2 replies to this topic

[Dolph]

http://www.ncbi.nlm....pubmed/25375133

 

This is interesting, as this pathway is not only important for apoptosis and as such for cancer prevention but also for longevity as such. But it seems pretty complicated. Increasing risk at some sites, decreasing at others.

 

Edited by Dolph, 07 November 2014 - 10:02 AM.

[Darryl]

Actually bad news for those of us experimenting with nicotinic acid as a NAD+ precursor, unless niacin also inhibits mTOR via other signalling pathways.

 

I should have paid more attention to this earlier paper from the same lab:

 

Lin, F., Xu, W., Guan, C., Zhou, M., Hong, W., Fu, L., ... & Xu, A. (2012). Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes. International journal of molecular medicine, 29(4), 593.

 

 

 

The PI3K/AKT inhibitor, LY294002, and the mTOR inhibitor, rapamycin, largely neutralized the protective effects of niacin, suggesting that AKT and downstream signaling mTOR/S6 activation are necessary for the niacin-induced protective effects against UV-induced cell death and cell apoptosis

 

 

 

 

 

Edited by Darryl, 08 November 2014 - 09:13 PM.

[Dolph]

That niacin induces mtor was known before. I'm just not completely certain how the mtor experiments in rodents translate. It's complicated and there are serious disorders associated with reduced expression of mtor. Also niacin seems to have other interesting benefits because of this influence on mtor.  http://www.ncbi.nlm....pubmed/22246168