821 replies to this topic

[Metagene]

Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy

http://www.ncbi.nlm....les/PMC2945467/

The article checked penetration of copper only, not of the whole compound.

That was what they were mainly interested in - delivering copper, not GHK.

It is possible that only the copper fraction dissociated from the GHK and penetrated. In fact, they acknowledge this explicitly. For example:

Such high tissue retention of copper may be attributed to intradermal decomplexation and re-binding to various endogenous amino acids of higher nucleophilic donor capacity than the original ligand.

In other words, they are saying the GHK may well have got left behind. They are certainly not testing for penetration of GHK at all.

Actually if you read the next paragraph the explanation is quite clear.

Assessing whether permeant retained in skin tissues, the stratum corneum in particular, eventually becomes available systemically is an issue of ongoing discussions. Reservoir formation in the course of in vitro studies has been addressed [17]. Retained drug may be lost to natural desquamation, limiting its eventual systemic availability. On closer analysis, however, it has been found that the fraction of chemical sloughing off versus the part that becomes systemically available depends on the ratio of lag time to the turnover time for the stratum corneum [18]. Accordingly, at least 80% of the amount in the stratum corneum will become available if the lag time for penetration through that tissue is less than approximately 16 h This corresponds to 5% of the typical stratum corneum turnover time of 14 days. Consequently, based on our results where lag times ranged from 2 to 7 h, the copper retained in the stratum corneum has the potential to become systemically available also. As a result of the experiment with dermatomed skin, by topical application of GHK-Cu under the present conditions 200–250 μg/cm2 copper may become systemically available. Since the experiment was conducted ex vivo, it is possible that even larger amounts will be retained in the deeper dermal tissue in vivo, to be followed by further diffusion.

http://www.ncbi.nlm....les/PMC2945467/

They are talking about penetration the COPPER. They explicitly hypothesize that they think the copper is retained well because it gets dissociated from the GHK, suggesting that they think the GHK would hinder retention. It is unclear why they think this and where they think the GHK goes - but they didn't try to detect GHK, so we can really not conclude anything about GHK penetration from their experiment. For all we know the GHK is lysed in the first surface cell it enters after donating the copper. Or not. The experiment doesn't say.

Such high tissue retention of copper may be attributed to intradermal decomplexation and re-binding to various endogenous amino acids of higher nucleophilic donor capacity than the original ligand.

Which makes perfect sense considering the purpose of the study:

Skin retention and penetration by copper applied as glycyl-l-histidyl-l-lysine cuprate diacetate was evaluated in vitro in order to assess its potential for its transdermal delivery as an anti-inflammatory agent.

So we're good here.

[nowayout]

 

 

 

 

Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy

http://www.ncbi.nlm....les/PMC2945467/

The article checked penetration of copper only, not of the whole compound.

That was what they were mainly interested in - delivering copper, not GHK.

It is possible that only the copper fraction dissociated from the GHK and penetrated. In fact, they acknowledge this explicitly. For example:

Such high tissue retention of copper may be attributed to intradermal decomplexation and re-binding to various endogenous amino acids of higher nucleophilic donor capacity than the original ligand.

In other words, they are saying the GHK may well have got left behind. They are certainly not testing for penetration of GHK at all.

Actually if you read the next paragraph the explanation is quite clear.

Assessing whether permeant retained in skin tissues, the stratum corneum in particular, eventually becomes available systemically is an issue of ongoing discussions. Reservoir formation in the course of in vitro studies has been addressed [17]. Retained drug may be lost to natural desquamation, limiting its eventual systemic availability. On closer analysis, however, it has been found that the fraction of chemical sloughing off versus the part that becomes systemically available depends on the ratio of lag time to the turnover time for the stratum corneum [18]. Accordingly, at least 80% of the amount in the stratum corneum will become available if the lag time for penetration through that tissue is less than approximately 16 h This corresponds to 5% of the typical stratum corneum turnover time of 14 days. Consequently, based on our results where lag times ranged from 2 to 7 h, the copper retained in the stratum corneum has the potential to become systemically available also. As a result of the experiment with dermatomed skin, by topical application of GHK-Cu under the present conditions 200–250 μg/cm2 copper may become systemically available. Since the experiment was conducted ex vivo, it is possible that even larger amounts will be retained in the deeper dermal tissue in vivo, to be followed by further diffusion.

http://www.ncbi.nlm....les/PMC2945467/

They are talking about penetration the COPPER. They explicitly hypothesize that they think the copper is retained well because it gets dissociated from the GHK, suggesting that they think the GHK would hinder retention. It is unclear why they think this and where they think the GHK goes - but they didn't try to detect GHK, so we can really not conclude anything about GHK penetration from their experiment. For all we know the GHK is lysed in the first surface cell it enters after donating the copper. Or not. The experiment doesn't say.

Such high tissue retention of copper may be attributed to intradermal decomplexation and re-binding to various endogenous amino acids of higher nucleophilic donor capacity than the original ligand.

Which makes perfect sense considering the purpose of the study:

Skin retention and penetration by copper applied as glycyl-l-histidyl-l-lysine cuprate diacetate was evaluated in vitro in order to assess its potential for its transdermal delivery as an anti-inflammatory agent.

So we're good here.

 

 

I'm not sure what makes sense.   But I should point out that they think copper is an anti-inflammatory, so copper was the anti-inflammatory they were trying to deliver (and testing for), not GHK. 

 

GHK-Cu doesn't just diffuse through cell membranes - copper get transported into and out of cells by a number of specialized chaperone proteins.  So there is a good chance the copper was taken from the GHK by other chaperones and the GHK was left behind, for all we know at the first cell membrane it encountered on the way in.  

 

Edited by nowayout, 12 March 2015 - 06:47 PM.

[Metagene]

Yeah I understand that much in context. It's a non issue for I.V and liposomal delivery.

An undetermined part of copper might transit through the skin as the undissociated original tripeptide, and another might diffuse bound to endogenous amino acids of higher complex stability constants such as the histidinate [21], the predominant copper complex in plasma, with cystinate as the secondary ligand.

Studies with labeled ligands (i.e., radio-labeled) may help with further understanding the complex skin penetration behavior of copper complexes. In the present study, only diffusion followed by copper analysis on isolated or separated tissue strata allowed a measure of insight.

http://www.ncbi.nlm....les/PMC2945467/

[Logic]

I Emailed TLR.

The GHK/GHK-Cu has landed in America.

It should be arriving soon.

[zorba990]

I Emailed TLR.
The GHK/GHK-Cu has landed in America.
It should be arriving soon.

Thanks !!

[zen]

I Emailed TLR.

The GHK/GHK-Cu has landed in America.

It should be arriving soon.

Hey Logic. do you have any information when TLR is going to ship the GHK/GHK-Cu to the US customers?

[Forty Six & 2]

Hey zen and All,

 

Ah, your post just reminded me I forgot to post this as I have been consumed with coordinating things as best as possible within all matters.   So...

 

While I always have great regret to be the bearer of unfavorable news, the pack shipped to us was to be set to a customs hold and as such we had our agent move to have it sent back to be re-shipped. Holds can be weeks no matter what, as largely they just do as they please, and this was deemed best to try to get it here as prompt as now is possible. I was awaiting firm word on all this and timing. It arrived here this past Monday and of course as much as we well know this is of inconvenience to all here, obviously we are most disappointed and affected. 

 

Still, though I assure you we have done all on our end on point, within this is still our onus to ensure we do as best for all of you, and within that we wish to suggest some compensatory measures as are herein and hope you find them worthwhile, of value, and of a respect for the circumstances that we wish to do all to show our respect.

 

As well, kindly let me note I have discussed this with Logic, who has acted most diligently in a sense as an intermediary. He is someone who I very much respect, within his dignity of manner, his insights and quest for knowledge and reason, and for all that he has helped foster to do so much to enable what has been very much looked for by both he and TLR to do something here of benefit to all so involved. I thank him for being of the character he displays and for all he indeed has done within this. He is beyond a pleasure to communicate with. I regret to have this have not gone to plan, which was all within that which otherwise should have been 'dead on-point', and hope perhaps even still we can look to perhaps coordinate together again to do as is best for the community.

 

Let me note we at TLR truly and sincerely respect the situation, and so very appreciate the graceful patience and understanding that most all of you have afforded here. It says something to the character of those so involved and know it is not going unnoticed by us. We are only and all about doing that which is 'Right', that which is “True”, and we admire all manner that shows those qualities.

 

As such, herein some things we believe may be of value, and will be done for all who made said purchase and wish to take advantage:

 

25% discount on ALL “Anti-Aging” Research Items, which include some of the following:

 

• SENOLYTIX A Dasatinib:Quercetin Optimized Senolytic Agent

• GHK/GHK-Cu Mix (for the next lot we will be preparing to have here in 2-4 weeks)

• Acetyl Epitalon

• NAD+

 

20% discount off ALL “Neurogenic Research” Items; including J147 99% to be in very shortly

 

Within respect to these offers such are just for those of course within this Group Buy. Kindly it is best to order via Alternative Methods and send us a follow-up e-mail with your Order Code; within that we will arrange what is best to offer the discounted pricing, and feel free to request other items you may desire some discount upon if desired. We want to do as best here for your research needs as is always and only our sole intent.

 

Further, seeing the difficulties the group has had within accommodating testing, we went proactive here and located a lab that seems to be able to accommodate the testing for a pricing that is reasonable, within most all came back with pricing well over a thousand dollars. As such, within if this is viable, if someone wants to volunteer a random sample to the lab we will pay the fee so agreed upon for their service of assessing the purity and ratio of the two materials, GHK and GHK-Cu, within the Mix. The material will be replaced of course and we will afford 30% off the next order for said person. The amount of material required is only 100mcg, 1 vial, so I assume someone can spare such.

 

If someone as well simply wants to make a suggestion as to our want to 'do the right thing' we are open to such within the want to afford some offers that are of value. Kindly all replies to be maintained with the respect and dignity that indeed is so appreciated to be seen by most all herein, and moreover shows respect to all herein as such.

 

Thanks again to all for your generous understanding within this trying circumstance; again we will more than look to do all to ensure all is as best!

 

Respectfully,

Forty Six & 2

& TeamTLR

[Heisenburger]

The amount of material required is only 100mcg, 1 vial, so I assume someone can spare such.

 

 For God's sake, don't you even know the difference between a milligram and a microgram?

 

[pleb]

Apparently not. This whole thing is becoming a farce.
Like fraggle rock meets the Muppets.

Edited by pleb, 23 March 2015 - 08:10 AM.

[pure]

I'd say 46 + 2 is either Nigerian, or a Hippie high or something 99.99% of the time.

"As such, within if this is viable.."

"He is someone who I very much respect, within his dignity of manner, his insights and quest for knowledge and reason, and for all that he has helped foster to do so much to enable what has been very much looked for by both he and TLR to do something here of benefit to all so involved. I thank him for being of the character he displays and for all he indeed has done within this. He is beyond a pleasure to communicate with."

hahahahahahahahahah .

Definitely high on something!

There's a touch of "jive talk" style there too.

Perhaps the next offer will be to share in $30 million in excess funds he's holding via his ministerial position which enabled him to approve and have the government pay an overstated invoice from a company owned by his uncle?

Keep on bringin it Jive-Turkey.

[pleb]

No he's not Nigerian. They use a colloquial English that's quite good and easily identified.
This guy's Chinese and uses English that he's not familiar with using Chinese expressions in English sentences.

[zen]

Hey zen and All,

 

Ah, your post just reminded me I forgot to post this as I have been consumed with coordinating things as best as possible within all matters.   So...

 

While I always have great regret to be the bearer of unfavorable news, the pack shipped to us was to be set to a customs hold and as such we had our agent move to have it sent back to be re-shipped. Holds can be weeks no matter what, as largely they just do as they please, and this was deemed best to try to get it here as prompt as now is possible. I was awaiting firm word on all this and timing. It arrived here this past Monday and of course as much as we well know this is of inconvenience to all here, obviously we are most disappointed and affected. 

 

Still, though I assure you we have done all on our end on point, within this is still our onus to ensure we do as best for all of you, and within that we wish to suggest some compensatory measures as are herein and hope you find them worthwhile, of value, and of a respect for the circumstances that we wish to do all to show our respect.

 

As well, kindly let me note I have discussed this with Logic, who has acted most diligently in a sense as an intermediary. He is someone who I very much respect, within his dignity of manner, his insights and quest for knowledge and reason, and for all that he has helped foster to do so much to enable what has been very much looked for by both he and TLR to do something here of benefit to all so involved. I thank him for being of the character he displays and for all he indeed has done within this. He is beyond a pleasure to communicate with. I regret to have this have not gone to plan, which was all within that which otherwise should have been 'dead on-point', and hope perhaps even still we can look to perhaps coordinate together again to do as is best for the community.

 

Let me note we at TLR truly and sincerely respect the situation, and so very appreciate the graceful patience and understanding that most all of you have afforded here. It says something to the character of those so involved and know it is not going unnoticed by us. We are only and all about doing that which is 'Right', that which is “True”, and we admire all manner that shows those qualities.

 

As such, herein some things we believe may be of value, and will be done for all who made said purchase and wish to take advantage:

 

25% discount on ALL “Anti-Aging” Research Items, which include some of the following:

 

• SENOLYTIX A Dasatinib:Quercetin Optimized Senolytic Agent

• GHK/GHK-Cu Mix (for the next lot we will be preparing to have here in 2-4 weeks)

• Acetyl Epitalon

• NAD+

 

20% discount off ALL “Neurogenic Research” Items; including J147 99% to be in very shortly

 

Within respect to these offers such are just for those of course within this Group Buy. Kindly it is best to order via Alternative Methods and send us a follow-up e-mail with your Order Code; within that we will arrange what is best to offer the discounted pricing, and feel free to request other items you may desire some discount upon if desired. We want to do as best here for your research needs as is always and only our sole intent.

 

Further, seeing the difficulties the group has had within accommodating testing, we went proactive here and located a lab that seems to be able to accommodate the testing for a pricing that is reasonable, within most all came back with pricing well over a thousand dollars. As such, within if this is viable, if someone wants to volunteer a random sample to the lab we will pay the fee so agreed upon for their service of assessing the purity and ratio of the two materials, GHK and GHK-Cu, within the Mix. The material will be replaced of course and we will afford 30% off the next order for said person. The amount of material required is only 100mcg, 1 vial, so I assume someone can spare such.

 

If someone as well simply wants to make a suggestion as to our want to 'do the right thing' we are open to such within the want to afford some offers that are of value. Kindly all replies to be maintained with the respect and dignity that indeed is so appreciated to be seen by most all herein, and moreover shows respect to all herein as such.

 

Thanks again to all for your generous understanding within this trying circumstance; again we will more than look to do all to ensure all is as best!

 

Respectfully,

Forty Six & 2

& TeamTLR

 

I am afraid that GHK can substantially deteriorate if hold in customs for the longer period of time without refrigeration.
If that happens to be the case are you ready to go ahead and refund the cost to all the people who participated in this group buy?




 

[nowayout]

 It's a non issue for I.V and liposomal delivery.

 

 

If I were to do this, I would wait until pharmaceutical quality GHK (without any copper) becomes available and simply inject it.  Anti-agers and bodybuilders, not to mention diabetics and people on fertility drugs, have been injecting various peptides for ages.  Injection is the canonical method of delivery for peptides. 

[Forty Six & 2]

Hi zen,

 

Judging by your moniker maybe you might show some appreciation for my manner, lol.  Seriously, to the respectable, relevant, and honorable question; yes, of course we bear responsibility to supplying a product of quality as indicated.  Within that we would refund or supply from a new production, as well in which we are commencing running one as well right now.  However, kindly note that GHK tripeptides should retain stability and not experience any significant degradation to compromise the indicated quality in the ambient temperatures it will experience, but of course we will within all this look to ensure such.

 

Respectfully,

Forty Six & 2

[Metagene]

It's a non issue for I.V and liposomal delivery.

If I were to do this, I would wait until pharmaceutical quality GHK (without any copper) becomes available and simply inject it. Anti-agers and bodybuilders, not to mention diabetics and people on fertility drugs, have been injecting various peptides for ages. Injection is the canonical method of delivery for peptides.

I happened to miss out on this particular group buy. Do you mind explaining the problem with copper bound to GHK? From what I understand free copper is toxic. Here the inclusion of copper seems desirable.

"Results from the Broad Institute's Connectivity Map and ChemBank found that GHK is a strong inhibitor of several HDACs. Although the data was collected for GHK without copper, we cannot exclude the possibility that the actual gene regulator was the GHK copper complex formed in the culture media, since, as it was mentioned above, GHK can easily obtain copper from other biological molecules such as albumin. It is also possible that GHK and GHK-Cu have complimentary effects on gene activity."

http://www.ncbi.nlm....?report=classic

Edited by Metagene, 23 March 2015 - 10:56 PM.

[nowayout]

In dry form many peptides can certainly be stable at ambient temperatures. For example, human chorionic gonadotropin (a fertility hormone that is also a peptide) is shipped and stored at ambient temperatures in U.S. pharmacies. High heat and/or freezing would possibly damage them, and I would worry about the temperatures in shipping containers or trucks especially during extended international shipping. A truck parked in the sun can easily reach temperatures I wouldn't trust to not damage even small molecule drugs, never mind a peptide. Once a peptide like HCG is reconstituted in a water solution, though, it has to be refrigerated and will remain good for about a month only. The same goes for various other peptides (GHRPs, melanotan, etc.) used in some antiaging and bodybuilding circles. These are for the most part significantly larger peptides though.

The above is a rule of thumb only though. Individual peptides might be either more or less stable. For example, HGH is notoriously fragile - however, it is a huge molecule. Presumably, GHK, being smallish, would be more stable, but I'd welcome any criticism from someone who knows more about this than I.

Edited by nowayout, 23 March 2015 - 11:39 PM.

[nowayout]

It's a non issue for I.V and liposomal delivery.

If I were to do this, I would wait until pharmaceutical quality GHK (without any copper) becomes available and simply inject it. Anti-agers and bodybuilders, not to mention diabetics and people on fertility drugs, have been injecting various peptides for ages. Injection is the canonical method of delivery for peptides.

I happened to miss out on this particular group buy. Do you mind explaining the problem with copper bound to GHK? From what I understand free copper is toxic. Here the inclusion of copper seems desirable.

"Results from the Broad Institute's Connectivity Map and ChemBank found that GHK is a strong inhibitor of several HDACs. Although the data was collected for GHK without copper, we cannot exclude the possibility that the actual gene regulator was the GHK copper complex formed in the culture media, since, as it was mentioned above, GHK can easily obtain copper from other biological molecules such as albumin. It is also possible that GHK and GHK-Cu have complimentary effects on gene activity."

http://www.ncbi.nlm....?report=classic

I don't know if the copper part is good or bad. GHK alone will chelates copper already in the body to form GHK-Cu complexes and I can't tell whether that chelation is good or bad either. I can't tell whether there is any consensus on that issue.

[Metagene]

In dry form many peptides can certainly be stable at ambient temperatures. For example, human chorionic gonadotropin (a fertility hormone that is also a peptide) is shipped and stored at ambient temperatures in U.S. pharmacies. High heat and/or freezing would possibly damage them, and I would worry about the temperatures in shipping containers or trucks especially during extended international shipping. A truck parked in the sun can easily reach temperatures I wouldn't trust to not damage even small molecule drugs, never mind a peptide. Once a peptide like HCG is reconstituted in a water solution, though, it has to be refrigerated and will remain good for about a month only. The same goes for various other peptides (GHRPs, melanotan, etc.) used in some antiaging and bodybuilding circles. These are for the most part significantly larger peptides though.

The above is a rule of thumb only though. Individual peptides might be either more or less stable. For example, HGH is notoriously fragile - however, it is a huge molecule. Presumably, GHK, being smallish, would be more stable, but I'd welcome any criticism from someone who knows more about this than I.

According to this PDF GHK-Cu is "stable at room temperature for one month and below 18°C for three years."

http://www.owndoc.co...tate-ghk-cu.pdf

[Forty Six & 2]

^^^

And in practice most all peptides are generally stable quite a bit longer than the these guidelines as are so given, with respect to the guidelines will vary for peptides of varying stability. 

 

Not quite the same, but similar in some respects to how pharmaceuticals have an expiration date, wherein such is just to err highly conservatively well on the side of safety as most are not going to degrade in any significant manner of pertinence if stored in any respectable conditions suitable for such.

Edited by Forty Six & 2, 23 March 2015 - 11:59 PM.

[nowayout]

 

In dry form many peptides can certainly be stable at ambient temperatures. For example, human chorionic gonadotropin (a fertility hormone that is also a peptide) is shipped and stored at ambient temperatures in U.S. pharmacies. High heat and/or freezing would possibly damage them, and I would worry about the temperatures in shipping containers or trucks especially during extended international shipping. A truck parked in the sun can easily reach temperatures I wouldn't trust to not damage even small molecule drugs, never mind a peptide. Once a peptide like HCG is reconstituted in a water solution, though, it has to be refrigerated and will remain good for about a month only. The same goes for various other peptides (GHRPs, melanotan, etc.) used in some antiaging and bodybuilding circles. These are for the most part significantly larger peptides though.

The above is a rule of thumb only though. Individual peptides might be either more or less stable. For example, HGH is notoriously fragile - however, it is a huge molecule. Presumably, GHK, being smallish, would be more stable, but I'd welcome any criticism from someone who knows more about this than I.

According to this PDF GHK-Cu is "stable at room temperature for one month and below 18°C for three years."

http://www.owndoc.co...tate-ghk-cu.pdf

 

 

But how long is it stable at 50-60°C, as might occur in a closed vehicle during shipping from UG labs? 

 

http://www.ggweather.../heat study.pdf

 

 

Edited by nowayout, 24 March 2015 - 03:13 PM.

[david ellis]

 

But how long is it stable at 50-60°C, as might occur in a closed vehicle during shipping from UG labs? 

 

http://www.ggweather.../heat study.pdf

 

Won't  testing provide enough data to answer questions about stability?   

 

[deetown]

Did anybody settle on a delivery method?  Would something like DMSO be helpful transporting it through the skin?

[Metagene]

Did anybody settle on a delivery method? Would something like DMSO be helpful transporting it through the skin?

For treating wounds yes.

"In theory, GHK could be infused into the blood stream of patients to repair the lung tissue, added to a misting solution or used in combination of a carrier like DMSO along with GHK (use a 1 : 1 molar ratio of GHK to DMSO). DMSO and GHK or GHK : Cu(2+) has always worked well together on wound healing. DMSO has been used in the past as a treatment for COPD, so there should be few safety issues."

http://www.hindawi.c...014/151479/#B64

Why was Zen's post marked "dangerous, irresponsible"? He's not wrong.

Edited by Metagene, 27 March 2015 - 06:35 AM.

[Infinite1]

1 March 2015 ordered and arrived today. Which was exactly as expected.

Any updates? I would be interested to hear what your experience has been. 

[1thoughtMaze1]

I'd say 46 + 2 is either Nigerian, or a Hippie high or something 99.99% of the time.
"As such, within if this is viable.."
"He is someone who I very much respect, within his dignity of manner, his insights and quest for knowledge and reason, and for all that he has helped foster to do so much to enable what has been very much looked for by both he and TLR to do something here of benefit to all so involved. I thank him for being of the character he displays and for all he indeed has done within this. He is beyond a pleasure to communicate with."
hahahahahahahahahah .
Definitely high on something!
There's a touch of "jive talk" style there too.
Perhaps the next offer will be to share in $30 million in excess funds he's holding via his ministerial position which enabled him to approve and have the government pay an overstated invoice from a company owned by his uncle?
Keep on bringin it Jive-Turkey.

I'd say you're on pure crack cracker, yes smile for me, look at that piano.

[1thoughtMaze1]

I Emailed TLR.
The GHK/GHK-Cu has landed in America.
It should be arriving soon.

Do t trust logic, he's another cracker, he'll steal your money for crack, true story.... Happened to me .

[johnross47]

 

I Emailed TLR.
The GHK/GHK-Cu has landed in America.
It should be arriving soon.

Do t trust logic, he's another cracker, he'll steal your money for crack, true story.... Happened to me .

 

That's a strong statement. Can you  back it up?

[Logic]

 

 

I Emailed TLR.
The GHK/GHK-Cu has landed in America.
It should be arriving soon.

Do t trust logic, he's another cracker, he'll steal your money for crack, true story.... Happened to me .

 

That's a strong statement. Can you  back it up?

 

 

No It cant Johnross47.

333 posts
-121 ₮

Means that It is here to cause trouble and start fights from the safety of its burrow.

________________________________________________

 

 

I have been conspicuous by my absence of posts here.

That is because I am extremely embarrassed by how this group buy has gone.

 

I am still in contact with TLR and doing what I can to salvage my rep here and this group buy.
FWIW TLR hopes that the GHK/GHK-Cu will have cleared customs by the 10th of this month and will start shipping to everyone soon after.

 

While 46&2 'speaks'/types some very strange english, I get the impression that he is a good person and that circumstances conspired to scupper what should have been a simple transaction:

 

Their web site went down at the same time as the mud slinging about their products started on this forum...

Now any one of those events could be happenstance, but when both occur together one begins to wonder if there was not a concerted effort to close TLR down?

It occurs to me that alarmist communiques to US customs  could and probably would be part of such an attempt..?

 

Anyway; it would seem that the only way to get a 'blocked' package out of indefinite storage at customs is to get it returned to its place of origin and try again.

 

So,  at this point I am holding thumbs that this ....'group buy'  will eventually reach a belated but  satisfactory conclusion and that the peptide mix is relatively unscathed by its extensive travels.

 

Do note that TLR has apologised profusely and offered extensive discounts for  those who bought into this group buy/order:

 

25% discount on ALL “Anti-Aging” Research Items, which include some of the following:

SENOLYTIX A Dasatinib:Quercetin Optimized Senolytic Agent
GHK/GHK-Cu Mix (for the next lot we will be preparing to have here in 2-4 weeks)
Acetyl Epitalon
NAD+

20% discount off ALL “Neurogenic Research” Items; including J147 99% to be in very shortly

 

http://www.longecity...ndpost&p=720177

 

Personally I plan to take advantage of this offer to get SENOLYTIX once its in stock!

http://teamtlr.com/a...arch-agent.html

 

As anyone who has been following the compelling senolytics thread knows; one dose of Dasatinib is $360

So 100 doses at $ 75 plus Quercetin is around 1/500th the price! 

http://www.longecity...nds-healthspan/

Edited by Logic, 02 April 2015 - 10:48 PM.

[ceridwen]

I can't get into team TLR

[ceridwen]

I'm also dying quiet fast and soon won't be able to do it. Help