

 

How long have you been using it now and may i ask the price you have been paying for the betaNGF, do you think its worth the cost?

 

Thanks, and keep up with your work 

 

 

 

[resveratrol_guy]

Resveratrol_guy any update? Really interesting to hear about your progress 

 

So what do you think about betaNGF and Ashitaba chalcone?

 

Beneficial overrall?

 

How long have you been using it now and may i ask the price you have been paying for the betaNGF, do you think its worth the cost?

 

Thanks, and keep up with your work 

 

Sorry I haven't been around much lately. In some sense, that has to do with neurological function, as I've been working like crazy. Then just yesterday I had a second surgery (septoplasty) to improve my breathing above and beyond what the jaw surgery had afforded vs. sleep apnea. (This is more just to relieve some persistent annoyances with dysfunctional nasal breathing. My throat airway obstruction has already been cured.) But of course this all complicates my particular case analysis, because it's impossible to tell the extent to which the betaNGF, fasting, supplements, LLLT, or surgery has helped. The truth is that it all runs together. Only by comparing objective recovery measurements with others can we hope to know any better.

 

While I was drinking chalcone up until about 3 weeks ago, I had to quit in order to allow my blood to coagulate better for surgery. (Preventing blood clots isn't always desirable!) But with that behind me, I plan to restart soon.

 

I haven't used betaNGF since I last reported it here. I had to stop because I did not want enhanced sensory neuron propagation to add to the pain of jaw surgery recovery. I'll probably wait a bit longer on account of the septoplasty. In any event, I suggest looking on the "Distributor" page on the Sino Biological website in order to find a distributor near you. This can keep costs down and product quality up, especially if you opt for refrigerated shipping. Price varies widely by distributor. Having said that, and based on the similar experiences of others who have taken it, I think it's been entirely worthwhile. 20 ug seems provide maximum bang for the buck in hindsight, but these things are very hard to ascertain.

 

For the record, my alternate-day fasting is going well, and has surely contributed to my brain function. I'll release full blood tests later on my thread (after I get some other results back), but glucose just 2 hours after literally stuffing myself with complex carbs and butter was 63, down from fasting glucose of 67 in 1/2015. So much for diabetes risk! That, and my kidney eGFR (filtration rate) has rejuvenated from 102 to 108 in the last 5 months (same exact lab facility). And do I follow the recommended "kidney health" diet, i.e. low potassium with high pasta and simple carbs? Hell no! I eat tons of fat, some complex carbs, and huge amounts of veggies laden with potassium. The only aspect of that diet which I do follow is the minimization of protein (especially phosphate-rich cheese) intake, which has helped keep my blood urea nitrogen at low normal and, I suspect, may be pushing longevity via FGF21. I've alternated between 3000 calories, or 4 hours of ad libidum eating, every other day, with current emphasis on the latter. But I digress.

 

Back on the neurological front, and thanks to a tip from a friend of mine, I've found an easy way to cram more MCT oil without getting stomach cramps. Basically, mix it with complex carbs (sweet potatoes, lentils, maybe oats, or whatever) which absorb it somewhat and allow it to sneak past the stomach without too much disruption. MCT, as you probably know, is touted as the poor man's dementia treatment, and is also helpful in cancer prevention.

 

Finally, I've been dumping loads of dried cilantro on my meals based on a tip from Playground that it may bind mercury and expedite its excretion. The studies aren't particularly strong on this theory, but I like the taste and it doesn't seem to hurt.

 

Edited by resveratrol_guy, 18 March 2016 - 08:10 PM.

[LongLife]

 

Resveratrol_guy any update? Really interesting to hear about your progress 

 

So what do you think about betaNGF and Ashitaba chalcone?

 

Beneficial overrall?

 

How long have you been using it now and may i ask the price you have been paying for the betaNGF, do you think its worth the cost?

 

Thanks, and keep up with your work 

 

Sorry I haven't been around much lately. In some sense, that has to do with neurological function, as I've been working like crazy. Then just yesterday I had a second surgery (septoplasty) to improve my breathing above and beyond what the jaw surgery had afforded vs. sleep apnea. (This is more just to relieve some persistent annoyances with dysfunctional nasal breathing. My throat airway obstruction has already been cured.) But of course this all complicates my particular case analysis, because it's impossible to tell the extent to which the betaNGF, fasting, supplements, LLLT, or surgery has helped. The truth is that it all runs together. Only by comparing objective recovery measurements with others can we hope to know any better.

 

While I was drinking chalcone up until about 3 weeks ago, I had to quit in order to allow my blood to coagulate better for surgery. (Preventing blood clots isn't always desirable!) But with that behind me, I plan to restart soon.

 

I haven't used betaNGF since I last reported it here. I had to stop because I did not want enhanced sensory neuron propagation to add to the pain of jaw surgery recovery. I'll probably wait a bit longer on account of the septoplasty. In any event, I suggest looking on the "Distributor" page on the Sino Biological website in order to find a distributor near you. This can keep costs down and product quality up, especially if you opt for refrigerated shipping. Price varies widely by distributor. Having said that, and based on the similar experiences of others who have taken it, I think it's been entirely worthwhile. 20 ug seems provide maximum bang for the buck in hindsight, but these things are very hard to ascertain.

 

For the record, my alternate-day fasting is going well, and has surely contributed to my brain function. I'll release full blood tests later on my thread (after I get some other results back), but glucose just 2 hours after literally stuffing myself with complex carbs and butter was 63, down from fasting glucose of 67 in 1/2015. So much for diabetes risk! That, and my kidney eGFR (filtration rate) has rejuvenated from 102 to 108 in the last 5 months (same exact lab facility). And do I follow the recommended "kidney health" diet, i.e. low potassium with high pasta and simple carbs? Hell no! I eat tons of fat, some complex carbs, and huge amounts of veggies laden with potassium. The only aspect of that diet which I do follow is the minimization of protein (especially phosphate-rich cheese) intake, which has helped keep my blood urea nitrogen at low normal and, I suspect, may be pushing longevity via FGF21. I've alternated between 3000 calories, or 4 hours of ad libidum eating, every other day, with current emphasis on the latter. But I digress.

 

Back on the neurological front, and thanks to a tip from a friend of mine, I've found an easy way to cram more MCT oil without getting stomach cramps. Basically, mix it with complex carbs (sweet potatoes, lentils, maybe oats, or whatever) which absorb it somewhat and allow it to sneak past the stomach without too much disruption. MCT, as you probably know, is touted as the poor man's dementia treatment, and is also helpful in cancer prevention.

 

Finally, I've been dumping loads of dried cilantro on my meals based on a tip from Playground that it may bind mercury and expedite its excretion. The studies aren't particularly strong on this theory, but I like the taste and it doesn't seem to hurt.

 

resveratrol_guy: Good to hear your recovering well. Your writing seems very chipper. I will throw you a little recipe as an extension of the cilantro tip. Cilantro does bind a few toxic metals but it does not do well at mobilizing it out. Mix in equal amounts of parsley which is synergistic with cilantro. A mix of equal portions of ginger root, turmeric root and garlic + a little water in the blender  makes a powerful salad dressing; add a bit of olive oil or sacha inchi oil, also a great soup enhancer. Always couple this with the parsley/cilantro for a real toxin eliminator. Of course it gives a good metabolic punch on various levels. It is dirt cheap too. Cheers.

[resveratrol_guy]

Sounds like a zesty salad dressing, LongLife! Do you have any studies regarding the parsley synergy, by which I assume you mean that it enhances the excretion of metal ions which cilantro binds? (Garlic has been linked to neurite lengthening, and ginger packs a perceptible cognitive punch, but -- yuck!)

 

On another note, I thought I should also mention some unexpected developments with auditory rendering, that is, the creation of credible "sounds" in my mind. Historically, my ability to recall melodies and sounds has been as good as Mozart's ability to play basketball. In other words, virtually nonexistent. But this has begun to change lately, which is odd, considering that I've been cutting back on my supplements for the reasons cited above. Now I can actually remember several notes in a row and "play" them with realistic environmental echo. Or I can "hear" various environmental sounds like construction equipment, sirens, or dripping water. Unless it's just straightforward apnea recovery, which it might well be, I have no explanation. However, it would seem odd that apnea recovery would improve this aspect of my mental synthesis to a level beyond that which I was ever capable. The only other observation of relevance here, come to think of it, is that this all started with some weird auditory memory events. The events were random recollections of sounds that I had heard, which would come out during right-hemisphere illumination with my 850 nm 48-LED LLLT device. Several times, I had been surprised by these events, only to realize that I was illuminating the usual hotspot, in particular, the region between my right ear and right temple. I've subsequently tried to look out for similar events occurring upon illumination of other cranial regions, to no avail. Only the auditory memories pop out during the actual LLLT session, and even then, it's not more than half the time.

 

Finally, I have this little gift for you all.

 

Edited by resveratrol_guy, 19 March 2016 - 06:13 AM.

[Irishdude]

How do you survive working on an empty stomach for over 24 hours? It must have been a horrible transition at first.

[playground]

For some weeks i've been mulling over an NGF theory

... and mulling over, putting this theory to the test.

 

What's the theory ?

The theory originates in the work of McMichael.

McMichael is the guy who tried giving micro-doses of NGF to dogs and horses and people.

He gave them a few percent of 1 microgram

(There's no typo here, i really do mean a few percent of a microgram - not milligram)

 

His subjects were:

Horses that were distressed at being alone.

Dogs that would tear the furniture to pieces when the owner left the house.

Humans that were suffering from anxiety/depression.

 

What did he do ?  He simply administered tiny-tiny doses to NGF to these 'subjects'

and then observed that the horse/dog/person exhibited less anxiety.

 

McMichael talks about his results in terms of "sending a nerve growth _signal_"

The receipt of this signal is all that was required to stop these 'creatures' from being distressed.

It didnt seem to matter what the dose was.

It didnt seem to matter what the route of administration was (oral administration was sufficient)

 

If you want to watch McMichael's presentation for yourself..  see here:

 

So this is an effect that doesnt seem to be dosage dependent.

This is an effect that doesnt seem to be too fussy about route of administration.

(These tiny dosages remind me a lot of a homeopathy type effect).

 

McMichael said that, in order to preserve the anti-anxiety effect of the NGF,

he had to repeat the dose every day (i.e. resend the signal, every day)

 

Now, for me, that's a key detail.  Because what this seems to mean is that the frequency

of the dose is more important than the size of the dose

 

 

So that's the introduction. 

 

Now here are my questions.

 

What happens if you send a signal 4 times a day, or 8 times a day?

A dose every 4 hours ?  A dose every 2 hours ?  

(assuming you're awake for 16 hours per day) 

 

Would dosing every 2 hours be equivalent to dosing once per day ?

What if it's not ?

 

What if a neurotrophic signal is acted upon by, say, a random X%

of neural cells.  And that this response, by this X%  sub-population, is sufficient

to eradicate anxiety in the subject. 

 

What if a separate signal, 2 hours later, stimulates a new sub-population

of neural cells.  Perhaps 2 * X% ?

And then another signal 2 hours after that  3 * X% ?  ... And so on...

 

So perhaps, 8 dosings, might stimulate a response from a much wider

population of neural cells.

Maybe not 8 times X%... maybe only 3 times X%.

 

So that's the concept. 

In my view it's a very interesting question.

And the potential neural rewards might be enormous.

(And, of-course, this might be of particular interest to a variety of patient groups...  dementia, depression, etc)

 

I'm fit, healthy and happy.

I have no neurological deficits and i'm not depressed or anxious.

So how do i know what 'benefits' to look for ? 

 

What do I measure ?

 

=> I can reflect on my general 'energy and enthusiasm' status.

=> I can record my sleeping pattern. I noticed that my sleeping duration went up significantly

       during the period of my initial daily dosing with beta-NGF around Xmas time.

=> I can report the lucidity or vividness of my dreams (these parameters also went up

       during the period of my first beta-NGF dosing)

=> I can report on my ability to solve sudoko puzzles (which i've been doing on a daily basis

       for over 3 months now....  my skills have probably plateau'd... will they suddenly get

       better in the presence of multiple daily NGF dosings ?

=> I can watch out for any increases in my visualisation abilities.   Resveratrol_Guy detailed

      significant boosting of his imagery/visualisation skills.

=> I can report any apparent increases in tinnitus volume.  (There's a protocol for relating

      tinnitus volume to a reference background noise (eg a ticking clock), whilst meditating)

=> I can also detail anything out of the ordinary. 

 

So... that's the plan.

 

I'll keep you all informed.

 

Feel free to join in.  The more observations the better.

Edited by playground, 19 March 2016 - 03:24 PM.

[resveratrol_guy]

How do you survive working on an empty stomach for over 24 hours? It must have been a horrible transition at first.

 

The conventional wisdom is that it takes a week, or sometimes 3, to adapt. A few things can help: When in severe hunger, take a hit of pterostilbene (200 mg works for me) or eat a bitter gourd. It will take the edge off within half an hour. The other avoidance route, which I practice a lot, is giving up and going to sleep for a while. After several weeks, when you adjust to lower caloric intake, your NAD+ output will increase and you'll generate new mitochondria, allowing you to do more with less. Also, while it may not offer much solace during a bout of intense hunger, you should realize that hunger comes in waves. After a few hours, it will retreat for a while. This is surely an evolutionary adaptation which ensures that hungry animals can still carry on some other critical functions, such as social interaction, without being completely paralyzed by food obsession.

 

There are also some techniques to preempt hunger in the first place. I've experimented widely with various food combinations. While there are definitely foods that will turn off your hunger, such as vegetable juice, and foods that will disgust you to the point of losing interest in food, such as raw coconut oil or fruit juice, there are very few which actually leave you satisfied and happy to stop thinking about your next meal. Oddly enough, I've found that the most satisfying foods, in the aforementioned sense, seem to involve the combination of healthy fat with carbs. For example, butter and a sweet potato tends to shut me down. But so does a Cliff bar (whole grains with raisins and nuts, basically crap masquerading as health food) with an equal volume of solid butter. This is one area where the keto enthusiasts are completely out to lunch, so to speak: eating pure fat does not satisfy! Fat induces a feeling of being overstuffed, which is a far cry from feeling satiated and happy with one's meal. Instead, it seems that it must be combined with complex carbs to deliver the desired result. Sorry I have no idea why.

 

And let's not forget the importance of gut bacteria. I suggest getting these bugs in order first, for example by eating unsweetened yoghurt with veggies, daily for a week before you start. You want them pulling the right hormonal levers, not the wrong ones, to induce you to eat what they crave. Forcing them to learn to eat veggies is a good start.

 

After another blood test later this month, I plan to try restricting protein instead of carbs or calories. I was impressed by Liz Parrish's (BioViva CEO) comment that turning on FGF21, a gene actived by protein restriction, was sufficient to increase a mouse's lifespan to 60 months -- well beyond what could be accomplished even with caloric restriction and good husbandry in that species -- without any limitation of chow consumption. The only de facto limitation was imposed by the chow itself, i.e. you can't just replace the protein with candy, but perhaps you can replace it with complex carbs, assuming that you're not excited about consuming fat. Indeed, the Okinawans are traditionally protein-restricted, and the ranks of supercentenarians are littered with them in a manner vastly disproportionate to their fraction of the global population.

[resveratrol_guy]

For some weeks i've been mulling over an NGF theory

... and mulling over, putting this theory to the test.

 

What's the theory ?

The theory originates in the work of McMichael.

McMichael is the guy who tried giving micro-doses of NGF to dogs and horses and people.

He gave them a few percent of 1 microgram

(There's no typo here, i really do mean a few percent of a microgram - not milligram)

 

His subjects were:

Horses that were distressed at being alone.

Dogs that would tear the furniture to pieces when the owner left the house.

Humans that were suffering from anxiety/depression.

 

What did he do ?  He simply administered tiny-tiny doses to NGF to these 'subjects'

and then observed that the horse/dog/person exhibited less anxiety.

 

McMichael talks about his results in terms of "sending a nerve growth _signal_"

The receipt of this signal is all that was required to stop these 'creatures' from being distressed.

It didnt seem to matter what the dose was.

It didnt seem to matter what the route of administration was (oral administration was sufficient)

 

If you want to watch McMichael's presentation for yourself..  see here:

 

So this is an effect that doesnt seem to be dosage dependent.

This is an effect that doesnt seem to be too fussy about route of administration.

(These tiny dosages remind me a lot of a homeopathy type effect).

 

McMichael said that, in order to preserve the anti-anxiety effect of the NGF,

he had to repeat the dose every day (i.e. resend the signal, every day)

 

Now, for me, that's a key detail.  Because what this seems to mean is that the frequency

of the dose is more important than the size of the dose

 

 

So that's the introduction. 

 

Now here are my questions.

 

What happens if you send a signal 4 times a day, or 8 times a day?

A dose every 4 hours ?  A dose every 2 hours ?  

(assuming you're awake for 16 hours per day) 

 

Would dosing every 2 hours be equivalent to dosing once per day ?

What if it's not ?

 

What if a neurotrophic signal is acted upon by, say, a random X%

of neural cells.  And that this response, by this X%  sub-population, is sufficient

to eradicate anxiety in the subject. 

 

What if a separate signal, 2 hours later, stimulates a new sub-population

of neural cells.  Perhaps 2 * X% ?

And then another signal 2 hours after that  3 * X% ?  ... And so on...

 

So perhaps, 8 dosings, might stimulate a response from a much wider

population of neural cells.

Maybe not 8 times X%... maybe only 3 times X%.

 

So that's the concept. 

In my view it's a very interesting question.

And the potential neural rewards might be enormous.

(And, of-course, this might be of particular interest to a variety of patient groups...  dementia, depression, etc)

 

I'm fit, healthy and happy.

I have no neurological deficits and i'm not depressed or anxious.

So how do i know what 'benefits' to look for ? 

 

What do I measure ?

 

=> I can reflect on my general 'energy and enthusiasm' status.

=> I can record my sleeping pattern. I noticed that my sleeping duration went up significantly

       during the period of my initial daily dosing with beta-NGF around Xmas time.

=> I can report the lucidity or vividness of my dreams (these parameters also went up

       during the period of my first beta-NGF dosing)

=> I can report on my ability to solve sudoko puzzles (which i've been doing on a daily basis

       for over 3 months now....  my skills have probably plateau'd... will they suddenly get

       better in the presence of multiple daily NGF dosings ?

=> I can watch out for any increases in my visualisation abilities.   Resveratrol_Guy detailed

      significant boosting of his imagery/visualisation skills.

=> I can report any apparent increases in tinnitus volume.  (There's a protocol for relating

      tinnitus volume to a reference background noise (eg a ticking clock), whilst meditating)

=> I can also detail anything out of the ordinary. 

 

So... that's the plan.

 

I'll keep you all informed.

 

Feel free to join in.  The more observations the better.

 

You raise some good points here about gradual accumulation of signalling benefits. Superficially, your low-dose protocol is merely a nootropic use of betaNGF, insufficient to achieve any lasting circuit changes. But on further analysis, I think it would do just that because throughput optimizes the system. Basically, repeated activation of healthy neural firing patterns is going to reinforce the desirable connections and prune the destabilizing ones. I suppose the best strategy is to combine betaNGF with continual stimulation of desired circuitry in the hopes of achieving a greater benefit than would be possible with training alone, rather like what you're doing with Sudoku. (Personally, I prefer real world problems to games because ultimately I want neurological benefits to have real world relevance. Of course, those benefits are not as measurable as Sudoku scores.)

 

Having said that, I'm rather puzzled by the visual and auditory memory enhancement that "just showed up" without any dedicated effort to improve them. Again, there may be some synergy on my part with LLLT, apnea surgery, etc. If others don't observe these effects, then they are probably not due to betaNGF.

 

Sleep improvement, as I've said before, is a common subjective indication of improved neurological health. I think you're on the right track!

[tunt01]

How do you survive working on an empty stomach for over 24 hours? It must have been a horrible transition at first.

Google "surfing the urge"

[resveratrol_guy]

One can also eat washed lemon peels. They're rich in limonene and fill your stomach with indigestible mass. OK, so it's not on the same level as mindfulness meditation (good recommendation, prophets!), but it's practical. By the way, hunger isn't all bad. I've never enjoyed so many cooking shows in my life! Obviously, this gets ridiculous at a certain point, though, which leaves me wondering what the optimal fasting period is. It's probably not my usual 44 hours; maybe 10 hours is more reasonable in the real world. If only protein restriction actually works, we can forget this whole debate...

[normalizing]

resveratrol guy, the way you talk is like you are on adderall or some actual drug stimulant. your sentences meanings intermingle and thoughts seem scattered all over them. not sure why start with "washed lemon peels" and end up with completely different thought about protein and to fast or not. i mean at least separate your thoughts and expressions by posts if you cant do it in just one

[playground]

Resveratrol_Guy (RG) is doing alternate day fasting.

Which, it seems to me, is pretty heroic.... and/or... hard core.

 

I remember reflecting recently that i doubted i could handle that.... unless

i had access to a supply of appetite suppressants.

(Most (all?) appetite suppressants, eg phentermine, are amphetamine based).

 

I wonder if RG is taking an appetite suppressant to help with that ?

It's a question, not an accusation.  :-)

Edited by playground, 22 March 2016 - 08:43 AM.

[resveratrol_guy]

Resveratrol_Guy (RG) is doing alternate day fasting.

Which, it seems to me, is pretty heroic.... and/or... hard core.

 

I remember reflecting recently that i doubted i could handle that.... unless

i had access to a supply of appetite suppressants.

(Most (all?) appetite suppressants, eg phentermine, are amphetamine based).

 

I wonder if RG is taking an appetite suppressant to help with that ?

It's a question, not an accusation.  :-)

 

On occasion, when the hunger is overpowering, I tend to turn to pterostilbene, about 200-300 mg. It works as well as anything to suppress the food obsession.

 

I just got my fasting blood tests back and will post those soon.

 

normalizing, I see how my paragraph may have been confusing. Actually, the points are related: fasting for a very long period of time in one session requires various means to cope with the hunger. Mindfulness meditation is probably the most effective, but it requires intense focus. Pterostilbene, lemon peels, and taking a nap are quick and moderately effective fixes. Sometimes, I just say to myself "Life is hard" then go on with my day and do other things unrelated to food.

 

[resveratrol_guy]

Moringa oleifera, a tree providing edible leaves, appears to protect against Alzheimer's disease as well as a long list of other ailments. Details here.

[normalizing]

resveratrol guy see you are doing this again. various random comments on a thread i started called "ngf spray". you way too often off topic on this thread about fasting and such.

 

and ill stay off topic just this once to tell you, i dont think taking any supplements like pterostilbene while you are fasting as a good idea. some studies show if you are doing fasting or calorie restriction and taking supplements like resveratrol or pterostilbene which are mimics of these states its actually detrimental to you. of course, go on high fat diet and take them, you are likely to benefit. anyway up to you, but main point is, stop directing my thread which is solely concentrated on ngf spray towards some fasting and lemon peel topics.

[resveratrol_guy]

I don't disagree that many comments here have been off topic, and many of those comments have been mine. What we need is a "miscellaneous ideas against dementia" thread or something like that. Most of these theories we have discussed are not backed by solid research, but they're not completely unfounded, either. There is no home for them. This thread is read by people interested in rebuilding their neural networks, so I don't think we are wasting time with such commentary. Having said that, if anyone wants to create a more appropriate thread, I'm happy to move such discussions there.

[LongLife]

Question: Has anyone tried DMSO with nasal spray NGF?

[resveratrol_guy]

Question: Has anyone tried DMSO with nasal spray NGF?

 

Perhaps I'm missing the point, but I don't suggest doing that. The olfactory bulbs are basically exposed special-purpose neurons. It's not like we're trying to get a substance to diffuse across the skin and into the blood. The biggest problem is just getting enough betaNGF to diffuse through the bulbs and into the brain. We can certainly deliver more of it intravenously, but then we're back to the diabetic neuropathy study with its pain enhancement problem.

[resveratrol_guy]

OMG! You have to see this, especially if you haven't experienced visions like those which I have described as being related to betaNGF and probably other factors that remain unclear. But before you click on the video below, allow me to explain what you're about to see.

As I've mentioned to you, I experience visions "more real than real". Sometimes they're so real that even though I'm awake and sitting at my desk, I flinch or duck to avoid getting hit by something, only to realize a split second later that nothing is present. I wished, beyond any realistic hope, that I could share this with anyone who wanted to experience it. Words are hopelessly inadequate.

Against all odds, there is a real (and I mean actually real) company developing "mixed reality" (MR) glasses. These are no video game goggles like you've ever seen. They do not immerse you in virtual reality. Nor are they augmented reality glasses like Google Glass which superimpose real world information on your field of view, for example, the name of the street in front of you.

What you're about to see, although obviously part real and part unreal, is exactly what you'll experience in a few years when Magic Leap releases their glasses. If you can imagine this video at razor sharp resolution, with sound so thundering that it shakes you in the chest, then I've succeeded in communicating to you.

 

In a few years, perhaps I'll finally be able to take you into the Maelstrom...
 

 

Edited by resveratrol_guy, 25 April 2016 - 05:08 AM.

[normalizing]

very relevant thanks

[normalizing]

^ his update was done in the ashitaba chalcone thread of his. from what i read, it seems NGF doesnt help him at all with intelligence and he makes stupid decisions, perhaps worst than before...

[Lsdium]

^ his update was done in the ashitaba chalcone thread of his. from what i read, it seems NGF doesnt help him at all with intelligence and he makes stupid decisions, perhaps worst than before...

 

Thanks, too bad the NGF didn't give him any benefits. Had some big hope about it, but i think i will just put this idea back on the shelf and wait and see if there will be any more report about NGF.

[resveratrol_guy]

If you all want to leave a link here pointing to another thread about 9/11 where you can continue the discussion, that's fine. But otherwise let's keep it related to NGF.

 

I do acknowledge that this is a big hammer which effects mood, perception, memory, and frankly all of cognition to some extent, but even in my own accounts of dreams, I do have a clinical point to make. In particular, I'm trying to provide a rough sense of how this stuff affects the brain, even if I'm unable to put it in chemical terms.

I also think it's time for some clarifications about my own experience.

I haven't taken betaNGF since I last mentioned it, several months ago. Initially, the reason was that I did not want to risk enhancing neurogenesis when I was (1) getting blasted by CT scans in preparation for surgery and (2) experiencing some pain as a result of the procedure. I literally had both my upper and lower jaws sawed off and moved forward. These are not the sort of circumstances under which one should seek an enhancement of sensory perception!

In addition, I wanted to spend some time trying ashitaba chalcone in the absence of betaNGF in order to compare the two. At this point, I think I have a good idea of their comparative effects. First of all, chalcone seems to hit a wide variety of systemic targets, some of which involving cancer suppression and blood pressure reduction, whereas betaNGF is a purely neurological molecule. Dose for dose, I would say that, betaNGF is substantially more effective on a neurological level. It remains to be seen, however, which is more economically efficient, especially since chalcone behaves like a variety of different supplements all in one. For example, I gave some powdered stems to a friend of mine, who has seen his blood pressure drop over the course of 2 months from 140-150 to 120-130, with no other lifestyle or diet changes which he could identify apart from a level tablespoon of the stuff dissolved in pomagranite juice daily.

Nevertheless, for a "quick hit" to improve mood, dream quality, sleep quality, visual processing, and (probably) visual memory, betaNGF rules. But we can't expect any single spike in neurogenesis to last forever. Neurons die everyday from exocitotoxicity and other causes. Remember, Rita used eye drops for many years on a regular basis. There is no doubt in my mind that if betaNGF is to be useful, it must be taken chronically -- not necessarily daily for life, but often enough to compensate for life's insults.

Before the rumors fly, it has not been a good couple of weeks for me. To blame this on the failure of 100 micrograms of betaNGF which I last took last autumn is quite a stretch, especially in light of the spike in Lumosity scores pursuant to initial dosing. As you can see, I made a couple of extremely stupid errors just recently, and plenty more privately: (1) I overdosed on chalcone and (2) I managed to misinterpret a rather straightforward study involving galantamine. Well, the background to this is that, sort of by luck, I ran out of honokiol, stopped taking MCT oil, ran out of eggs, ate lots of nuts, ingested some metal debris from a removed metal (not mercury) dental filling, and got whacked by some pollution insults within the same couple of weeks. It was a perfect storm for excitotoxicity, especially in the absence of honokiol. When I finally figured out what was going on, I rectified the situation such that I think I'm mostly back on track at this point. Which brings me to a larger point: betaNGF is only going to improve mood and upregulate neurogenesis. That's what the science clearly says, and nothing more. It's not going to protect you from pollution or provide you with proper neural nutrition. This can be clearly seen in Alzheimer's patients, many of whom actually have excessive NGF activation, yet whose new neurons divide into a toxic environment and suffer its effects. And to be sure, more neurons are meaningless without intensive training.

We can't just divide them willy nilly and expect to enhance cognition. Doing so haphazardly is just as likely to cause cancer as make us smarter. That's why cleaning out plaque and preventing its formation is so important. We could probably do just fine with half as many neurons if we could halt the protein misfolding chain reaction that occurs in Alzheimer's, Parkinson's, ALS, and mad cow disease. That's what makes Longvida, honokiol, nilotinib, tau vaccine, and other promising antiplaque compounds so important.

I have other experiments in the planning stages, but I'm not prepared to comment on them at the moment. Meanwhile, I welcome your comments about your own experiences and research involving NGF and related substances.
 

[YOLF]

Please take off topic discussions to an appropriate area of the forum.

[resveratrol_guy]

I just posted a detailed comparison of betaNGF and ashitaba chalcone effects with respect to excitotoxicity threats. Was this deleted because it was somehow perceived as irrelevant?

[YOLF]

Oops, looks like I went overboard. I didn't read everything, just scanned for strings of text related to the off topic discussion, probably went too fast unless I missed it this time. Your post is back.

[resveratrol_guy]

Oops, looks like I went overboard. I didn't read everything, just scanned for strings of text related to the off topic discussion, probably went too fast unless I missed it this time. Your post is back.

 

No worries, and thank you. You can delete our little exchange here, or leave it in the public record as evidence of how Longecity manages such matters, however you prefer.
 

[Nero]

what happened to this group buy