5 replies to this topic

[Matthew Butler]

I have looked into milk thistle ( not sure if it significantly does anything or not) and TA-65. With TA-65 being so expensive, I was wondering if anyone had any ideas as to what Telomerase activators  are both economical and make a difference in Telomere activity.

[Darryl]

Cycloastrogenol (TA-65) is the only compound with any demonstrated capacity to lengthen shorter telomeres in peer reviewed studies.

 

Personally, I'd pay attention to dietary factors. Higher vegetable, fruit, and fiber intakes are associated with longer telomeres, while higher processed meat, dairy fat (butter, cheese, whole milk), and linoleic acid intakes are linked to shorter ones.

 

Nettleton, J. A., Diez-Roux, A., Jenny, N. S., Fitzpatrick, A. L., & Jacobs, D. R. (2008). Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA). The American journal of clinical nutrition,88(5), 1405-1412.

Cassidy, A., De Vivo, I., Liu, Y., Han, J., Prescott, J., Hunter, D. J., & Rimm, E. B. (2010). Associations between diet, lifestyle factors, and telomere length in women. The American journal of clinical nutrition, ajcn-28947.

Marcon, F., Siniscalchi, E., Crebelli, R., Saieva, C., Sera, F., Fortini, P., ... & Palli, D. (2012). Diet-related telomere shortening and chromosome stability.Mutagenesis, 27(1), 49-57.

Song, Y., You, N. C. Y., Song, Y., Kang, M. K., Hou, L., Wallace, R., ... & Liu, S. (2013). Intake of small-to-medium-chain saturated fatty acids Is associated with peripheral leukocyte telomere length in postmenopausal women. The Journal of nutrition, jn-113.

 

[niner]

In the realm of substances that affect the human body in useful ways, the following usually applies:  Cheap, Safe, Effective-- Pick any two; you don't get all three.

 

The cheap way to deal with telomeres is, as Darryl suggests, preventing them from shortening as fast.  The primary cause of shortening (other than cell division) is oxidative damage.  In that regard, diet and lifestyle can be helpful.  You might also want to look into c60-olive oil for oxidative protection.

[Darryl]

New study:

 

Gu, Y., Honig, L. S., Schupf, N., Lee, J. H., Luchsinger, J. A., Stern, Y., & Scarmeas, N. (2015). Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population. AGE, 37(2), 1-13.

Leukocyte telomere length (LTL) is considered as the marker of biological aging and may be related to environmental factors. The current study aimed to examine the relation between Mediterranean-type diet and LTL. We used a cross-sectional study of 1743 multi-ethnic community residents of New York aged 65 years or older. Mediterranean-type diet (MeDi) was calculated from dietary information collected using a food frequency questionnaire. LTL was measured from leukocyte DNA using a real-time PCR method to measure T/S ratio, the ratio of telomere (T) to single-copy gene (S) sequence. Regression analysis showed that the MeDi score was not associated with LTL in the overall study population (β = 12.5; p = 0.32) after adjusting for age, sex, education, ethnicity, caloric intake, smoking, and physical and leisure activities. However, we found a significant association between MeDi and LTL among non-Hispanic whites (β = 48.3; p = 0.05), and the results held after excluding dementia subjects (β = 49.6; p = 0.05). We further found that, in the whole population, vegetable and cereal consumption above the sex-specific population median was associated with longer LTL (β = 89.1, p = 0.04) and shorter LTL (β = −93.5; p = 0.03), respectively. Among non-Hispanic whites, intake of meat or dairy below sex-specific population medians was associated with longer LTL (β = 154.7, p = 0.05; β = 240.5, p < 0.001, respectively). We found that higher adherence to a MeDi was associated with longer LTL among whites but not among African Americans and Hispanics. Additionally, a diet high in vegetables but low in cereal, meat, and dairy might be associated with longer LTL among healthy elderly.

 

 

 

[hav]

The cheapest telomerase activators I know of are soluble fiber and iron. There are down sides with iron, however, and some astragalus extracts specifically target removing it. Soluble fiber can also be problematic if taken with oil soluble activators like cycloastragenol.

 

Howard

 

[Logic]

Purslane is considered a weed.

This means its easy to grow and someone may actually pay you to eat it!?  

 

 

Neuroprotective effects of purslane herb aquenous extracts against D-galactose induced neurotoxicity.

"...PHAS also could up-regulate telomere lengths and telomerase activity in PHAS-fed groups..."

http://www.ncbi.nlm....pubmed/17764668

 

This retracted study is interesting.  Why was it retracted..?

Antiaging effect of purslane herb aqueous extracts and its mechanism of Action

http://www.researchg...anism_of_Action

 

Reason for retraction:

The following article from Phytotherapy Research, 'Antiaging effect of purslane herb aqueous extracts and its mechanism of Action' by Huang Hao, Yu Nancai, Fu Lei, Su Wen, Huang Guofu, Wu Yanxia, Huang Hanju, Liu Qian published online on 15(th) April 2009 in Wiley InterScience (www.interscience.wiley.com) has been retracted by agreement between the journal Editor in Chief, Elizabeth Williamson and John Wiley & Sons, Ltd. The retraction has been agreed due to overlap with the following article: Zhang Hongxing, Yu Nancai, Huang Guofu, Shao Jianbo, Wu Yanxia, Huang Hanju, Liu Qian, Ma Wei, Yi Yandong and Huang Hao. Neuroprotective effects of purslane herb aquenous extracts against d-galactose induced neurotoxicity. 

http://www.ncbi.nlm....pubmed/19670213

 

Ginkgo biloba extract reduces endothelial progenitor-cell senescence through augmentation of telomerase activity.

http://www.ncbi.nlm....pubmed/17312453

 

http://www.longecity...and-telomerase/

 

green coffee bean?

http://www.longecity...ndpost&p=667827