So, as most of you know I've, along with many others, have been looking for a "great" nootropic. I've spent a whole deal of time and money looking for something that could actually noticeably improve my memory and word recall, mainly for school matters. I had high hopes for PRL; but, the research was based on one iffy paper from long ago. I also hoped ISRIB and IDRA-21 would be potent nootropics; but, they mostly turned out to be duds. They're research was based on rats and animals. So, with college coming up I decided to look at something that was actually tested on humans and had some hard science backing it up. I came across GTS-21 which is the only novel nootropic apart from the good 'ol Piracetam that has some very strong nootropic qualities. Attached is the pdf and I'll include a link here. I hope some people show interest in something that actually will work instead of chasing after large claims. Here is the paper online.
Scroll down to page 546 where it reads:
"The data in this study indicate a clear effect of GTS-21 over placebo on a range of cognitive functions. Table 6 summarizes the results of the ANOVA analysis of the cognitive data. For the primary analysis, statistically significant
effects of GTS-21 were observed for at least one measure of all three attention-related tasks (simple reaction time, choice reaction time and digit vigilance), two secondary episodic recognition memory tasks (word recognition
and picture recognition), and for the numeric working memory task. Additionally, both the visual tracking tasks and the immediate word recall task exhibited statistically significant improvements in performance fol- lowing dosing
with GTS-21. Tasks for which there were no effects on performance as indicated by the primary analysis were the spatial working memory task, the delayed word recall task, overnight face recognition task, and the Bond– Lader
self-ratings of mood and alertness. The secondary analysis confirmed the main effects of GTS-21 seen in the primary analysis (Figures 3–5) and, in addition, showed significant improvement for immediate and delayed word
recall (Figures 6 and 7) as well as one measure of spatial working memory."
Here are some graphs just to see visually how significant the gains were in word recall and other aspects of cognition:
The authors of the research paper write in conclusion:
"In conclusion, GTS-21 was well tolerated up to doses of 450 mg/day (150 mg t.i.d.) and shows improvements in cognitive behavior in normal subjects. The pharmacokinetics appear to be linear over the range of dose
studies and the variability, primarily intersubject, decrease with con- tinued dosing. The data provide important evidence that GTS-21 has the potential to improve human cognitive function. The range of the
effects is important, clear benefits being seen to three major cognitive functions (attention, working memory, episodic secondary memory). In addi- tion, there appears to be a relationship between the duration and
magnitude of exposure to GTS-21 and/or 4-OH-GTS-21 and the magnitude of effect, with doses between 75 and 150 mg t.i.d. approaching maximal effect. GTS-21 may represent a novel treatment for dementia, and should
be investigated further for its potential therapeutic effects in a variety of conditions in which cognitive function is compromised, not least of all Alzheimer’s disease."
Large emphasis on the "in normal subjects" as most nootropics discussed around here are based on improving cognition in people already below baseline; while this compounds improves cognition above baseline, which I think any real nootropic should do. Also, the added benefit of improved attention in correspondence with other similar compounds that are being made and geared towards AD(H)D is definitely an added benefit. Anyway, I don't mean to sound harsh; but, I don't really want to f*ck around with other nonsense compounds on which research was based on rats or monkeys when I have the chance to get a real nootropic that has already been tested on humans and has the data to back it up.
So, just wondering if any supplier would be willing to stock this awesome compound. And if possible a show of interest would be great in promoting this compound for not only obvious nootropic qualities; but, also the added benefit of treating positive symptoms of schizophrenia, ADHD, and cognitive decline (as it is prominently neuroprotective).
Thoughts?