What? One single suggestion of Memantine? That's it?? No other NMDA-antagonists either?
As some of you may be aware, the amyloid-beta hypothesis of Alzheimers has come into question, as no greater improvements have been seen in patients wherein the amyloid beta plaque was significantly lessened with drugs inhibiting their formation - the conclusion then is that they could possibly be a result of excitotoxicity from glutamate, and not the other way around.
As such, glutamate activity needs to be inhibited in order for the amyloid beta dissolvers to work properly - as such, NMDA-antagonists could be the answer.
Since many here are into research-chemicals and willing to take big risks, I suggest a group buy custom-synthesis of NITRO-Memantine - this compound showed immense promise in a multitude of diseases related to the NMDA-networks - Alzheimers one of them - this would be because it's many, many times STRONGER than its predecessor Memantine. Memantine was previously shown to have some effect in slowing the disease's progression, but unable to reverse the course of the disease - Nitromemantine looked like the drug that could do that.
Research was bagged though, for unclear reasons... But one of the possible reasons is of course the fact that it's a Nitrate-compound - such compounds, like nitroglycerine, are known to cause... CANCER!! I can see how curing Alzheimers but causing the patients to instead develop brain-cancer is an unacceptable side-effect. But such reactions are somewhat exagerated and Nitroglycerine is as a matter of fact still in wide use and has not been proven to cause any greater amounts of cancer in adult subjects - as such, for some, the risk may well be worth it - we know it's the strongest non-competitive NMDA-antagonist ever created - the power is real, but the effects are of course untested.
Btw - someone mentioned how there's been some success with ketogenic diet for Alzheimers - that could be because Keto increases production of Kynurenic Acid for some reason - KYNA is the brain's own natural NMDA-antagonist, and presumed to be involved in the pathology of Schizophrenia even! This implies some rather hefty effects... There's also a drug in development for the treatment of Alzheimers and depression - it's a pro-drug for none other than KYNA!
