2 replies to this topic

[Logic]

"...telomerase sits poised as a “preassembly” complex, missing a critical molecular subunit. But when the genome has been fully duplicated, the missing subunit joins its companions to form a complete, fully active telomerase complex, at which point telomerase can replenish the ends of eroding chromosomes...immediately after the full telomerase complex has been assembled, it rapidly disassembles to form an inactive “disassembly” complex..."
http://www.salk.edu/...p?press_id=2052

Regulated assembly and disassembly of the yeast telomerase quaternary complex
http://genesdev.cshl...56.114.abstract


This paper seems related to the above, but I am heading out of my depth here.

Involvement of 14-3-3 proteins in nuclear localization of telomerase
http://www.ncbi.nlm....cles/PMC212742/

Now; what the hell are telomerase activators actually doing?

 

[niner]

 

Now; what the hell are telomerase activators actually doing?

 

And what is happening in a cancer cell where telomerase is constitutively active?

[Logic]

Now; what the hell are telomerase activators actually doing?

 
And what is happening in a cancer cell where telomerase is constitutively active?

Yep..?

I also wonder about the effect of C60oo if telomerase are protecting and/or weeding out dysfunctional mitochondria and perhaps cells???

These posts discuss this, but were made before this knowledge was known.
Maybe I should invite the contributors here.

http://www.longecity...ing-telomerase/
http://www.longecity...ndpost&p=115053
http://www.longecity...rase-apocrypha/
https://www.fightagi...dysfunction.php

(Anyone know who Guest is?)

Edited by Logic, 23 September 2014 - 02:04 PM.