Posted 27 November 2014 - 12:27 PM
Edited by medicineman, 27 November 2014 - 12:29 PM.
Posted 05 May 2016 - 11:44 PM
on second though isnt it much better and easier to just acquire this; https://en.wikipedia...wiki/Rapastinel
On January 29, 2016, Allergan (who acquired Naurex in July 2015) announced that rapastinel had received Breakthrough Therapy designation from the U.S. FDA for adjunctive treatment of major depressive disorder.
wow its going to be on the market soon might as well go for it now and buy it cheaper than what it would cost after its trademarked
Posted 05 May 2016 - 11:58 PM
on second though isnt it much better and easier to just acquire this; https://en.wikipedia...wiki/Rapastinel
On January 29, 2016, Allergan (who acquired Naurex in July 2015) announced that rapastinel had received Breakthrough Therapy designation from the U.S. FDA for adjunctive treatment of major depressive disorder.
wow its going to be on the market soon might as well go for it now and buy it cheaper than what it would cost after its trademarked
Doesnt glx have a different MOA re partial glycine agonist where as hydroxynorketamine is targeting AMPA re agonist?
Posted 30 May 2016 - 10:43 PM
on second though isnt it much better and easier to just acquire this; https://en.wikipedia...wiki/Rapastinel
On January 29, 2016, Allergan (who acquired Naurex in July 2015) announced that rapastinel had received Breakthrough Therapy designation from the U.S. FDA for adjunctive treatment of major depressive disorder.
wow its going to be on the market soon might as well go for it now and buy it cheaper than what it would cost after its trademarked
Note that this is intravenous only. Not orally active.
Posted 01 June 2016 - 06:30 PM
yeh they have different mechanism i guess taking both of them might give a nice result but still now im more interested in glyx since its proven safe and its about to hit the market
Will this produce dissociative effects similar to ketamine?
Edited by sativa, 01 June 2016 - 06:35 PM.
Posted 22 August 2016 - 04:47 PM
As I am sick of my anxious depression, I want to try hydroxynorketamine.
Why?
1. Ketamine has been reported to quickly relieve depression in appr 75% or TRD (treatment resistant depression) either at a dosage of 0.5 mg / kg i. v. or sublingual (30% bioavailibility). Literature: There is a great book on Amazon "Ketamine for depression".
2. It has been shown that Ketamine is especially effective in "anxious depression" rather than in the depression without anxiety. This was to the astonishment of the researchers as anxious depression has been shown to react worse to regular SSRI/SNRI and to CBT (cognitive behavioral therapy) than depression without anxiety. However, for all anxious depressed, this is good news. Lit: Ionescu et al., "Effect of baseline anxious depression on initial and sustained antidepressant response to ketamine".
3. Recently, the same group from the NIH (!) published an important study in Nature (!!!). In rats, they showed that neither does ketamine lift depression via the NMDA-receptor nor does it lift depression at all. Rather, it is its metabolite (2R, 6R)-hydroxynorketamine, which lifts the depression! Good news: it does that via the AMPA-receptor and does NOT induce dissociation or addiction (at least as the rats are concerned).
Interestingly, there are more data that support that ketamine/NMDAR fails to work against depression: a) esketamine works less than the R-ketamine (because the metabolite 2S,6S-hydroxynoketamine is not as potent as 2R,6R), b) a couple of studies of NMDAR-antagonists have already failed from some pharma companies.
4. Approximately 15% of Ketamine is metabolized into (2R,6R)-Hydroxynorketamine (more in female rats than in males). The oral bioavailibility of HNK is supposedly 50% according to the literature. Thus, I calculate: 0.5 mg/kg of ketamine i.v. equals approximately 80 kg * 0.5 mg/kg = 40 mg of ketamine or 15% of that: 6 mg of HNK. Given orally, 12 mg should be used and if the product contains (2S, 6S) and (2R, 6R), then appr. 24 mg should be taken orally (I guess).
Of course, this could be all bogus, but I have the feeling that this may actually work. After many different antidepressants, the only drug to temporarily lift my anxious depression is lorazepam (a benzo), which of course leads to addiction and doesnt work in the long run anyway, but it also works on that GABA/AMPA-receptors.
I have found 2 companies now that produce HNK at a high purity of 99%. The companies reside in UK and USA and seem to be reliable. Price would be around U$ 3,000 for 1 gram. That would be 50 dosages a 20 mg.
Anyone interested?
Edited by hnk6, 22 August 2016 - 04:59 PM.
Posted 22 August 2016 - 05:05 PM
I am in for 250mg at 750 usd, pending confirmation of details. I.e. I would like to reserve 1/4 but prefer not to commit until the arrangement has been vetted to my satisfaction. (Please deem actual receipt of funds to constitute confirmed commitment.)
Posted 23 August 2016 - 07:54 AM
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