821 replies to this topic

[Forty Six & 2]

Many peptides, especially very short chain simple peptides such as GHK, indeed are relatively highly stable.  

 

I would think we may be doing a next batch to be stocked in ~4-6 weeks.  If the last couple of available lots become sold, we may as such place the item as a designated pre-order status and note the anticipated lead time as such.

 

 

[johnross47]

 

Very interesting substance. I suffer from a few health issues that might, in my unscientific opinion, share a common feature of collagen problems: contractures in both hands, a leaky heart valve and a badly stretched bladder that requires self catheterisation. If it was available I would jump at the chance of trying it.

 

have you been tested for ehlers danlos syndrome ?

 

I'd never even heard of it, but I've looked it up and don't think it's likely. Thanks for the suggestion.

[smithx]

I'm still willing to do an analysis, but someone has to send me the sample. I'm not willing to pay for it in advance myself. 

 

[smccomas01]

I have been doing so reading comparing sublingual versus Intra-nasal from what I have read intra-nasal seems to be more efficient for B12 versus sublingual. The question is would the be the same with GHK?

 

Source on the B12 http://www.greatplai...ome/eng/b12.pdf

 

 

[Logic]

I'm still willing to do an analysis, but someone has to send me the sample. I'm not willing to pay for it in advance myself.

I thought this was done and dusted?
How do we know that your sample is the same as what everyone else is getting if its shipped to you FOC??

 

 

[smithx]

Very true, so someone would have to purchase more than they need and then send me some of theirs to test. 

 

 

 

I'm still willing to do an analysis, but someone has to send me the sample. I'm not willing to pay for it in advance myself.

I thought this was done and dusted?
How do we know that your sample is the same as what everyone else is getting if its shipped to you FOC??

 

 

[Logic]

 

Very true, so someone would have to purchase more than they need and then send me some of theirs to test. 

 

 

 

I'm still willing to do an analysis, but someone has to send me the sample. I'm not willing to pay for it in advance myself.

I thought this was done and dusted?
How do we know that your sample is the same as what everyone else is getting if its shipped to you FOC??

 

 

 

So you are willing to do the testing FOC now??
 

[tepol]

I'm still willing to do an analysis, but someone has to send me the sample. I'm not willing to pay for it in advance myself. 

 

where are you ?

[david ellis]

Quick question - what effect would GHK have on genetic diseases ( specifically connective tissue ones like EDS ) , any ideas or rough guesses  ?

 

 

Tepol, I have a rough guess.  I am no kind of expert, I was in a college biology class two years ago, and we spent maybe two weeks on DNA and genetics.  I haven't read any thing yet, about GHK repairing genetic diseases.   GHK's renewal action is a result of GHK loosening the histones that bind DNA into the chromatin.   Unbound, the DNA is free to be expressed.  Without GHK, the histones become tightly bound to the  and DNA is not released.    It doesn't seem to me that GHK can fix errors in the DNA.

 

When I was younger my GHK was strong enough to open the slightly bound DNA and allow the expression of regenerative properties. Now,  I am a lot older, I don't know what will happen, many genes are probably very tightly bound.  I am afraid that a lot of them will need something stronger than GHK to unbind them.   I am worried that the sequence of gene activation could disrupt metabolism.  Gene activation could be too soon, or too late or never happen.     The only bright spot is that our hormone systems are not very fussy about an exact level.   Maybe this gene expression sequence is not supercritical.  I have hyperaldosteronism, and it took doctors 35 years to diagnose, so maybe I can skate out of this too.  (If I decide to commit)

 

About what testing I shall do, I have a plan.   My dog Molly was born black.  Her mother was white, the father was black.  They are poodles, so the dogs are all one solid color.   Molly's color genes changed their expression from black dominance to a black/white mix at 2-3 years old.   She became a charcoal color.  She is charcoal most everywhere but her face.  Her face is white because of her age. The places where boils erupted are a solid black.   Injury, I believe reactivates the dominance of black at those spots.   GHK, if it works,   should reactivate her original color, and maybe her face too.

 

 ( I will be disappointed if there is not a significant change in 4(?) weeks)

[tepol]

 

Quick question - what effect would GHK have on genetic diseases ( specifically connective tissue ones like EDS ) , any ideas or rough guesses  ?

 

 

Tepol, I have a rough guess.  I am no kind of expert, I was in a college biology class two years ago, and we spent maybe two weeks on DNA and genetics.  I haven't read any thing yet, about GHK repairing genetic diseases.   GHK's renewal action is a result of GHK loosening the histones that bind DNA into the chromatin.   Unbound, the DNA is free to be expressed.  Without GHK, the histones become tightly bound to the  and DNA is not released.    It doesn't seem to me that GHK can fix errors in the DNA.

 

When I was younger my GHK was strong enough to open the slightly bound DNA and allow the expression of regenerative properties. Now,  I am a lot older, I don't know what will happen, many genes are probably very tightly bound.  I am afraid that a lot of them will need something stronger than GHK to unbind them.   I am worried that the sequence of gene activation could disrupt metabolism.  Gene activation could be too soon, or too late or never happen.     The only bright spot is that our hormone systems are not very fussy about an exact level.   Maybe this gene expression sequence is not supercritical.  I have hyperaldosteronism, and it took doctors 35 years to diagnose, so maybe I can skate out of this too.  (If I decide to commit)

 

About what testing I shall do, I have a plan.   My dog Molly was born black.  Her mother was white, the father was black.  They are poodles, so the dogs are all one solid color.   Molly's color genes changed their expression from black dominance to a black/white mix at 2-3 years old.   She became a charcoal color.  She is charcoal most everywhere but her face.  Her face is white because of her age. The places where boils erupted are a solid black.   Injury, I believe reactivates the dominance of black at those spots.   GHK, if it works,   should reactivate her original color, and maybe her face too.

 

 ( I will be disappointed if there is not a significant change in 4(?) weeks)

 

 

Very interesting , but couldnt something like Heterochromia be responsible for the colour change too ?

 

 

Edited by tepol, 23 February 2015 - 07:43 PM.

[resting]

Just to say I have some on its way.

[smithx]

I am still willing to do testing, with the following provisos: 

 

- I need 1 gm for myself and 100mg for testing

- the componds should be provided in the sealed containers provided by the manufacturer

- the test performed will be LCMS

- I will provide raw results which people here can interpret. We do not have a known spectrum for the GHK so the test may or may not be diagnostic

- If we want a really good test, I need to get a separate known-good sample of GHK, probably from GenScript or another known-reliable manufacturer. This will allow us to get baseline data which we can then compare with our unknown. 

 

 

 

 

 

Very true, so someone would have to purchase more than they need and then send me some of theirs to test. 

 

 

 

I'm still willing to do an analysis, but someone has to send me the sample. I'm not willing to pay for it in advance myself.

I thought this was done and dusted?
How do we know that your sample is the same as what everyone else is getting if its shipped to you FOC??

 

 

 

So you are willing to do the testing FOC now??
 

 

 

[lifescience]

We (www.activepeptide.com) would like to provide 1.1 gram free sample(GHK-Cu 2:1) for test purpose, we can also provide LC method and our MS test result if you need it.

Please give me your address. Thanks.

 

I am still willing to do testing, with the following provisos: 

 

- I need 1 gm for myself and 100mg for testing

- the componds should be provided in the sealed containers provided by the manufacturer

- the test performed will be LCMS

- I will provide raw results which people here can interpret. We do not have a known spectrum for the GHK so the test may or may not be diagnostic

- If we want a really good test, I need to get a separate known-good sample of GHK, probably from GenScript or another known-reliable manufacturer. This will allow us to get baseline data which we can then compare with our unknown. 

 

 

[Logic]

We (www.activepeptide.com) would like to provide 1.1 gram free sample(GHK-Cu 2:1) for test purpose, we can also provide LC method and our MS test result if you need it.
Please give me your address. Thanks.

Are you saying that you are willing to provide a sample that TLR's sample can be tested against?
ie: That your sample should be considered the 'known-good sample to compare to the unknown' sample, on par with a 'highly reliable source such as GenScript in order to verify' TLR's unknown sample?
http://www.longecity...ndpost&p=709264

Or do you simply want to get your stuff tested by a trusted person on this forum Lifescience?

Smithx:
I and everyone else, I assume, was under the impression that you were going to order GHK/GHK-Cu, do the tests, and then get a refund from TLR?

I have re-read your posts and at no point do you raise any objection to this suggestion by TLR here:
http://www.longecity...ndpost&p=709813

Its too late to put in a order now as TR could now guess that the order would be destined to you?

I don't know about everyone else, but I am little disappointed that you did not raise any objections to this plan, as I saw it, when it was initially raised?

Someone who has ordered a large amount may be willing to send you some, but I doubt they would be willing to send you your prerequisite 1.1 grams FOC?
I hope someone will be so generous, but even then there is still no 'known good' sample or data to compare to in the possession of the testers?
 
I think TLR will be willing to send you a sample FOC, but then we have to trust that yours is the same as everyone else's.
Thought everyone?

At least we might get some info on contaminants without a 'known good' sample for comparison.

Edited by Logic, 24 February 2015 - 05:42 PM.

[pure]

How do you know that Lifescience is not the actual supplier of GHK to TLR, and this is not just a covert attempt to have the product supplied also accepted as the reference standard so that all seems kosher if the product supplied is tested.
You don't know.
You have to trust the word of someone who says they have been dealing with their supplier of GHK for years, but who didn't know about Chinese New Year and the fact that all of China shuts down over that period, and particularly they were caught unawares that their own supplier also closed down during the CNY period.
If they had indeed been dealing with their supplier for years as claimed, surely they would remember CNY last year?

[Logic]

How do you know that Lifescience is not the actual supplier of GHK to TLR, and this is not just a covert attempt to have the product supplied also accepted as the reference standard so that all seems kosher if the product supplied is tested.
You don't know.
You have to trust the word of someone who says they have been dealing with their supplier of GHK for years, but who didn't know about Chinese New Year and the fact that all of China shuts down over that period, and particularly they were caught unawares that their own supplier also closed down during the CNY period.
If they had indeed been dealing with their supplier for years as claimed, surely they would remember CNY last year?

Quite simply by the fact that no-one is going to accept LifeScience's sample as the reference sample.
I think he would just like to get his stuff tested at the same time.
The problem he faces is that no one would then know if his sample would be the same as what he sells...

As I understood it lyophilisation was delayed due to the Mannitol issue you brought up.
The Chinese close down for their new year in much the same way as the western world does for theirs.
ie: Different business close at different times as and when they see fit.
So while hopeful to get everything done before one link in the chain took a holiday; luck was not on our side.

As I said: Shit happens. It is in fact happening right here and now!
The question you need to ask yourself is: Where does everyone think its coming from!?

[Logic]

I found this skincare thread interesting and relevant:
http://eskinstore.co...sp?TOPIC_ID=103

[smithx]

Sorry for any misunderstanding. It was suggested that I should order it myself, but it wasn't clear how I would be reimbursed or by whom. Another alternative would have been for people to send me sufficient funds via PayPal to make the purchase.

 

One possibility would be for someone who already ordered to send me their order and then for them to get funds via Paypal to order more for themselves. That way I would get a random sample from someone known to the forum. The potential flaw in this would be if that person was not actually trustworthy and sent something else instead.

 

 

Edited by smithx, 24 February 2015 - 10:40 PM.

[Heisenburger]

You can have one of my vials. I’ll even pay the postage. You’ll know exactly who I am from the return address on the parcel. I’m the only person on Facebook with my name, so it will be easy for you to clearly identify me and determine whether or not I have a vested interest in the results (which I don’t).

[pure]

But now the supplier would know which user to send the 'good gear' to

[smithx]

I think Heisenburger's offer is a good one, particularly if we were to accept it and he were to send the sample tomorrow. In that case unless he happened to have a known-good sample from another source handy, we could be assured he was really sending the correct one.  

[Heisenburger]

Unfortunately, like everybody else, I'm still waiting for the product. But since everybody will probably gets theirs at pretty much the same time, we can compare notes on arrival dates and I'll send mine out the next day.

[Logic]

Sorry for any misunderstanding. It was suggested that I should order it myself, but it wasn't clear how I would be reimbursed or by whom. Another alternative would have been for people to send me sufficient funds via PayPal to make the purchase.

 

One possibility would be for someone who already ordered to send me their order and then for them to get funds via Paypal to order more for themselves. That way I would get a random sample from someone known to the forum. The potential flaw in this would be if that person was not actually trustworthy and sent something else instead.

 

Good plan SmithX and you aren't the only one thinking along those lines, (I have received a PM from an 'anonomous' person) so I expect you will get a gram of GHK/GHK-Cu soon... 

I don't know if TLR know who's nic goes with who's real name but if they do; I'm afraid you're out Heisenburger .  Thx for the kind gesture though.  Much appreciated. 

 

Anyways, SmithX wants and deserves a full gram for his trouble.

Please do not post offers to send SmithX samples here:  we want to keep the batch he gets 'anonymous'...

PM me.  

Edited by Logic, 24 February 2015 - 11:43 PM.

[Forty Six & 2]

Kindly note, we (TeamTLR) were clear we would support the process with the material to be tested to be afforded gratis, within affording replacement of a lot of 10 x 100mg that would be anonymously ordered by "smithx".  As such, whoever sends smithx the material, will once such is confirmed who such is by smithx, be sent a free replacement lot of 10 x 100mg. 

 

To note, there was a handful of people who ordered more than 1 x 10 100mg vial lot.  Hopefully one of those fine individuals will contribute to this endeavor, which I am quite certain will happen soon enough as there are many herein who are obviously quite supportive of making for the best process.
 

Best,

Forty Six & 2

TeamTLR

Edited by Forty Six & 2, 25 February 2015 - 12:03 AM.

[lifescience]

You are right, Logic, we can provide samples that Smithx can compare with. We are manufacture of GHK-Cu 1:1, 2:1 and GHK without copper, so we know their analytic method well.

 

I know that the group buy is from TLR,  it doesn't matter Smithx need samples from activepeptide.com or not, I just hope our sample and analytic method can help. Even though we do not have the standard of GHK, we can still compare different samples to see their purity and content.

 

 

 

 

We (www.activepeptide.com) would like to provide 1.1 gram free sample(GHK-Cu 2:1) for test purpose, we can also provide LC method and our MS test result if you need it.
Please give me your address. Thanks.

Are you saying that you are willing to provide a sample that TLR's sample can be tested against?
ie: That your sample should be considered the 'known-good sample to compare to the unknown' sample, on par with a 'highly reliable source such as GenScript in order to verify' TLR's unknown sample?
http://www.longecity...ndpost&p=709264

Or do you simply want to get your stuff tested by a trusted person on this forum Lifescience?

 

 

[Logic]

You are right, Logic, we can provide samples that Smithx can compare with. We are manufacture of GHK-Cu 1:1, 2:1 and GHK without copper, so we know their analytic method well.
 
I know that the group buy is from TLR,  it doesn't matter Smithx need samples from activepeptide.com or not, I just hope our sample and analytic method can help. Even though we do not have the standard of GHK, we can still compare different samples to see their purity and content.

Your sample will not be accepted a known good sample Lifescience, as you are an unknown manufacturer to us, whereas GenScript is already held in very high regard by this community.

Also, as you know the sample is going to be tested; no-one can be sure that the sample you supply for testing is the same as what people will get when ordering from you... Hence the plan to test a random sample from TLR.

Your sample may provide an interesting counterpoint to the sample from TLR?
I don't know whether SmithX is prepared to carry the cost of the extra testing?
You would have to ask him.
 
Would you be so kind as to expand on the 'analytic method' and how it may of assistance in the testing of GHK/GHK-Cu?

Edited by Logic, 25 February 2015 - 05:50 PM.

[smithx]

I do have to pay for these tests, so would rather not do too many of them. If TLR would like to supply a suggested method, I can forward that to the technician who will be doing the test. 

[niner]

I do have to pay for these tests, so would rather not do too many of them. If TLR would like to supply a suggested method, I can forward that to the technician who will be doing the test. 

 

Are you at least getting a deal on the tests?  Commercial rates can be pretty brutal.  I'm not sure exactly what the best method would be here, but if you used LC/MS, then you should be able to at least tell if you have the right parent ion mass.   You can still have a wrong structure with the right mass, but you can't have the right structure with the wrong mass.  The LC alone will give you a pretty good idea of purity, but not of identity.

[lifescience]

No problem at all,  we used to supply kilograms GHK-Cu to our customers.  let me know if we can help more.   I'd like to post our GHK-Cu 2:1 LC spectra for reference. It need to mention that the first peak is Cu ion, the second peak is GHK, the other samll peaks are also exist in blank sample.

Your sample will not be accepted a known good sample Lifescience, as you are an unknown manufacturer to us, whereas GenScript is already held in very high regard by this community.

Also, as you know the sample is going to be tested; no-one can be sure that the sample you supply for testing is the same as what people will get when ordering from you... Hence the plan to test a random sample from TLR.

Your sample may provide an interesting counterpoint to the sample from TLR?
I don't know whether SmithX is prepared to carry the cost of the extra testing?
You would have to ask him.
 
Would you be so kind as to expand on the 'analytic method' and how it may of assistance in the testing of GHK/GHK-Cu?

 

 

 

Attached Files

•  GHK-Cu 2-1.png   13.53KB   7 downloads

[smithx]

Yes, I have a hookup. The test will be done by a dedicated analytical laboratory at a major university.

 

 

 

I do have to pay for these tests, so would rather not do too many of them. If TLR would like to supply a suggested method, I can forward that to the technician who will be doing the test. 

 

Are you at least getting a deal on the tests?  Commercial rates can be pretty brutal.  I'm not sure exactly what the best method would be here, but if you used LC/MS, then you should be able to at least tell if you have the right parent ion mass.   You can still have a wrong structure with the right mass, but you can't have the right structure with the wrong mass.  The LC alone will give you a pretty good idea of purity, but not of identity.