14 replies to this topic

[Raptor87]

Talalay and his team treated 40 autistic boys and men with autism over 18 weeks.  Twenty-six of them took pills with sulforaphane, a broccoli sprout extract, and the rest received a placebo.

Study authors found that patients who took sulforaphane improved. Almost half of the patients treated with sulforaphane had “much improved” or “very much improved” social interaction and verbal communication, and more than half exhibited less aberrant behavior. When the patients stopped taking the extract, they returned to baseline levels for these symptoms within four weeks.

 

 

http://abcnews.go.co...utism-symptoms/

 

Has anyone really tested this stuff? I'm thinking of trying it but at what dosages and which brand exactly?

 

Any recommendations?

[lostfalco]

In this study they gave human subjects 68g.  http://www.ncbi.nlm....les/PMC2267876/

 

"In human subjects, a single dose of 68 g BroccoSprouts inhibited HDAC activity significantly in peripheral blood mononuclear cells (PBMC) 3 and 6 hrs following consumption. These findings provide evidence that one mechanism through which SFN acts as a cancer chemopreventive agent in vivo is through the inhibition of HDAC activity."

 

Here is the Johns Hopkins tested product.   http://www.broccosprouts.com

[lostfalco]

The autism study used 9 to 27 mg sulforaphane daily. 

 

"Twenty-six of the subjects were randomly selected to receive, based on their weight, 9 to 27 milligrams of sulforaphane daily, and 14 received placebos. Behavioral assessments were again completed at four, 10 and 18 weeks while treatment continued. A final assessment was completed for most of the participants four weeks after the treatment had stopped."

 

http://www.scienceda...41013152608.htm

 

This is a fascinating proposed mechanism of action. Nice find, Brainfogged!

 

"In addition, the chemical (sulforaphane) later turned out to improve the body's heat-shock response -- a cascade of events used to protect cells from the stress caused by high temperatures, including those experienced when people have fever."

 

"Intriguingly, he says, about one-half of parents report that their children's autistic behavior improves noticeably when they have a fever, then reverts back when the fever is gone."

 

"Because fevers, like sulforaphane, initiate the body's heat-shock response, Zimmerman and Talalay wondered if sulforaphane could cause the same temporary improvement in autism that fevers do. The current study was designed to find out."

 

Edited by lostfalco, 14 October 2014 - 05:20 AM.

[Monostereo]

The autism study reports, "The participants were dosed according to body weight: 50 μmol (one capsule) of sulforaphane for <100 lb, 100 μmol (two capsules) for 101–199 lb, and 150 μmol (three capsules) for >200 lb." Is 9-27mg an accurate conversion from μmol? It seems like a particularly low dose. OTC Sulforaphane/Broccoli Sprouts on Amazon are 500mg divided into 2 pills. If I understand correctly, it isn't a simple calculation.... you need to know atomic weights of the substance you are converting or something. Obviously, I'm not a chemist
 

http://www.pnas.org/...1.full.pdf html

Interestingly, the cancer study used 68g, which would indicate that sulforaphane is very well tolerated by the body. http://www.ncbi.nlm....les/PMC2267876/

However, this reporting on the current autism study warns, "He also cautioned against taking sulforaphane until more is known about possible side effects. Some study participants showed a small increase in liver enzymes, a sign sulforaphane might cause liver inflammation. He noted the lack of safety data and less-rigorous testing of nutritional supplements. The supplement used in the study isn’t available over-the-counter."

http://www.washingto...tism-treatment/

Also, lol, "An unexpected side effect among those who took the supplement was significant weight gain. Less surprisingly, they also experienced more flatulence."

 

On the more serious side, I've read that either one or two people in the study had a seizure, though both participants have had a history of seizures, so its unclear whether the sulforaphane was to blame.

On a side note, there is some speculation that Autism and Chronic Fatigue/Fibromyalgia are related. Perhaps sulforaphane would work for CFS/ME too?

 

http://www.psycholog...nd-fibromyalgia

 

http://phoenixrising...rome-and-autism

Anyway, back to my original question, does anyone know how to convert Sulforaphane μmol to mg to see if the 9-27mg that is being reported is correct?

 

[Flex]

I couldnt find anything how Sulforaphane aids autism.

 

According to this paper

http://www.fasebj.or...785fje.full.pdf

a Sulforaphane metabolite is responsible for HDAC inhibition and it inhibits just HDAC2 (not group II)

Perhaps its Nrf2 altering effect could be also taken in account

http://en.wikipedia.org/wiki/NFE2L2

But this does Gardenia Jasminoides too

http://www.researchg...bellar_ataxia_3

 

Nevertheless Sulforaphane penetrates the BBB

http://www.ncbi.nlm....pubmed/19515491

http://examine.com/s...s/Sulforaphane/

So it could be related to HDAC2

 

Btw does anybody know some herbal, OTC or medicinal related HDAC inhibitor apart from valproic acid, Curcumin and vorinostat, especially group 2 HDAC´s ?

 

 

 

 

[Monostereo]

I don't know if the math is legit or not, but here's one answer on how to convert umol to g:

 

"Trials used between 50 and 150 micromoles of Sulforaphane. Rather unhelpfully they do not equate this to a measure accessible to lay people. If you recall your high school chemistry just go to Wikipedia and look up Sulforaphane:

 

Molecular formula

C₆H₁₁NOS₂

Molar mass

177.29 g/mol

 

To convert to grams you just multiply by 177.29. So the trials used dosages between 8.8 mg and 26.6 mg of sulforaphane."

 

http://epiphanyasd.b...t=1414515611560

[Kalliste]

I try to eat broccoli as often as possible. I'm sure there is more to it than sulfopharane. I recall that some group was trying to create broccolisprouts that contain more sulfopharane. Wonder how that is coming along.

[Raptor87]

Sulforaphane is enzyme dependent.

 

http://www.tandfonli...95#.VGMJL8lWVhc

http://www.medicalne...cles/215179.php

Edited by Leapmind, 12 November 2014 - 07:16 AM.

[PWAIN]

I just wish Sulforaphane wasn't so expensive!!!

[Monostereo]

In the US its pretty cheap. Not sure about Australia. But if we go by the dose in the latest study, 8-26mg a day, and take into account that most OTC Sulforaphane is around 400mg a pill… then one pill broken down could provide dose enough for 2-6 weeks. Thinking about it that way, a single bottle could last for years

[ShadowFox]

On eBay I found "60x Broccoli Extract 500mg Standardized to 30mg Sulforaphane Glucosinolates") whatever that means) for 26 pound sterling.

 

In the US its pretty cheap. Not sure about Australia. But if we go by the dose in the latest study, 8-26mg a day, and take into account that most OTC Sulforaphane is around 400mg a pill… then one pill broken down could provide dose enough for 2-6 weeks. Thinking about it that way, a single bottle could last for years

 

I only managed to find ones with mcg as in micrograms. :o

Edited by ShadowFox, 12 November 2014 - 05:40 PM.

[PWAIN]

Can you post any links to sources with 400mg per tablet? Not just the extract. I would jump at such an opportunity.
Edit typo.

In the US its pretty cheap. Not sure about Australia. But if we go by the dose in the latest study, 8-26mg a day, and take into account that most OTC Sulforaphane is around 400mg a pill… then one pill broken down could provide dose enough for 2-6 weeks. Thinking about it that way, a single bottle could last for years

Edited by PWAIN, 12 November 2014 - 07:52 PM.

[Monostereo]

The Amazon site in the US has several options: http://www.amazon.co...ds=sulforaphane

[ShadowFox]

The Amazon site in the US has several options: http://www.amazon.co...ds=sulforaphane

 

I checked several of those and they all vere either in micrograms or the same type of extract I listed above.

[Monostereo]

Ah, lol. If I hadn't made it clear before, math and attention to detail aren't my strong suits. Yep, you're absolutely right.