17 replies to this topic

[VERITAS INCORRUPTUS]

JDTic as well as other agents that induce JNK activation may restore axonal neuropathy and neuronal polarity.

 

JNK activation is a potent activator of axonogenesis.  JNK is activated in a potent manner by JDTic.

http://flipper.diff....hways/info/5873 (A "Review":  JNK activation, axonogenesis, and related)

http://www.ncbi.nlm....pubmed/17702750 (JDTic (among other JNK activating KOR antagonists) activation of JNK)

"Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase."

 

Notably, JNK activation as per the above is responsible for the potent and long-acting disruption/corruption of KOR/KOR signalling.  This is shared by some other KOR antagonists, but not by all.

 

Notably, axonal damage(neuropathy) may be the main factor within the long-acting neurological damage that is relatively prevalent with MDMA usage, as well as a factor in other neurodegenerative states.

 

Edited by VERITAS INCORRUPTUS, 26 August 2014 - 06:58 PM.

[bocor]

any ideas on compounds or supplements that might upregulate JNK i have bad neuropathy and axonal damage thx

[StevesPetRat]

Have fun becoming an addict while on this stuff. Have to be better ways to encourage axonal growth.

Well, hell, if you're careful with it, maybe you could turn that bug into a feature...

Edited by StevesPetRat, 30 August 2014 - 10:35 AM.

[VERITAS INCORRUPTUS]

Have fun becoming an addict while on this stuff. Have to be better ways to encourage axonal growth.
 

 

Kindly allow me to correct you that JDTic and kappa antagonists have demonstrated just the opposite within having anti-addiction capacity.

 

http://www.ncbi.nlm....pubmed/16236279 (potential treatment for opiate abuse)

http://www.ncbi.nlm....pubmed/22515275 (against alcohol and withdrawal anxiety)

http://www.ncbi.nlm....pubmed/20232057 (smoking cessation)

http://www.ncbi.nlm....pubmed/16184376 (cocaine reinstatement)

http://alert.psychia...igning-new.html (counteraction of addictive drugs article)

 

Notable as well, the issues with VT have been seen entirely not present within proper administrative techniques as have been found in unpublished animal studies conducted.  For more information:

http://teamtlr.com/o...jdtic-2hcl.html

 

Within all this more research into this area and pathway as a whole seems both promising and warranted.

Edited by VERITAS INCORRUPTUS, 30 August 2014 - 04:03 PM.

[StevesPetRat]

So both agonists and certain antagonists can treat addiction? The brain is a damned mess...

[Logic]

I have invited Forty Six & 2 to this thread. 

He should have more info as well as product at a reasonable price.

[Forty Six & 2]

So both agonists and certain antagonists can treat addiction? The brain is a damned mess...

 

Actually the brain is a beyond amazing construct of extraordinarily complex and well-regulated systems, that indeed can be confusing to unravel within all the many aspects that afford the brain its ability to respond to stimulus in so many astoundingly complex manners.  The more we reveal, the more the brain reveals itself to be so profoundly intricately regulated.

 

One simple answer here that directly relates to your confusion within what appears to be paradoxical, is that a short-duration, potent agonist (salvinorin A) can cause subsequent downregulation of the KOR which can in some manner have an equivalent effect as to the receptor being inhibited by an antagonist.  The antagonist directly within its duration of antagonist occupancy (or in the case of JDTic a corruption of KOR via JNK) has the effect of disabling the receptor from the endogenous agonist dynorphin.

 

As well, though most all KOR agonists to date produce dysphoria and dissociation they do foster the upregulation of pathways that are corrupted by addictive behaviors/responses.

 

Here is something that may shed some light, though then again may further confound some, lol:

http://www.nature.co...pp2010137a.html

http://www.upf.edu/n...24_Jul_2012.pdf

 

There is much new science over the past several years in this and related areas, most of which is further revealing incredibly complex dynamics and interactions.  For those working to unravel the 'complex code' within, there appears fascinating, exciting, and groundbreaking things to come within deciphering it all.  We're working hard here to do just that.

Edited by Forty Six & 2, 30 August 2014 - 08:51 PM.

[Haray]

So both agonists and certain antagonists can treat addiction? The brain is a damned mess...

 

It sounds like it.

[Flex]

Just one of many compounds/herbs that promote Axonal repair.

Interrestingly, no one mentions the possible risks of using research chemicals..

Even 20 Year old antidepressants reveal new actions, which are sometimes good and sometimes not good.

 

Have fun to find the cause and the fitting compound if something went wrong with research chemicals

and then to reverse the additional actions of the antidote and so on...Do You get it ?

 

 

any ideas on compounds or supplements that might upregulate JNK i have bad neuropathy and axonal damage thx

 

Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells.

http://www.ncbi.nlm....pubmed/22490436

 

[Effects of Chinese herbal medicine Danzhi Jiangtang Capsule and exercise on JNK signaling pathway in pancreatic tissues of diabetic rats].

http://www.ncbi.nlm....pubmed/23158947

 

Edited by Flex, 01 September 2014 - 02:05 AM.

[VERITAS INCORRUPTUS]

Would you care to perhaps read over those two studies a little more thoroughly my friend.

 

I believe you will see you may be in error in one case, and within the other it is induction of ROS that is the mechanism which was inhibited by the addition of the antioxidant NAC.

Increase in ROS will induce JNK, as will other stressors, such as induction of diabetic conditions.

 

 

Effects of Chinese herbal medicine Danzhi Jiangtang Capsule and exercise on JNK signaling pathway in pancreatic tissues of diabetic rats.

Results:  In pancreatic tissues of diabetes group, the expression level of p-JNK protein was significantly higher than that in the normal group ... After administration of exercise and DJC, the expression level of p-JNK protein in pancreatic tissues of the diabetes group was decreased significantly,...

 

 

Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells

This is evidenced by the findings that CPT induced ROS in a concentration- and time-dependent manner; CPT induction of ROS was inhibited by N-acetyl-L-cysteine (NAC), a ROS scavenger; and NAC attenuated CPT activation of p38/JNK,

 

 

Edited by VERITAS INCORRUPTUS, 01 September 2014 - 06:41 PM.

[Flex]

Yes my bad.

Anyway, I hope at least that I´ve hereby intorduced the user bocor to ncbi

Edited by Flex, 01 September 2014 - 07:03 PM.

[bocor]

Danzhi jiangtang I'm trying to find out which herbs are used in this formula and where I can buy it? When I google it all I get is the study you posted much thx for info

[VERITAS INCORRUPTUS]

Better yet, just exercise vigorously.  

 

This is being mediated by ROS, so anything that which generates stress/ROS will do so.  Exercise is of course generally a eustress, if not done overtly excessively or compulsively.

As well, you would need to intentionally avoid antioxidants, just to be clear.

[Flex]

Danzhi jiangtang I'm trying to find out which herbs are used in this formula and where I can buy it? When I google it all I get is the study you posted much thx for info

 

Ok this one is surprisingly hard to find, usually I need a few minutes to find the ingredients of compositions.

Up till now, I´ve found this:

[Dan Zhi J iang Tang Nang Gan Yu Pu Tao Tang Nai Liang Di Jian Liao Xiao Guan Cha]

http://books.google....an Cha]&f=false

 

I believe this is the reciepment of the Herbs. If so then ( I guess) it has to be read as followed:

 Dan is from mou dan pi = Paeonia suffruticosa and so on.

 ZHI is from...

 

But (!) I guess I know why compounds or herbs arent checked for the action on JNK:

Activation of JNK leads to Cell death

Therefore a Parkinson medicament is researched which inhibits JNK

http://www.scienceda...30620111138.htm

But its good for cancer..

http://www.biomedcen...6882-13-233.pdf

http://en.wikipedia....erminal_kinases

 

This is one of the moments where You have to ask our self whether this (JNK) is the right target and maybe rethink Your hypothesis.

 

I´m right busy now so I cant check this from the bottom to the top.

I will post more tomorrow.

Edited by Flex, 01 September 2014 - 09:32 PM.

[VERITAS INCORRUPTUS]

It is not that simple, as most all within complex signalling pathways.  This sums it up well as to its role without getting into details that may be extraneous to the scope, though one can look further if so desired>

 

Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis.  Bioessays. 2003 Jan;25(1):17-24.

Ben May Institute for Cancer Research, The University of Chicago, 5841 S. Maryland Avenue, MC 6027, Chicago, Il 60637, USA. alin@huggins.bsd.uchicago.edu

Abstract: The JNK signaling pathway is involved in regulation of many cellular events, including growth control, transformation and programmed cell death (apoptosis). The role of JNK activation in apoptosis is highly controversial, being suggested to have a pro-apoptotic, anti-apoptotic or no role in this process. It appears that the JNK pathway functions in a cell-type and stimulus-dependent manner and its different components can sometimes play opposing roles in apoptosis. Recent studies reveal that the effect of JNK activation on apoptosis depends on the activity of other signaling pathways like the NF-kappaB pathway. Here we propose a model that can explain how activation of the JNK pathway "breaks the brake" on apoptosis, thereby regulating, but not initiating the apoptotic process.

 

 

http://www.ncbi.nlm....__ffn_sectitle 

Conclusion

An overview of apoptotic pathway indicates that JNK signaling is involved in the extrinsic apoptotic pathway initiated by death receptors as well as the intrinsic pathway initiated at the mitochondria. In response to both the extrinsic and intrinsic apoptotic stimuli, JNK plays an essential role through its ability to interact and modulate the activities of diverse pro- and anti-apoptotic proteins. Through the coordinated regulation of the nuclear- and mitochondrial events, JNK ensures the efficient execution of apoptosis. With the identification of primary apoptotic signaling nodes regulated by JNK, the finer details of JNK-signaling in apoptosis specifically in relation to other growth stimulating stimuli 

Edited by VERITAS INCORRUPTUS, 01 September 2014 - 09:53 PM.

[tritium]

Have you tried the JDTic yourself which you are selling?  If so, please let us know your personal effects from it.

[VERITAS INCORRUPTUS]

In various animal models of extreme stress conditions that members of TeamTLR have conducted research within JDTic demonstrated considerable efficacy.

These have included social defeat, learned helplessness, among others.  Psychoactive poly-drug withdrawal assays are slated for the near future.

 

A member of TeamTLR creates animal modeling and may be engaging to set up some unique modeling challenges within theories of complex challenges and integrative protocols with JDTic and other substances demonstrating high efficacy within current animal models.  We are looking to explore some concepts that have been worked on for the past few years, though it may be some time before such comes to any fruition..

[Flex]

Lionsmane is a jnk activator

http://www.longecity...ind-lions-mane/