Next to the HGH + DHEA also very promising is the FOXN1 up regulation, see here and here which I would feel more comfortable with to try because of real HGH long term sides. But how? FOXN1 is a transcription factor which in mice, when isolated from young mice glands and then introduced in old, has been shown to stimulate the thymus regrowth, see here. Are there drugs being in trial?
See also Josh Mitteldorf's post:
"1. Thymus Regrowth with FOXN1
The thymus gland is a time bomb that would kill us at a certain age, if nothing else got us first. It shrinks (the medical word is “involution”) gradually through life, beginning in childhood and culminating in disastrous results in old age.
The thymus is a small gland located just behind the top of the breastbone. Among your white blood cells, your first-defense cells are the T-cells, named for their association with the thymus. The thymus is training ground for the T-cells, where they learn to distinguish friend from foe. The body has many types of cells, and the T-cells must not attack any of them; but they also must reliably identify invading microbes.
These immune functions are related to many aspects of health, and not just attacking invasive microbes. The immune system is continually eliminating errant, pre-cancerous cells before they can become cancers, as well as cells in the body that have been taken over by a viral infection. Rampant inflammation and auto-immune disorders are the consequence when the immune system begins to turn against self late in life.
As the thymus shrinks year by year, the immune system breaks down. A 90-year-old thymus may be one tenth the size it was in the bloom of childhood, and this goes a long way toward explaining the vulnerability of older people to viral infections that would not be serious for a young person. Arthritis is well-characterized as an auto-immune disease, but there are auto-immune aspects of other diseases including Alzheimer’s
There is good reason to think that if we can preserve or even regrow the shrinking thymus, then there will be benefits that echo through many or all the diseases of old age. Human growth hormone has been used with some success, but reactions to HGH vary, and there is reason to worry about its long-term effects. There is a recent breakthrough in treatment for the thymus that looks very promising. A transcription factor is a coded chemical signal capable of switching the expression of many genes at once, turning some on and others off in one sweep. FOXN1 is a transcription factor that has been isolated from the thymus of young mice, and by re-introducing it to old mice, a Scottish research team succeeded in consistently stimulating the thymus to regrow [ref]. The larger thymus looked and functioned much like the thymus of a young mouse.
The most glaring absence in the blood as we age is naive T-cells, cells that are not pre-trained to fight any specific infection from the past, but are primed to look out for new invaders. So it is most promising that the thymus glands regenerated with FOXN1 produced copious naive T cells.
In the Scottish experiments, mice were genetically engineered with extra copies of the FOXN1 gene that could be turned on with a drug as trigger. You and I don’t have these extra copies, so we need another means to get FOXN1 into our aging thymi. FOXN1 is not something we can take in a pill, because it is a large protein molecule that is routinely chopped up for recycling during digestion. A research group at University of Texas is injecting little snippets of DNA (called plasmids) containing the FOXN1 gene directly into the thymus with some success [ref]. Turning on the cell’s own FOXN1 gene would be ideal, and there are already candidates that can do this. There is no reason to doubt the feasibility of FOXN1 drugs, but for now we have only rumors that they are under development."
https://joshmitteldo...og.com/2014/11/
Edited by albedo, 01 March 2018 - 03:04 PM.
