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[ta5]

There's something going on with Boron and NAD. Can someone explain this? If we want to boost NAD, should we avoid Boron? I admit, I don't understand the quote below, but the first sentence concerns me.

 

Rev Environ Contam Toxicol. 2013;225:57-75. 

Biological effects of boron.

Kabu M1, Akosman MS.

PMID: 23494556 | Full text

 

Borate also inhibited nicotinamide adenine dinucleotide (NAD) (Roush and Norris 1950; Strittmatter 1964; Deitrich 1967; Deal 1969). Moreover, it is known that the hydroxyl groups of NAD forms complexes with the borate compound (Johnson and Smith 1976). Boron having adjacent hydroxyl groups (transferases) has a tendency to form complexes with organic molecules. It may have an interaction with important biological substances, containing polysaccharides, pyridoxine, riboflavin, dehydroascorbic acid, and the pyridine nucleotides. (Samman et al. 1998; Deviran and Volpe 2003) It binds strongly to furanoid cis-diols, which include erythritan, ribose, and apiose; apiose is present throughout the cell walls of vascularplants (Loomis and Durst 1992; Hunt 2012).

 

Nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP) contain ribose components that are active in energy metabolism; binding to them affects certain metabolic pathway processes (Hunt 2012). Hunt (2012) reported that NAD+ is an essential cofactor for five sub-sub-classes of oxidoreductase enzymes and has a strong relevance for boron. The diadenosine-phosphates (ApnA) are structurally similar to NAD+. Compared to NAD+, boron binding by Ap4A, Ap5A, and Ap6A is greatly enhanced; however, the binding is still less than that to S-adenosylmethionine (SAM).

 

Thanks.

 

[niner]

It's kind of screwy to say that boron "inhibited" NAD.  You can inhibit an enzyme, but you can't inhibit a small molecule.  I think what they mean is that boron (B(OH)3) binds to NAD.  If that's the case, it might effectively take it out of service, or maybe not.  There's a lot of evidence that boron is essential and health-promoting, so it's not like you'd want to avoid it.  Maybe you don't want to megadose on it, but that's pretty much the case with everything.