130 replies to this topic

[Nate-2004]

It also bothers me that all study participants were active in the field of life extension, and their age was already pushed back at the beginning of the study.

However, it is unlikely that all 9 people took the same drugs, except for those that they needed for the study.

The likelihood that an unknown combination of drugs has affected is minimal.

 

Yeah it's time to repeat the study on older, average men AND women.

Edited by Nate-2004, 14 September 2019 - 04:01 PM.

[Kentavr]

Yeah it's time to repeat the study on older, average men AND women.

Nate, I am surprised how fast life extension technologies are developing.

Only 2 years ago there was a lot of incomprehensibility, but now there is even a choice!

1. In a few years, Senolytics will be officially available, and statistics will begin to be collected on a large number of patients.

2. After 5 years, it is planned to release a preparation based on SkQ1, which on mice shows a slowdown or stop of about 30 signs of aging.

3. ResTORbio will also launch its medicine

4. TAME research results will be available in a few years

5. For several years, the results of the TRIIM study will be refined.

And there are tocotrienols, peptides, NMN, "protocol Turnbuckle" etc.

...WOW!!!

Edited by Kentavr, 14 September 2019 - 04:45 PM.

[sthira]

I think these TRIIM trial results are really, really positive! And so I hope Fahy is able to obtain more funding now to broaden the scope.

Aren’t you glad he tested on healthy, aged people (who evidently already clocked in with lower epigentic markers...), rather than on sick people, or rodents? This alone is good news — to start experimental testing in people more often than rodents is what we all want to see happen.

I find this quote pretty cool (and alternative to Longo’s FMD work, which led me to believe periodically lowering IGF-1 is one goal as we age): “...Human longevity seems more consistently linked to insulin sensitivity than to IGF‐1 levels, and the effects of IGF‐1 on human longevity are confounded by its inverse proportionality to insulin sensitivity (Vitale, Pellegrino, Vollery, & Hofland, 2019). We therefore believe our approach of increasing GH/IGF‐1 for a limited time in the more natural context of elevated DHEA while maximizing insulin sensitivity is justified, particularly in view of the positive role of GH and IGF‐1 in immune maintenance, the role of immune maintenance in the retardation of aging (Fabris et al., 1988), and our present results....”

Increase it, then decrease it. Do this over and over again to potentially slow aging. I’ve assumed dropping chronic IGF-1 levels as we age is beneficial. Maybe change chronic dropping to acute, keep those levels rising and falling. Keep insulin mostly averaging low; obviously it must rise when we eat, but control the spikes... . Fasting periodically (>5 days, water-only or FMD) and doing it regularly — so benefits compound over time — is going to accomplish all sorts of benefits, even for the healthiest. My knee jerk response is to combine fasting with the growth hormone, DHEA and metformin, then blood test to see by how much is adding those compounds overdoing fasting by itself. Who knows, since we need more fasting studies in healthy humans...

I’m happy to see the thymus benefited in this trial, since that was the aim. Thymus regeneration seems like a huge advance forward.

[Kentavr]

I think these TRIIM trial results are really, really positive! And so I hope Fahy is able to obtain more funding now to broaden the scope.

Aren’t you glad he tested on healthy, aged people (who evidently already clocked in with lower epigentic markers...), rather than on sick people, or rodents? This alone is good news — to start experimental testing in people more often than rodents is what we all want to see happen.

I find this quote pretty cool (and alternative to Longo’s FMD work, which led me to believe periodically lowering IGF-1 is one goal as we age): “...Human longevity seems more consistently linked to insulin sensitivity than to IGF‐1 levels, and the effects of IGF‐1 on human longevity are confounded by its inverse proportionality to insulin sensitivity (Vitale, Pellegrino, Vollery, & Hofland, 2019). We therefore believe our approach of increasing GH/IGF‐1 for a limited time in the more natural context of elevated DHEA while maximizing insulin sensitivity is justified, particularly in view of the positive role of GH and IGF‐1 in immune maintenance, the role of immune maintenance in the retardation of aging (Fabris et al., 1988), and our present results....”

Increase it, then decrease it. Do this over and over again to potentially slow aging. I’ve assumed dropping chronic IGF-1 levels as we age is beneficial. Maybe change chronic dropping to acute, keep those levels rising and falling. Keep insulin mostly averaging low; obviously it must rise when we eat, but control the spikes... . Fasting periodically (>5 days, water-only or FMD) and doing it regularly — so benefits compound over time — is going to accomplish all sorts of benefits, even for the healthiest. My knee jerk response is to combine fasting with the growth hormone, DHEA and metformin, then blood test to see by how much is adding those compounds overdoing fasting by itself. Who knows, since we need more fasting studies in healthy humans...

I’m happy to see the thymus benefited in this trial, since that was the aim. Thymus regeneration seems like a huge advance forward.

Yes, thymus regeneration is a huge step forward!

By the way, instead of fasting for 5 days, you can use the FMD diet. Compliance with this diet provides a result comparable to fasting.

Fasting for 5 days without medical supervision is dangerous, as there is a risk of a strong drop in the level of potassium in the blood. Low potassium levels can lead to death.

Keep this in mind if you are engaged in fasting.

Edited by Kentavr, 14 September 2019 - 06:51 PM.

[Oakman]

Major features of immunosenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood

https://www.ncbi.nlm...les/PMC5847865/

 

Abstract

It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (55-79 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age-matched older adults and 55 young adults not involved in regular exercise. The frequency of naïve T cells and recent thymic emigrants (RTE) were both higher in cyclists compared with inactive elders, and RTE frequency in cyclists was no different to young adults. Compared with their less active counterparts, the cyclists had significantly higher serum levels of the thymoprotective cytokine IL-7 and lower IL-6, which promotes thymic atrophy. 

 

[Rocket]

Word of caution... Hgh can negatively impact prostate health and cause bph. People with gigantism are found to suffer from bph. There are studies out there on Hgh and the prostate. I suspect its the combination of hgh and androgen and estrogen, but there are no studies out there to reference. I would use finisteride or avodart along with hgh and anti estrogens when playing with hgh.

[sthira]

Word of caution... Hgh can negatively impact prostate health and cause bph. People with gigantism are found to suffer from bph. There are studies out there on Hgh and the prostate. I suspect its the combination of hgh and androgen and estrogen, but there are no studies out there to reference. I would use finisteride or avodart along with hgh and anti estrogens when playing with hgh.

“A primary concern in this study was whether increased levels of a mitogen (IGF‐1) might exacerbate cancerous or precancerous foci in the prostate. Both of these changes should be detectable by measuring PSA or percent free PSA levels. However, PSA, percent free PSA, and the ratio of PSA to percent free PSA, an overall index of prostate cancer risk, improved significantly by day 15 of treatment and remained favorably altered to the end of 12 months (Figure 1a–c). A brief spike in PSA at 6 months in two volunteers was rapidly reversed and, after volunteer consultation, was interpreted as reflecting sexual activity close to the time of PSA testing. No change in testosterone levels was observed...”

[Kentavr]

“A primary concern in this study was whether increased levels of a mitogen (IGF‐1) might exacerbate cancerous or precancerous foci in the prostate. Both of these changes should be detectable by measuring PSA or percent free PSA levels. However, PSA, percent free PSA, and the ratio of PSA to percent free PSA, an overall index of prostate cancer risk, improved significantly by day 15 of treatment and remained favorably altered to the end of 12 months (Figure 1a–c). A brief spike in PSA at 6 months in two volunteers was rapidly reversed and, after volunteer consultation, was interpreted as reflecting sexual activity close to the time of PSA testing. No change in testosterone levels was observed...”

Yes, in fact, after using these drugs:

There is a decrease in the number of CD38-positive monocytes (which means that the synthesis of NMN is increased, which is the precursor of NAD +, which in turn activates sirtuins and is used in DNA repair)

The number of PD-1 positive cells that cancer uses to hide from the immune system is decreasing.

TRIIM is also a powerful cancer prevention.

[Rocket]

“A primary concern in this study was whether increased levels of a mitogen (IGF‐1) might exacerbate cancerous or precancerous foci in the prostate. Both of these changes should be detectable by measuring PSA or percent free PSA levels. However, PSA, percent free PSA, and the ratio of PSA to percent free PSA, an overall index of prostate cancer risk, improved significantly by day 15 of treatment and remained favorably altered to the end of 12 months (Figure 1a–c). A brief spike in PSA at 6 months in two volunteers was rapidly reversed and, after volunteer consultation, was interpreted as reflecting sexual activity close to the time of PSA testing. No change in testosterone levels was observed...”

 

I am not referencing the cancer studies at all I am merely talking about run of the mill BPH. Growth hormone can and has caused it. There are studies out there. Why do people confuse bph with cancer? I am not talking about cancer. BPH. There are studies. I've read them.  As i stated above, people with gigantism suffer from BPH from the never ending cascade of HGH their bodies get. They should probably put those people on Finisteride or Avodart as a preventative measure.

 

Everyone needs to be cautious when experimenting with their bodies HGH levels. Take the precautions to avoid BPH: an AI blocker, finsteride or Avodart.

Edited by Rocket, 15 September 2019 - 03:02 PM.

[Rocket]

My own levels using hgh or a ghrp without an estrogen blocker or dht inhibitor when from 1.0 to 1.5. I know it was the gh because it was the only the only thing I was taking besides c60 and supplements. That is in my pre and post blood work.

I would like to expand on the protections people (men only) need to take as I forgot one.

Prami or caber for prolactin. Proloactin is a hormone that acts on the prostate much like how it grows breast tissue.
Arimidex or nolvadex
Finisteride or avodart
(I left out dhea for insulin)

Wonder why bodybuilders don't get prostate issues like bph? They control their estrogen and prolactin when using hgh stacked with test and deca. Or when they run test with a dht type drug like winy or masteron? They control estrogen as there is no proloactin from not taking deca. Controlling the estrogen while flooding the body with dht derivatives seems prostate protective.

Hgh is WONDERFUL! Not very anabolic at all. But awesome body effects like healing injuries as you get older.

But factually speaking, hgh by itself will or maybe its precise to say it can grow the prostate if precautions are not taken.

The hgh decline in adulthood seems prostate protective at the expense of weakening the body and making it frail.

Edited by Rocket, 16 September 2019 - 12:27 AM.

[JamesPaul]

Some info on BPH is here:

 

“An Integrative Approach to an Enlarged Prostate and Lower Urinary Tract Symptoms,” by Geo Espinosa, ND, LAc, IFMCP, CNS

https://www.townsend...ative-approach/

Edited by JamesPaul, 02 May 2022 - 04:21 AM.