Better You look out for something modulating i.e. that increase D2 mrna,than something that You have to use every day.
But since its genetically set, dont know.
You could try a MAO-B and/or MAO-A inhibitors. this works at least for me and "could" be safer than DRI.
The problem with 23andMe is that the result could distract from another problem.
This was IIRC the Reason why it was forbidden to diagnose Your results.
What if it turns out that You have a damaged dopamine system which is loosely related to the genetics ?
E.g. chronic stress is known to cause damage.
I would think about it.
I would advise You to stay away from Methylphenidate.
Prefrontal cortical and striatal transcriptional responses to the reinforcing effect of repeated methylphenidate treatment in the spontaneously hypertensive rat, animal model of attention-deficit/hyperactivity disorder (ADHD)
http://www.behaviora...content/10/1/17
Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice
http://www.plosone.o...al.pone.0033693
Anyway I could uptill now only find this:
Pukatein is a DRI and a Dopamine agonist.
If You have trouble to find the solely compound, look out for the Herb/ Herb extract.
Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission.
http://www.ncbi.nlm....pubmed/10211594
http://en.wikipedia.org/wiki/Pukateine
But I dont know nothing about Pukateine and DAWS ( dopamine agonist withdrawal syndrom) or anything.
Usually an increase in Dopamine means sometimes an icrease in oxidation, so damage.
Therefore use it on Your own risk.
Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia.
....Consistent with a D(2)-action, PGD did not affect PRL in rat pituitary lactotropic tumor-derived GH3 cells that lack the D(2) receptor expression but significantly increased the expression of D(2) receptors and dopamine transporters (DAT) in PC12 cells...
http://www.optimalrx..._1349155441.pdf
http://www.ncbi.nlm....pubmed/22796279
But if You look in the ingredients of this below, You´ll find vitamins, aminoacids &etc.
So either, simple compounds or a mixture of them are responsible for this and do work, or they are selling Snakeoil...
Natural Dopaminergic Activator Improves Outcomes of Addiction Recovery
SynaptaGenX will increase proliferation of D2 receptors, enhancing dopamine sensitivity and increasing the sense of happiness, particularly in carriers of DRD2 A1 allele.
http://www.holisticp...ction-recovery-
Edited by Flex, 31 August 2014 - 05:05 PM.